Protein: SIK1
Serine/threonine-protein kinase SIK1 (EC 2.7.11.1) (Salt-inducible kinase 1) (SIK-1) (Serine/threonine-protein kinase SNF1-like kinase 1) (Serine/threonine-protein kinase SNF1LK)

Gene: SIK1
Organism: Homo sapiens
Interactions: 64
UniProt ID: P57059

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0002028 - regulation of sodium ion transport
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

883234

SIK2
Serine/threonine-protein kinase SIK2

2

18

High-throughput

0.811

High

883243

SIK3
Serine/threonine-protein kinase SIK3

2

18

High-throughput

0.811

High

883233

SLD5
DNA replication complex GINS protein SLD5

5

1

Small-scale

0.725

High

883214

1433E
14-3-3 protein epsilon

4

20

Small-scale

0.683

High

883215

1433Z
14-3-3 protein zeta/delta

3

20

Small-scale

0.681

High

646758

1433T
14-3-3 protein theta

3

20

Small-scale

0.656

High

568603

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

13

Small-scale

0.647

High

883224

STK11
Serine/threonine-protein kinase STK11

1

19

Small-scale

0.647

High

201283

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

7

Small-scale

0.618

High

672056

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

9

High-throughput

0.618

High

681760

AKT1
RAC-alpha serine/threonine-protein kinase

1

16

Small-scale

0.618

High

883219

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

18

Small-scale

0.618

High

683233

1433B
14-3-3 protein beta/alpha

2

20

Small-scale

0.611

High

883212

1433G
14-3-3 protein gamma

2

20

Small-scale

0.611

High

883218

1433F
14-3-3 protein eta

2

20

Small-scale

0.611

High

883240

HDAC5
Histone deacetylase 5

2

10

Small-scale

0.602

High

883241

PSF2
DNA replication complex GINS protein PSF2

2

0

High-throughput

0.602

High

832276

MCM2
DNA replication licensing factor MCM2

1

3

Small-scale

0.561

High

883230

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

11

Small-scale

0.561

High

883232

RING2
E3 ubiquitin-protein ligase RING2

1

5

Small-scale

0.561

High

123889

SPT5H
Transcription elongation factor SPT5

1

1

High-throughput

0.541

High

759954

RL3
Large ribosomal subunit protein uL3

1

2

High-throughput

0.541

High

198426

KLK10
Kallikrein-10

1

2

High-throughput

0.536

High

397018

PAI2
Plasminogen activator inhibitor 2

1

1

High-throughput

0.536

High

443431

VIME
Vimentin

1

6

High-throughput

0.536

High

470309

H2A1
Histone H2A type 1

1

2

High-throughput

0.536

High

533969

ANXA8
Annexin A8

1

1

High-throughput

0.536

High

594236

MX1
Interferon-induced GTP-binding protein Mx1

1

1

High-throughput

0.536

High

737285

LONM
Lon protease homolog, mitochondrial

1

4

High-throughput

0.536

High

815964

ATPO
ATP synthase subunit O, mitochondrial

1

1

High-throughput

0.536

High

851797

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

1

High-throughput

0.536

High

883211

DCAF7
DDB1- and CUL4-associated factor 7

1

4

High-throughput

0.536

High

883235

NMNA1
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

1

0

High-throughput

0.518

High

543009

GLNA
Glutamine synthetase

1

0

High-throughput

0.513

High

682540

ABC3A
DNA dC->dU-editing enzyme APOBEC-3A

1

0

High-throughput

0.513

High

883221

EXOS2
Exosome complex component RRP4

1

0

High-throughput

0.513

High

883231

SIN3A
Paired amphipathic helix protein Sin3a

1

0

High-throughput

0.513

High

496670

TAU
Microtubule-associated protein tau

1

8

Small-scale

0.501

High

883226

CRTC2
CREB-regulated transcription coactivator 2

1

6

Small-scale

0.501

High

451658

CLCB
Clathrin light chain B

1

2

High-throughput

0.489

High

661223

S10A2
Protein S100-A2

1

2

High-throughput

0.489

High

701679

DSG3
Desmoglein-3

1

3

High-throughput

0.489

High

883217

PITX1
Pituitary homeobox 1

1

1

High-throughput

0.481

High

883227

LHX8
LIM/homeobox protein Lhx8

1

1

High-throughput

0.481

High

883236

PRDC1
Phosphoribosyltransferase domain-containing protein 1

1

1

High-throughput

0.481

High

162557

XPO1
Exportin-1

1

4

High-throughput

0.479

High

308544

KI20A
Kinesin-like protein KIF20A

1

3

High-throughput

0.479

High

650809

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

Small-scale

0.479

High

683925

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

883216

EF1A1
Elongation factor 1-alpha 1

1

4

Small-scale

0.479

High

883228

FBX22
F-box only protein 22

1

1

Small-scale

0.479

High

883229

APBP2
Amyloid protein-binding protein 2

1

1

Small-scale

0.479

High

883237

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

3

Small-scale

0.479

High

776631

STAT3
Signal transducer and activator of transcription 3

1

0

Small-scale

0.458

High

883220

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

Small-scale

0.458

High

883225

H2B2E
Histone H2B type 2-E

1

0

Small-scale

0.458

High

883213

TIM10
Mitochondrial import inner membrane translocase subunit Tim10

1

1

High-throughput

0.439

High

883222

MESD
LRP chaperone MESD

1

1

High-throughput

0.439

High

596525

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

High-throughput

0.426

High

654211

CALX
Calnexin

1

0

High-throughput

0.279

Low

883223

RRS1
Ribosome biogenesis regulatory protein homolog

1

0

High-throughput

0.279

Low

883238

IL36G
Interleukin-36 gamma

1

0

High-throughput

0.279

Low

883239

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

High-throughput

0.279

Low

883242

NCKP1
Nck-associated protein 1

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024