Protein: C1TM
C-1-tetrahydrofolate synthase, mitochondrial (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)]

Gene: C1TM, MIS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 216
UniProt ID: P09440

Gene Ontology (top 5):
GO:0004329 - formate-tetrahydrofolate ligase activity
GO:0004477 - methenyltetrahydrofolate cyclohydrolase activity
GO:0004488 - methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

423497

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

5

High-throughput

0.665

High

450410

ZUO1
Zuotin

3

2

High-throughput

0.662

High

450441

IF2P
Eukaryotic translation initiation factor 5B

3

4

High-throughput

0.662

High

450422

GBLP
Small ribosomal subunit protein RACK1

3

4

High-throughput

0.656

High

450367

RL2A
Large ribosomal subunit protein uL2A

3

1

High-throughput

0.640

High

425672

RS19A
Small ribosomal subunit protein eS19A

3

1

High-throughput

0.633

High

404943

RL6B
Large ribosomal subunit protein eL6B

2

1

High-throughput

0.611

High

405097

RL17A
Large ribosomal subunit protein uL22A

2

1

High-throughput

0.611

High

450390

RS3A2
Small ribosomal subunit protein eS1B

2

2

High-throughput

0.611

High

450431

SSZ1
Ribosome-associated complex subunit SSZ1

2

5

High-throughput

0.611

High

450486

BRE5
UBP3-associated protein BRE5

2

2

High-throughput

0.611

High

450417

AP1B1
AP-1 complex subunit beta-1

2

0

High-throughput

0.602

High

450427

HEK2
Heterogeneous nuclear rnp K-like protein 2

2

0

High-throughput

0.595

High

450481

LSG1
Large subunit GTPase 1

2

0

High-throughput

0.595

High

450406

FUN30
ATP-dependent helicase FUN30

2

2

High-throughput

0.588

High

450398

RL5
Large ribosomal subunit protein uL18

2

0

High-throughput

0.585

High

450459

RL10
Large ribosomal subunit protein uL16

2

0

High-throughput

0.585

High

141068

RS9A
Small ribosomal subunit protein uS4A

2

1

High-throughput

0.584

High

405341

RL26A
Large ribosomal subunit protein uL24A

2

1

High-throughput

0.584

High

450357

RL31A
Large ribosomal subunit protein eL31A

2

1

High-throughput

0.584

High

450368

RL18B
Large ribosomal subunit protein eL18B

2

1

High-throughput

0.584

High

450400

RL16A
Large ribosomal subunit protein uL13A

2

2

High-throughput

0.584

High

450415

RS3A1
Small ribosomal subunit protein eS1A

2

2

High-throughput

0.584

High

450359

HSP77
Import motor subunit, mitochondrial

2

5

High-throughput

0.571

High

450385

HSC82
ATP-dependent molecular chaperone HSC82

2

7

High-throughput

0.571

High

450413

RSSA1
Small ribosomal subunit protein uS2A

2

1

High-throughput

0.571

High

450414

HSP78
Heat shock protein 78, mitochondrial

2

1

High-throughput

0.571

High

450475

RL4B
Large ribosomal subunit protein uL4B

2

2

High-throughput

0.571

High

450381

ERF1
Eukaryotic peptide chain release factor subunit 1

2

0

High-throughput

0.563

High

357794

RS17A
Small ribosomal subunit protein eS17A

2

0

High-throughput

0.559

High

382865

RL25
Large ribosomal subunit protein uL23

2

0

High-throughput

0.559

High

406670

RS3
Small ribosomal subunit protein uS3

2

0

High-throughput

0.559

High

407634

RS13
Small ribosomal subunit protein uS15

2

0

High-throughput

0.559

High

413218

RS14A
Small ribosomal subunit protein uS11A

2

0

High-throughput

0.559

High

450364

RS6A
Small ribosomal subunit protein eS6A

2

0

High-throughput

0.559

High

450365

RS8A
Small ribosomal subunit protein eS8A

2

0

High-throughput

0.559

High

399274

RLA0
Large ribosomal subunit protein uL10

2

1

High-throughput

0.558

High

450376

HSP72
Heat shock protein SSA2

2

7

High-throughput

0.552

High

450379

SSB1
Ribosome-associated molecular chaperone SSB1

2

8

High-throughput

0.552

High

450377

RLA3
Large ribosomal subunit protein P1B

2

1

High-throughput

0.549

High

450443

KC13
Casein kinase I homolog 3

1

1

High-throughput

0.536

High

450469

PTK2
Serine/threonine-protein kinase PTK2/STK2

1

3

High-throughput

0.536

High

450495

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.536

High

450434

NACA
Nascent polypeptide-associated complex subunit alpha

2

1

High-throughput

0.521

High

450394

HAL4
Serine/threonine-protein kinase HAL4/SAT4

1

0

High-throughput

0.513

High

450420

LONM
Lon protease homolog, mitochondrial

1

0

High-throughput

0.513

High

450424

YPK3
Serine/threonine-protein kinase YPK3

1

0

High-throughput

0.513

High

450435

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

0

High-throughput

0.513

High

450504

PKH3
Serine/threonine-protein kinase PKH3

1

0

High-throughput

0.513

High

145673

RL36B
Large ribosomal subunit protein eL36B

1

1

High-throughput

0.479

High

357427

RLA4
Large ribosomal subunit protein P2B

1

3

High-throughput

0.479

High

365613

HSP82
ATP-dependent molecular chaperone HSP82

1

7

High-throughput

0.479

High

382678

RL24A
Large ribosomal subunit protein eL24A

1

1

High-throughput

0.479

High

404450

RL7A
Large ribosomal subunit protein uL30A

1

1

High-throughput

0.479

High

404769

RL9A
Large ribosomal subunit protein uL6A

1

1

High-throughput

0.479

High

405923

RL33A
Large ribosomal subunit protein eL33A

1

1

High-throughput

0.479

High

406092

RL36A
Large ribosomal subunit protein eL36A

1

1

High-throughput

0.479

High

406445

RL22A
Large ribosomal subunit protein eL22A

1

1

High-throughput

0.479

High

407446

RS9B
Small ribosomal subunit protein uS4B

1

1

High-throughput

0.479

High

426238

RS19B
Small ribosomal subunit protein eS19B

1

1

High-throughput

0.479

High

450352

RS25B
Small ribosomal subunit protein eS25B

1

1

High-throughput

0.479

High

450355

RL27A
Large ribosomal subunit protein eL27A

1

1

High-throughput

0.479

High

450356

RL27B
Large ribosomal subunit protein eL27B

1

1

High-throughput

0.479

High

450358

RL31B
Large ribosomal subunit protein eL31B

1

1

High-throughput

0.479

High

450369

RS16B
Small ribosomal subunit protein uS9B

1

2

High-throughput

0.479

High

450378

RL4A
Large ribosomal subunit protein uL4A

1

2

High-throughput

0.479

High

450384

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

450388

RL8A
Large ribosomal subunit protein eL8A

1

1

High-throughput

0.479

High

450389

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.479

High

450391

RL24B
Large ribosomal subunit protein eL24B

1

1

High-throughput

0.479

High

450393

SIS1
Protein SIS1

1

2

High-throughput

0.479

High

450401

RL16B
Large ribosomal subunit protein uL13B

1

2

High-throughput

0.479

High

450402

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.479

High

450405

RL8B
Large ribosomal subunit protein eL8B

1

1

High-throughput

0.479

High

450407

HS104
Heat shock protein 104

1

1

High-throughput

0.479

High

450419

RL14A
Large ribosomal subunit protein eL14A

1

1

High-throughput

0.479

High

450430

RL14B
Large ribosomal subunit protein eL14B

1

1

High-throughput

0.479

High

450438

DHH1
ATP-dependent RNA helicase DHH1

1

2

High-throughput

0.479

High

450439

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

450445

ARB1
ABC transporter ATP-binding protein ARB1

1

1

Small-scale

0.479

High

450450

RL13B
Large ribosomal subunit protein eL13B

1

1

High-throughput

0.479

High

450454

RL34B
Large ribosomal subunit protein eL34B

1

1

High-throughput

0.479

High

450457

RL33B
Large ribosomal subunit protein eL33B

1

1

High-throughput

0.479

High

450466

RSSA2
Small ribosomal subunit protein uS2B

1

1

High-throughput

0.479

High

450468

RL17B
Large ribosomal subunit protein uL22B

1

1

High-throughput

0.479

High

450471

RS7B
Small ribosomal subunit protein eS7B

1

2

High-throughput

0.479

High

450473

RL37A
Large ribosomal subunit protein eL37A

1

1

High-throughput

0.479

High

450477

RL9B
Large ribosomal subunit protein uL6B

1

1

High-throughput

0.479

High

450478

RL37B
Large ribosomal subunit protein eL37B

1

1

High-throughput

0.479

High

450482

RL26B
Large ribosomal subunit protein uL24B

1

1

High-throughput

0.479

High

450484

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.479

High

450489

SAM50
Sorting assembly machinery 50 kDa subunit

1

2

High-throughput

0.479

High

450492

RL22B
Large ribosomal subunit protein eL22B

1

1

High-throughput

0.479

High

450493

RL34A
Large ribosomal subunit protein eL34A

1

1

High-throughput

0.479

High

450494

NUM1
Nuclear migration protein NUM1

1

2

High-throughput

0.479

High

450497

RL6A
Large ribosomal subunit protein eL6A

1

1

High-throughput

0.479

High

450499

RL21A
Large ribosomal subunit protein eL21A

1

2

High-throughput

0.479

High

450500

XRN2
5'-3' exoribonuclease 2

1

1

High-throughput

0.479

High

450508

DHR1
Probable ATP-dependent RNA helicase DHR1

1

1

High-throughput

0.479

High

450520

TMA46
Translation machinery-associated protein 46

1

1

High-throughput

0.479

High

450522

CHS5
Chitin biosynthesis protein CHS5

1

1

High-throughput

0.479

High

450523

RL7B
Large ribosomal subunit protein uL30B

1

1

High-throughput

0.479

High

450525

RL21B
Large ribosomal subunit protein eL21B

1

2

High-throughput

0.479

High

450526

RL13A
Large ribosomal subunit protein eL13A

1

1

High-throughput

0.479

High

450529

RS25A
Small ribosomal subunit protein eS25A

1

1

High-throughput

0.479

High

357164

RMAR
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.458

High

376587

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

Small-scale

0.458

High

387857

RL39
Large ribosomal subunit protein eL39

1

0

High-throughput

0.458

High

406180

RL29
Large ribosomal subunit protein eL29

1

0

High-throughput

0.458

High

406262

RL15A
Large ribosomal subunit protein eL15A

1

0

High-throughput

0.458

High

450353

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.458

High

450354

RS28B
Small ribosomal subunit protein eS28B

1

0

High-throughput

0.458

High

450360

RL20B
Large ribosomal subunit protein eL20B

1

0

High-throughput

0.458

High

450361

RL43B
Large ribosomal subunit protein eL43B

1

0

High-throughput

0.458

High

450362

RS30A
Small ribosomal subunit protein eS30A

1

0

High-throughput

0.458

High

450363

RS4A
Small ribosomal subunit protein eS4A

1

0

High-throughput

0.458

High

450366

RL1A
Large ribosomal subunit protein uL1A

1

0

High-throughput

0.458

High

450370

RL12B
Large ribosomal subunit protein uL11B

1

0

High-throughput

0.458

High

450371

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

450372

RL19B
Large ribosomal subunit protein eL19

1

0

High-throughput

0.458

High

450373

RL35A
Large ribosomal subunit protein uL29A

1

0

High-throughput

0.458

High

450374

RS32B
Small ribosomal subunit protein eS32B

1

0

High-throughput

0.458

High

450380

PDR1
Transcription factor PDR1

1

0

High-throughput

0.458

High

450383

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.458

High

450392

DBP2
ATP-dependent RNA helicase DBP2

1

0

High-throughput

0.458

High

450395

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

450399

RS5
Small ribosomal subunit protein uS7

1

0

High-throughput

0.458

High

450416

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

450421

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

0

High-throughput

0.458

High

450423

RL32
Large ribosomal subunit protein eL32

1

0

High-throughput

0.458

High

450429

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

450442

RS26A
Small ribosomal subunit protein eS26A

1

0

High-throughput

0.458

High

450449

RIO2
Serine/threonine-protein kinase RIO2

1

0

High-throughput

0.458

High

450458

RS29B
Small ribosomal subunit protein uS14B

1

0

High-throughput

0.458

High

450463

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.458

High

450472

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

450474

RL38
Large ribosomal subunit protein eL38

1

0

High-throughput

0.458

High

450476

UBC9
SUMO-conjugating enzyme UBC9

1

0

High-throughput

0.458

High

450480

DXO
Decapping nuclease RAI1

1

0

High-throughput

0.458

High

450491

ORC1
Origin recognition complex subunit 1

1

0

High-throughput

0.458

High

450496

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

450498

NACB1
Nascent polypeptide-associated complex subunit beta-1

1

0

High-throughput

0.458

High

450502

ESP1
Separin

1

0

High-throughput

0.458

High

450509

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

0

High-throughput

0.458

High

450510

LCB5
Sphingoid long chain base kinase 5

1

0

High-throughput

0.458

High

450515

ELP1
Elongator complex protein 1

1

0

High-throughput

0.458

High

450519

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.458

High

450521

AEP3
ATPase expression protein 3

1

0

Small-scale

0.458

High

450527

RS21B
Small ribosomal subunit protein eS21B

1

0

High-throughput

0.458

High

450528

RL11B
Large ribosomal subunit protein uL5B

1

0

High-throughput

0.458

High

367633

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.445

High

449867

HSP73
Heat shock protein SSA3

1

7

High-throughput

0.445

High

450375

HSP71
Heat shock protein SSA1

1

7

High-throughput

0.445

High

450408

EF2
Elongation factor 2

1

2

High-throughput

0.445

High

450412

HSP7F
Heat shock protein homolog SSE1

1

8

High-throughput

0.445

High

450437

CAJ1
Protein CAJ1

1

1

High-throughput

0.445

High

450444

HSP7E
Heat shock protein SSC3, mitochondrial

1

5

High-throughput

0.445

High

450448

SSB2
Ribosome-associated molecular chaperone SSB2

1

8

High-throughput

0.445

High

450505

GCN5
Histone acetyltransferase GCN5

1

4

High-throughput

0.445

High

450514

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

2

High-throughput

0.445

High

399705

RLA1
Large ribosomal subunit protein P1A

1

1

High-throughput

0.437

High

399821

RLA2
Large ribosomal subunit protein P2A

1

3

High-throughput

0.437

High

410256

SC160
Protein SCP160

1

1

High-throughput

0.437

High

450382

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

450387

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.437

High

450404

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

450426

NU170
Nucleoporin NUP170

1

2

High-throughput

0.437

High

450440

RBG1
Ribosome-interacting GTPase 1

1

1

High-throughput

0.437

High

450453

TM108
Protein TMA108

1

1

High-throughput

0.437

High

450455

ULP2
Ubiquitin-like-specific protease 2

1

1

High-throughput

0.437

High

450456

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.437

High

450460

MID1
Stretch-activated cation channel MID1

1

1

Small-scale

0.437

High

450462

ELP2
Elongator complex protein 2

1

2

High-throughput

0.437

High

450470

MOG1
Nuclear import protein MOG1

1

1

High-throughput

0.437

High

450487

GIS2
Zinc finger protein GIS2

1

1

High-throughput

0.437

High

450488

NST1
Stress response protein NST1

1

2

High-throughput

0.437

High

450490

FAP1
FKBP12-associated protein 1

1

2

High-throughput

0.437

High

450503

TOM1
E3 ubiquitin-protein ligase TOM1

1

5

High-throughput

0.437

High

450507

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

1

High-throughput

0.437

High

450511

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

424283

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

450386

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.426

High

450396

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.426

High

450464

SA155
SIT4-associating protein SAP155

1

0

High-throughput

0.426

High

450461

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.407

High

450479

SEH1
Nucleoporin SEH1

1

2

High-throughput

0.407

High

356178

H4
Histone H4

2

0

High-throughput

0.324

High

427322

ARD1
N-terminal acetyltransferase A complex catalytic subunit ARD1

2

0

High-throughput

0.313

High

450411

SPT16
FACT complex subunit SPT16

2

0

High-throughput

0.313

High

450403

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

2

0

High-throughput

0.307

High

450425

DPOA2
DNA polymerase alpha subunit B

2

0

High-throughput

0.307

High

450428

NCL1
Multisite-specific tRNA:(cytosine-C(5))-methyltransferase

2

0

High-throughput

0.307

High

450465

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.279

Low

355305

H2B1
Histone H2B.1

1

0

High-throughput

0.249

Low

450397

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.249

Low

450409

SRP21
Signal recognition particle subunit SRP21

1

0

High-throughput

0.249

Low

450418

YKH1
Uncharacterized oxidoreductase YKL071W

1

0

High-throughput

0.249

Low

450433

LSM12
Protein LSM12

1

0

High-throughput

0.249

Low

450436

STM1
Suppressor protein STM1

1

0

High-throughput

0.249

Low

450446

THO1
Protein THO1

1

0

High-throughput

0.249

Low

450447

NSA2
Ribosome biogenesis protein NSA2

1

0

High-throughput

0.249

Low

450452

YIQ1
Uncharacterized protein YIL161W

1

0

High-throughput

0.249

Low

450483

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.249

Low

450485

H1
Histone H1

1

0

High-throughput

0.249

Low

450501

ELP3
Elongator complex protein 3

1

0

High-throughput

0.249

Low

450506

ESC1
Silent chromatin protein ESC1

1

0

High-throughput

0.249

Low

450512

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

450513

ESF1
Pre-rRNA-processing protein ESF1

1

0

Small-scale

0.249

Low

450516

PBP4
Protein PBP4

1

0

High-throughput

0.249

Low

450517

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

450518

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

450524

SIZ2
E3 SUMO-protein ligase SIZ2

1

0

High-throughput

0.249

Low

450351

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.232

Low

450432

RRP4
Exosome complex component RRP4

1

0

High-throughput

0.232

Low

450451

JEM1
DnaJ-like chaperone JEM1

1

0

High-throughput

0.232

Low

450467

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024