Protein: PLXA1
Plexin-A1 (Semaphorin receptor NOV)

Gene: PLXA1, PLXNA1
Organism: Homo sapiens
Interactions: 131
UniProt ID: Q9UIW2

Gene Ontology (top 5):
GO:0002116 - semaphorin receptor complex
GO:0002291 - T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

164467

NRP1
Neuropilin-1

4

20

Small-scale

0.874

High

1460510

PLXA1
Plexin-A1

3

20

Small-scale

0.829

High

126863

RHOD
Rho-related GTP-binding protein RhoD

2

20

Small-scale

0.768

High

988807

RAC1
Ras-related C3 botulinum toxin substrate 1

2

20

Small-scale

0.768

High

351746

SG1D1
Secretoglobin family 1D member 1

3

4

High-throughput

0.765

High

375000

RASH
GTPase HRas

2

18

High-throughput

0.754

High

376071

RASK
GTPase KRas

2

20

High-throughput

0.754

High

978386

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

65956

LIRA5
Leukocyte immunoglobulin-like receptor subfamily A member 5

1

3

High-throughput

0.691

High

168465

NCTR3
Natural cytotoxicity triggering receptor 3

1

2

High-throughput

0.691

High

1430742

SIRPD
Signal-regulatory protein delta

1

3

High-throughput

0.691

High

1460476

BTNL2
Butyrophilin-like protein 2

1

13

High-throughput

0.691

High

125656

LEG9
Galectin-9

3

7

High-throughput

0.667

High

1448310

FBX6
F-box only protein 6

3

17

High-throughput

0.650

High

948028

DEF1
Neutrophil defensin 1

2

5

High-throughput

0.628

High

1397278

TAFA4
Chemokine-like protein TAFA-4

2

2

High-throughput

0.628

High

208141

PLXB1
Plexin-B1

1

19

Small-scale

0.621

High

249066

NRP2
Neuropilin-2

1

20

Small-scale

0.621

High

374267

RASN
GTPase NRas

1

20

High-throughput

0.618

High

466516

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

581364

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

778112

VGFR2
Vascular endothelial growth factor receptor 2

1

14

Small-scale

0.618

High

901659

RAB7A
Ras-related protein Rab-7a

1

7

High-throughput

0.618

High

953748

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

955733

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

962615

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

1015893

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

1145161

RAB35
Ras-related protein Rab-35

1

4

High-throughput

0.618

High

1271042

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

1366906

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.618

High

1433568

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1438230

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1116323

PTC1
Protein patched homolog 1

2

9

High-throughput

0.611

High

1295044

TMM25
Transmembrane protein 25

2

2

High-throughput

0.611

High

1030821

DEF5
Defensin alpha 5

3

5

High-throughput

0.604

High

480924

LEG1
Galectin-1

2

7

High-throughput

0.601

High

1460511

FBX2
F-box only protein 2

2

17

High-throughput

0.601

High

1105585

OS9
Protein OS-9

2

2

High-throughput

0.574

High

1362535

SIA8D
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

2

5

High-throughput

0.574

High

1160457

TAZ
Tafazzin

2

3

High-throughput

0.558

High

880075

DNSL1
Deoxyribonuclease-1-like 1

2

4

High-throughput

0.549

High

1245939

BRID5
BRICHOS domain-containing protein 5

2

6

High-throughput

0.549

High

1359274

CA054
Uncharacterized protein C1orf54

2

9

High-throughput

0.549

High

154904

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

1

3

High-throughput

0.536

High

224526

PI15
Peptidase inhibitor 15

1

4

High-throughput

0.536

High

231347

EFNA2
Ephrin-A2

1

1

High-throughput

0.536

High

341376

ECEL1
Endothelin-converting enzyme-like 1

1

2

High-throughput

0.536

High

380496

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

14

High-throughput

0.536

High

409623

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

15

High-throughput

0.536

High

506915

CFC1
Cryptic protein

1

5

High-throughput

0.536

High

561394

TDGF1
Protein Cripto

1

5

High-throughput

0.536

High

568010

PRG2
Bone marrow proteoglycan

1

7

High-throughput

0.536

High

593529

PGFRA
Platelet-derived growth factor receptor alpha

1

19

High-throughput

0.536

High

607428

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

6

High-throughput

0.536

High

656029

CAH6
Carbonic anhydrase 6

1

3

High-throughput

0.536

High

688644

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

17

High-throughput

0.536

High

717637

PDIA3
Protein disulfide-isomerase A3

1

7

Small-scale

0.536

High

933242

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

6

High-throughput

0.536

High

1030229

IL5RA
Interleukin-5 receptor subunit alpha

1

11

High-throughput

0.536

High

1098950

KLRD1
Natural killer cells antigen CD94

1

17

High-throughput

0.536

High

1147459

EPHA7
Ephrin type-A receptor 7

1

14

High-throughput

0.536

High

1369082

GGH
Gamma-glutamyl hydrolase

1

4

High-throughput

0.536

High

1382091

T106A
Transmembrane protein 106A

1

6

High-throughput

0.536

High

1419504

CNTP3
Contactin-associated protein-like 3

1

8

High-throughput

0.536

High

1432265

CLC4M
C-type lectin domain family 4 member M

1

17

High-throughput

0.536

High

1449632

CBLN4
Cerebellin-4

1

12

High-throughput

0.536

High

1460514

PCDB3
Protocadherin beta-3

1

6

High-throughput

0.536

High

316699

LY6H
Lymphocyte antigen 6H

1

0

High-throughput

0.513

High

1009810

IN35
Interferon-induced 35 kDa protein

1

0

High-throughput

0.513

High

1333789

TM87A
Transmembrane protein 87A

1

0

High-throughput

0.513

High

1435246

ANTR1
Anthrax toxin receptor 1

1

0

High-throughput

0.513

High

73866

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

1

7

High-throughput

0.489

High

191469

SIA8E
Alpha-2,8-sialyltransferase 8E

1

5

High-throughput

0.489

High

342691

LY86
Lymphocyte antigen 86

1

5

High-throughput

0.489

High

388747

C1QB
Complement C1q subcomponent subunit B

1

12

High-throughput

0.489

High

465862

MSMB
Beta-microseminoprotein

1

1

High-throughput

0.489

High

548146

PSPC
Surfactant protein C

1

7

High-throughput

0.489

High

597816

CRIS2
Cysteine-rich secretory protein 2

1

4

High-throughput

0.489

High

935813

MFAP4
Microfibril-associated glycoprotein 4

1

4

High-throughput

0.489

High

1177898

CL12B
C-type lectin domain family 12 member B

1

16

High-throughput

0.489

High

1225870

WDR25
WD repeat-containing protein 25

1

1

High-throughput

0.489

High

1248808

LYZL1
Lysozyme-like protein 1

1

4

High-throughput

0.489

High

1279042

TAFA1
Chemokine-like protein TAFA-1

1

2

High-throughput

0.489

High

1347305

FIBIN
Fin bud initiation factor homolog

1

3

High-throughput

0.489

High

1392495

TECT2
Tectonic-2

1

1

High-throughput

0.489

High

1432127

KLK15
Kallikrein-15

1

10

High-throughput

0.489

High

1439377

SDF2L
Stromal cell-derived factor 2-like protein 1

1

7

High-throughput

0.489

High

731942

L1CAM
Neural cell adhesion molecule L1

1

7

Small-scale

0.481

High

218932

TGON2
Trans-Golgi network integral membrane protein 2

1

17

High-throughput

0.479

High

363994

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.479

High

380377

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

11

High-throughput

0.479

High

411105

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.479

High

447554

NPM
Nucleophosmin

1

1

High-throughput

0.479

High

463828

LYN
Tyrosine-protein kinase Lyn

1

16

High-throughput

0.479

High

774697

BASI
Basigin

1

11

High-throughput

0.479

High

787265

BMR1A
Bone morphogenetic protein receptor type-1A

1

3

High-throughput

0.479

High

975304

ARF6
ADP-ribosylation factor 6

1

4

High-throughput

0.479

High

1144683

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

16

High-throughput

0.479

High

1381995

CK052
Uncharacterized protein C11orf52

1

3

High-throughput

0.479

High

1431673

GAN
Gigaxonin

1

2

High-throughput

0.479

High

1448849

TMPS4
Transmembrane protease serine 4

1

18

High-throughput

0.479

High

346464

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

996383

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.458

High

1358487

CANT1
Soluble calcium-activated nucleotidase 1

1

0

High-throughput

0.458

High

222330

PSCA
Prostate stem cell antigen

1

1

High-throughput

0.445

High

255269

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

4

High-throughput

0.445

High

449629

KLK1
Kallikrein-1

1

16

High-throughput

0.445

High

530539

TAU
Microtubule-associated protein tau

1

6

High-throughput

0.445

High

722658

CTR1
High affinity cationic amino acid transporter 1

1

1

High-throughput

0.445

High

1119350

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

6

High-throughput

0.445

High

1197905

S39AC
Zinc transporter ZIP12

1

7

High-throughput

0.445

High

1308310

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

4

High-throughput

0.445

High

1323780

S39AB
Zinc transporter ZIP11

1

7

High-throughput

0.445

High

1324284

LYPD1
Ly6/PLAUR domain-containing protein 1

1

1

High-throughput

0.445

High

1363486

S39A7
Zinc transporter SLC39A7

1

7

High-throughput

0.445

High

1420297

S13A1
Solute carrier family 13 member 1

1

1

High-throughput

0.445

High

1460512

NTNG1
Netrin-G1

1

2

High-throughput

0.445

High

106815

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

1219221

SUSD4
Sushi domain-containing protein 4

1

2

High-throughput

0.437

High

1256004

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.437

High

1334614

RN149
E3 ubiquitin-protein ligase RNF149

1

4

High-throughput

0.437

High

1397819

CCDC7
Coiled-coil domain-containing protein 7

1

6

High-throughput

0.437

High

1460275

XPO7
Exportin-7

1

2

High-throughput

0.437

High

171011

CLGN
Calmegin

1

11

High-throughput

0.407

High

505853

C1T9A
Complement C1q and tumor necrosis factor-related protein 9A

1

7

High-throughput

0.407

High

976876

LCN6
Epididymal-specific lipocalin-6

1

1

High-throughput

0.407

High

1360165

PATE1
Prostate and testis expressed protein 1

1

5

High-throughput

0.407

High

1460513

PRG3
Proteoglycan 3

1

7

High-throughput

0.407

High

1458507

MGT4C
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

2

0

High-throughput

0.328

High

294497

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025