Protein: HIPK2
Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1)

Gene: HIPK2
Organism: Homo sapiens
Interactions: 89
UniProt ID: Q9H2X6

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001654 - eye development
GO:0001934 - positive regulation of protein phosphorylation
GO:0003016 - respiratory system process
GO:0003713 - transcription coactivator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1329771

HIPK2
Homeodomain-interacting protein kinase 2

6

17

Small-scale

0.942

High

170718

AXIN1
Axin-1

3

4

Small-scale

0.827

High

1122503

ACTBL
Beta-actin-like protein 2

2

10

High-throughput

0.789

High

201433

M3K7
Mitogen-activated protein kinase kinase kinase 7

2

20

Small-scale

0.777

High

387496

P53
Cellular tumor antigen p53

12

15

Small-scale

0.760

High

1329778

ZBTB4
Zinc finger and BTB domain-containing protein 4

1

3

Small-scale

0.756

High

337559

ABL1
Tyrosine-protein kinase ABL1

1

20

Small-scale

0.747

High

1216711

SIAH1
E3 ubiquitin-protein ligase SIAH1

5

12

Small-scale

0.732

High

930386

UBC9
SUMO-conjugating enzyme UBC9

5

13

Small-scale

0.719

High

668974

PML
Protein PML

4

20

Small-scale

0.694

High

1028431

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

20

Small-scale

0.691

High

962969

MDM2
E3 ubiquitin-protein ligase Mdm2

3

8

Small-scale

0.686

High

903022

DCAF7
DDB1- and CUL4-associated factor 7

3

18

Small-scale

0.680

High

1329779

NLK
Serine/threonine-protein kinase NLK

1

18

Small-scale

0.680

High

928194

SUMO1
Small ubiquitin-related modifier 1

3

8

Small-scale

0.667

High

1329781

DAXX
Death domain-associated protein 6

3

3

Small-scale

0.664

High

999086

EP300
Histone acetyltransferase p300

2

19

Small-scale

0.657

High

385510

NTRK1
High affinity nerve growth factor receptor

1

20

Small-scale

0.647

High

486830

MYB
Transcriptional activator Myb

2

20

Small-scale

0.636

High

199145

SIAH2
E3 ubiquitin-protein ligase SIAH2

2

16

Small-scale

0.634

High

214371

SPOP
Speckle-type POZ protein

2

5

Small-scale

0.634

High

1312691

MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

1

20

High-throughput

0.621

High

964433

RUNX1
Runt-related transcription factor 1

1

1

Small-scale

0.620

High

1044150

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

17

Small-scale

0.618

High

1329785

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

1

20

Small-scale

0.618

High

1329772

P63
Tumor protein 63

2

15

Small-scale

0.594

High

848125

MECP2
Methyl-CpG-binding protein 2

1

7

Small-scale

0.578

High

1087399

H2B2E
Histone H2B type 2-E

1

20

Small-scale

0.578

High

1289433

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

16

Small-scale

0.578

High

1310137

LZTS2
Leucine zipper putative tumor suppressor 2

2

20

High-throughput

0.574

High

455862

PARP1
Poly [ADP-ribose] polymerase 1

1

16

Small-scale

0.561

High

521302

SKI
Ski oncogene

1

5

Small-scale

0.561

High

641560

PAX6
Paired box protein Pax-6

1

7

Small-scale

0.561

High

1027254

CBX3
Chromobox protein homolog 3

1

4

Small-scale

0.561

High

1078758

SMAD1
Mothers against decapentaplegic homolog 1

1

18

Small-scale

0.561

High

1080778

ZYX
Zyxin

1

17

Small-scale

0.561

High

1065185

DAZP2
DAZ-associated protein 2

1

0

Small-scale

0.554

High

1301784

RANB9
Ran-binding protein 9

1

17

Small-scale

0.552

High

1329786

WSB1
WD repeat and SOCS box-containing protein 1

1

19

Small-scale

0.542

High

1283553

T53I1
Tumor protein p53-inducible nuclear protein 1

1

0

Small-scale

0.537

High

1329776

AATF
Protein AATF

1

0

Small-scale

0.537

High

1044702

FHL3
Four and a half LIM domains protein 3

1

15

High-throughput

0.536

High

1050780

FHL2
Four and a half LIM domains protein 2

1

15

High-throughput

0.536

High

1285140

RGMA
Repulsive guidance molecule A

1

1

High-throughput

0.536

High

980647

TLE1
Transducin-like enhancer protein 1

1

19

Small-scale

0.527

High

1188062

SETX
Probable helicase senataxin

1

6

Small-scale

0.508

High

1329773

CHM4B
Charged multivesicular body protein 4b

1

4

High-throughput

0.508

High

362105

MBP
Myelin basic protein

1

1

Small-scale

0.501

High

486862

MYBA
Myb-related protein A

1

20

Small-scale

0.501

High

565031

HMGA1
High mobility group protein HMG-I/HMG-Y

1

2

Small-scale

0.501

High

879151

SUMO3
Small ubiquitin-related modifier 3

1

8

Small-scale

0.501

High

902752

SUMO2
Small ubiquitin-related modifier 2

1

8

Small-scale

0.501

High

950281

SMAD3
Mothers against decapentaplegic homolog 3

1

18

Small-scale

0.501

High

1078658

SMAD2
Mothers against decapentaplegic homolog 2

1

18

Small-scale

0.501

High

1329777

SENP1
Sentrin-specific protease 1

1

2

Small-scale

0.501

High

987232

MEF2C
Myocyte-specific enhancer factor 2C

1

7

Small-scale

0.500

High

175925

P73
Tumor protein p73

1

15

Small-scale

0.481

High

799149

NKX21
Homeobox protein Nkx-2.1

1

4

Small-scale

0.481

High

123320

CBX4
E3 SUMO-protein ligase CBX4

1

4

Small-scale

0.479

High

169307

MDM4
Protein Mdm4

1

8

Small-scale

0.479

High

206857

FOXO3
Forkhead box protein O3

1

13

Small-scale

0.479

High

303479

HEXI1
Protein HEXIM1

1

6

High-throughput

0.479

High

486967

MYBB
Myb-related protein B

1

20

Small-scale

0.479

High

487758

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

507506

ERG
Transcriptional regulator ERG

1

2

High-throughput

0.479

High

617374

SP100
Nuclear autoantigen Sp-100

1

19

Small-scale

0.479

High

881285

CTBP2
C-terminal-binding protein 2

1

13

High-throughput

0.479

High

1020922

TRAF2
TNF receptor-associated factor 2

1

15

Small-scale

0.479

High

1032606

CTBP1
C-terminal-binding protein 1

1

13

High-throughput

0.479

High

1038055

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

5

Small-scale

0.479

High

1041196

CUL1
Cullin-1

1

15

Small-scale

0.479

High

1151554

XAF1
XIAP-associated factor 1

1

2

Small-scale

0.479

High

1260907

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.479

High

1270792

CBP
CREB-binding protein

1

18

Small-scale

0.479

High

1273635

DVL3
Segment polarity protein dishevelled homolog DVL-3

1

20

Small-scale

0.479

High

1281385

FBXW7
F-box/WD repeat-containing protein 7

1

20

Small-scale

0.479

High

1329774

SENP2
Sentrin-specific protease 2

1

2

Small-scale

0.479

High

1329780

ZMYM2
Zinc finger MYM-type protein 2

1

1

High-throughput

0.479

High

1329782

FBX3
F-box only protein 3

1

1

Small-scale

0.479

High

1329783

CHIP
E3 ubiquitin-protein ligase CHIP

1

15

Small-scale

0.479

High

1329784

FBW1A
F-box/WD repeat-containing protein 1A

1

20

Small-scale

0.479

High

1075536

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

0

Small-scale

0.458

High

1245338

KNL1
Kinetochore scaffold 1

1

0

High-throughput

0.458

High

1046167

DX39B
Spliceosome RNA helicase DDX39B

1

18

Small-scale

0.457

High

1295235

SPTCS
Spatacsin

1

0

Small-scale

0.438

High

1298795

CF418
Cilia- and flagella-associated protein 418

1

0

Small-scale

0.438

High

1329775

DISC1
Disrupted in schizophrenia 1 protein

1

3

High-throughput

0.417

High

449004

GROA
Growth-regulated alpha protein

1

0

Small-scale

0.292

High


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Last updated: 15 Jul 2024