Protein: BRAF
Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1)

Gene: BRAF
Organism: Homo sapiens
Interactions: 175
UniProt ID: P15056

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0002318 - myeloid progenitor cell differentiation
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004708 - MAP kinase kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

542865

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

23

20

Small-scale

0.993

High

373632

RAF1
RAF proto-oncogene serine/threonine-protein kinase

24

17

Small-scale

0.990

High

349101

RASH
GTPase HRas

16

20

Small-scale

0.984

High

542857

1433Z
14-3-3 protein zeta/delta

15

20

High-throughput

0.984

High

542847

1433G
14-3-3 protein gamma

13

20

High-throughput

0.982

High

542827

1433B
14-3-3 protein beta/alpha

14

20

Small-scale

0.982

High

542820

1433T
14-3-3 protein theta

13

20

Small-scale

0.980

High

542849

1433E
14-3-3 protein epsilon

10

11

High-throughput

0.975

High

542868

1433F
14-3-3 protein eta

9

20

High-throughput

0.974

High

542832

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

10

20

Small-scale

0.973

High

349847

RASK
GTPase KRas

9

20

High-throughput

0.968

High

488557

ARAF
Serine/threonine-protein kinase A-Raf

8

15

Small-scale

0.968

High

348493

RASN
GTPase NRas

9

20

Small-scale

0.968

High

542810

BRAF
Serine/threonine-protein kinase B-raf

8

17

Small-scale

0.964

High

542828

1433S
14-3-3 protein sigma

7

20

High-throughput

0.954

High

542837

IQGA1
Ras GTPase-activating-like protein IQGAP1

4

11

Small-scale

0.906

High

542929

KS6B2
Ribosomal protein S6 kinase beta-2

3

17

Small-scale

0.853

High

542852

RAP1A
Ras-related protein Rap-1A

3

20

Small-scale

0.834

High

542908

ITCH
E3 ubiquitin-protein ligase Itchy homolog

2

13

Small-scale

0.819

High

542826

AKT1
RAC-alpha serine/threonine-protein kinase

2

18

Small-scale

0.812

High

542876

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

2

15

High-throughput

0.789

High

542822

MK01
Mitogen-activated protein kinase 1

2

20

Small-scale

0.778

High

542864

KPCE
Protein kinase C epsilon type

2

12

Small-scale

0.776

High

542896

KSR1
Kinase suppressor of Ras 1

2

17

Small-scale

0.776

High

153076

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

2

20

Small-scale

0.768

High

542875

M3K1
Mitogen-activated protein kinase kinase kinase 1

2

14

Small-scale

0.768

High

542909

NED4L
E3 ubiquitin-protein ligase NEDD4-like

2

13

Small-scale

0.768

High

542884

RHEB
GTP-binding protein Rheb

2

20

Small-scale

0.754

High

542915

SPTN4
Spectrin beta chain, non-erythrocytic 4

2

8

High-throughput

0.737

High

542886

CDC37
Hsp90 co-chaperone Cdc37

6

11

High-throughput

0.729

High

431496

HS90A
Heat shock protein HSP 90-alpha

6

20

Small-scale

0.719

High

437860

HS90B
Heat shock protein HSP 90-beta

5

20

High-throughput

0.706

High

501634

BIP
Endoplasmic reticulum chaperone BiP

5

15

High-throughput

0.706

High

542873

PAK2
Serine/threonine-protein kinase PAK 2

1

17

High-throughput

0.698

High

542842

LIMK1
LIM domain kinase 1

1

14

High-throughput

0.691

High

503368

HSP7C
Heat shock cognate 71 kDa protein

4

10

High-throughput

0.683

High

542834

GRP75
Stress-70 protein, mitochondrial

4

20

High-throughput

0.683

High

542897

RPTOR
Regulatory-associated protein of mTOR

3

10

High-throughput

0.650

High

160356

AURKA
Aurora kinase A

1

12

High-throughput

0.647

High

542836

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

20

High-throughput

0.647

High

542840

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

1

20

High-throughput

0.647

High

542885

STK11
Serine/threonine-protein kinase STK11

1

7

High-throughput

0.647

High

542923

LATS2
Serine/threonine-protein kinase LATS2

1

20

High-throughput

0.647

High

542924

RASF1
Ras association domain-containing protein 1

1

12

High-throughput

0.647

High

421280

LIPF
Gastric triacylglycerol lipase

3

0

High-throughput

0.638

High

388199

HSPB1
Heat shock protein beta-1

3

2

High-throughput

0.633

High

542930

DJB11
DnaJ homolog subfamily B member 11

3

10

High-throughput

0.633

High

542867

KCNC4
Potassium voltage-gated channel subfamily C member 4

2

5

High-throughput

0.628

High

542877

DELE1
DAP3-binding cell death enhancer 1

2

1

High-throughput

0.628

High

542931

ARMX3
Armadillo repeat-containing X-linked protein 3

2

3

High-throughput

0.628

High

542932

FKBPL
FK506-binding protein-like

2

16

High-throughput

0.628

High

542821

MK03
Mitogen-activated protein kinase 3

1

20

High-throughput

0.621

High

156090

RASM
Ras-related protein M-Ras

1

20

Small-scale

0.618

High

254868

CPNE3
Copine-3

1

5

High-throughput

0.618

High

435525

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.618

High

542813

KPCA
Protein kinase C alpha type

1

14

Small-scale

0.618

High

542845

RAP1B
Ras-related protein Rap-1b

1

20

High-throughput

0.618

High

542851

RAB1A
Ras-related protein Rab-1A

1

8

High-throughput

0.618

High

542874

STK3
Serine/threonine-protein kinase 3

1

14

Small-scale

0.618

High

542883

KS6A2
Ribosomal protein S6 kinase alpha-2

1

15

Small-scale

0.618

High

542893

KSR2
Kinase suppressor of Ras 2

1

19

Small-scale

0.618

High

542914

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

13

Small-scale

0.618

High

542919

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

13

Small-scale

0.618

High

542927

MYOF
Myoferlin

1

2

High-throughput

0.618

High

542880

RB3GP
Rab3 GTPase-activating protein catalytic subunit

2

0

High-throughput

0.602

High

542887

MAPK3
MAP kinase-activated protein kinase 3

1

8

High-throughput

0.590

High

542830

HSP74
Heat shock 70 kDa protein 4

2

15

Small-scale

0.584

High

542863

VIGLN
Vigilin

2

13

Small-scale

0.584

High

542859

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

12

Small-scale

0.578

High

542823

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

20

Small-scale

0.575

High

130427

NDUA4
Cytochrome c oxidase subunit NDUFA4

2

1

High-throughput

0.571

High

423128

PDIA1
Protein disulfide-isomerase

2

7

High-throughput

0.571

High

474909

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

6

High-throughput

0.571

High

475303

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

6

High-throughput

0.571

High

542811

DESP
Desmoplakin

2

9

High-throughput

0.571

High

542812

HSP76
Heat shock 70 kDa protein 6

2

9

High-throughput

0.571

High

542815

NUCL
Nucleolin

2

11

High-throughput

0.571

High

542835

PRS6B
26S proteasome regulatory subunit 6B

2

1

High-throughput

0.571

High

542853

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

2

6

High-throughput

0.571

High

542854

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

2

6

High-throughput

0.571

High

542866

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

2

11

High-throughput

0.571

High

542892

ATD3B
ATPase family AAA domain-containing protein 3B

2

4

High-throughput

0.571

High

542926

ATD3A
ATPase family AAA domain-containing protein 3A

2

4

High-throughput

0.571

High

208091

SPY2
Protein sprouty homolog 2

1

3

Small-scale

0.561

High

214070

SPOP
Speckle-type POZ protein

1

3

Small-scale

0.561

High

542858

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

5

Small-scale

0.561

High

542911

CRBN
Protein cereblon

1

2

Small-scale

0.561

High

542918

NANOG
Homeobox protein NANOG

1

4

Small-scale

0.561

High

275717

ZN189
Zinc finger protein 189

1

2

High-throughput

0.541

High

450700

F16P1
Fructose-1,6-bisphosphatase 1

1

2

High-throughput

0.541

High

542833

DHB3
17-beta-hydroxysteroid dehydrogenase type 3

1

3

High-throughput

0.541

High

542888

GRDN
Girdin

1

11

High-throughput

0.541

High

542934

ZN510
Zinc finger protein 510

1

1

High-throughput

0.541

High

396878

HMGN1
Non-histone chromosomal protein HMG-14

1

2

High-throughput

0.536

High

469937

H2AZ
Histone H2A.Z

1

1

High-throughput

0.536

High

542819

S100P
Protein S100-P

1

10

High-throughput

0.536

High

542878

MDC1
Mediator of DNA damage checkpoint protein 1

1

8

High-throughput

0.536

High

542906

KPBB
Phosphorylase b kinase regulatory subunit beta

1

1

High-throughput

0.536

High

542910

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

8

High-throughput

0.536

High

364771

HEMO
Hemopexin

2

2

High-throughput

0.521

High

431170

CATB
Cathepsin B

2

5

High-throughput

0.521

High

542844

TMM33
Transmembrane protein 33

2

1

High-throughput

0.521

High

542917

GHC1
Mitochondrial glutamate carrier 1

2

12

High-throughput

0.521

High

542920

SDF2L
Stromal cell-derived factor 2-like protein 1

2

1

High-throughput

0.521

High

542843

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.518

High

283641

JTB
Protein JTB

1

0

High-throughput

0.513

High

542816

PTMS
Parathymosin

1

0

High-throughput

0.513

High

542895

JAZF1
Juxtaposed with another zinc finger protein 1

1

0

High-throughput

0.513

High

153986

TERT
Telomerase reverse transcriptase

1

1

High-throughput

0.501

High

542824

PEBP1
Phosphatidylethanolamine-binding protein 1

1

4

Small-scale

0.501

High

542838

RPGP1
Rap1 GTPase-activating protein 1

1

3

Small-scale

0.501

High

542905

BAD
Bcl2-associated agonist of cell death

1

2

Small-scale

0.501

High

245784

CATL2
Cathepsin L2

1

2

High-throughput

0.494

High

542916

CPVL
Probable serine carboxypeptidase CPVL

1

2

High-throughput

0.489

High

125134

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

13

Small-scale

0.479

High

135356

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

16

High-throughput

0.479

High

159326

PLD2
Phospholipase D2

1

4

High-throughput

0.479

High

226425

PRKN
E3 ubiquitin-protein ligase parkin

1

8

High-throughput

0.479

High

257018

DJC13
DnaJ homolog subfamily C member 13

1

12

High-throughput

0.479

High

257905

DNJB6
DnaJ homolog subfamily B member 6

1

9

High-throughput

0.479

High

320806

HS74L
Heat shock 70 kDa protein 4L

1

16

High-throughput

0.479

High

375866

ALDOA
Fructose-bisphosphate aldolase A

1

2

High-throughput

0.479

High

391319

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

12

High-throughput

0.479

High

403073

LA
Lupus La protein

1

14

High-throughput

0.479

High

430856

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

3

High-throughput

0.479

High

443299

VIME
Vimentin

1

6

High-throughput

0.479

High

455049

PARP1
Poly [ADP-ribose] polymerase 1

1

8

High-throughput

0.479

High

538082

ENPL
Endoplasmin

1

20

High-throughput

0.479

High

542163

PLAK
Junction plakoglobin

1

10

High-throughput

0.479

High

542814

PGAM1
Phosphoglycerate mutase 1

1

1

High-throughput

0.479

High

542817

NDKB
Nucleoside diphosphate kinase B

1

5

High-throughput

0.479

High

542818

ATPA
ATP synthase subunit alpha, mitochondrial

1

4

High-throughput

0.479

High

542825

DNJA1
DnaJ homolog subfamily A member 1

1

10

High-throughput

0.479

High

542829

PRDX2
Peroxiredoxin-2

1

5

High-throughput

0.479

High

542831

PHB1
Prohibitin 1

1

6

High-throughput

0.479

High

542839

FAS
Fatty acid synthase

1

5

High-throughput

0.479

High

542841

COPA
Coatomer subunit alpha

1

5

High-throughput

0.479

High

542848

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

11

High-throughput

0.479

High

542850

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

12

High-throughput

0.479

High

542855

AP2B1
AP-2 complex subunit beta

1

7

High-throughput

0.479

High

542856

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

11

High-throughput

0.479

High

542861

DHI2
11-beta-hydroxysteroid dehydrogenase type 2

1

4

High-throughput

0.479

High

542862

ARF5
ADP-ribosylation factor 5

1

10

High-throughput

0.479

High

542869

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

8

Small-scale

0.479

High

542870

TRAF2
TNF receptor-associated factor 2

1

11

Small-scale

0.479

High

542871

TRAF3
TNF receptor-associated factor 3

1

14

Small-scale

0.479

High

542872

REST
RE1-silencing transcription factor

1

2

High-throughput

0.479

High

542879

RRP5
Protein RRP5 homolog

1

6

High-throughput

0.479

High

542881

KIF14
Kinesin-like protein KIF14

1

5

High-throughput

0.479

High

542894

BRAP
BRCA1-associated protein

1

6

Small-scale

0.479

High

542898

RN149
E3 ubiquitin-protein ligase RNF149

1

3

Small-scale

0.479

High

542899

VANG1
Vang-like protein 1

1

2

High-throughput

0.479

High

542900

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1

3

High-throughput

0.479

High

542901

FNIP1
Folliculin-interacting protein 1

1

1

Small-scale

0.479

High

542903

UBCP1
Ubiquitin-like domain-containing CTD phosphatase 1

1

1

High-throughput

0.479

High

542904

RAD50
DNA repair protein RAD50

1

13

High-throughput

0.479

High

542907

FBXW7
F-box/WD repeat-containing protein 7

1

3

Small-scale

0.479

High

542912

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

1

3

High-throughput

0.479

High

542913

TCPH
T-complex protein 1 subunit eta

1

9

High-throughput

0.479

High

542921

WDR6
tRNA

1

14

High-throughput

0.479

High

542925

DJC11
DnaJ homolog subfamily C member 11

1

13

High-throughput

0.479

High

542928

FNIP2
Folliculin-interacting protein 2

1

1

Small-scale

0.479

High

542933

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

1

High-throughput

0.479

High

542846

PSME3
Proteasome activator complex subunit 3

1

0

Small-scale

0.458

High

542922

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

204285

MS18B
Protein Mis18-beta

1

1

Small-scale

0.457

High

542889

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

6

Small-scale

0.457

High

542890

H90B3
Putative heat shock protein HSP 90-beta-3

1

20

High-throughput

0.445

High

542860

NOMO3
BOS complex subunit NOMO3

1

8

High-throughput

0.437

High

542882

NOMO1
BOS complex subunit NOMO1

1

8

High-throughput

0.437

High

542891

NOMO2
BOS complex subunit NOMO2

1

8

High-throughput

0.437

High

327161

TXD12
Thioredoxin domain-containing protein 12

2

0

High-throughput

0.298

High

542902

FACR1
Fatty acyl-CoA reductase 1

2

0

High-throughput

0.298

High

542935

DJC15
DnaJ homolog subfamily C member 15

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024