HitPredict - High confidence protein-protein interactions

Protein: PEN2
Gamma-secretase subunit pen-2 (Presenilin enhancer protein 2)

Gene: PEN2, pen-2
Organism: Drosophila melanogaster
Interactions: 7
UniProt ID: Q86BE9

Gene Ontology (top 5):
GO:0005770 - late endosome
GO:0006509 - membrane protein ectodomain proteolysis
GO:0007219 - Notch signaling pathway
GO:0007220 - Notch receptor processing
GO:0010950 - positive regulation of endopeptidase activity

Download interactions: TXT MITAB-2.5

Interaction	Interactor	Experiments	Homologs	Category	Interaction Score	Confidence
145760	PSN Presenilin homolog	1	5	Small-scale	0.618	High
1285554	NICA Nicastrin	1	2	Small-scale	0.618	High
1285555	APH1 Gamma-secretase subunit Aph-1	2	3	Small-scale	0.584	High
661943	PP2A Serine/threonine-protein phosphatase PP2A	1	0	High-throughput	0.265	Low
1263591	Q7JZC9 Nnf1a	1	0	High-throughput	0.265	Low
1285553	Q8MYW2 RH02374p	1	0	High-throughput	0.265	Low
1285556	Q9W221 MIP04282p	1	0	High-throughput	0.265	Low

Service provided by Combinatics, Japan

Last updated: 11Aug2025