Protein: ARHGC
Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF)

Gene: ARHGC, ARHGEF12
Organism: Homo sapiens
Interactions: 91
UniProt ID: Q9NZN5

Gene Ontology (top 5):
GO:0001664 - G protein-coupled receptor binding
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005096 - GTPase activator activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

900985

RHOA
Transforming protein RhoA

9

20

Small-scale

0.971

High

158242

GIPC1
PDZ domain-containing protein GIPC1

5

4

High-throughput

0.935

High

436545

RHOC
Rho-related GTP-binding protein RhoC

3

20

High-throughput

0.861

High

167113

ARHGB
Rho guanine nucleotide exchange factor 11

3

17

High-throughput

0.839

High

1053447

GNA13
Guanine nucleotide-binding protein subunit alpha-13

3

14

Small-scale

0.827

High

1299922

PKH4B
Pleckstrin homology domain-containing family G member 4B

2

18

High-throughput

0.767

High

435784

IGF1R
Insulin-like growth factor 1 receptor

1

20

Small-scale

0.767

High

916029

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

1349327

VAPA
Vesicle-associated membrane protein-associated protein A

6

3

High-throughput

0.736

High

1349331

MYO6
Unconventional myosin-VI

5

8

Small-scale

0.723

High

490033

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

6

Small-scale

0.713

High

310847

VAPB
Vesicle-associated membrane protein-associated protein B/C

4

3

High-throughput

0.699

High

1343719

ANLN
Anillin

1

3

High-throughput

0.691

High

1349328

SH3B4
SH3 domain-binding protein 4

1

0

High-throughput

0.678

High

789009

TEC
Tyrosine-protein kinase Tec

1

16

Small-scale

0.647

High

1042701

CUL3
Cullin-3

2

10

Small-scale

0.631

High

837658

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

13

Small-scale

0.618

High

892637

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

894523

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

974739

GNA12
Guanine nucleotide-binding protein subunit alpha-12

1

14

Small-scale

0.618

High

1172040

TRI67
Tripartite motif-containing protein 67

1

18

High-throughput

0.618

High

1256728

ARH40
Rho guanine nucleotide exchange factor 40

1

19

High-throughput

0.618

High

1257222

GIPC2
PDZ domain-containing protein GIPC2

1

4

High-throughput

0.618

High

1331486

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.618

High

1349326

ARHGC
Rho guanine nucleotide exchange factor 12

1

14

Small-scale

0.618

High

850719

KS6A3
Ribosomal protein S6 kinase alpha-3

2

6

High-throughput

0.611

High

1133665

CC183
Coiled-coil domain-containing protein 183

3

8

High-throughput

0.609

High

1235168

S2541
Mitochondrial carrier protein SCaMC-3L

3

2

High-throughput

0.609

High

1291640

TRM61
tRNA

3

1

High-throughput

0.609

High

370588

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1260788

DEP1B
DEP domain-containing protein 1B

2

8

High-throughput

0.571

High

555209

CD44
CD44 antigen

1

2

Small-scale

0.561

High

195990

PLXB1
Plexin-B1

1

15

Small-scale

0.552

High

198737

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

1

High-throughput

0.536

High

260621

TP4A3
Protein tyrosine phosphatase type IVA 3

1

3

High-throughput

0.536

High

422111

LDHB
L-lactate dehydrogenase B chain

1

1

High-throughput

0.536

High

686085

ARRB2
Beta-arrestin-2

1

1

High-throughput

0.536

High

770699

TXLNA
Alpha-taxilin

1

6

High-throughput

0.536

High

1236910

KC1AL
Casein kinase I isoform alpha-like

1

5

High-throughput

0.536

High

1284832

EFMT3
EEF1A lysine methyltransferase 3

1

4

High-throughput

0.536

High

1318408

UBXN6
UBX domain-containing protein 6

1

2

High-throughput

0.536

High

1349334

SMC3
Structural maintenance of chromosomes protein 3

1

6

High-throughput

0.536

High

453669

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

2

High-throughput

0.515

High

730371

PRS7
26S proteasome regulatory subunit 7

1

0

High-throughput

0.513

High

1062886

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

0

High-throughput

0.513

High

1289718

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

0

High-throughput

0.513

High

1349332

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

0

High-throughput

0.513

High

339059

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.501

High

1349335

KLH20
Kelch-like protein 20

1

3

Small-scale

0.501

High

165264

PLXB2
Plexin-B2

1

16

Small-scale

0.479

High

279737

FLOT1
Flotillin-1

1

8

High-throughput

0.479

High

315266

ABCA1
Phospholipid-transporting ATPase ABCA1

1

1

Small-scale

0.479

High

409257

K2C8
Keratin, type II cytoskeletal 8

1

1

High-throughput

0.479

High

430357

PROF1
Profilin-1

1

5

High-throughput

0.479

High

518784

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

1

High-throughput

0.479

High

522230

CADH1
Cadherin-1

1

2

High-throughput

0.479

High

547251

EZRI
Ezrin

1

6

High-throughput

0.479

High

610518

CBL
E3 ubiquitin-protein ligase CBL

1

18

High-throughput

0.479

High

823504

PAXI
Paxillin

1

7

High-throughput

0.479

High

835544

GSK3A
Glycogen synthase kinase-3 alpha

1

8

High-throughput

0.479

High

836040

GSK3B
Glycogen synthase kinase-3 beta

1

8

High-throughput

0.479

High

840589

VASP
Vasodilator-stimulated phosphoprotein

1

2

High-throughput

0.479

High

981465

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

2

High-throughput

0.479

High

1026788

PRDX4
Peroxiredoxin-4

1

2

High-throughput

0.479

High

1329101

VP33B
Vacuolar protein sorting-associated protein 33B

1

3

High-throughput

0.479

High

1329210

GAN
Gigaxonin

1

5

High-throughput

0.479

High

1349329

ANFY1
Rabankyrin-5

1

7

High-throughput

0.479

High

1349330

FZR1
Fizzy-related protein homolog

1

10

High-throughput

0.479

High

1039345

DCTN2
Dynactin subunit 2

1

0

High-throughput

0.458

High

1343346

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

Small-scale

0.458

High

833829

CLK1
Dual specificity protein kinase CLK1

1

2

High-throughput

0.457

High

901837

STXB1
Syntaxin-binding protein 1

1

3

High-throughput

0.457

High

264424

GGYF1
GRB10-interacting GYF protein 1

1

5

High-throughput

0.445

High

483965

CALM1
Calmodulin-1

1

2

High-throughput

0.445

High

484045

CALM2
Calmodulin-2

1

2

High-throughput

0.445

High

484212

CALM3
Calmodulin-3

1

2

High-throughput

0.445

High

1047295

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

2

High-throughput

0.445

High

385628

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.437

High

1084212

OCLN
Occludin

1

2

High-throughput

0.437

High

1269786

ESR2
Estrogen receptor beta

1

20

High-throughput

0.437

High

893613

SEM1
26S proteasome complex subunit SEM1

1

0

High-throughput

0.426

High

1073489

KS6A1
Ribosomal protein S6 kinase alpha-1

1

9

Small-scale

0.408

High

1017248

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

High-throughput

0.279

Low

1288834

ERLEC
Endoplasmic reticulum lectin 1

1

0

High-throughput

0.279

Low

1294564

DYDC2
DPY30 domain-containing protein 2

1

0

High-throughput

0.279

Low

1307169

SSX3
Protein SSX3

1

0

High-throughput

0.279

Low

1308560

NIPS1
Protein NipSnap homolog 1

1

0

High-throughput

0.279

Low

1349336

RCL1
RNA 3'-terminal phosphate cyclase-like protein

1

0

High-throughput

0.279

Low

1173052

SEML
Putative protein SEM1, isoform 2

1

0

High-throughput

0.249

Low

1349333

SATB2
DNA-binding protein SATB2

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024