Protein: ITA6
Integrin alpha-6 (CD49 antigen-like family member F) (VLA-6) (CD antigen CD49f) [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain; Processed integrin alpha-6 (Alpha6p)]

Gene: ITA6, ITGA6
Organism: Homo sapiens
Interactions: 144
UniProt ID: P23229

Gene Ontology (top 5):
GO:0005178 - integrin binding
GO:0005886 - plasma membrane
GO:0005925 - focal adhesion
GO:0007044 - cell-substrate junction assembly
GO:0007160 - cell-matrix adhesion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

431710

ITB1
Integrin beta-1

7

20

Small-scale

0.956

High

654981

BTNL8
Butyrophilin-like protein 8

3

11

High-throughput

0.861

High

592620

ITB4
Integrin beta-4

3

20

Small-scale

0.847

High

580730

PVR
Poliovirus receptor

1

2

High-throughput

0.691

High

654938

CEAM8
Cell adhesion molecule CEACAM8

1

7

High-throughput

0.691

High

654977

CEA21
Cell adhesion molecule CEACAM21

1

8

High-throughput

0.691

High

654982

BTNL3
Butyrophilin-like protein 3

1

11

High-throughput

0.691

High

655024

BTNL2
Butyrophilin-like protein 2

1

11

High-throughput

0.691

High

127278

LEG8
Galectin-8

3

20

High-throughput

0.667

High

520744

HLAC
HLA class I histocompatibility antigen, C alpha chain

3

1

High-throughput

0.667

High

568035

HLAE
HLA class I histocompatibility antigen, alpha chain E

3

1

High-throughput

0.667

High

654943

CD151
CD151 antigen

3

20

Small-scale

0.667

High

654968

PTC1
Protein patched homolog 1

3

5

High-throughput

0.667

High

654970

PON2
Serum paraoxonase/arylesterase 2

3

1

High-throughput

0.667

High

655016

PICK1
PRKCA-binding protein

3

4

High-throughput

0.667

High

375176

RASK
GTPase KRas

3

20

High-throughput

0.640

High

251143

B4GT4
Beta-1,4-galactosyltransferase 4

3

0

High-throughput

0.638

High

654994

CANT1
Soluble calcium-activated nucleotidase 1

3

0

High-throughput

0.638

High

50760

TSN11
Tetraspanin-11

2

20

High-throughput

0.628

High

655029

PCDG5
Protocadherin gamma-A5

2

6

High-throughput

0.628

High

167571

GIPC1
PDZ domain-containing protein GIPC1

2

1

Small-scale

0.606

High

480703

LEG1
Galectin-1

2

20

High-throughput

0.601

High

654948

CD81
CD81 antigen

2

20

Small-scale

0.601

High

654975

HFE
Hereditary hemochromatosis protein

2

2

High-throughput

0.601

High

654999

T106A
Transmembrane protein 106A

2

5

High-throughput

0.601

High

373775

RASN
GTPase NRas

2

20

High-throughput

0.584

High

374404

RASH
GTPase HRas

2

13

High-throughput

0.584

High

540312

LAMP1
Lysosome-associated membrane glycoprotein 1

2

5

High-throughput

0.584

High

654957

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.584

High

654995

TMED6
Transmembrane emp24 domain-containing protein 6

2

2

High-throughput

0.574

High

641910

CD9
CD9 antigen

2

20

Small-scale

0.570

High

222249

PSCA
Prostate stem cell antigen

2

4

High-throughput

0.552

High

547969

PSPC
Surfactant protein C

2

5

High-throughput

0.549

High

655025

FBX2
F-box only protein 2

2

11

High-throughput

0.549

High

244534

SI1L3
Signal-induced proliferation-associated 1-like protein 3

1

1

High-throughput

0.536

High

351816

BY55
CD160 antigen

1

4

High-throughput

0.536

High

380614

DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain

1

4

High-throughput

0.536

High

654937

PDIA3
Protein disulfide-isomerase A3

1

4

Small-scale

0.536

High

654962

ACHE
Acetylcholine receptor subunit epsilon

1

1

High-throughput

0.536

High

654986

TM11B
Transmembrane protease serine 11B

1

10

High-throughput

0.536

High

654990

PCD20
Protocadherin-20

1

8

High-throughput

0.536

High

655000

ASIC4
Acid-sensing ion channel 4

1

2

High-throughput

0.536

High

655004

TSN18
Tetraspanin-18

1

20

High-throughput

0.536

High

655005

GML
Glycosyl-phosphatidylinositol-anchored molecule-like protein

1

1

High-throughput

0.536

High

655007

TX101
Testis-expressed protein 101

1

4

High-throughput

0.536

High

655012

RTN4
Reticulon-4

1

2

High-throughput

0.536

High

655017

PCDBG
Protocadherin beta-16

1

6

High-throughput

0.536

High

655021

GPC5B
G-protein coupled receptor family C group 5 member B

1

1

High-throughput

0.536

High

655026

CLC4A
C-type lectin domain family 4 member A

1

6

High-throughput

0.536

High

655027

PCDB7
Protocadherin beta-7

1

6

High-throughput

0.536

High

655028

PCDB1
Protocadherin beta-1

1

6

High-throughput

0.536

High

655030

ST14
Suppressor of tumorigenicity 14 protein

1

11

High-throughput

0.536

High

655015

FBX6
F-box only protein 6

2

11

High-throughput

0.521

High

655008

IL25
Interleukin-25

1

0

High-throughput

0.513

High

421515

A4
Amyloid-beta precursor protein

1

4

High-throughput

0.501

High

337163

APOM
Apolipoprotein M

1

1

High-throughput

0.489

High

567799

PRG2
Bone marrow proteoglycan

1

3

High-throughput

0.489

High

654934

CALX
Calnexin

1

10

High-throughput

0.489

High

654939

COPB2
Coatomer subunit beta'

1

1

High-throughput

0.489

High

654946

EP3B
Epididymal secretory protein E3-beta

1

4

High-throughput

0.489

High

654980

BRID5
BRICHOS domain-containing protein 5

1

4

High-throughput

0.489

High

138449

BIN1
Myc box-dependent-interacting protein 1

1

3

Small-scale

0.481

High

126464

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

164254

NRP1
Neuropilin-1

1

4

Small-scale

0.479

High

165165

TSN4
Tetraspanin-4

1

20

Small-scale

0.479

High

181683

CTDSL
CTD small phosphatase-like protein

1

2

High-throughput

0.479

High

217839

TGON2
Trans-Golgi network integral membrane protein 2

1

9

High-throughput

0.479

High

340984

DIRA3
GTP-binding protein Di-Ras3

1

8

High-throughput

0.479

High

410621

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

15

High-throughput

0.479

High

466108

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

468079

HS90B
Heat shock protein HSP 90-beta

1

4

High-throughput

0.479

High

555874

CADH1
Cadherin-1

1

5

High-throughput

0.479

High

580877

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

598580

CD36
Platelet glycoprotein 4

1

1

Small-scale

0.479

High

601173

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

651149

CBL
E3 ubiquitin-protein ligase CBL

1

6

High-throughput

0.479

High

654935

EPHA2
Ephrin type-A receptor 2

1

11

High-throughput

0.479

High

654936

MARCS
Myristoylated alanine-rich C-kinase substrate

1

2

High-throughput

0.479

High

654941

MAP1B
Microtubule-associated protein 1B

1

3

High-throughput

0.479

High

654944

RAB5C
Ras-related protein Rab-5C

1

6

High-throughput

0.479

High

654945

RAB7A
Ras-related protein Rab-7a

1

7

High-throughput

0.479

High

654947

RAB25
Ras-related protein Rab-25

1

4

High-throughput

0.479

High

654949

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

Small-scale

0.479

High

654950

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

654951

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

654953

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

654955

ARF6
ADP-ribosylation factor 6

1

7

High-throughput

0.479

High

654958

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

654959

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

High-throughput

0.479

High

654960

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

654961

CAV1
Caveolin-1

1

4

High-throughput

0.479

High

654967

SMAD4
Mothers against decapentaplegic homolog 4

1

1

High-throughput

0.479

High

654969

CKAP5
Cytoskeleton-associated protein 5

1

3

High-throughput

0.479

High

654971

RAB35
Ras-related protein Rab-35

1

7

High-throughput

0.479

High

654972

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

654974

CAH9
Carbonic anhydrase 9

1

6

High-throughput

0.479

High

654984

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

654993

PDC6I
Programmed cell death 6-interacting protein

1

7

High-throughput

0.479

High

655006

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

1

High-throughput

0.479

High

655009

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

655010

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

655013

ANLN
Anillin

1

1

High-throughput

0.479

High

655018

TMPS4
Transmembrane protease serine 4

1

10

High-throughput

0.479

High

655023

DDX20
Probable ATP-dependent RNA helicase DDX20

1

8

High-throughput

0.479

High

635773

PTMS
Parathymosin

1

0

High-throughput

0.458

High

654992

MCLN3
Mucolipin-3

1

0

High-throughput

0.458

High

654963

LG3BP
Galectin-3-binding protein

1

2

Small-scale

0.457

High

160996

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

4

High-throughput

0.445

High

330044

VENTX
Homeobox protein VENTX

1

1

High-throughput

0.445

High

349375

TSN15
Tetraspanin-15

1

20

High-throughput

0.445

High

380522

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

1

4

High-throughput

0.445

High

609576

LEG3
Galectin-3

1

20

High-throughput

0.445

High

654954

TSN5
Tetraspanin-5

1

20

High-throughput

0.445

High

654965

TRDN
Triadin

1

3

High-throughput

0.445

High

654988

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

2

High-throughput

0.445

High

654989

DND1
Dead end protein homolog 1

1

5

High-throughput

0.445

High

654942

MSS4
Guanine nucleotide exchange factor MSS4

1

3

Small-scale

0.439

High

105346

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

173859

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

1

High-throughput

0.437

High

654952

RAB2A
Ras-related protein Rab-2A

1

6

High-throughput

0.437

High

654956

RB11A
Ras-related protein Rab-11A

1

4

High-throughput

0.437

High

654991

THOC2
THO complex subunit 2

1

4

High-throughput

0.437

High

655002

CCDC7
Coiled-coil domain-containing protein 7

1

5

High-throughput

0.437

High

655014

ST7
Suppressor of tumorigenicity 7 protein

1

2

High-throughput

0.437

High

655019

OTULL
Inactive ubiquitin thioesterase OTULINL

1

3

High-throughput

0.437

High

655022

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.437

High

654973

UT2
Urea transporter 2

1

0

High-throughput

0.426

High

654983

ZNT10
Calcium/manganese antiporter SLC30A10

1

0

High-throughput

0.426

High

654985

NIPA1
Magnesium transporter NIPA1

1

0

High-throughput

0.426

High

170661

CLGN
Calmegin

1

10

High-throughput

0.407

High

654976

DB109
Beta-defensin 109B

1

3

High-throughput

0.407

High

654979

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.407

High

654996

CA054
Uncharacterized protein C1orf54

1

5

High-throughput

0.407

High

654997

S35B4
Nucleotide sugar transporter SLC35B4

1

1

High-throughput

0.407

High

655003

MF14A
Hippocampus abundant transcript 1 protein

1

1

High-throughput

0.407

High

655011

SACA1
Sperm acrosome membrane-associated protein 1

1

0

High-throughput

0.279

Low

654966

SF3B2
Splicing factor 3B subunit 2

1

0

High-throughput

0.269

Low

654978

P4R3B
Serine/threonine-protein phosphatase 4 regulatory subunit 3B

1

0

High-throughput

0.269

Low

655020

UBP40
Ubiquitin carboxyl-terminal hydrolase 40

1

0

Small-scale

0.251

Low

654940

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

654964

TRAF2
TNF receptor-associated factor 2

1

0

Small-scale

0.249

Low

654987

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

654998

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.249

Low

655001

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025