Protein: TNKS2
Poly [ADP-ribose] polymerase tankyrase-2 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (Poly [ADP-ribose] polymerase 5B) (Protein poly-ADP-ribosyltransferase tankyrase-2) (EC 2.4.2.-) (TNKS-2) (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase II) (Tankyrase-2) (TANK2) (Tankyrase-like protein) (Tankyrase-related protein)

Gene: TNKS2
Organism: Homo sapiens
Interactions: 75
UniProt ID: Q9H2K2

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0000209 - protein polyubiquitination
GO:0000242 - pericentriolar material
GO:0000781 - chromosome, telomeric region
GO:0003950 - NAD+ ADP-ribosyltransferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1329536

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

5

12

Small-scale

0.937

High

170717

AXIN1
Axin-1

2

6

Small-scale

0.768

High

1318220

PP12C
Protein phosphatase 1 regulatory subunit 12C

2

15

Small-scale

0.757

High

869742

TERF1
Telomeric repeat-binding factor 1

9

2

Small-scale

0.754

High

1329543

AXIN2
Axin-2

2

6

Small-scale

0.737

High

1329539

LCAP
Leucyl-cystinyl aminopeptidase

4

2

Small-scale

0.709

High

1329537

BABA1
BRISC and BRCA1-A complex member 1

4

1

Small-scale

0.708

High

167014

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

13

High-throughput

0.698

High

225160

MYPT2
Protein phosphatase 1 regulatory subunit 12B

1

19

High-throughput

0.691

High

1329538

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

4

5

Small-scale

0.688

High

1185293

3BP5L
SH3 domain-binding protein 5-like

3

3

Small-scale

0.667

High

1283421

RN166
E3 ubiquitin-protein ligase RNF166

3

3

High-throughput

0.667

High

1287489

AP2M1
AP-2 complex subunit mu

3

3

High-throughput

0.667

High

1310963

S35A5
UDP-sugar transporter protein SLC35A5

3

1

High-throughput

0.667

High

1328936

EPN3
Epsin-3

3

3

High-throughput

0.667

High

1329534

DISC1
Disrupted in schizophrenia 1 protein

3

4

Small-scale

0.658

High

659047

MK01
Mitogen-activated protein kinase 1

1

2

Small-scale

0.647

High

992198

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

1

1

Small-scale

0.647

High

1301539

FNBP1
Formin-binding protein 1

1

4

Small-scale

0.647

High

1329533

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

1

13

Small-scale

0.647

High

1329540

TAOK2
Serine/threonine-protein kinase TAO2

1

9

Small-scale

0.647

High

1318943

TB182
182 kDa tankyrase-1-binding protein

3

16

Small-scale

0.647

High

236565

GMDS
GDP-mannose 4,6 dehydratase

2

2

High-throughput

0.628

High

992707

LRP1
Prolow-density lipoprotein receptor-related protein 1

2

6

High-throughput

0.628

High

1203233

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

2

2

High-throughput

0.628

High

1236637

CELF5
CUGBP Elav-like family member 5

2

4

High-throughput

0.628

High

1329541

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

2

10

High-throughput

0.628

High

1262757

ARAP3
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

1

8

Small-scale

0.621

High

1079151

STK11
Serine/threonine-protein kinase STK11

1

1

Small-scale

0.618

High

242132

PAGE4
P antigen family member 4

2

3

High-throughput

0.611

High

1061241

NUMA1
Nuclear mitotic apparatus protein 1

2

12

Small-scale

0.606

High

888500

NANO2
Nanos homolog 2

2

0

High-throughput

0.602

High

538742

HXB2
Homeobox protein Hox-B2

3

17

Small-scale

0.600

High

1329535

RN146
E3 ubiquitin-protein ligase RNF146

2

1

Small-scale

0.594

High

940674

3BP2
SH3 domain-binding protein 2

2

5

Small-scale

0.593

High

299128

SASH1
SAM and SH3 domain-containing protein 1

1

0

Small-scale

0.589

High

1044901

CAC1S
Voltage-dependent L-type calcium channel subunit alpha-1S

2

5

Small-scale

0.586

High

506657

BCR
Breakpoint cluster region protein

1

12

Small-scale

0.586

High

1269165

RAD54
DNA repair and recombination protein RAD54-like

1

1

Small-scale

0.586

High

225246

3BP5
SH3 domain-binding protein 5

2

3

Small-scale

0.576

High

225047

ZNRD2
Protein ZNRD2

2

1

High-throughput

0.574

High

1158429

F117B
Protein FAM117B

2

1

High-throughput

0.574

High

1054044

GRB14
Growth factor receptor-bound protein 14

1

8

Small-scale

0.573

High

1256726

ARH40
Rho guanine nucleotide exchange factor 40

2

12

High-throughput

0.571

High

890841

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

7

Small-scale

0.561

High

1329542

AMOL2
Angiomotin-like protein 2

1

15

Small-scale

0.561

High

215269

STRN
Striatin

1

5

Small-scale

0.550

High

234284

PEPL
Periplakin

1

20

High-throughput

0.536

High

280069

MPDZ
Multiple PDZ domain protein

1

4

High-throughput

0.536

High

1274043

CUL5
Cullin-5

1

7

High-throughput

0.536

High

600670

EPHA1
Ephrin type-A receptor 1

1

6

High-throughput

0.528

High

1288300

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

8

High-throughput

0.515

High

1190089

MAVS
Mitochondrial antiviral-signaling protein

1

9

Small-scale

0.512

High

1131844

CE170
Centrosomal protein of 170 kDa

1

16

Small-scale

0.501

High

1216417

MY18B
Unconventional myosin-XVIIIb

1

6

Small-scale

0.501

High

1311994

DIDO1
Death-inducer obliterator 1

1

11

Small-scale

0.501

High

1299905

CC85A
Coiled-coil domain-containing protein 85A

1

1

High-throughput

0.489

High

1305522

CGRE1
Cell growth regulator with EF hand domain protein 1

1

1

High-throughput

0.489

High

1309358

SOST
Sclerostin

1

1

High-throughput

0.489

High

1056981

MDC1
Mediator of DNA damage checkpoint protein 1

1

7

Small-scale

0.481

High

758334

CDN1A
Cyclin-dependent kinase inhibitor 1

1

2

Small-scale

0.479

High

839981

F10A1
Hsc70-interacting protein

1

6

High-throughput

0.479

High

1119054

AMOT
Angiomotin

1

16

Small-scale

0.479

High

1146832

A16L1
Autophagy-related protein 16-1

1

8

Small-scale

0.479

High

1222268

AMOL1
Angiomotin-like protein 1

1

17

Small-scale

0.479

High

1301783

RANB9
Ran-binding protein 9

1

2

High-throughput

0.479

High

1317604

IFIH1
Interferon-induced helicase C domain-containing protein 1

1

1

Small-scale

0.479

High

1296246

Z512B
Zinc finger protein 512B

1

5

High-throughput

0.464

High

1167037

FAT4
Protocadherin Fat 4

1

1

Small-scale

0.457

High

1201906

TAXB1
Tax1-binding protein 1

1

8

Small-scale

0.457

High

957287

FBLN2
Fibulin-2

1

8

Small-scale

0.417

High

1191959

ARPIN
Arpin

1

0

Small-scale

0.295

High

1052862

FASTK
Fas-activated serine/threonine kinase

1

0

Small-scale

0.261

Low

886335

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024