Protein: NICA
Nicastrin

Gene: NICA, Nct
Organism: Drosophila melanogaster
Interactions: 10
UniProt ID: Q9VC27

Gene Ontology (top 5):
GO:0005770 - late endosome
GO:0005886 - plasma membrane
GO:0006509 - membrane protein ectodomain proteolysis
GO:0007219 - Notch signaling pathway
GO:0007220 - Notch receptor processing

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1285554

PEN2
Gamma-secretase subunit pen-2

1

2

Small-scale

0.618

High

1469861

APH1
Gamma-secretase subunit Aph-1

2

6

Small-scale

0.584

High

1321060

Q8MRA3
Hibris, isoform A

1

0

Small-scale

0.458

High

828132

PNUT
Protein peanut

1

2

High-throughput

0.445

High

837972

SEPT1
Septin-1

1

2

High-throughput

0.407

High

929192

SEPT2
Septin-2

1

2

High-throughput

0.407

High

145764

PSN
Presenilin homolog

1

6

High-throughput

0.381

High

1067077

UGGG
UDP-glucose:glycoprotein glucosyltransferase

1

0

High-throughput

0.282

High

384928

HSP26
Heat shock protein 26

1

0

High-throughput

0.265

Low

1469862

Q9VZU6
BTB-VII protein domain

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025