Protein: ITB3
Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61)

Gene: ITB3, ITGB3
Organism: Homo sapiens
Interactions: 69
UniProt ID: P05106

Gene Ontology (top 5):
GO:0001618 - virus receptor activity
GO:0001934 - positive regulation of protein phosphorylation
GO:0001938 - positive regulation of endothelial cell proliferation
GO:0001954 - positive regulation of cell-matrix adhesion
GO:0001968 - fibronectin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

396554

ITA2B
Integrin alpha-IIb

16

20

Small-scale

0.987

High

396549

ITAV
Integrin alpha-V

9

20

Small-scale

0.969

High

396546

ITB3
Integrin beta-3

3

14

Small-scale

0.843

High

396566

FLNA
Filamin-A

2

20

Small-scale

0.793

High

362672

FINC
Fibronectin

2

14

Small-scale

0.768

High

380894

VWF
von Willebrand factor

2

10

Small-scale

0.768

High

396555

ITA5
Integrin alpha-5

2

20

Small-scale

0.768

High

396567

PTPRZ
Receptor-type tyrosine-protein phosphatase zeta

2

10

Small-scale

0.754

High

396601

TLN1
Talin-1

6

20

Small-scale

0.733

High

396595

DOK1
Docking protein 1

1

4

Small-scale

0.647

High

396582

FAK1
Focal adhesion kinase 1

3

20

Small-scale

0.646

High

361965

FIBG
Fibrinogen gamma chain

3

4

Small-scale

0.631

High

396561

PA2GA
Phospholipase A2, membrane associated

2

1

Small-scale

0.629

High

261179

FLNB
Filamin-B

1

20

Small-scale

0.621

High

396560

CEAM1
Carcinoembryonic antigen-related cell adhesion molecule 1

1

8

Small-scale

0.618

High

396569

EPHA2
Ephrin type-A receptor 2

1

16

Small-scale

0.618

High

396574

MUC18
Cell surface glycoprotein MUC18

1

9

High-throughput

0.618

High

396587

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

1

16

Small-scale

0.618

High

396580

X3CL1
Fractalkine

2

4

Small-scale

0.612

High

396585

CENPR
Centromere protein R

2

1

Small-scale

0.609

High

396552

TSP1
Thrombospondin-1

2

20

Small-scale

0.595

High

396581

CO4A3
Collagen alpha-3(IV) chain

2

2

Small-scale

0.584

High

396570

SHC1
SHC-transforming protein 1

2

15

Small-scale

0.563

High

393908

A4
Amyloid-beta precursor protein

1

3

Small-scale

0.561

High

396573

GRIA2
Glutamate receptor 2

1

2

Small-scale

0.561

High

396576

PA24A
Cytosolic phospholipase A2

1

6

Small-scale

0.561

High

396564

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

14

Small-scale

0.536

High

158598

RGS12
Regulator of G-protein signaling 12

1

1

Small-scale

0.501

High

349061

RASH
GTPase HRas

1

15

Small-scale

0.501

High

396550

PDIA1
Protein disulfide-isomerase

1

5

Small-scale

0.501

High

396558

FGFR1
Fibroblast growth factor receptor 1

1

20

Small-scale

0.501

High

396559

SRC
Proto-oncogene tyrosine-protein kinase Src

1

13

Small-scale

0.501

High

396568

MK03
Mitogen-activated protein kinase 3

1

2

Small-scale

0.501

High

396571

AKT1
RAC-alpha serine/threonine-protein kinase

1

12

Small-scale

0.501

High

396578

PAXI
Paxillin

1

20

Small-scale

0.501

High

396584

EPS8
Epidermal growth factor receptor kinase substrate 8

1

8

Small-scale

0.501

High

396588

FAK2
Protein-tyrosine kinase 2-beta

1

20

Small-scale

0.501

High

396592

TENS2
Tensin-2

1

5

Small-scale

0.501

High

396593

ANS1B
Ankyrin repeat and sterile alpha motif domain-containing protein 1B

1

8

Small-scale

0.501

High

396599

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

1

11

Small-scale

0.501

High

396548

CDK1
Cyclin-dependent kinase 1

1

0

Small-scale

0.480

High

330809

PAK4
Serine/threonine-protein kinase PAK 4

1

4

Small-scale

0.479

High

372973

VTNC
Vitronectin

1

4

Small-scale

0.479

High

373504

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.479

High

396547

KPCB
Protein kinase C beta type

1

13

Small-scale

0.479

High

396551

LYN
Tyrosine-protein kinase Lyn

1

14

Small-scale

0.479

High

396553

MMP2
72 kDa type IV collagenase

1

13

Small-scale

0.479

High

396557

PGFRB
Platelet-derived growth factor receptor beta

1

11

Small-scale

0.479

High

396562

PGFRA
Platelet-derived growth factor receptor alpha

1

13

Small-scale

0.479

High

396563

CD36
Platelet glycoprotein 4

1

1

Small-scale

0.479

High

396565

PTN
Pleiotrophin

1

1

Small-scale

0.479

High

396572

VGFR2
Vascular endothelial growth factor receptor 2

1

9

Small-scale

0.479

High

396575

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.479

High

396577

TISD
mRNA decay activator protein ZFP36L2

1

1

High-throughput

0.479

High

396586

ILK
Integrin-linked protein kinase

1

6

Small-scale

0.479

High

396589

CASL
Enhancer of filamentation 1

1

2

Small-scale

0.479

High

396594

URP2
Fermitin family homolog 3

1

17

Small-scale

0.479

High

396556

VIME
Vimentin

1

0

Small-scale

0.458

High

396596

CIB1
Calcium and integrin-binding protein 1

1

0

Small-scale

0.458

High

396598

GULP1
PTB domain-containing engulfment adapter protein 1

1

11

Small-scale

0.457

High

396600

RBGP1
Rab GTPase-activating protein 1

1

5

Small-scale

0.457

High

396579

CX3C1
CX3C chemokine receptor 1

1

1

Small-scale

0.445

High

396583

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

11

Small-scale

0.445

High

396597

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

3

High-throughput

0.437

High

361724

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

1

4

Small-scale

0.408

High

396591

MIIP
Migration and invasion-inhibitory protein

1

0

Small-scale

0.292

High

352857

IFNB
Interferon beta

1

0

Small-scale

0.261

Low

396590

PDK1
[Pyruvate dehydrogenase

1

0

Small-scale

0.261

Low


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Last updated: 15 Jul 2024