Protein: BPL1
Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin--[methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin--[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)]

Gene: BPL1, HLCS
Organism: Homo sapiens
Interactions: 38
UniProt ID: P50747

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0004077 - biotin--[biotin carboxyl-carrier protein] ligase activity
GO:0005524 - ATP binding
GO:0005652 - nuclear lamina
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

144240

ACACB
Acetyl-CoA carboxylase 2

1

0

Small-scale

0.708

High

897537

BPL1
Biotin--protein ligase

1

0

Small-scale

0.674

High

685822

KRA59
Keratin-associated protein 5-9

2

0

High-throughput

0.580

High

897538

RAB9A
Ras-related protein Rab-9A

2

0

High-throughput

0.547

High

897553

DUS15
Dual specificity protein phosphatase 15

1

1

High-throughput

0.536

High

897555

DUS22
Dual specificity protein phosphatase 22

1

1

High-throughput

0.536

High

897548

TP4A1
Protein tyrosine phosphatase type IVA 1

1

0

High-throughput

0.530

High

897551

SNX27
Sorting nexin-27

1

0

High-throughput

0.518

High

897552

QKI
KH domain-containing RNA-binding protein QKI

1

0

High-throughput

0.518

High

897554

SYSM
Serine--tRNA ligase, mitochondrial

1

0

High-throughput

0.518

High

897558

DDX52
Probable ATP-dependent RNA helicase DDX52

1

0

High-throughput

0.518

High

897539

CDKN3
Cyclin-dependent kinase inhibitor 3

1

0

High-throughput

0.513

High

67537

MYH7B
Myosin-7B

1

0

High-throughput

0.493

High

897546

THOC2
THO complex subunit 2

1

0

High-throughput

0.493

High

156607

DC1I1
Cytoplasmic dynein 1 intermediate chain 1

1

0

High-throughput

0.458

High

323241

TRI37
E3 ubiquitin-protein ligase TRIM37

1

0

High-throughput

0.458

High

446777

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

588222

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

830357

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

878792

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

897542

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

897543

HOOK3
Protein Hook homolog 3

1

0

High-throughput

0.458

High

897547

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.458

High

897557

DCTN4
Dynactin subunit 4

1

0

High-throughput

0.458

High

897540

SPT46
Spermatogenesis-associated protein 46

5

0

High-throughput

0.374

High

897541

TMC7
Transmembrane channel-like protein 7

2

0

High-throughput

0.328

High

897544

CTSRD
Cation channel sperm-associated auxiliary subunit delta

2

0

High-throughput

0.319

High

897549

TBC20
TBC1 domain family member 20

2

0

High-throughput

0.319

High

48925

MED19
Mediator of RNA polymerase II transcription subunit 19

2

0

High-throughput

0.316

High

897545

ANR29
Ankyrin repeat domain-containing protein 29

2

0

High-throughput

0.316

High

897556

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.299

High

897550

TXD15
Thioredoxin domain-containing protein 15

1

0

High-throughput

0.282

High

477411

CD63
CD63 antigen

1

0

High-throughput

0.279

Low

342130

BRD1
Bromodomain-containing protein 1

1

0

High-throughput

0.249

Low

642726

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.249

Low

694949

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

767717

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025