Protein: SMAD7
Mothers against decapentaplegic homolog 7 (MAD homolog 7) (Mothers against DPP homolog 7) (Mothers against decapentaplegic homolog 8) (MAD homolog 8) (Mothers against DPP homolog 8) (SMAD family member 7) (SMAD 7) (Smad7) (hSMAD7)

Gene: SMAD7
Organism: Homo sapiens
Interactions: 113
UniProt ID: O15105

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0001650 - fibrillar center
GO:0001657 - ureteric bud development
GO:0002725 - negative regulation of T cell cytokine production

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

167356

SMAD4
Mothers against decapentaplegic homolog 4

4

18

Small-scale

0.896

High

167312

SMAD6
Mothers against decapentaplegic homolog 6

2

19

Small-scale

0.800

High

167366

SMAD2
Mothers against decapentaplegic homolog 2

2

18

Small-scale

0.768

High

167394

SMUF2
E3 ubiquitin-protein ligase SMURF2

19

20

Small-scale

0.766

High

167338

TGFR1
TGF-beta receptor type-1

19

20

Small-scale

0.763

High

167395

SMUF1
E3 ubiquitin-protein ligase SMURF1

14

20

Small-scale

0.761

High

167349

SMAD3
Mothers against decapentaplegic homolog 3

1

18

Small-scale

0.713

High

167343

YAP1
Transcriptional coactivator YAP1

3

20

Small-scale

0.696

High

167384

ITCH
E3 ubiquitin-protein ligase Itchy homolog

4

20

Small-scale

0.691

High

167385

NED4L
E3 ubiquitin-protein ligase NEDD4-like

3

20

Small-scale

0.689

High

167371

RN111
E3 ubiquitin-protein ligase Arkadia

4

9

Small-scale

0.680

High

125003

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

3

20

Small-scale

0.675

High

167357

HDAC1
Histone deacetylase 1

3

12

Small-scale

0.664

High

167337

ACV1B
Activin receptor type-1B

3

20

Small-scale

0.657

High

167309

HDAC3
Histone deacetylase 3

3

12

Small-scale

0.640

High

167339

TGFR2
TGF-beta receptor type-2

3

20

Small-scale

0.640

High

167393

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

3

20

Small-scale

0.640

High

167414

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

3

13

Small-scale

0.640

High

167374

PIAS4
E3 SUMO-protein ligase PIAS4

2

16

Small-scale

0.627

High

167308

SMAD9
Mothers against decapentaplegic homolog 9

1

18

Small-scale

0.618

High

167326

SKI
Ski oncogene

1

16

Small-scale

0.618

High

167367

SMAD1
Mothers against decapentaplegic homolog 1

1

18

Small-scale

0.618

High

167307

AXIN1
Axin-1

2

6

Small-scale

0.601

High

167334

CTNB1
Catenin beta-1

2

5

Small-scale

0.601

High

167365

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

2

4

Small-scale

0.601

High

167368

MK14
Mitogen-activated protein kinase 14

2

6

Small-scale

0.601

High

167406

LEF1
Lymphoid enhancer-binding factor 1

2

20

Small-scale

0.601

High

167401

RNF12
E3 ubiquitin-protein ligase RLIM

2

8

Small-scale

0.595

High

167412

AXIN2
Axin-2

2

6

Small-scale

0.595

High

167380

CSN5
COP9 signalosome complex subunit 5

1

5

Small-scale

0.594

High

167336

BMR1A
Bone morphogenetic protein receptor type-1A

2

20

Small-scale

0.584

High

167342

NEDD4
E3 ubiquitin-protein ligase NEDD4

2

20

Small-scale

0.584

High

167344

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

2

16

Small-scale

0.584

High

167378

HDAC2
Histone deacetylase 2

2

12

Small-scale

0.584

High

167398

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

2

1

Small-scale

0.584

High

167404

HDAC6
Histone deacetylase 6

2

17

Small-scale

0.584

High

167410

HDAC5
Histone deacetylase 5

2

17

Small-scale

0.584

High

167413

STRAP
Serine-threonine kinase receptor-associated protein

2

8

Small-scale

0.584

High

167370

OTUD1
OTU domain-containing protein 1

2

1

Small-scale

0.579

High

167314

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

13

Small-scale

0.578

High

167351

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.578

High

167310

TGFI1
Transforming growth factor beta-1-induced transcript 1 protein

1

13

Small-scale

0.561

High

167331

CBL
E3 ubiquitin-protein ligase CBL

1

3

Small-scale

0.561

High

167340

ZEB1
Zinc finger E-box-binding homeobox 1

1

20

Small-scale

0.561

High

167382

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

1

Small-scale

0.561

High

167415

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

7

Small-scale

0.561

High

167321

STABP
STAM-binding protein

1

3

Small-scale

0.552

High

167347

FKB1A
Peptidyl-prolyl cis-trans isomerase FKBP1A

1

1

Small-scale

0.543

High

167400

ANM7
Protein arginine N-methyltransferase 7

1

5

High-throughput

0.536

High

167403

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

4

Small-scale

0.529

High

167315

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

Small-scale

0.529

High

167311

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

8

Small-scale

0.515

High

167375

TAB3
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

1

3

Small-scale

0.515

High

167318

PSMG1
Proteasome assembly chaperone 1

1

0

High-throughput

0.513

High

167319

VNN1
Pantetheinase

1

0

High-throughput

0.513

High

167381

PSMG2
Proteasome assembly chaperone 2

1

0

High-throughput

0.513

High

167402

DCA16
DDB1- and CUL4-associated factor 16

1

0

High-throughput

0.513

High

167316

PIAS1
E3 SUMO-protein ligase PIAS1

1

16

High-throughput

0.508

High

167320

ZBT11
Zinc finger and BTB domain-containing protein 11

1

4

High-throughput

0.508

High

167328

XRCC6
X-ray repair cross-complementing protein 6

1

1

High-throughput

0.508

High

167329

MYOD1
Myoblast determination protein 1

1

4

High-throughput

0.508

High

167335

SOX5
Transcription factor SOX-5

1

20

High-throughput

0.508

High

167363

TTF1
Transcription termination factor 1

1

1

High-throughput

0.508

High

167373

CXXC5
CXXC-type zinc finger protein 5

1

3

High-throughput

0.508

High

167388

SOX7
Transcription factor SOX-7

1

14

High-throughput

0.508

High

167396

HEYL
Hairy/enhancer-of-split related with YRPW motif-like protein

1

6

High-throughput

0.508

High

167399

ASH1L
Histone-lysine N-methyltransferase ASH1L

1

11

High-throughput

0.508

High

167405

ZN107
Zinc finger protein 107

1

1

High-throughput

0.508

High

167407

MRTFB
Myocardin-related transcription factor B

1

9

High-throughput

0.508

High

167408

SOX13
Transcription factor SOX-13

1

20

High-throughput

0.508

High

167409

TTF2
Transcription termination factor 2

1

5

High-throughput

0.508

High

167411

KDM2A
Lysine-specific demethylase 2A

1

3

High-throughput

0.508

High

150650

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

18

Small-scale

0.501

High

167376

PARD3
Partitioning defective 3 homolog

1

6

Small-scale

0.501

High

167377

SETD7
Histone-lysine N-methyltransferase SETD7

1

2

Small-scale

0.501

High

167386

ERBIN
Erbin

1

10

Small-scale

0.501

High

153491

ANM5
Protein arginine N-methyltransferase 5

1

4

Small-scale

0.479

High

154072

OVOL1
Putative transcription factor Ovo-like 1

1

10

Small-scale

0.479

High

167313

MED24
Mediator of RNA polymerase II transcription subunit 24

1

5

Small-scale

0.479

High

167317

TRI37
E3 ubiquitin-protein ligase TRIM37

1

5

Small-scale

0.479

High

167322

MYC
Myc proto-oncogene protein

1

11

Small-scale

0.479

High

167323

P53
Cellular tumor antigen p53

1

4

Small-scale

0.479

High

167324

PAI1
Plasminogen activator inhibitor 1

1

3

Small-scale

0.479

High

167325

SRF
Serum response factor

1

3

Small-scale

0.479

High

167327

CADH1
Cadherin-1

1

4

Small-scale

0.479

High

167330

EGR1
Early growth response protein 1

1

6

Small-scale

0.479

High

167332

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

12

Small-scale

0.479

High

167333

AKT1
RAC-alpha serine/threonine-protein kinase

1

9

Small-scale

0.479

High

167341

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

17

Small-scale

0.479

High

167345

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

1

17

Small-scale

0.479

High

167350

ACVR1
Activin receptor type-1

1

20

Small-scale

0.479

High

167352

BAMBI
BMP and activin membrane-bound inhibitor homolog

1

1

Small-scale

0.479

High

167354

SKP2
S-phase kinase-associated protein 2

1

4

Small-scale

0.479

High

167355

ATM
Serine-protein kinase ATM

1

1

Small-scale

0.479

High

167358

CUL4A
Cullin-4A

1

7

High-throughput

0.479

High

167359

CUL4B
Cullin-4B

1

7

High-throughput

0.479

High

167360

AVR2B
Activin receptor type-2B

1

20

Small-scale

0.479

High

167361

BMPR2
Bone morphogenetic protein receptor type-2

1

20

Small-scale

0.479

High

167362

HERC3
Probable E3 ubiquitin-protein ligase HERC3

1

20

Small-scale

0.479

High

167364

T22D1
TSC22 domain family protein 1

1

10

Small-scale

0.479

High

167369

TBR1
T-box brain protein 1

1

6

Small-scale

0.479

High

167372

ARK2C
E3 ubiquitin-protein ligase ARK2C

1

10

Small-scale

0.479

High

167379

KAT2B
Histone acetyltransferase KAT2B

1

13

Small-scale

0.479

High

167383

STALP
AMSH-like protease

1

3

Small-scale

0.479

High

167387

OVOL2
Transcription factor Ovo-like 2

1

10

Small-scale

0.479

High

167389

UBP26
Ubiquitin carboxyl-terminal hydrolase 26

1

16

Small-scale

0.479

High

167390

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

1

4

Small-scale

0.479

High

167391

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

2

Small-scale

0.479

High

167397

TF7L2
Transcription factor 7-like 2

1

20

Small-scale

0.479

High

167346

PSME3
Proteasome activator complex subunit 3

1

0

Small-scale

0.458

High

167392

TOLIP
Toll-interacting protein

1

0

Small-scale

0.458

High

167348

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

1

Small-scale

0.408

High

167353

CHIT1
Chitotriosidase-1

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024