Protein: FAS1
Fatty acid synthase subunit beta (EC 2.3.1.86) [Includes: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase [NADH] (EC 1.3.1.9); [Acyl-carrier-protein] acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] malonyltransferase (EC 2.3.1.39); S-acyl fatty acid synthase thioesterase (EC 3.1.2.14)]

Gene: FAS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 198
UniProt ID: P07149

Gene Ontology (top 5):
GO:0004312 - fatty acid synthase activity
GO:0004313 - [acyl-carrier-protein] S-acetyltransferase activity
GO:0004314 - [acyl-carrier-protein] S-malonyltransferase activity
GO:0004317 - (3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
GO:0004318 - enoyl-[acyl-carrier-protein] reductase (NADH) activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

421570

FAS2
Fatty acid synthase subunit alpha

8

5

Small-scale

0.967

High

421539

FAS1
Fatty acid synthase subunit beta

1

8

High-throughput

0.618

High

421658

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

3

0

High-throughput

0.613

High

421700

TRM3
tRNA

2

0

High-throughput

0.585

High

421623

ATG8
Autophagy-related protein 8

2

7

Small-scale

0.584

High

421578

SIS1
Protein SIS1

2

0

High-throughput

0.576

High

372783

CARB
Carbamoyl phosphate synthase arginine-specific large chain

1

3

High-throughput

0.536

High

421546

TBA3
Tubulin alpha-3 chain

1

2

High-throughput

0.536

High

421576

MPCP
Mitochondrial phosphate carrier protein

1

3

High-throughput

0.536

High

421673

BRE5
UBP3-associated protein BRE5

1

1

High-throughput

0.536

High

421680

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

5

High-throughput

0.536

High

421688

GCN5
Histone acetyltransferase GCN5

1

3

High-throughput

0.536

High

421540

PHO4
Phosphate system positive regulatory protein PHO4

1

0

High-throughput

0.513

High

421554

SSBP1
Single-stranded nucleic acid-binding protein

1

0

High-throughput

0.513

High

421557

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.513

High

421618

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.513

High

421627

TSL1
Trehalose synthase complex regulatory subunit TSL1

1

0

High-throughput

0.513

High

421712

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.513

High

421550

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

5

High-throughput

0.501

High

421560

YPK1
Serine/threonine-protein kinase YPK1

1

3

High-throughput

0.501

High

419758

SNF1
Carbon catabolite-derepressing protein kinase

1

1

High-throughput

0.500

High

421564

YAK1
Dual specificity protein kinase YAK1

1

3

High-throughput

0.500

High

421566

ABP1
Actin-binding protein

1

1

High-throughput

0.500

High

421713

DUF1
DUB-associated factor 1

1

4

High-throughput

0.500

High

421610

SLA2
Protein SLA2

1

1

High-throughput

0.489

High

421574

RFA1
Replication factor A protein 1

1

3

Small-scale

0.481

High

389605

DNLI1
DNA ligase 1

1

0

High-throughput

0.479

High

421561

RAD50
DNA repair protein RAD50

1

0

High-throughput

0.479

High

421597

CDC11
Cell division control protein 11

1

0

High-throughput

0.479

High

421670

CWC22
Pre-mRNA-splicing factor CWC22

1

0

High-throughput

0.479

High

421702

RBX1
RING-box protein HRT1

1

0

High-throughput

0.479

High

365565

HSP82
ATP-dependent molecular chaperone HSP82

1

5

High-throughput

0.479

High

410248

SC160
Protein SCP160

1

2

High-throughput

0.479

High

413202

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

421542

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.479

High

421556

HSP72
Heat shock protein SSA2

1

6

High-throughput

0.479

High

421559

SSB1
Ribosome-associated molecular chaperone SSB1

1

5

High-throughput

0.479

High

421565

HSC82
ATP-dependent molecular chaperone HSC82

1

5

High-throughput

0.479

High

421571

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.479

High

421572

HSP74
Heat shock protein SSA4

1

6

High-throughput

0.479

High

421581

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

421592

BMH1
Protein BMH1

1

3

Small-scale

0.479

High

421598

HOG1
Mitogen-activated protein kinase HOG1

1

3

High-throughput

0.479

High

421604

HFA1
Acetyl-CoA carboxylase, mitochondrial

1

3

High-throughput

0.479

High

421606

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.479

High

421613

BMH2
Protein BMH2

1

3

Small-scale

0.479

High

421614

SQT1
Ribosome assembly protein SQT1

1

2

High-throughput

0.479

High

421621

GBLP
Small ribosomal subunit protein RACK1

1

2

High-throughput

0.479

High

421628

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

421631

ECM29
Proteasome component ECM29

1

1

High-throughput

0.479

High

421632

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.479

High

421639

DHH1
ATP-dependent RNA helicase DHH1

1

1

High-throughput

0.479

High

421640

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

421648

TM108
Protein TMA108

1

1

High-throughput

0.479

High

421667

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.479

High

421678

NUM1
Nuclear migration protein NUM1

1

2

High-throughput

0.479

High

421681

MDM1
Structural protein MDM1

1

1

Small-scale

0.479

High

421687

TOM1
E3 ubiquitin-protein ligase TOM1

1

5

High-throughput

0.479

High

421692

DHR1
Probable ATP-dependent RNA helicase DHR1

1

1

High-throughput

0.479

High

141056

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

357779

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.458

High

375205

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.458

High

382853

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

399264

RLA0
Large ribosomal subunit protein uL10

1

0

Small-scale

0.458

High

402837

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

0

Small-scale

0.458

High

405327

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.458

High

406651

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

407620

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

421541

KAPR
cAMP-dependent protein kinase regulatory subunit

1

0

Small-scale

0.458

High

421548

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.458

High

421549

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.458

High

421551

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.458

High

421552

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.458

High

421553

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

421562

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

421563

DPOZ
DNA polymerase zeta catalytic subunit

1

0

Small-scale

0.458

High

421586

RL16A
Large ribosomal subunit protein uL13A

1

0

High-throughput

0.458

High

421587

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

421599

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

0

High-throughput

0.458

High

421607

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

421608

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

421611

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.458

High

421615

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

421616

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

421624

GID4
Vacuolar import and degradation protein 24

1

0

High-throughput

0.458

High

421625

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.458

High

421626

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.458

High

421636

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

421643

ARB1
ABC transporter ATP-binding protein ARB1

1

0

Small-scale

0.458

High

421653

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.458

High

421656

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.458

High

421657

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

421661

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

421674

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

1

0

Small-scale

0.458

High

421676

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.458

High

421679

RAGAB
GTP-binding protein GTR1

1

0

Small-scale

0.458

High

421682

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

421703

SGO1
Shugoshin

1

0

High-throughput

0.458

High

421704

MCA1
Metacaspase-1

1

0

High-throughput

0.458

High

421706

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.458

High

421708

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

421711

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.458

High

421573

DBF2
Cell cycle protein kinase DBF2

1

3

High-throughput

0.457

High

421612

DCA13
Protein SOF1

1

2

High-throughput

0.457

High

421654

COPB2
Coatomer subunit beta'

1

2

High-throughput

0.457

High

343250

TRPG
Multifunctional tryptophan biosynthesis protein [Includes: Anthranilate synthase component 2

1

1

High-throughput

0.445

High

389810

VDAC1
Mitochondrial outer membrane protein porin 1

1

1

High-throughput

0.445

High

421555

HSP71
Heat shock protein SSA1

1

6

High-throughput

0.445

High

421558

CDC24
Cell division control protein 24

1

2

High-throughput

0.445

High

421588

KCC1
Calcium/calmodulin-dependent protein kinase I

1

1

High-throughput

0.445

High

421596

APE2
Aminopeptidase 2, mitochondrial

1

1

High-throughput

0.445

High

421601

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

5

High-throughput

0.445

High

421602

HSP7F
Heat shock protein homolog SSE1

1

6

High-throughput

0.445

High

421605

DLD1
D-lactate dehydrogenase [cytochrome] 1, mitochondrial

1

1

High-throughput

0.445

High

421644

PIC2
Mitochondrial phosphate carrier protein 2

1

3

High-throughput

0.445

High

421650

SCC3
Cohesin subunit SCC3

1

1

High-throughput

0.445

High

421690

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.437

High

421710

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.437

High

409929

NOT3
General negative regulator of transcription subunit 3

1

0

High-throughput

0.426

High

421543

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

0

High-throughput

0.426

High

421545

EI2BG
Translation initiation factor eIF2B subunit gamma

1

0

High-throughput

0.426

High

421547

CDC16
Anaphase-promoting complex subunit CDC16

1

0

High-throughput

0.426

High

421567

HSP26
Heat shock protein 26

1

0

High-throughput

0.426

High

421568

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

0

High-throughput

0.426

High

421575

MRS4
Mitochondrial RNA-splicing protein MRS4

1

0

High-throughput

0.426

High

421577

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

0

High-throughput

0.426

High

421579

ATX10
Ataxin-10 homolog

1

0

High-throughput

0.426

High

421580

LSB5
LAS seventeen-binding protein 5

1

0

High-throughput

0.426

High

421585

SYLC
Leucine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.426

High

421589

BUD14
Bud site selection protein 14

1

0

High-throughput

0.426

High

421594

RENT1
ATP-dependent helicase NAM7

1

0

High-throughput

0.426

High

421595

BTAF1
TATA-binding protein-associated factor MOT1

1

0

High-throughput

0.426

High

421609

PLSC
1-acyl-sn-glycerol-3-phosphate acyltransferase

1

0

High-throughput

0.426

High

421620

PXL1
Paxillin-like protein 1

1

0

High-throughput

0.426

High

421622

SEA4
SEH-associated protein 4

1

0

High-throughput

0.426

High

421629

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.426

High

421634

GGA2
ADP-ribosylation factor-binding protein GGA2

1

0

High-throughput

0.426

High

421641

ECM1
Shuttling pre-60S factor ECM1

1

0

High-throughput

0.426

High

421649

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

0

High-throughput

0.426

High

421664

SOL1
6-phosphogluconolactonase-like protein 1

1

0

High-throughput

0.426

High

421665

LSG1
Large subunit GTPase 1

1

0

High-throughput

0.426

High

421669

RBG2
Ribosome-interacting GTPase 2

1

0

High-throughput

0.426

High

421684

RPM2
Ribonuclease P protein component, mitochondrial

1

0

High-throughput

0.426

High

421686

YMY9
Glucose-6-phosphate 1-epimerase

1

0

High-throughput

0.426

High

421698

RHC31
DNA damage tolerance protein RHC31

1

0

High-throughput

0.426

High

421699

SSK1
Osmolarity two-component system protein SSK1

1

0

High-throughput

0.426

High

421705

GPN2
GPN-loop GTPase 2

1

0

High-throughput

0.426

High

421709

MAM3
Protein MAM3

1

0

High-throughput

0.426

High

421630

DBP8
ATP-dependent RNA helicase DBP8

1

1

High-throughput

0.407

High

421645

UTP7
U3 small nucleolar RNA-associated protein 7

1

3

High-throughput

0.407

High

421663

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

3

High-throughput

0.407

High

421685

PDR12
ATP-dependent permease PDR12

1

1

High-throughput

0.407

High

421691

PDR15
ATP-dependent permease PDR15

1

1

High-throughput

0.407

High

421582

RAD51
DNA repair protein RAD51

1

0

High-throughput

0.279

Low

421593

SEC1
Protein transport protein SEC1

1

0

High-throughput

0.279

Low

421637

SPT8
Transcription factor SPT8

1

0

High-throughput

0.279

Low

420202

CALM
Calmodulin

1

0

High-throughput

0.261

Low

421544

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.261

Low

421584

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

High-throughput

0.261

Low

421603

SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

1

0

High-throughput

0.261

Low

421635

UTP9
U3 small nucleolar RNA-associated protein 9

1

0

High-throughput

0.261

Low

421666

YGI1
Uncharacterized protein YGL081W

1

0

High-throughput

0.261

Low

421683

MEC3
DNA damage checkpoint control protein MEC3

1

0

High-throughput

0.261

Low

421693

PEX12
Peroxisome assembly protein 12

1

0

High-throughput

0.261

Low

421694

KU80
ATP-dependent DNA helicase II subunit 2

1

0

High-throughput

0.261

Low

421701

NOP6
Nucleolar protein 6

1

0

High-throughput

0.261

Low

421619

MID2
Cell wall integrity sensor MID2

1

0

Small-scale

0.251

Low

421677

SLG1
Protein SLG1

1

0

Small-scale

0.251

Low

421583

SGF29
SAGA-associated factor 29

1

0

Small-scale

0.249

Low

421591

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

421617

CENPA
Histone H3-like centromeric protein CSE4

1

0

High-throughput

0.249

Low

421638

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

0

Small-scale

0.249

Low

421651

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

421652

RLP7
Ribosome biogenesis protein RLP7

1

0

High-throughput

0.249

Low

421655

MID1
Stretch-activated cation channel MID1

1

0

Small-scale

0.249

Low

421660

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

421662

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

421697

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.249

Low

421707

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

421714

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.249

Low

141812

RPN13
26S proteasome regulatory subunit RPN13

1

0

High-throughput

0.232

Low

421569

ERD2
ER lumen protein-retaining receptor

1

0

High-throughput

0.232

Low

421590

FUN19
SWIRM domain-containing protein FUN19

1

0

High-throughput

0.232

Low

421600

SMI1
Cell wall assembly regulator SMI1

1

0

High-throughput

0.232

Low

421633

SSF1
Ribosome biogenesis protein SSF1

1

0

High-throughput

0.232

Low

421642

SAW1
Single-strand annealing weakened protein 1

1

0

High-throughput

0.232

Low

421646

GET2
Golgi to ER traffic protein 2

1

0

High-throughput

0.232

Low

421647

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

0

High-throughput

0.232

Low

421659

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.232

Low

421668

NNF2
Protein NNF2

1

0

High-throughput

0.232

Low

421671

ALG12
Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase

1

0

High-throughput

0.232

Low

421672

DBP6
ATP-dependent RNA helicase DBP6

1

0

High-throughput

0.232

Low

421675

SFB2
SED5-binding protein 2

1

0

High-throughput

0.232

Low

421689

HAS1
ATP-dependent RNA helicase HAS1

1

0

High-throughput

0.232

Low

421695

TAF9
Transcription initiation factor TFIID subunit 9

1

0

High-throughput

0.232

Low

421696

ESF1
Pre-rRNA-processing protein ESF1

1

0

High-throughput

0.232

Low

421715

HTL1
High temperature lethal protein 1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024