Protein: MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (EC 2.7.11.18)

Gene: MYLK2
Organism: Homo sapiens
Interactions: 110
UniProt ID: Q9H1R3

Gene Ontology (top 5):
GO:0004683 - calmodulin-dependent protein kinase activity
GO:0004687 - myosin light chain kinase activity
GO:0005516 - calmodulin binding
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

272899

KS6A4
Ribosomal protein S6 kinase alpha-4

4

15

High-throughput

0.903

High

432254

HS90A
Heat shock protein HSP 90-alpha

4

20

Small-scale

0.881

High

438519

HS90B
Heat shock protein HSP 90-beta

3

20

High-throughput

0.817

High

241364

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

2

4

High-throughput

0.737

High

243599

DNJA2
DnaJ homolog subfamily A member 2

2

7

High-throughput

0.737

High

432919

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

2

4

High-throughput

0.737

High

453608

ROA1
Heterogeneous nuclear ribonucleoprotein A1

2

9

High-throughput

0.737

High

681591

DNJA1
DnaJ homolog subfamily A member 1

2

7

High-throughput

0.737

High

852166

ROA3
Heterogeneous nuclear ribonucleoprotein A3

2

10

High-throughput

0.737

High

1073559

SAFB1
Scaffold attachment factor B1

2

5

High-throughput

0.737

High

1077863

MYLK
Myosin light chain kinase, smooth muscle

2

16

High-throughput

0.737

High

1082978

CDC37
Hsp90 co-chaperone Cdc37

2

8

High-throughput

0.737

High

1104179

RA1L2
Heterogeneous nuclear ribonucleoprotein A1-like 2

2

11

High-throughput

0.737

High

1328816

RALY
RNA-binding protein Raly

2

3

High-throughput

0.737

High

370414

ESR1
Estrogen receptor

5

16

High-throughput

0.700

High

1204463

FBX11
F-box only protein 11

4

1

High-throughput

0.699

High

415060

CDK1
Cyclin-dependent kinase 1

1

9

High-throughput

0.691

High

960410

CDK16
Cyclin-dependent kinase 16

1

15

High-throughput

0.691

High

986395

BTK
Tyrosine-protein kinase BTK

1

11

Small-scale

0.691

High

647269

1433T
14-3-3 protein theta

3

20

High-throughput

0.633

High

675617

GSTT1
Glutathione S-transferase theta-1

2

1

High-throughput

0.628

High

927515

1433Z
14-3-3 protein zeta/delta

3

20

High-throughput

0.624

High

228658

PRKN
E3 ubiquitin-protein ligase parkin

1

16

High-throughput

0.618

High

429119

ADRB2
Beta-2 adrenergic receptor

1

2

High-throughput

0.618

High

961437

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

10

High-throughput

0.618

High

1026879

MK07
Mitogen-activated protein kinase 7

1

20

Small-scale

0.618

High

1028430

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

19

High-throughput

0.618

High

1306379

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

16

High-throughput

0.618

High

1328807

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

1

17

High-throughput

0.618

High

1269585

ESR2
Estrogen receptor beta

2

16

High-throughput

0.601

High

1123459

H90B3
Putative heat shock protein HSP 90-beta-3

1

20

High-throughput

0.575

High

133665

NOP56
Nucleolar protein 56

2

5

High-throughput

0.571

High

229492

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

2

2

High-throughput

0.571

High

388721

HSPB1
Heat shock protein beta-1

2

10

High-throughput

0.571

High

391900

H2A1B
Histone H2A type 1-B/E

2

10

High-throughput

0.571

High

470154

H2AZ
Histone H2A.Z

2

14

High-throughput

0.571

High

504743

HSP7C
Heat shock cognate 71 kDa protein

2

5

High-throughput

0.571

High

508712

TOP1
DNA topoisomerase 1

2

1

High-throughput

0.571

High

578481

RCC1
Regulator of chromosome condensation

2

3

High-throughput

0.571

High

714406

HSP74
Heat shock 70 kDa protein 4

2

8

High-throughput

0.571

High

730355

PRS7
26S proteasome regulatory subunit 7

2

8

High-throughput

0.571

High

858327

TXTP
Tricarboxylate transport protein, mitochondrial

2

1

High-throughput

0.571

High

876890

NP1L1
Nucleosome assembly protein 1-like 1

2

3

High-throughput

0.571

High

877359

DSRAD
Double-stranded RNA-specific adenosine deaminase

2

3

High-throughput

0.571

High

905102

1433G
14-3-3 protein gamma

2

20

High-throughput

0.571

High

906920

PRS4
26S proteasome regulatory subunit 4

2

7

High-throughput

0.571

High

917909

H4
Histone H4

2

3

High-throughput

0.571

High

935227

H31
Histone H3.1

2

14

High-throughput

0.571

High

952620

H33
Histone H3.3

2

14

High-throughput

0.571

High

1086315

H31T
Histone H3.1t

2

14

High-throughput

0.571

High

1157228

H3C
Histone H3.3C

2

14

High-throughput

0.571

High

1174651

H32
Histone H3.2

2

14

High-throughput

0.571

High

1175312

H2AV
Histone H2A.V

2

14

High-throughput

0.571

High

1185211

H2A3
Histone H2A type 3

2

10

High-throughput

0.571

High

1274388

H2A1C
Histone H2A type 1-C

2

10

High-throughput

0.571

High

1303736

CDC5L
Cell division cycle 5-like protein

2

2

High-throughput

0.571

High

1306086

NP1L4
Nucleosome assembly protein 1-like 4

2

3

High-throughput

0.571

High

1328811

DDX18
ATP-dependent RNA helicase DDX18

2

2

High-throughput

0.571

High

1317437

TRI54
Tripartite motif-containing protein 54

1

17

High-throughput

0.568

High

987231

MEF2C
Myocyte-specific enhancer factor 2C

1

3

Small-scale

0.561

High

198718

PSMD3
26S proteasome non-ATPase regulatory subunit 3

2

0

High-throughput

0.547

High

397504

ADT2
ADP/ATP translocase 2

2

0

High-throughput

0.547

High

1230535

CCAR2
Cell cycle and apoptosis regulator protein 2

2

0

High-throughput

0.547

High

1327349

NAT10
RNA cytidine acetyltransferase

2

0

High-throughput

0.547

High

1328813

TECR
Very-long-chain enoyl-CoA reductase

2

0

High-throughput

0.547

High

529703

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.541

High

214663

MYO1B
Unconventional myosin-Ib

1

13

High-throughput

0.536

High

477690

TRI49
Tripartite motif-containing protein 49

1

3

High-throughput

0.536

High

625034

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

2

High-throughput

0.536

High

676999

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

1

High-throughput

0.536

High

929654

RACK1
Small ribosomal subunit protein RACK1

1

6

High-throughput

0.536

High

1044573

FHL1
Four and a half LIM domains protein 1

1

8

High-throughput

0.536

High

1303099

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

1

High-throughput

0.536

High

1328815

TES
Testin

1

4

High-throughput

0.536

High

324026

BAG2
BAG family molecular chaperone regulator 2

2

3

High-throughput

0.521

High

363537

FETUA
Alpha-2-HS-glycoprotein

2

2

High-throughput

0.521

High

975729

LMNB2
Lamin-B2

2

10

High-throughput

0.521

High

1067243

WDR43
WD repeat-containing protein 43

2

5

High-throughput

0.521

High

1222399

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

2

5

High-throughput

0.521

High

1255208

BRX1
Ribosome biogenesis protein BRX1 homolog

2

1

High-throughput

0.521

High

1328818

NOP58
Nucleolar protein 58

2

5

High-throughput

0.521

High

305816

ELP1
Elongator complex protein 1

1

2

Small-scale

0.515

High

281883

WFS1
Wolframin

1

2

High-throughput

0.515

High

790278

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

2

High-throughput

0.489

High

607717

NDKB
Nucleoside diphosphate kinase B

1

1

High-throughput

0.479

High

684320

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

724465

PCKGC
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

1

1

Small-scale

0.479

High

795793

MAGA3
Melanoma-associated antigen 3

1

6

Small-scale

0.479

High

910017

1433E
14-3-3 protein epsilon

1

9

High-throughput

0.479

High

1020920

TRAF2
TNF receptor-associated factor 2

1

6

High-throughput

0.479

High

1282036

TRI63
E3 ubiquitin-protein ligase TRIM63

1

17

High-throughput

0.479

High

1302757

RUFY1
RUN and FYVE domain-containing protein 1

1

9

High-throughput

0.479

High

1317508

TRI55
Tripartite motif-containing protein 55

1

17

High-throughput

0.479

High

1328810

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

11

Small-scale

0.479

High

855420

TF2AA
Transcription initiation factor IIA subunit 1

1

0

High-throughput

0.458

High

1104209

Q32Q12
Nucleoside diphosphate kinase

1

1

High-throughput

0.445

High

591411

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

3

High-throughput

0.437

High

1328817

RTRAF
RNA transcription, translation and transport factor protein

1

0

Small-scale

0.426

High

882047

BACE1
Beta-secretase 1

1

2

Small-scale

0.407

High

1328812

TM260
Protein O-mannosyl-transferase TMEM260

3

0

High-throughput

0.347

High

1328808

MTRFR
Mitochondrial translation release factor in rescue

3

0

High-throughput

0.342

High

1328809

EMRE
Essential MCU regulator, mitochondrial

3

0

High-throughput

0.342

High

132215

PESC
Pescadillo homolog

2

0

High-throughput

0.298

High

433085

QCR6
Cytochrome b-c1 complex subunit 6, mitochondrial

2

0

High-throughput

0.298

High

1065882

RRS1
Ribosome biogenesis regulatory protein homolog

2

0

High-throughput

0.298

High

1306810

EBP2
Probable rRNA-processing protein EBP2

2

0

High-throughput

0.298

High

1328814

QCR9
Cytochrome b-c1 complex subunit 9

2

0

High-throughput

0.298

High

375779

GBA1
Lysosomal acid glucosylceramidase

1

0

Small-scale

0.249

Low

1328819

CIA30
Complex I intermediate-associated protein 30, mitochondrial

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024