Protein: BRE1
E3 ubiquitin-protein ligase BRE1 (EC 2.3.2.27) (Brefeldin A-sensitivity protein 1) (RING-type E3 ubiquitin transferase BRE1)

Gene: BRE1
Organism: Saccharomyces cerevisiae S288C
Interactions: 161
UniProt ID: Q07457

Gene Ontology (top 5):
GO:0000722 - telomere maintenance via recombination
GO:0000724 - double-strand break repair via homologous recombination
GO:0000781 - chromosome, telomeric region
GO:0000785 - chromatin
GO:0003688 - DNA replication origin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

410240

UBC2
Ubiquitin-conjugating enzyme E2 2

18

20

Small-scale

0.990

High

991279

BRE1
E3 ubiquitin-protein ligase BRE1

11

15

Small-scale

0.756

High

355667

H2B1
Histone H2B.1

5

20

Small-scale

0.726

High

539489

UBC3
Ubiquitin-conjugating enzyme E2-34 kDa

1

20

Small-scale

0.724

High

972705

LGE1
Transcriptional regulatory protein LGE1

7

0

Small-scale

0.713

High

356028

H2B2
Histone H2B.2

4

20

Small-scale

0.686

High

708063

NUF2
Kinetochore protein NUF2

3

13

High-throughput

0.645

High

607349

RFA1
Replication factor A protein 1

2

7

Small-scale

0.624

High

512910

SSB1
Ribosome-associated molecular chaperone SSB1

3

15

High-throughput

0.624

High

392215

H2A1
Histone H2A.1

2

18

Small-scale

0.602

High

558279

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

2

Small-scale

0.584

High

544495

HSC82
ATP-dependent molecular chaperone HSC82

3

14

Small-scale

0.578

High

663453

TF2B
Transcription initiation factor IIB

2

2

High-throughput

0.576

High

366973

HSP82
ATP-dependent molecular chaperone HSP82

2

14

High-throughput

0.571

High

769599

SSB2
Ribosome-associated molecular chaperone SSB2

2

15

Small-scale

0.571

High

965497

NOP3
Serine/arginine

2

16

Small-scale

0.571

High

523452

SRS2
ATP-dependent DNA helicase SRS2

1

3

Small-scale

0.561

High

632587

RAD51
DNA repair protein RAD51

1

6

Small-scale

0.561

High

810373

SET2
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

10

Small-scale

0.561

High

597907

PWP1
Periodic tryptophan protein 1

1

20

High-throughput

0.541

High

691594

EIF3C
Eukaryotic translation initiation factor 3 subunit C

2

1

Small-scale

0.533

High

700650

RSSA1
Small ribosomal subunit protein uS2A

2

2

High-throughput

0.521

High

987190

SP382
Pre-mRNA-splicing factor SPP382

1

0

High-throughput

0.518

High

986580

JIP5
WD repeat-containing protein JIP5

1

14

High-throughput

0.515

High

700804

SMC1
Structural maintenance of chromosomes protein 1

1

12

High-throughput

0.508

High

758759

SMC2
Structural maintenance of chromosomes protein 2

1

12

High-throughput

0.508

High

810777

SMC3
Structural maintenance of chromosomes protein 3

1

11

High-throughput

0.508

High

711001

HSL1
Probable serine/threonine-protein kinase HSL1

1

18

High-throughput

0.501

High

732690

SWD2
COMPASS component SWD2

1

20

Small-scale

0.501

High

749010

PAF1
RNA polymerase II-associated protein 1

1

2

Small-scale

0.501

High

974189

FRK1
Fatty acyl-CoA synthetase and RNA processing-associated kinase 1

1

20

High-throughput

0.501

High

710097

TFC3
Transcription factor tau 138 kDa subunit

1

0

High-throughput

0.493

High

988456

HDA2
HDA1 complex subunit 2

1

0

High-throughput

0.486

High

375519

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

3

Small-scale

0.479

High

407350

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

624182

DBP2
ATP-dependent RNA helicase DBP2

1

6

Small-scale

0.479

High

633991

GBP2
Serine/arginine

1

6

Small-scale

0.479

High

648444

NSR1
Nuclear localization sequence-binding protein

1

7

Small-scale

0.479

High

688450

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

2

High-throughput

0.479

High

730142

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.479

High

730680

EF1G2
Elongation factor 1-gamma 2

1

4

Small-scale

0.479

High

743020

GBLP
Small ribosomal subunit protein RACK1

1

20

High-throughput

0.479

High

775272

ULP2
Ubiquitin-like-specific protease 2

1

1

High-throughput

0.479

High

783367

ERG10
Acetyl-CoA acetyltransferase

1

3

Small-scale

0.479

High

858504

SAP4
SIT4-associating protein SAP4

1

1

High-throughput

0.479

High

978317

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.479

High

986143

IMB1
Importin subunit beta-1

1

4

Small-scale

0.479

High

991284

NCBP2
Nuclear cap-binding protein subunit 2

1

9

High-throughput

0.479

High

991289

RIO1
Serine/threonine-protein kinase RIO1

1

2

High-throughput

0.479

High

991281

SLK19
Kinetochore protein SLK19

1

17

High-throughput

0.464

High

688672

MCM10
Minichromosome maintenance protein 10

1

0

Small-scale

0.458

High

733031

YKR18
IML2-like protein YKR018C

1

0

High-throughput

0.458

High

812136

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

977854

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.458

High

991280

RSC58
Chromatin structure-remodeling complex protein RSC58

1

0

High-throughput

0.458

High

991286

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

991288

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

991291

CSN10
COP9 signalosome complex subunit 10

1

0

Small-scale

0.458

High

758582

HAL5
Serine/threonine-protein kinase HAL5

1

19

High-throughput

0.457

High

341840

IPYR
Inorganic pyrophosphatase

1

1

High-throughput

0.445

High

356753

H4
Histone H4

1

12

High-throughput

0.445

High

392585

H2A2
Histone H2A.2

1

18

High-throughput

0.445

High

424143

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

4

High-throughput

0.445

High

424244

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

4

High-throughput

0.445

High

454474

TBA1
Tubulin alpha-1 chain

1

2

High-throughput

0.445

High

492585

HSP71
Heat shock protein SSA1

1

15

High-throughput

0.445

High

495082

HSP72
Heat shock protein SSA2

1

15

High-throughput

0.445

High

540646

CYPH
Peptidyl-prolyl cis-trans isomerase

1

5

High-throughput

0.445

High

577182

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

1

18

High-throughput

0.445

High

605699

KIN3
Serine/threonine-protein kinase KIN3

1

20

High-throughput

0.445

High

622085

SSD1
Protein SSD1

1

2

High-throughput

0.445

High

633617

MAS5
Mitochondrial protein import protein MAS5

1

5

High-throughput

0.445

High

687755

BTAF1
TATA-binding protein-associated factor MOT1

1

15

High-throughput

0.445

High

689297

SP110
Spindle pole body component 110

1

17

High-throughput

0.445

High

690642

FKBP2
Peptidyl-prolyl cis-trans isomerase FPR2

1

4

High-throughput

0.445

High

695632

HSP7F
Heat shock protein homolog SSE1

1

17

High-throughput

0.445

High

696263

STH1
Nuclear protein STH1/NPS1

1

15

High-throughput

0.445

High

715243

TOR1
Serine/threonine-protein kinase TOR1

1

10

High-throughput

0.445

High

715741

TAF14
Transcription initiation factor TFIID subunit 14

1

1

High-throughput

0.445

High

733315

SET3
SET domain-containing protein 3

1

7

High-throughput

0.445

High

744568

SWD3
COMPASS component SWD3

1

20

High-throughput

0.445

High

744703

TAF5
Transcription initiation factor TFIID subunit 5

1

15

High-throughput

0.445

High

744918

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

1

15

High-throughput

0.445

High

752223

KSP1
Serine/threonine-protein kinase KSP1

1

17

High-throughput

0.445

High

754751

SSZ1
Ribosome-associated complex subunit SSZ1

1

13

High-throughput

0.445

High

755806

SET1
Histone-lysine N-methyltransferase, H3 lysine-4 specific

1

10

High-throughput

0.445

High

761329

CAJ1
Protein CAJ1

1

8

High-throughput

0.445

High

762884

IMDH1
Putative inosine-5'-monophosphate dehydrogenase 1

1

5

High-throughput

0.445

High

797137

MOB2
CBK1 kinase activator protein MOB2

1

4

High-throughput

0.445

High

865501

JJJ1
J protein JJJ1

1

10

High-throughput

0.445

High

865852

CBK1
Serine/threonine-protein kinase CBK1

1

14

High-throughput

0.445

High

887692

ACT
Actin

1

20

High-throughput

0.445

High

902098

H3
Histone H3

1

14

High-throughput

0.445

High

961495

CDC14
Tyrosine-protein phosphatase CDC14

1

14

High-throughput

0.445

High

977529

TAF12
Transcription initiation factor TFIID subunit 12

1

2

High-throughput

0.445

High

141546

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.437

High

340752

PGK
Phosphoglycerate kinase

1

1

Small-scale

0.437

High

358281

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.437

High

383374

RL25
Large ribosomal subunit protein uL23

1

2

High-throughput

0.437

High

405853

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.437

High

408148

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.437

High

413730

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.437

High

426176

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.437

High

471279

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.437

High

480339

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.437

High

480909

RS8A
Small ribosomal subunit protein eS8A

1

3

High-throughput

0.437

High

482482

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.437

High

561075

EF3A
Elongation factor 3A

1

4

Small-scale

0.437

High

599991

RIR3
Ribonucleoside-diphosphate reductase large chain 2

1

1

High-throughput

0.437

High

632113

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.437

High

635077

ADY2
Accumulation of dyads protein 2

1

1

High-throughput

0.437

High

645678

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.437

High

700749

ATO2
Ammonia transport outward protein 2

1

1

High-throughput

0.437

High

706513

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

752695

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.437

High

762601

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

774155

TM108
Protein TMA108

1

1

High-throughput

0.437

High

785236

MPG1
Mannose-1-phosphate guanyltransferase

1

1

Small-scale

0.437

High

820198

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.437

High

967785

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.437

High

991282

RS10A
Small ribosomal subunit protein eS10A

1

5

High-throughput

0.437

High

419637

RAD52
DNA repair and recombination protein RAD52

1

0

High-throughput

0.426

High

424925

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.426

High

612280

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.426

High

705961

SPC29
Spindle pole component 29

1

0

High-throughput

0.426

High

732519

SPC42
Spindle pole body component SPC42

1

0

High-throughput

0.426

High

858821

DXO
Decapping nuclease RAI1

1

0

High-throughput

0.426

High

862742

H1
Histone H1

1

0

High-throughput

0.426

High

973723

TFB2
General transcription and DNA repair factor IIH subunit TFB2

1

0

High-throughput

0.426

High

975945

SDC1
COMPASS component SDC1

1

0

High-throughput

0.426

High

978573

PPN1
Endopolyphosphatase

1

0

High-throughput

0.426

High

991287

TAF10
Transcription initiation factor TFIID subunit 10

1

0

High-throughput

0.426

High

416811

CDC31
Cell division control protein 31

1

4

High-throughput

0.407

High

478558

HSP77
Import motor subunit, mitochondrial

1

18

High-throughput

0.407

High

526307

KIN2
Serine/threonine-protein kinase KIN2

1

8

High-throughput

0.407

High

541805

SEC63
Protein translocation protein SEC63

1

7

High-throughput

0.407

High

585380

MYO2
Myosin-2

1

19

High-throughput

0.407

High

687894

NUD1
Protein NUD1

1

11

High-throughput

0.407

High

691283

MYO4
Myosin-4

1

20

High-throughput

0.407

High

705714

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.407

High

743933

AKL1
Serine/threonine-protein kinase AKL1

1

10

High-throughput

0.407

High

756587

KOG1
Target of rapamycin complex 1 subunit KOG1

1

16

High-throughput

0.407

High

783349

LST8
Target of rapamycin complex subunit LST8

1

14

High-throughput

0.407

High

810178

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.407

High

859584

MLC1
Myosin light chain 1

1

16

High-throughput

0.407

High

988589

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

8

High-throughput

0.407

High

991290

HSP42
Heat shock protein 42

1

1

High-throughput

0.407

High

700132

SKG6
Protein SKG6

1

0

High-throughput

0.279

Low

368437

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.269

Low

991283

YO365
Uncharacterized membrane protein YOR365C

1

0

High-throughput

0.269

Low

696989

YEF3
Uncharacterized protein YEL043W

1

0

High-throughput

0.265

Low

865928

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.265

Low

701111

SMY2
Protein SMY2

1

0

High-throughput

0.249

Low

691720

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.232

Low

696757

RTG2
Retrograde regulation protein 2

1

0

High-throughput

0.232

Low

810738

NET1
Nucleolar protein NET1

1

0

High-throughput

0.232

Low

811861

BFA1
Mitotic check point protein BFA1

1

0

High-throughput

0.232

Low

837541

PSP2
Protein PSP2

1

0

High-throughput

0.232

Low

987566

ATG33
Autophagy-related protein 33

1

0

High-throughput

0.232

Low

991285

TCO89
Target of rapamycin complex 1 subunit TCO89

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024