Protein: MAK21
Ribosome biogenesis protein MAK21 (Maintenance of killer protein 21) (Nucleolar complex protein 1)

Gene: MAK21
Organism: Saccharomyces cerevisiae S288C
Interactions: 211
UniProt ID: Q12176

Gene Ontology (top 5):
GO:0000027 - ribosomal large subunit assembly
GO:0003729 - mRNA binding
GO:0005634 - nucleus
GO:0005730 - nucleolus
GO:0030687 - preribosome, large subunit precursor

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

764274

NOC2
Nucleolar complex protein 2

17

6

Small-scale

0.764

High

982917

RRP5
rRNA biogenesis protein RRP5

11

4

Small-scale

0.757

High

754937

SSF1
Ribosome biogenesis protein SSF1

11

3

Small-scale

0.752

High

976890

HAS1
ATP-dependent RNA helicase HAS1

9

17

High-throughput

0.751

High

860913

PESC
Pescadillo homolog

9

3

Small-scale

0.749

High

733978

RPF2
Ribosome biogenesis protein RPF2

8

2

Small-scale

0.748

High

742089

NOP4
Nucleolar protein 4

7

3

High-throughput

0.748

High

776547

RLP7
Ribosome biogenesis protein RLP7

7

6

High-throughput

0.743

High

1015251

RRP12
Ribosomal RNA-processing protein 12

6

2

High-throughput

0.730

High

754223

CIC1
Proteasome-interacting protein CIC1

6

4

High-throughput

0.729

High

1014870

YTM1
Ribosome biogenesis protein YTM1

6

7

High-throughput

0.729

High

792628

UTP10
U3 small nucleolar RNA-associated protein 10

6

2

High-throughput

0.722

High

549527

FBRL
rRNA 2'-O-methyltransferase fibrillarin

5

4

High-throughput

0.714

High

744259

MAK5
ATP-dependent RNA helicase MAK5

5

14

High-throughput

0.712

High

980181

ERB1
Ribosome biogenesis protein ERB1

5

6

High-throughput

0.712

High

1015241

MAK21
Ribosome biogenesis protein MAK21

5

4

High-throughput

0.707

High

710941

URB1
Nucleolar pre-ribosomal-associated protein 1

5

1

Small-scale

0.704

High

778890

NOP2
25S rRNA

4

5

Small-scale

0.691

High

866288

NOP15
Ribosome biogenesis protein 15

4

5

High-throughput

0.691

High

986626

DBP9
ATP-dependent RNA helicase DBP9

4

10

High-throughput

0.691

High

994064

NOP12
Nucleolar protein 12

4

8

High-throughput

0.691

High

994471

BRX1
Ribosome biogenesis protein BRX1

4

13

High-throughput

0.691

High

699750

DRS1
ATP-dependent RNA helicase DRS1

4

14

High-throughput

0.680

High

766613

NOP16
Nucleolar protein 16

4

2

High-throughput

0.680

High

973489

NOG1
Nucleolar GTP-binding protein 1

4

3

High-throughput

0.680

High

864707

NOG2
Nucleolar GTP-binding protein 2

3

9

High-throughput

0.670

High

716007

UTP20
U3 small nucleolar RNA-associated protein 20

3

1

High-throughput

0.662

High

997036

NIP7
60S ribosome subunit biogenesis protein NIP7

3

3

High-throughput

0.662

High

985410

RSA3
Ribosome assembly protein 3

4

0

Small-scale

0.661

High

731892

EBP2
rRNA-processing protein EBP2

3

2

High-throughput

0.658

High

996384

RRS1
Regulator of ribosome biosynthesis

3

4

High-throughput

0.646

High

1014980

NOP53
Ribosome biogenesis protein NOP53

3

2

High-throughput

0.646

High

766369

SNU13
13 kDa ribonucleoprotein-associated protein

3

7

High-throughput

0.643

High

704448

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

3

2

High-throughput

0.640

High

715509

RRP1
Ribosomal RNA-processing protein 1

3

5

Small-scale

0.640

High

859532

NSA1
Ribosome biogenesis protein NSA1

3

2

Small-scale

0.640

High

1015247

NOP58
Nucleolar protein 58

3

8

High-throughput

0.640

High

797419

LOC1
60S ribosomal subunit assembly/export protein LOC1

2

2

High-throughput

0.634

High

987654

RRP15
Ribosomal RNA-processing protein 15

2

2

High-throughput

0.634

High

404738

RL7A
Large ribosomal subunit protein uL30A

2

6

High-throughput

0.611

High

499117

RL4A
Large ribosomal subunit protein uL4A

2

3

High-throughput

0.611

High

535160

RL3
Large ribosomal subunit protein uL3

2

3

High-throughput

0.611

High

645159

RL16A
Large ribosomal subunit protein uL13A

2

5

High-throughput

0.611

High

859459

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

2

2

High-throughput

0.611

High

492802

HSP71
Heat shock protein SSA1

2

6

High-throughput

0.601

High

513158

SSB1
Ribosome-associated molecular chaperone SSB1

2

5

High-throughput

0.601

High

810954

MTR4
ATP-dependent RNA helicase DOB1

2

2

Small-scale

0.601

High

634468

SPB1
27S pre-rRNA

2

4

High-throughput

0.594

High

755351

RPF1
Ribosome production factor 1

2

3

High-throughput

0.594

High

768068

NSA2
Ribosome biogenesis protein NSA2

2

2

High-throughput

0.594

High

1015245

DBP10
ATP-dependent RNA helicase DBP10

2

8

High-throughput

0.594

High

501270

MAK16
Protein MAK16

2

5

High-throughput

0.584

High

634822

KRR1
KRR1 small subunit processome component

2

3

High-throughput

0.584

High

638898

SPB4
ATP-dependent rRNA helicase SPB4

2

16

High-throughput

0.584

High

703142

MRT4
Ribosome assembly factor MRT4

2

6

High-throughput

0.584

High

748744

ENP1
Essential nuclear protein 1

2

3

High-throughput

0.584

High

756891

RIX1
Pre-rRNA-processing protein RIX1

2

2

Small-scale

0.584

High

864516

DBP6
ATP-dependent RNA helicase DBP6

2

14

Small-scale

0.584

High

979748

UTP14
U3 small nucleolar RNA-associated protein 14

2

2

High-throughput

0.584

High

985834

UTP21
U3 small nucleolar RNA-associated protein 21

2

7

High-throughput

0.584

High

994484

REXO4
RNA exonuclease 4

2

3

High-throughput

0.584

High

994600

NOP8
60S ribosome subunit biogenesis protein NOP8

2

1

Small-scale

0.584

High

997064

BMS1
Ribosome biogenesis protein BMS1

2

3

High-throughput

0.584

High

1015246

NOP56
Nucleolar protein 56

2

8

High-throughput

0.584

High

376972

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

2

2

Small-scale

0.571

High

408182

RS13
Small ribosomal subunit protein uS15

2

2

High-throughput

0.571

High

859991

CGR1
rRNA-processing protein CGR1

2

0

High-throughput

0.569

High

357578

RLA4
Large ribosomal subunit protein P2B

2

1

High-throughput

0.567

High

454671

TBA3
Tubulin alpha-3 chain

2

0

High-throughput

0.563

High

862712

DCP2
m7GpppN-mRNA hydrolase

2

0

High-throughput

0.563

High

495274

HSP72
Heat shock protein SSA2

2

6

High-throughput

0.552

High

357741

RL28
Large ribosomal subunit protein uL15

1

1

High-throughput

0.536

High

405077

RL6B
Large ribosomal subunit protein eL6B

1

2

High-throughput

0.536

High

413765

RS14A
Small ribosomal subunit protein uS11A

1

4

High-throughput

0.536

High

641103

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.536

High

676465

XPO1
Exportin-1

1

3

High-throughput

0.536

High

780506

RL33B
Large ribosomal subunit protein eL33B

1

1

High-throughput

0.536

High

810307

RL17B
Large ribosomal subunit protein uL22B

1

4

High-throughput

0.536

High

860271

RL26B
Large ribosomal subunit protein uL24B

1

4

High-throughput

0.536

High

864635

BRE5
UBP3-associated protein BRE5

1

1

High-throughput

0.536

High

965070

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

2

High-throughput

0.536

High

974196

FRK1
Fatty acyl-CoA synthetase and RNA processing-associated kinase 1

1

3

High-throughput

0.536

High

985914

MRD1
Multiple RNA-binding domain-containing protein 1

1

6

Small-scale

0.536

High

1015252

RL11B
Large ribosomal subunit protein uL5B

1

3

High-throughput

0.536

High

472450

RL31A
Large ribosomal subunit protein eL31A

2

5

High-throughput

0.533

High

482511

RS18A
Small ribosomal subunit protein uS13A

2

2

High-throughput

0.533

High

593725

DBP4
ATP-dependent RNA helicase HCA4

1

18

High-throughput

0.515

High

733174

DBP7
ATP-dependent RNA helicase DBP7

1

14

High-throughput

0.515

High

633906

SGF29
SAGA-associated factor 29

1

0

High-throughput

0.513

High

763641

OAF1
Oleate-activated transcription factor 1

1

0

High-throughput

0.493

High

145800

RL36B
Large ribosomal subunit protein eL36B

1

3

High-throughput

0.489

High

406426

RL15A
Large ribosomal subunit protein eL15A

1

2

High-throughput

0.489

High

479545

RS24A
Small ribosomal subunit protein eS24A

1

3

High-throughput

0.489

High

534862

RL30
Large ribosomal subunit protein eL30

1

2

High-throughput

0.489

High

667306

RL8B
Large ribosomal subunit protein eL8B

1

7

High-throughput

0.489

High

770475

RL13B
Large ribosomal subunit protein eL13B

1

4

High-throughput

0.489

High

1015250

RL13A
Large ribosomal subunit protein eL13A

1

4

High-throughput

0.489

High

1015253

RS22B
Small ribosomal subunit protein uS8B

1

2

High-throughput

0.489

High

1015244

SMT3
Ubiquitin-like protein SMT3

1

2

High-throughput

0.481

High

141579

RS9A
Small ribosomal subunit protein uS4A

1

3

High-throughput

0.479

High

356787

H4
Histone H4

1

1

High-throughput

0.479

High

383405

RL25
Large ribosomal subunit protein uL23

1

4

High-throughput

0.479

High

392602

H2A2
Histone H2A.2

1

4

High-throughput

0.479

High

405883

RL26A
Large ribosomal subunit protein uL24A

1

4

High-throughput

0.479

High

407391

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

482009

RL12B
Large ribosomal subunit protein uL11B

1

1

High-throughput

0.479

High

593572

DBP3
ATP-dependent RNA helicase DBP3

1

4

High-throughput

0.479

High

594085

MAK11
Protein MAK11

1

7

High-throughput

0.479

High

597921

PWP1
Periodic tryptophan protein 1

1

8

High-throughput

0.479

High

604638

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

1

High-throughput

0.479

High

628580

SIS1
Protein SIS1

1

1

High-throughput

0.479

High

630291

RRP43
Exosome complex component RRP43

1

2

High-throughput

0.479

High

635176

YCQ6
Uncharacterized protein YCR016W

1

1

High-throughput

0.479

High

635668

PWP2
Periodic tryptophan protein 2

1

7

High-throughput

0.479

High

648453

NSR1
Nuclear localization sequence-binding protein

1

3

High-throughput

0.479

High

655912

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

1

1

High-throughput

0.479

High

663642

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

688489

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

691441

NHP2
H/ACA ribonucleoprotein complex subunit NHP2

1

7

High-throughput

0.479

High

707159

DCA13
Protein SOF1

1

7

High-throughput

0.479

High

732263

RRP14
Ribosomal RNA-processing protein 14

1

2

High-throughput

0.479

High

752727

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.479

High

757375

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

6

High-throughput

0.479

High

766731

NUG1
Nuclear GTP-binding protein NUG1

1

9

High-throughput

0.479

High

772356

ATAD2
ATPase histone chaperone YTA7

1

3

High-throughput

0.479

High

791292

KRI1
Protein KRI1

1

2

High-throughput

0.479

High

811374

NOP9
Nucleolar protein 9

1

1

Small-scale

0.479

High

811578

MPP10
U3 small nucleolar RNA-associated protein MPP10

1

2

High-throughput

0.479

High

811812

URB2
Nucleolar pre-ribosomal-associated protein 2

1

1

High-throughput

0.479

High

819884

TRF5
Poly(A) RNA polymerase protein 1

1

1

Small-scale

0.479

High

860414

EIF2A
Eukaryotic translation initiation factor 2A

1

1

High-throughput

0.479

High

860773

UTP22
U3 small nucleolar RNA-associated protein 22

1

1

High-throughput

0.479

High

861628

YG5X
Putative methyltransferase YGR283C

1

1

High-throughput

0.479

High

863706

PAP2
Poly(A) RNA polymerase protein 2

1

1

Small-scale

0.479

High

865507

JJJ1
J protein JJJ1

1

3

Small-scale

0.479

High

865633

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

6

High-throughput

0.479

High

865779

NOP13
Nucleolar protein 13

1

2

High-throughput

0.479

High

866083

NAT10
RNA cytidine acetyltransferase

1

2

High-throughput

0.479

High

866551

APJ1
J domain-containing protein APJ1

1

4

High-throughput

0.479

High

902133

H3
Histone H3

1

4

High-throughput

0.479

High

963183

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

2

High-throughput

0.479

High

965514

NOP3
Serine/arginine

1

11

High-throughput

0.479

High

973696

UTP17
NET1-associated nuclear protein 1

1

10

High-throughput

0.479

High

979078

DHR1
Probable ATP-dependent RNA helicase DHR1

1

2

High-throughput

0.479

High

979263

UTP15
U3 small nucleolar RNA-associated protein 15

1

6

High-throughput

0.479

High

981820

YM91
Putative methyltransferase YMR310C

1

1

High-throughput

0.479

High

985441

UTP13
U3 small nucleolar RNA-associated protein 13

1

8

High-throughput

0.479

High

987619

RRP9
Ribosomal RNA-processing protein 9

1

6

High-throughput

0.479

High

987692

NOC4
Nucleolar complex protein 4

1

4

High-throughput

0.479

High

991549

NOP6
Nucleolar protein 6

1

1

High-throughput

0.479

High

992253

RIX7
Ribosome biogenesis ATPase RIX7

1

1

High-throughput

0.479

High

995835

SGO1
Shugoshin

1

2

High-throughput

0.479

High

1015125

RRP6
Exosome complex exonuclease RRP6

1

3

High-throughput

0.479

High

1015243

UTP12
U3 small nucleolar RNA-associated protein 12

1

7

High-throughput

0.479

High

1015248

CMR1
DNA damage-binding protein CMR1

1

5

High-throughput

0.479

High

1015249

IF6
Eukaryotic translation initiation factor 6

1

3

Small-scale

0.479

High

1015254

NOP10
H/ACA ribonucleoprotein complex subunit NOP10

1

1

High-throughput

0.479

High

1015255

NOP14
Nucleolar complex protein 14

1

2

High-throughput

0.479

High

763924

IF2P
Eukaryotic translation initiation factor 5B

1

1

High-throughput

0.470

High

501423

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

0

High-throughput

0.458

High

692711

RPA12
DNA-directed RNA polymerase I subunit RPA12

1

0

High-throughput

0.458

High

775289

ULP2
Ubiquitin-like-specific protease 2

1

0

High-throughput

0.458

High

775897

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

975865

TOM1
E3 ubiquitin-protein ligase TOM1

1

0

High-throughput

0.458

High

1015242

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

367073

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.445

High

399671

RLA0
Large ribosomal subunit protein uL10

1

6

High-throughput

0.445

High

416107

DED1
ATP-dependent RNA helicase DED1

1

2

High-throughput

0.445

High

645289

RL16B
Large ribosomal subunit protein uL13B

1

5

High-throughput

0.445

High

645710

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.445

High

695780

HSP7F
Heat shock protein homolog SSE1

1

9

High-throughput

0.445

High

715411

SPT7
Transcriptional activator SPT7

1

3

High-throughput

0.445

High

754806

SSZ1
Ribosome-associated complex subunit SSZ1

1

1

High-throughput

0.445

High

761342

CAJ1
Protein CAJ1

1

1

High-throughput

0.445

High

784250

RL10
Large ribosomal subunit protein uL16

1

2

High-throughput

0.445

High

970417

ADA2
Transcriptional adapter 2

1

1

High-throughput

0.445

High

979474

PUF6
Pumilio homology domain family member 6

1

2

Small-scale

0.445

High

426204

RS19A
Small ribosomal subunit protein eS19A

1

5

High-throughput

0.437

High

471847

RL27A
Large ribosomal subunit protein eL27A

1

1

High-throughput

0.437

High

479008

RL20B
Large ribosomal subunit protein eL20B

1

3

High-throughput

0.437

High

481246

RL1A
Large ribosomal subunit protein uL1A

1

7

High-throughput

0.437

High

481442

RL2A
Large ribosomal subunit protein uL2A

1

3

High-throughput

0.437

High

481715

RL18B
Large ribosomal subunit protein eL18B

1

3

High-throughput

0.437

High

481837

RS16B
Small ribosomal subunit protein uS9B

1

1

High-throughput

0.437

High

524484

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

706553

RS3A1
Small ribosomal subunit protein eS1A

1

4

High-throughput

0.437

High

730172

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.437

High

737239

LONM
Lon protease homolog, mitochondrial

1

1

High-throughput

0.437

High

762662

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

820232

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.437

High

967823

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.437

High

977485

BUL2
Ubiquitin ligase-binding protein BUL2

1

1

Small-scale

0.437

High

991350

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.437

High

996348

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.437

High

837383

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

0

High-throughput

0.426

High

975993

GCN5
Histone acetyltransferase GCN5

1

0

High-throughput

0.426

High

368505

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.407

High

535294

RS17B
Small ribosomal subunit protein eS17B

1

2

High-throughput

0.407

High

613770

RS3A2
Small ribosomal subunit protein eS1B

1

4

High-throughput

0.407

High

700679

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.407

High

705799

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.407

High

985291

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

8

High-throughput

0.407

High

858780

YOR1
Oligomycin resistance ATP-dependent permease YOR1

2

0

High-throughput

0.324

High

424764

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.279

Low

446249

MYO1
Myosin-1

1

0

Small-scale

0.249

Low

361078

TBB
Tubulin beta chain

1

0

High-throughput

0.232

Low

556373

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.232

Low

785274

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low

810195

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low

811494

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024