Protein: SIK2
Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2)

Gene: SIK2
Organism: Homo sapiens
Interactions: 106
UniProt ID: Q9H0K1

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

883234

SIK1
Serine/threonine-protein kinase SIK1

2

18

High-throughput

0.811

High

875301

TERA
Transitional endoplasmic reticulum ATPase

4

6

Small-scale

0.697

High

727031

FUS
RNA-binding protein FUS

1

2

High-throughput

0.691

High

822151

KC1A
Casein kinase I isoform alpha

1

17

High-throughput

0.691

High

1316198

DUS16
Dual specificity protein phosphatase 16

1

4

High-throughput

0.691

High

910013

1433E
14-3-3 protein epsilon

3

20

Small-scale

0.667

High

647266

1433T
14-3-3 protein theta

3

20

Small-scale

0.656

High

682207

AKT2
RAC-beta serine/threonine-protein kinase

1

13

Small-scale

0.647

High

1327874

SIK2
Serine/threonine-protein kinase SIK2

1

17

Small-scale

0.647

High

1327883

2ABG
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform

4

5

Small-scale

0.633

High

1120147

CRTC2
CREB-regulated transcription coactivator 2

2

6

Small-scale

0.629

High

124525

TULP2
Tubby-related protein 2

2

1

High-throughput

0.628

High

161452

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

4

Small-scale

0.618

High

225158

MYPT2
Protein phosphatase 1 regulatory subunit 12B

1

4

Small-scale

0.618

High

256055

OBSL1
Obscurin-like protein 1

1

1

High-throughput

0.618

High

433470

YES
Tyrosine-protein kinase Yes

1

6

Small-scale

0.618

High

521610

ACTN1
Alpha-actinin-1

1

4

Small-scale

0.618

High

568791

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

12

High-throughput

0.618

High

624365

MYL9
Myosin regulatory light polypeptide 9

1

9

Small-scale

0.618

High

672294

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

11

Small-scale

0.618

High

892025

ACTB
Actin, cytoplasmic 1

1

4

Small-scale

0.618

High

894405

CDC42
Cell division control protein 42 homolog

1

20

Small-scale

0.618

High

896819

ARP3
Actin-related protein 3

1

3

Small-scale

0.618

High

896970

ARP2
Actin-related protein 2

1

5

Small-scale

0.618

High

1025211

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

18

Small-scale

0.618

High

1122497

ACTBL
Beta-actin-like protein 2

1

4

Small-scale

0.618

High

927511

1433Z
14-3-3 protein zeta/delta

2

20

Small-scale

0.611

High

1029857

TIF1B
Transcription intermediary factor 1-beta

2

4

Small-scale

0.611

High

1327882

HDAC5
Histone deacetylase 5

2

10

Small-scale

0.602

High

927874

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

3

5

Small-scale

0.578

High

672472

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

11

Small-scale

0.575

High

612116

PROZ
Vitamin K-dependent protein Z

2

1

High-throughput

0.574

High

891314

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

2

High-throughput

0.573

High

930991

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

2

9

Small-scale

0.571

High

1313528

CP250
Centrosome-associated protein CEP250

1

9

Small-scale

0.561

High

999077

EP300
Histone acetyltransferase p300

1

6

Small-scale

0.561

High

1164913

CRTC3
CREB-regulated transcription coactivator 3

1

5

Small-scale

0.561

High

1281380

FBXW7
F-box/WD repeat-containing protein 7

1

4

Small-scale

0.561

High

905098

1433G
14-3-3 protein gamma

1

20

High-throughput

0.554

High

982480

1433F
14-3-3 protein eta

1

20

High-throughput

0.554

High

639078

S100P
Protein S100-P

1

2

High-throughput

0.536

High

683699

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.536

High

858326

TXTP
Tricarboxylate transport protein, mitochondrial

1

5

High-throughput

0.536

High

871773

HSP72
Heat shock-related 70 kDa protein 2

1

4

High-throughput

0.536

High

933607

TBA4A
Tubulin alpha-4A chain

1

3

High-throughput

0.536

High

1283456

SPSB4
SPRY domain-containing SOCS box protein 4

1

8

High-throughput

0.536

High

1327876

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.536

High

388716

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.513

High

839120

EMD
Emerin

1

0

High-throughput

0.513

High

1313633

LRC61
Leucine-rich repeat-containing protein 61

1

0

High-throughput

0.513

High

395726

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

655461

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

1

Small-scale

0.501

High

1024092

ACACA
Acetyl-CoA carboxylase 1

1

6

Small-scale

0.501

High

661437

S10A2
Protein S100-A2

1

2

High-throughput

0.489

High

1056244

I13R2
Interleukin-13 receptor subunit alpha-2

1

2

High-throughput

0.489

High

1327879

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

3

High-throughput

0.489

High

163256

XPO1
Exportin-1

1

4

High-throughput

0.479

High

168829

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

3

Small-scale

0.479

High

168974

ARPC2
Actin-related protein 2/3 complex subunit 2

1

1

Small-scale

0.479

High

176640

FANCA
Fanconi anemia group A protein

1

1

Small-scale

0.479

High

181351

ARPC5
Actin-related protein 2/3 complex subunit 5

1

1

Small-scale

0.479

High

209164

NCK2
Cytoplasmic protein NCK2

1

5

High-throughput

0.479

High

211660

ACTN4
Alpha-actinin-4

1

4

Small-scale

0.479

High

444784

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

1

Small-scale

0.479

High

598313

FLNA
Filamin-A

1

5

Small-scale

0.479

High

684316

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

714402

HSP74
Heat shock 70 kDa protein 4

1

6

Small-scale

0.479

High

725010

MYH9
Myosin-9

1

11

Small-scale

0.479

High

725242

MYH10
Myosin-10

1

11

Small-scale

0.479

High

728513

MYH11
Myosin-11

1

11

Small-scale

0.479

High

738035

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

10

Small-scale

0.479

High

809431

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

2

Small-scale

0.479

High

877577

CAD13
Cadherin-13

1

4

Small-scale

0.479

High

906123

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

9

Small-scale

0.479

High

906593

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

9

Small-scale

0.479

High

928460

DYL1
Dynein light chain 1, cytoplasmic

1

1

Small-scale

0.479

High

1052312

SRC8
Src substrate cortactin

1

5

Small-scale

0.479

High

1189798

MYH14
Myosin-14

1

11

Small-scale

0.479

High

1270210

ARC1A
Actin-related protein 2/3 complex subunit 1A

1

3

Small-scale

0.479

High

1300077

SMG1
Serine/threonine-protein kinase SMG1

1

4

Small-scale

0.479

High

1308631

ARP5L
Actin-related protein 2/3 complex subunit 5-like protein

1

1

Small-scale

0.479

High

1327875

YTDC2
3'-5' RNA helicase YTHDC2

1

3

Small-scale

0.479

High

1327880

FBW1B
F-box/WD repeat-containing protein 11

1

4

High-throughput

0.479

High

169130

ARPC3
Actin-related protein 2/3 complex subunit 3

1

0

Small-scale

0.458

High

534217

CD59
CD59 glycoprotein

1

0

Small-scale

0.458

High

545033

AMPN
Aminopeptidase N

1

0

Small-scale

0.458

High

547589

FOLR1
Folate receptor alpha

1

0

Small-scale

0.458

High

887498

ARPC4
Actin-related protein 2/3 complex subunit 4

1

0

Small-scale

0.458

High

946307

BASP1
Brain acid soluble protein 1

1

0

Small-scale

0.458

High

958766

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

5

High-throughput

0.442

High

166308

GRRE1
Granule associated Rac and RHOG effector protein 1

1

3

High-throughput

0.437

High

434431

TPM2
Tropomyosin beta chain

1

4

Small-scale

0.437

High

441677

MYL3
Myosin light chain 3

1

9

Small-scale

0.437

High

451729

CLCB
Clathrin light chain B

1

2

Small-scale

0.437

High

537181

CBPM
Carboxypeptidase M

1

1

Small-scale

0.437

High

891601

MYL6
Myosin light polypeptide 6

1

9

Small-scale

0.437

High

984661

CALD1
Caldesmon

1

13

Small-scale

0.437

High

1299935

FMNL2
Formin-like protein 2

1

2

Small-scale

0.437

High

1327878

LIMA1
LIM domain and actin-binding protein 1

1

2

Small-scale

0.437

High

1327881

COR1C
Coronin-1C

1

6

Small-scale

0.437

High

324023

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.279

Low

1257308

SHRM3
Protein Shroom3

1

0

High-throughput

0.279

Low

1290936

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.279

Low

398478

PPBT
Alkaline phosphatase, tissue-nonspecific isozyme

1

0

Small-scale

0.249

Low

1327877

ENAM
Enamelin

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024