Protein: LSM4
U6 snRNA-associated Sm-like protein LSm4 (Like-SM protein 4)

Gene: LSM4
Organism: Saccharomyces cerevisiae S288C
Interactions: 171
UniProt ID: P40070

Gene Ontology (top 5):
GO:0000290 - deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0000387 - spliceosomal snRNP assembly
GO:0000398 - mRNA splicing, via spliceosome
GO:0000932 - P-body
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

767790

LSM1
Sm-like protein LSm1

11

20

Small-scale

0.979

High

635868

PAT1
Deadenylation-dependent mRNA-decapping factor PAT1

10

2

Small-scale

0.976

High

767815

LSM3
U6 snRNA-associated Sm-like protein LSm3

9

20

Small-scale

0.974

High

767791

LSM8
U6 snRNA-associated Sm-like protein LSm8

8

20

Small-scale

0.974

High

767833

LSM6
U6 snRNA-associated Sm-like protein LSm6

7

8

Small-scale

0.972

High

746296

LSM2
U6 snRNA-associated Sm-like protein LSm2

6

14

Small-scale

0.955

High

767810

LSM7
U6 snRNA-associated Sm-like protein LSm7

6

20

Small-scale

0.955

High

767779

LSM5
U6 snRNA-associated Sm-like protein LSm5

4

3

Small-scale

0.909

High

766909

RSMB
Small nuclear ribonucleoprotein-associated protein B

4

6

Small-scale

0.894

High

767832

SMD2
Small nuclear ribonucleoprotein Sm D2

3

5

High-throughput

0.858

High

767823

PRP3
U4/U6 small nuclear ribonucleoprotein PRP3

3

3

High-throughput

0.855

High

767780

RUXG
Small nuclear ribonucleoprotein G

3

20

High-throughput

0.830

High

767777

LSM4
U6 snRNA-associated Sm-like protein LSm4

2

4

Small-scale

0.800

High

704674

PRP8
Pre-mRNA-splicing factor 8

2

3

High-throughput

0.789

High

731729

SN114
Pre-mRNA-splicing factor SNU114

2

6

High-throughput

0.789

High

767788

SMD3
Small nuclear ribonucleoprotein Sm D3

2

15

Small-scale

0.789

High

767796

PRP24
U4/U6 snRNA-associated-splicing factor PRP24

2

1

Small-scale

0.754

High

697214

BRR2
Pre-mRNA-splicing helicase BRR2

7

9

Small-scale

0.741

High

605054

XRN1
5'-3' exoribonuclease 1

5

1

High-throughput

0.716

High

368104

EF1A
Elongation factor 1-alpha

2

0

Small-scale

0.699

High

586493

PRP9
Pre-mRNA-splicing factor PRP9

1

2

High-throughput

0.691

High

767821

SMD1
Small nuclear ribonucleoprotein Sm D1

1

4

High-throughput

0.691

High

761950

DHH1
ATP-dependent RNA helicase DHH1

3

2

High-throughput

0.669

High

767794

PRP31
Pre-mRNA-processing factor 31

3

4

High-throughput

0.662

High

767849

SNU66
66 kDa U4/U6.U5 small nuclear ribonucleoprotein component

3

2

Small-scale

0.656

High

767852

DCP1
mRNA-decapping enzyme subunit 1

3

0

Small-scale

0.638

High

402963

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

1

Small-scale

0.618

High

767814

RUXF
Small nuclear ribonucleoprotein F

1

8

High-throughput

0.618

High

767843

RU2A
U2 small nuclear ribonucleoprotein A'

1

5

High-throughput

0.618

High

586409

PRP6
Pre-mRNA-splicing factor 6

2

7

High-throughput

0.611

High

589079

PRP4
U4/U6 small nuclear ribonucleoprotein PRP4

2

7

High-throughput

0.611

High

764958

IF4F1
Eukaryotic initiation factor 4F subunit p150

2

1

Small-scale

0.611

High

767837

DIB1
Spliceosomal protein DIB1

2

2

High-throughput

0.611

High

511486

SSB1
Ribosome-associated molecular chaperone SSB1

2

3

High-throughput

0.601

High

767802

DCP2
m7GpppN-mRNA hydrolase

2

0

High-throughput

0.594

High

415988

DED1
ATP-dependent RNA helicase DED1

2

0

Small-scale

0.588

High

767807

GIS2
Zinc finger protein GIS2

2

0

High-throughput

0.587

High

376804

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

2

0

Small-scale

0.585

High

767801

EIF2A
Eukaryotic translation initiation factor 2A

2

1

High-throughput

0.561

High

629425

PUF4
Pumilio homology domain family member 4

1

1

High-throughput

0.541

High

634149

SRO9
RNA-binding protein SRO9

1

4

High-throughput

0.541

High

694063

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

4

High-throughput

0.541

High

759493

MPT5
Suppressor protein MPT5

1

1

High-throughput

0.541

High

767789

SCD6
Protein SCD6

1

1

High-throughput

0.541

High

676089

XPO1
Exportin-1

1

3

High-throughput

0.536

High

692402

PRP21
Pre-mRNA-splicing factor PRP21

1

3

High-throughput

0.536

High

767795

SF3B1
U2 snRNP component HSH155

1

3

High-throughput

0.536

High

767829

RSE1
Pre-mRNA-splicing factor RSE1

1

1

High-throughput

0.536

High

767848

SNU23
23 kDa U4/U6.U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.536

High

622032

SSD1
Protein SSD1

1

0

High-throughput

0.518

High

636145

NOT1
General negative regulator of transcription subunit 1

1

0

High-throughput

0.518

High

728254

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.518

High

766453

EDC3
Enhancer of mRNA-decapping protein 3

1

0

High-throughput

0.518

High

767806

CAF40
Protein CAF40

1

0

High-throughput

0.518

High

767797

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

0

High-throughput

0.513

High

767805

BRE5
UBP3-associated protein BRE5

1

0

High-throughput

0.513

High

767816

TPS1
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit

1

0

High-throughput

0.513

High

767817

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

High-throughput

0.513

High

609094

SIN3
Transcriptional regulatory protein SIN3

1

1

High-throughput

0.508

High

767787

GZF3
Protein GZF3

1

1

High-throughput

0.508

High

767812

NST1
Stress response protein NST1

1

1

High-throughput

0.508

High

767838

PRP11
Pre-mRNA-splicing factor PRP11

1

3

High-throughput

0.508

High

767841

SLK19
Kinetochore protein SLK19

1

2

High-throughput

0.508

High

577157

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

1

0

High-throughput

0.486

High

696617

F26
Fructose-2,6-bisphosphatase

1

0

High-throughput

0.486

High

757940

CSK2C
Casein kinase II subunit beta'

1

0

High-throughput

0.486

High

767819

GCR2
Glycolytic genes transcriptional activator GCR2

1

0

High-throughput

0.486

High

767824

VPS72
Vacuolar protein sorting-associated protein 72

1

0

High-throughput

0.486

High

767825

PPN1
Endopolyphosphatase

1

0

High-throughput

0.486

High

767826

MUS81
Crossover junction endonuclease MUS81

1

0

High-throughput

0.486

High

767830

RT103
Regulator of Ty1 transposition protein 103

1

0

High-throughput

0.486

High

767840

YL032
KH domain-containing protein YLL032C

1

0

High-throughput

0.486

High

756504

KOG1
Target of rapamycin complex 1 subunit KOG1

1

3

High-throughput

0.481

High

767851

CMR1
DNA damage-binding protein CMR1

1

5

High-throughput

0.481

High

767799

ATG1
Serine/threonine-protein kinase ATG1

1

0

High-throughput

0.480

High

636638

CDC48
Cell division control protein 48

1

0

High-throughput

0.479

High

408376

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

2

High-throughput

0.479

High

485530

SSBP1
Single-stranded nucleic acid-binding protein

1

2

High-throughput

0.479

High

548407

MS116
ATP-dependent RNA helicase MSS116, mitochondrial

1

1

High-throughput

0.479

High

558081

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.479

High

662350

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

675744

RENT1
ATP-dependent helicase NAM7

1

1

Small-scale

0.479

High

692011

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

1

High-throughput

0.479

High

759295

MET30
F-box protein MET30

1

4

High-throughput

0.479

High

765125

IF4F2
Eukaryotic initiation factor 4F subunit p130

1

1

Small-scale

0.479

High

767818

NOP3
Serine/arginine

1

3

Small-scale

0.479

High

767842

NCBP2
Nuclear cap-binding protein subunit 2

1

2

High-throughput

0.479

High

767845

RIO1
Serine/threonine-protein kinase RIO1

1

2

High-throughput

0.479

High

471503

RS28B
Small ribosomal subunit protein eS28B

1

1

High-throughput

0.464

High

767803

COPA
Coatomer subunit alpha

1

2

High-throughput

0.464

High

696505

TOR2
Serine/threonine-protein kinase TOR2

1

0

High-throughput

0.460

High

424872

IF4E
Eukaryotic translation initiation factor 4E

1

0

Small-scale

0.458

High

543822

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.458

High

634622

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.458

High

767783

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

767813

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

767827

RM34
Large ribosomal subunit protein bL34m

1

0

High-throughput

0.458

High

767834

MHR1
Large ribosomal subunit protein mL67

1

0

High-throughput

0.458

High

767839

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

767844

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

767846

RPN5
26S proteasome regulatory subunit RPN5

1

0

Small-scale

0.458

High

767847

UTP23
rRNA-processing protein UTP23

1

0

High-throughput

0.458

High

713289

WHI3
Protein WHI3

1

5

High-throughput

0.457

High

491367

HSP71
Heat shock protein SSA1

1

4

High-throughput

0.445

High

494084

HSP72
Heat shock protein SSA2

1

4

High-throughput

0.445

High

498946

RL4A
Large ribosomal subunit protein uL4A

1

1

High-throughput

0.445

High

633951

GBP2
Serine/arginine

1

2

High-throughput

0.445

High

692303

PRP19
Pre-mRNA-processing factor 19

1

8

Small-scale

0.445

High

704892

LHP1
La protein homolog

1

3

High-throughput

0.445

High

742822

GBLP
Small ribosomal subunit protein RACK1

1

6

High-throughput

0.445

High

767793

RL4B
Large ribosomal subunit protein uL4B

1

1

High-throughput

0.445

High

767853

RS28A
Small ribosomal subunit protein eS28A

1

1

High-throughput

0.439

High

735275

RM07
Large ribosomal subunit protein uL5m

1

1

High-throughput

0.437

High

762239

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

333804

ADH1
Alcohol dehydrogenase 1

1

0

High-throughput

0.426

High

767786

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.426

High

767781

JEM1
DnaJ-like chaperone JEM1

1

1

High-throughput

0.407

High

689791

RIM1
Single-stranded DNA-binding protein RIM1, mitochondrial

1

0

High-throughput

0.282

High

767785

COPB
Coatomer subunit beta

1

0

High-throughput

0.279

Low

522419

STE6
Alpha-factor-transporting ATPase

1

0

High-throughput

0.265

Low

707971

STE13
Dipeptidyl aminopeptidase A

1

0

High-throughput

0.265

Low

758432

STN1
Protein STN1

1

0

High-throughput

0.265

Low

767778

DSE1
Protein DSE1

1

0

High-throughput

0.265

Low

767782

YIC9
Uncharacterized protein YIL029C

1

0

High-throughput

0.265

Low

767792

IML1
Vacuolar membrane-associated protein IML1

1

0

High-throughput

0.265

Low

767836

VAC14
Vacuole morphology and inheritance protein 14

1

0

High-throughput

0.265

Low

520420

RT13
Small ribosomal subunit protein mS27

1

0

High-throughput

0.249

Low

520526

RM02
Large ribosomal subunit protein bL27m

1

0

High-throughput

0.249

Low

534486

RM31
Large ribosomal subunit protein mL60

1

0

High-throughput

0.249

Low

589382

RM33
Large ribosomal subunit protein uL30m

1

0

High-throughput

0.249

Low

607418

RM08
Large ribosomal subunit protein bL17m

1

0

High-throughput

0.249

Low

607487

RM20
Large ribosomal subunit protein mL58

1

0

High-throughput

0.249

Low

615610

RM25
Large ribosomal subunit protein mL59

1

0

High-throughput

0.249

Low

629856

RM32
Large ribosomal subunit protein bL32m

1

0

High-throughput

0.249

Low

635371

IMG1
Large ribosomal subunit protein bL19m

1

0

High-throughput

0.249

Low

635781

IMG2
Large ribosomal subunit protein mL49

1

0

High-throughput

0.249

Low

679561

RM09
Large ribosomal subunit protein uL3m

1

0

High-throughput

0.249

Low

689501

RM41
Large ribosomal subunit protein uL23m

1

0

High-throughput

0.249

Low

689585

RM49
Large ribosomal subunit protein mL61

1

0

High-throughput

0.249

Low

696869

RML2
Large ribosomal subunit protein uL2m

1

0

High-throughput

0.249

Low

729798

RM38
Large ribosomal subunit protein uL14m

1

0

High-throughput

0.249

Low

735141

RM03
Large ribosomal subunit protein mL44

1

0

High-throughput

0.249

Low

735206

RM04
Large ribosomal subunit protein uL29m

1

0

High-throughput

0.249

Low

735330

RM10
Large ribosomal subunit protein uL15m

1

0

High-throughput

0.249

Low

735395

RM11
Large ribosomal subunit protein uL10m

1

0

High-throughput

0.249

Low

735447

RM15
Large ribosomal subunit protein mL57

1

0

High-throughput

0.249

Low

735509

RM24
Large ribosomal subunit protein bL28m

1

0

High-throughput

0.249

Low

735558

RM27
Large ribosomal subunit protein mL41

1

0

High-throughput

0.249

Low

735599

RM28
Large ribosomal subunit protein mL40

1

0

High-throughput

0.249

Low

735659

RM17
Large ribosomal subunit protein mL46

1

0

High-throughput

0.249

Low

735722

RM36
Large ribosomal subunit protein bL31m

1

0

High-throughput

0.249

Low

735764

RM37
Large ribosomal subunit protein mL54

1

0

High-throughput

0.249

Low

735792

RM39
Large ribosomal subunit protein bL33m

1

0

High-throughput

0.249

Low

735825

RM40
Large ribosomal subunit protein uL24m

1

0

High-throughput

0.249

Low

743347

RM16
Large ribosomal subunit protein uL16m

1

0

High-throughput

0.249

Low

767784

RN49
Large ribosomal subunit protein bL21m

1

0

High-throughput

0.249

Low

767798

RL4P
Large ribosomal subunit protein uL4m

1

0

High-throughput

0.249

Low

767800

MNP1
Large ribosomal subunit protein bL12m

1

0

High-throughput

0.249

Low

767804

RM50
Large ribosomal subunit protein bL9m

1

0

High-throughput

0.249

Low

767808

RM19
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.249

Low

767809

RM22
Large ribosomal subunit protein uL22m

1

0

High-throughput

0.249

Low

767811

RN35
Large ribosomal subunit protein bL35m

1

0

High-throughput

0.249

Low

767820

RM13
Large ribosomal subunit protein mL50

1

0

High-throughput

0.249

Low

767822

ATP25
ATPase synthesis protein 25, mitochondrial

1

0

High-throughput

0.249

Low

767828

RM01
Large ribosomal subunit protein uL1m

1

0

High-throughput

0.249

Low

767831

RM51
Large ribosomal subunit protein mL43

1

0

High-throughput

0.249

Low

767835

RM35
Large ribosomal subunit protein mL38

1

0

High-throughput

0.249

Low

767850

RM23
Large ribosomal subunit protein uL13m

1

0

High-throughput

0.249

Low

141786

YL269
Putative uncharacterized protein YLR269C

1

0

High-throughput

0.238

Low

700443

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024