Protein: RPN2
26S proteasome regulatory subunit RPN2

Gene: RPN2
Organism: Saccharomyces cerevisiae S288C
Interactions: 197
UniProt ID: P32565

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0005634 - nucleus
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0008540 - proteasome regulatory particle, base subcomplex
GO:0030234 - enzyme regulator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

693323

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

22

15

Small-scale

0.988

High

693297

RPN1
26S proteasome regulatory subunit RPN1

12

10

Small-scale

0.979

High

693372

RPN8
26S proteasome regulatory subunit RPN8

5

14

High-throughput

0.922

High

693266

RAD23
UV excision repair protein RAD23

4

20

Small-scale

0.881

High

693308

RPN3
26S proteasome regulatory subunit RPN3

4

8

Small-scale

0.881

High

693271

PRS7
26S proteasome regulatory subunit 7 homolog

11

20

Small-scale

0.755

High

339520

CDK1
Cyclin-dependent kinase 1

2

6

High-throughput

0.754

High

693376

RPN5
26S proteasome regulatory subunit RPN5

7

16

Small-scale

0.746

High

693270

PRS6B
26S proteasome regulatory subunit 6B homolog

8

20

Small-scale

0.745

High

693349

PRS8
26S proteasome regulatory subunit 8 homolog

7

20

Small-scale

0.737

High

141839

RPN13
26S proteasome regulatory subunit RPN13

6

1

Small-scale

0.737

High

693299

RPN10
26S proteasome regulatory subunit RPN10

6

7

Small-scale

0.734

High

693330

PSD10
Probable 26S proteasome regulatory subunit p28

5

5

Small-scale

0.716

High

693366

RPN7
26S proteasome regulatory subunit RPN7

5

17

High-throughput

0.716

High

693324

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

5

7

High-throughput

0.714

High

691450

RPN12
26S proteasome regulatory subunit RPN12

5

7

Small-scale

0.712

High

693362

RPN9
26S proteasome regulatory subunit RPN9

5

10

Small-scale

0.712

High

693378

RPN6
26S proteasome regulatory subunit RPN6

5

14

Small-scale

0.709

High

294106

SEM1
26S proteasome complex subunit SEM1

5

1

Small-scale

0.706

High

454578

TBA3
Tubulin alpha-3 chain

1

1

High-throughput

0.691

High

693082

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

1

1

Small-scale

0.691

High

693290

HSM3
DNA mismatch repair protein HSM3

4

1

Small-scale

0.683

High

604769

PSB4
Proteasome subunit beta type-4

4

20

Small-scale

0.683

High

693269

PRS6A
26S proteasome regulatory subunit 6A

4

20

High-throughput

0.683

High

597302

PSA1
Proteasome subunit alpha type-1

3

20

Small-scale

0.660

High

693311

PSA4
Proteasome subunit alpha type-4

3

20

Small-scale

0.660

High

693334

RPN14
26S proteasome regulatory subunit RPN14

3

5

High-throughput

0.660

High

693296

ECM29
Proteasome component ECM29

3

5

High-throughput

0.656

High

490667

HSP71
Heat shock protein SSA1

3

7

High-throughput

0.650

High

693312

PRS4
26S proteasome regulatory subunit 4 homolog

3

20

Small-scale

0.650

High

693337

PRS10
26S proteasome subunit RPT4

3

20

High-throughput

0.650

High

412691

KAPA
cAMP-dependent protein kinase type 1

1

3

High-throughput

0.647

High

419836

SNF1
Carbon catabolite-derepressing protein kinase

1

1

High-throughput

0.647

High

477186

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

16

High-throughput

0.647

High

565500

PHO85
Cyclin-dependent protein kinase PHO85

1

6

High-throughput

0.647

High

614580

KC11
Casein kinase I homolog 1

1

1

High-throughput

0.647

High

693325

IKS1
Probable serine/threonine-protein kinase IKS1

1

1

High-throughput

0.647

High

693355

SKY1
Serine/threonine-protein kinase SKY1

1

7

High-throughput

0.647

High

409622

KAPC
cAMP-dependent protein kinase type 3

1

3

High-throughput

0.646

High

539324

KSS1
Mitogen-activated protein kinase KSS1

1

2

High-throughput

0.646

High

605502

DBF2
Cell cycle protein kinase DBF2

1

3

High-throughput

0.646

High

693316

PSMD9
Probable 26S proteasome regulatory subunit p27

3

3

Small-scale

0.640

High

605955

RAD53
Serine/threonine-protein kinase RAD53

1

1

High-throughput

0.618

High

693264

RPN2
26S proteasome regulatory subunit RPN2

1

10

High-throughput

0.618

High

693292

PSB1
Proteasome subunit beta type-1

2

20

High-throughput

0.611

High

627832

SIS1
Protein SIS1

2

3

High-throughput

0.601

High

597216

PSA7
Probable proteasome subunit alpha type-7

2

20

Small-scale

0.595

High

689159

PSA5
Proteasome subunit alpha type-5

2

20

Small-scale

0.595

High

693310

PSA6
Proteasome subunit alpha type-6

2

20

Small-scale

0.595

High

693341

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

2

7

Small-scale

0.595

High

543407

HSC82
ATP-dependent molecular chaperone HSC82

2

6

High-throughput

0.584

High

619434

PSA2
Proteasome subunit alpha type-2

2

20

High-throughput

0.584

High

693353

RPN4
Protein RPN4

2

0

Small-scale

0.582

High

687579

DBF20
Serine/threonine-protein kinase DBF20

1

3

High-throughput

0.578

High

412540

CDC7
Cell division control protein 7

1

11

Small-scale

0.575

High

493479

HSP72
Heat shock protein SSA2

2

7

High-throughput

0.571

High

693380

RUVB2
RuvB-like protein 2

2

3

High-throughput

0.571

High

498474

METK1
S-adenosylmethionine synthase 1

2

2

High-throughput

0.567

High

587298

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

Small-scale

0.537

High

510645

SSB1
Ribosome-associated molecular chaperone SSB1

1

6

High-throughput

0.536

High

693276

SPT7
Transcriptional activator SPT7

1

2

High-throughput

0.536

High

693279

EF1G2
Elongation factor 1-gamma 2

1

2

High-throughput

0.536

High

693331

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

2

High-throughput

0.536

High

693356

ESC1
Silent chromatin protein ESC1

2

3

High-throughput

0.533

High

693291

RCK2
Serine/threonine-protein kinase RCK2

1

0

High-throughput

0.517

High

693284

SN114
Pre-mRNA-splicing factor SNU114

1

3

High-throughput

0.515

High

605723

NPR1
Nitrogen permease reactivator protein

1

7

High-throughput

0.514

High

693332

TAF6
Transcription initiation factor TFIID subunit 6

1

0

High-throughput

0.513

High

693333

HUL5
E3 ubiquitin-protein ligase HUL5

1

9

Small-scale

0.501

High

610957

ESS1
Peptidyl-prolyl cis-trans isomerase ESS1

1

1

High-throughput

0.500

High

693293

RFC3
Replication factor C subunit 3

1

4

High-throughput

0.500

High

693313

RFC4
Replication factor C subunit 4

1

1

High-throughput

0.500

High

693336

BUD32
EKC/KEOPS complex subunit BUD32

1

1

High-throughput

0.500

High

693370

RBX1
RING-box protein HRT1

1

2

High-throughput

0.500

High

636117

NOT1
General negative regulator of transcription subunit 1

1

0

High-throughput

0.493

High

693320

SPG5
Stationary phase protein 5

1

0

High-throughput

0.493

High

657212

URA7
CTP synthase 1

1

1

High-throughput

0.489

High

693274

MFT1
THO complex subunit MFT1

1

1

High-throughput

0.489

High

693282

MAOM
NAD-dependent malic enzyme, mitochondrial

1

1

High-throughput

0.489

High

693295

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.489

High

693319

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.489

High

693343

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

1

High-throughput

0.489

High

640304

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

High-throughput

0.479

High

693347

RU17
U1 small nuclear ribonucleoprotein 70 kDa homolog

1

0

High-throughput

0.479

High

693368

PRP11
Pre-mRNA-splicing factor PRP11

1

0

High-throughput

0.479

High

693375

RAD59
DNA repair protein RAD59

1

0

High-throughput

0.479

High

365995

HSP82
ATP-dependent molecular chaperone HSP82

1

6

High-throughput

0.479

High

406896

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

566146

EST1
Telomere elongation protein EST1

1

1

High-throughput

0.479

High

606592

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

2

High-throughput

0.479

High

619340

PSA3
Proteasome subunit alpha type-3

1

20

High-throughput

0.479

High

619960

PSB6
Proteasome subunit beta type-6

1

20

High-throughput

0.479

High

625919

PSB2
Proteasome subunit beta type-2

1

20

High-throughput

0.479

High

632475

PSB3
Proteasome subunit beta type-3

1

20

High-throughput

0.479

High

661664

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

664712

BMH1
Protein BMH1

1

3

High-throughput

0.479

High

675399

PSB5
Proteasome subunit beta type-5

1

20

High-throughput

0.479

High

675452

PSB7
Proteasome subunit beta type-7

1

20

High-throughput

0.479

High

680540

HS104
Heat shock protein 104

1

3

High-throughput

0.479

High

691947

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

1

High-throughput

0.479

High

693281

CENPA
Histone H3-like centromeric protein CSE4

1

3

High-throughput

0.479

High

693283

POC2
Proteasome assembly chaperone 2

1

1

High-throughput

0.479

High

693286

GBLP
Small ribosomal subunit protein RACK1

1

4

High-throughput

0.479

High

693288

UMP1
Proteasome maturation factor UMP1

1

1

High-throughput

0.479

High

693322

BLM10
Proteasome activator BLM10

1

4

High-throughput

0.479

High

693342

APJ1
J domain-containing protein APJ1

1

5

High-throughput

0.479

High

693346

CDC14
Tyrosine-protein phosphatase CDC14

1

8

Small-scale

0.479

High

693350

ULP1
Ubiquitin-like-specific protease 1

1

1

High-throughput

0.479

High

693351

ESP1
Separin

1

1

High-throughput

0.479

High

693352

TOM1
E3 ubiquitin-protein ligase TOM1

1

5

High-throughput

0.479

High

693359

RUVB1
RuvB-like protein 1

1

3

High-throughput

0.479

High

693364

POC1
Proteasome chaperone 1

1

1

High-throughput

0.479

High

693367

TFC6
Transcription factor tau 91 kDa subunit

1

1

High-throughput

0.479

High

693371

SGO1
Shugoshin

1

1

High-throughput

0.479

High

693374

NSL1
Kinetochore-associated protein NSL1

1

1

Small-scale

0.479

High

693277

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

693360

CSN9
COP9 signalosome complex subunit 9

1

0

Small-scale

0.458

High

693361

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

693377

CSN10
COP9 signalosome complex subunit 10

1

0

Small-scale

0.458

High

693306

RBG1
Ribosome-interacting GTPase 1

1

2

High-throughput

0.457

High

693379

LAS17
Proline-rich protein LAS17

1

2

High-throughput

0.457

High

633051

MAS5
Mitochondrial protein import protein MAS5

1

6

High-throughput

0.445

High

679857

FUN30
ATP-dependent helicase FUN30

1

2

High-throughput

0.445

High

693265

HSP7F
Heat shock protein homolog SSE1

1

9

High-throughput

0.445

High

693300

SPT8
Transcription factor SPT8

1

1

High-throughput

0.445

High

693309

MGDP1
Putative magnesium-dependent phosphatase YER134C

1

1

High-throughput

0.445

High

693335

RAGCD
GTP-binding protein GTR2

1

1

High-throughput

0.445

High

693338

NOG2
Nucleolar GTP-binding protein 2

1

2

High-throughput

0.445

High

693339

HCH1
Hsp90 co-chaperone HCH1

1

3

High-throughput

0.445

High

693340

NOP13
Nucleolar protein 13

1

2

High-throughput

0.445

High

141226

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.437

High

357954

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.437

High

383023

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.437

High

402911

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

3

Small-scale

0.437

High

405506

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.437

High

407807

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.437

High

413386

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.437

High

425834

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.437

High

470937

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

472090

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

479995

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.437

High

480557

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

482153

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.437

High

578516

SEC18
Vesicular-fusion protein SEC18

1

4

High-throughput

0.437

High

631749

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.437

High

636216

FUB1
Silencing boundary-establishment protein FUB1

1

1

High-throughput

0.437

High

638686

SPB4
ATP-dependent rRNA helicase SPB4

1

2

High-throughput

0.437

High

645331

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.437

High

693267

RSSA1
Small ribosomal subunit protein uS2A

1

2

High-throughput

0.437

High

693268

SMY2
Protein SMY2

1

1

High-throughput

0.437

High

693275

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.437

High

693278

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.437

High

693285

LONM
Lon protease homolog, mitochondrial

1

16

High-throughput

0.437

High

693287

PHO88
SRP-independent targeting protein 3

1

1

High-throughput

0.437

High

693294

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.437

High

693315

MLP2
Protein MLP2

1

2

High-throughput

0.437

High

693321

UTP10
U3 small nucleolar RNA-associated protein 10

1

1

High-throughput

0.437

High

693326

MPS3
Spindle pole body assembly component MPS3

1

1

High-throughput

0.437

High

693328

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.437

High

693329

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.437

High

693345

NUM1
Nuclear migration protein NUM1

1

2

High-throughput

0.437

High

693348

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.437

High

693354

HAS1
ATP-dependent RNA helicase HAS1

1

2

High-throughput

0.437

High

693357

BUL2
Ubiquitin ligase-binding protein BUL2

1

1

Small-scale

0.437

High

693363

DHR1
Probable ATP-dependent RNA helicase DHR1

1

1

High-throughput

0.437

High

693369

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.437

High

693373

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.437

High

693383

ENV10
SRP-independent targeting protein 2

1

1

High-throughput

0.437

High

561224

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

0

High-throughput

0.426

High

693289

ENP1
Essential nuclear protein 1

1

0

High-throughput

0.426

High

693344

2ABA
Protein phosphatase PP2A regulatory subunit B

1

0

High-throughput

0.426

High

343283

TRPG
Multifunctional tryptophan biosynthesis protein [Includes: Anthranilate synthase component 2

1

4

High-throughput

0.407

High

427210

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

3

High-throughput

0.407

High

628941

SCJ1
DnaJ-related protein SCJ1

1

4

High-throughput

0.407

High

693272

PLSC
1-acyl-sn-glycerol-3-phosphate acyltransferase

1

1

High-throughput

0.407

High

693273

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.407

High

693301

TCPG
T-complex protein 1 subunit gamma

1

3

High-throughput

0.407

High

693302

TCPZ
T-complex protein 1 subunit zeta

1

2

High-throughput

0.407

High

693303

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

1

High-throughput

0.407

High

693307

RV167
Reduced viability upon starvation protein 167

1

2

High-throughput

0.407

High

693317

DJP1
DnaJ-like protein 1

1

4

High-throughput

0.407

High

693318

LCB2
Serine palmitoyltransferase 2

1

1

High-throughput

0.407

High

693327

GPN1
GPN-loop GTPase 1

1

1

High-throughput

0.407

High

693365

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

11

High-throughput

0.407

High

693382

GLT1
Glutamate synthase [NADH]

1

2

High-throughput

0.407

High

141724

THP2
THO complex subunit THP2

1

0

High-throughput

0.279

Low

693381

YO098
Uncharacterized protein YOL098C

1

0

High-throughput

0.279

Low

516855

SIR4
Regulatory protein SIR4

1

0

High-throughput

0.269

Low

693280

DHR2
Probable ATP-dependent RNA helicase DHR2

1

0

High-throughput

0.261

Low

693298

GPI16
GPI transamidase component GPI16

1

0

High-throughput

0.261

Low

523253

NAT1
N-terminal acetyltransferase A complex subunit NAT1

1

0

Small-scale

0.249

Low

693305

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

693314

VPS27
Vacuolar protein sorting-associated protein 27

1

0

Small-scale

0.249

Low

693358

PML39
Pre-mRNA leakage protein 39

1

0

High-throughput

0.249

Low

690651

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

0

High-throughput

0.232

Low

693304

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024