Protein: ITK
Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk)

Gene: ITK
Organism: Homo sapiens
Interactions: 55
UniProt ID: Q08881

Gene Ontology (top 5):
GO:0001819 - positive regulation of cytokine production
GO:0001865 - NK T cell differentiation
GO:0002250 - adaptive immune response
GO:0004715 - non-membrane spanning protein tyrosine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

996556

LCP2
Lymphocyte cytosolic protein 2

6

20

Small-scale

0.938

High

338331

EGFR
Epidermal growth factor receptor

3

20

High-throughput

0.843

High

580990

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

2

18

Small-scale

0.812

High

996553

ITK
Tyrosine-protein kinase ITK/TSK

2

20

Small-scale

0.812

High

683994

1433S
14-3-3 protein sigma

2

20

High-throughput

0.789

High

383767

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

High-throughput

0.778

High

412155

FYN
Tyrosine-protein kinase Fyn

2

19

Small-scale

0.778

High

601907

ERBB3
Receptor tyrosine-protein kinase erbB-3

2

20

High-throughput

0.778

High

924520

GRB2
Growth factor receptor-bound protein 2

2

20

Small-scale

0.778

High

996558

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

2

0

High-throughput

0.770

High

181852

SOCS1
Suppressor of cytokine signaling 1

2

20

Small-scale

0.768

High

441493

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.692

High

996561

GAB1
GRB2-associated-binding protein 1

1

20

High-throughput

0.692

High

991737

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

4

19

Small-scale

0.679

High

996564

CDC37
Hsp90 co-chaperone Cdc37

3

12

High-throughput

0.675

High

431782

HS90A
Heat shock protein HSP 90-alpha

3

20

High-throughput

0.667

High

438107

HS90B
Heat shock protein HSP 90-beta

3

20

High-throughput

0.667

High

522941

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.647

High

996562

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

996567

ABI1
Abl interactor 1

1

20

Small-scale

0.647

High

996573

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

12

Small-scale

0.647

High

147720

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

2

3

High-throughput

0.628

High

655339

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

20

Small-scale

0.618

High

909481

1433E
14-3-3 protein epsilon

1

5

High-throughput

0.618

High

996563

ELOB
Elongin-B

1

1

High-throughput

0.618

High

996568

A16L2
Protein Atg16l2

1

12

High-throughput

0.618

High

996569

AURKB
Aurora kinase B

1

11

High-throughput

0.618

High

790666

WASP
Actin nucleation-promoting factor WAS

2

20

Small-scale

0.613

High

207442

LAT
Linker for activation of T-cells family member 1

2

4

Small-scale

0.595

High

923654

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

4

Small-scale

0.586

High

815674

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

12

Small-scale

0.578

High

853251

IMA1
Importin subunit alpha-1

1

0

Small-scale

0.561

High

996576

NEMO
NF-kappa-B essential modulator

1

20

High-throughput

0.561

High

996574

IBTK
Inhibitor of Bruton tyrosine kinase

1

8

Small-scale

0.553

High

996566

HS905
Putative heat shock protein HSP 90-alpha A5

2

20

High-throughput

0.552

High

722888

SPR2A
Small proline-rich protein 2A

1

4

Small-scale

0.536

High

826630

TCPG
T-complex protein 1 subunit gamma

1

20

High-throughput

0.536

High

996559

TCOF
Treacle protein

1

13

High-throughput

0.536

High

996571

PININ
Pinin

1

3

High-throughput

0.536

High

996575

SRRM2
Serine/arginine repetitive matrix protein 2

1

7

High-throughput

0.536

High

507964

FGFR1
Fibroblast growth factor receptor 1

1

20

Small-scale

0.527

High

996570

DOK1
Docking protein 1

1

20

Small-scale

0.527

High

996555

AHNK
Neuroblast differentiation-associated protein AHNAK

1

8

High-throughput

0.515

High

610373

CBL
E3 ubiquitin-protein ligase CBL

1

20

Small-scale

0.501

High

903901

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

12

Small-scale

0.501

High

996560

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

1

20

Small-scale

0.501

High

996572

WDCP
WD repeat and coiled-coil-containing protein

1

1

High-throughput

0.489

High

152277

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

20

Small-scale

0.479

High

209924

PRC1
Protein regulator of cytokinesis 1

1

8

High-throughput

0.479

High

416917

CD2
T-cell surface antigen CD2

1

17

Small-scale

0.479

High

726772

FUS
RNA-binding protein FUS

1

6

High-throughput

0.479

High

996554

EP300
Histone acetyltransferase p300

1

17

Small-scale

0.479

High

996557

G3BP1
Ras GTPase-activating protein-binding protein 1

1

7

Small-scale

0.479

High

996565

H90B3
Putative heat shock protein HSP 90-beta-3

1

20

High-throughput

0.445

High


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Last updated: 15 Jul 2024