Protein: PPM1D
Protein phosphatase 1D (EC 3.1.3.16) (Protein phosphatase 2C isoform delta) (PP2C-delta) (Protein phosphatase magnesium-dependent 1 delta) (p53-induced protein phosphatase 1)

Gene: PPM1D
Organism: Homo sapiens
Interactions: 56
UniProt ID: O15297

Gene Ontology (top 5):
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0004674 - protein serine/threonine kinase activity
GO:0004722 - protein serine/threonine phosphatase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

175362

CHK2
Serine/threonine-protein kinase Chk2

2

9

Small-scale

0.825

High

175368

H2AX
Histone H2AX

3

4

Small-scale

0.687

High

175390

MK11
Mitogen-activated protein kinase 11

1

13

Small-scale

0.647

High

175364

P53
Cellular tumor antigen p53

3

1

Small-scale

0.646

High

175374

IMA1
Importin subunit alpha-1

2

2

High-throughput

0.628

High

175396

CDC5L
Cell division cycle 5-like protein

2

5

Small-scale

0.628

High

175387

IMB1
Importin subunit beta-1

2

0

High-throughput

0.602

High

175357

KDM1A
Lysine-specific histone demethylase 1A

1

1

Small-scale

0.578

High

175379

H31
Histone H3.1

1

3

Small-scale

0.561

High

175380

H33
Histone H3.3

1

3

Small-scale

0.561

High

175381

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.554

High

175385

RUNX2
Runt-related transcription factor 2

1

0

Small-scale

0.554

High

131344

IMA4
Importin subunit alpha-4

1

2

High-throughput

0.536

High

175354

ACTN4
Alpha-actinin-4

1

1

High-throughput

0.536

High

175358

IMA7
Importin subunit alpha-7

1

2

High-throughput

0.536

High

175363

TBB4A
Tubulin beta-4A chain

1

2

High-throughput

0.536

High

175369

1433B
14-3-3 protein beta/alpha

1

3

High-throughput

0.536

High

175370

PRS7
26S proteasome regulatory subunit 7

1

1

High-throughput

0.536

High

175372

NU153
Nuclear pore complex protein Nup153

1

5

High-throughput

0.536

High

175377

PRS8
26S proteasome regulatory subunit 8

1

1

High-throughput

0.536

High

175384

TBB2A
Tubulin beta-2A chain

1

2

High-throughput

0.536

High

175386

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

1

High-throughput

0.536

High

175397

PARK7
Parkinson disease protein 7

1

1

High-throughput

0.536

High

175400

TBB6
Tubulin beta-6 chain

1

2

High-throughput

0.536

High

175367

ARY2
Arylamine N-acetyltransferase 2

1

0

High-throughput

0.518

High

175393

CASZ1
Zinc finger protein castor homolog 1

1

0

High-throughput

0.518

High

175401

BEX2
Protein BEX2

1

0

High-throughput

0.518

High

175403

NSD3
Histone-lysine N-methyltransferase NSD3

1

0

High-throughput

0.518

High

175407

ERRFI
ERBB receptor feedback inhibitor 1

1

0

High-throughput

0.518

High

175356

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

0

High-throughput

0.513

High

175365

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.513

High

175373

RBP2
E3 SUMO-protein ligase RanBP2

1

0

High-throughput

0.513

High

175375

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

High-throughput

0.513

High

175378

TPM4
Tropomyosin alpha-4 chain

1

0

High-throughput

0.513

High

175382

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

0

High-throughput

0.513

High

175383

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.513

High

175388

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

0

High-throughput

0.513

High

175389

TEBP
Prostaglandin E synthase 3

1

0

High-throughput

0.513

High

175391

H2B2E
Histone H2B type 2-E

1

0

High-throughput

0.513

High

175398

TBA1C
Tubulin alpha-1C chain

1

0

High-throughput

0.513

High

175366

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

High-throughput

0.501

High

175402

RHBT2
Rho-related BTB domain-containing protein 2

1

2

High-throughput

0.494

High

175405

MRC2
C-type mannose receptor 2

1

1

High-throughput

0.494

High

175371

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

Small-scale

0.480

High

175376

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

1

Small-scale

0.479

High

175355

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.458

High

175395

CK5P3
CDK5 regulatory subunit-associated protein 3

1

0

Small-scale

0.458

High

175359

GLCE
D-glucuronyl C5-epimerase

1

0

High-throughput

0.282

High

175360

LYPD3
Ly6/PLAUR domain-containing protein 3

1

0

High-throughput

0.282

High

175361

DIRA3
GTP-binding protein Di-Ras3

1

0

High-throughput

0.282

High

175392

ITIH5
Inter-alpha-trypsin inhibitor heavy chain H5

1

0

High-throughput

0.282

High

175394

ESIP1
Epithelial-stromal interaction protein 1

1

0

High-throughput

0.282

High

175406

DKK3
Dickkopf-related protein 3

1

0

High-throughput

0.282

High

175408

OSGI1
Oxidative stress-induced growth inhibitor 1

1

0

High-throughput

0.282

High

175399

NTPCR
Cancer-related nucleoside-triphosphatase

1

0

High-throughput

0.279

Low

175404

TMOD3
Tropomodulin-3

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024