Protein: IRAK2
Interleukin-1 receptor-associated kinase-like 2 (IRAK-2)

Gene: IRAK2
Organism: Homo sapiens
Interactions: 61
UniProt ID: O43187

Gene Ontology (top 5):
GO:0001959 - regulation of cytokine-mediated signaling pathway
GO:0002755 - MyD88-dependent toll-like receptor signaling pathway
GO:0004672 - protein kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

197890

IRAK1
Interleukin-1 receptor-associated kinase 1

4

20

Small-scale

0.904

High

197912

MYD88
Myeloid differentiation primary response protein MyD88

4

20

Small-scale

0.896

High

197919

IRAK4
Interleukin-1 receptor-associated kinase 4

2

20

Small-scale

0.811

High

197925

IRAK3
Interleukin-1 receptor-associated kinase 3

2

19

Small-scale

0.789

High

197880

ARAF
Serine/threonine-protein kinase A-Raf

1

19

High-throughput

0.757

High

197898

TADBP
TAR DNA-binding protein 43

1

2

High-throughput

0.757

High

197923

TRAF6
TNF receptor-associated factor 6

9

12

Small-scale

0.755

High

197874

LYN
Tyrosine-protein kinase Lyn

1

3

High-throughput

0.691

High

197879

HCK
Tyrosine-protein kinase HCK

1

3

High-throughput

0.691

High

197896

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

20

High-throughput

0.691

High

197900

CDC37
Hsp90 co-chaperone Cdc37

1

1

High-throughput

0.691

High

179917

TLR3
Toll-like receptor 3

1

20

Small-scale

0.665

High

197892

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

2

3

Small-scale

0.621

High

197867

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

20

Small-scale

0.618

High

197870

RASH
GTPase HRas

1

2

Small-scale

0.618

High

197873

HS90A
Heat shock protein HSP 90-alpha

1

6

High-throughput

0.618

High

197875

HS90B
Heat shock protein HSP 90-beta

1

6

High-throughput

0.618

High

197884

AKT1
RAC-alpha serine/threonine-protein kinase

1

3

Small-scale

0.618

High

197887

CTCF
Transcriptional repressor CTCF

1

1

Small-scale

0.618

High

197901

ZC12A
Endoribonuclease ZC3H12A

1

1

High-throughput

0.586

High

197916

TOLIP
Toll-interacting protein

1

2

High-throughput

0.586

High

197903

SARM1
NAD(+) hydrolase SARM1

1

2

High-throughput

0.578

High

197868

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

2

High-throughput

0.536

High

197869

BAG3
BAG family molecular chaperone regulator 3

1

2

High-throughput

0.536

High

197871

TRFL
Lactotransferrin

1

1

High-throughput

0.536

High

197876

ELNE
Neutrophil elastase

1

2

High-throughput

0.536

High

197877

CATG
Cathepsin G

1

2

High-throughput

0.536

High

197908

COQ8A
Atypical kinase COQ8A, mitochondrial

1

2

High-throughput

0.536

High

197909

N42L2
NEDD4-binding protein 2-like 2

1

1

High-throughput

0.536

High

197913

YTHD1
YTH domain-containing family protein 1

1

6

High-throughput

0.536

High

197914

ZC12C
Probable ribonuclease ZC3H12C

1

1

High-throughput

0.536

High

197918

SHLB2
Endophilin-B2

1

1

High-throughput

0.536

High

197920

SENP1
Sentrin-specific protease 1

1

1

High-throughput

0.536

High

197921

SHLB1
Endophilin-B1

1

1

High-throughput

0.536

High

197881

IL1R1
Interleukin-1 receptor type 1

1

12

Small-scale

0.515

High

197888

PSN1
Presenilin-1

1

1

Small-scale

0.515

High

197872

PERM
Myeloperoxidase

1

0

High-throughput

0.513

High

197878

NEP
Neprilysin

1

0

Small-scale

0.513

High

197891

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

0

High-throughput

0.513

High

197894

TBA4A
Tubulin alpha-4A chain

1

0

High-throughput

0.513

High

197899

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.513

High

197883

CALX
Calnexin

1

2

High-throughput

0.489

High

197902

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

1

High-throughput

0.489

High

197882

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

1

Small-scale

0.479

High

197889

PSN2
Presenilin-2

1

1

Small-scale

0.479

High

197906

PELI3
E3 ubiquitin-protein ligase pellino homolog 3

1

11

Small-scale

0.479

High

197911

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

11

Small-scale

0.479

High

197917

PELI2
E3 ubiquitin-protein ligase pellino homolog 2

1

11

Small-scale

0.479

High

197924

YTHD2
YTH domain-containing family protein 2

1

6

High-throughput

0.479

High

197885

TNFL9
Tumor necrosis factor ligand superfamily member 9

1

0

Small-scale

0.458

High

197897

RBBP4
Histone-binding protein RBBP4

1

0

High-throughput

0.458

High

197907

RN152
E3 ubiquitin-protein ligase RNF152

1

5

Small-scale

0.437

High

197910

CCD47
PAT complex subunit CCDC47

1

1

High-throughput

0.437

High

197922

TMED7
Transmembrane emp24 domain-containing protein 7

1

1

Small-scale

0.437

High

197893

DEF1
Neutrophil defensin 1

1

0

High-throughput

0.426

High

197905

SESD1
SEC14 domain and spectrin repeat-containing protein 1

3

0

High-throughput

0.352

High

197886

STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

0

High-throughput

0.306

High

197895

NGAL
Neutrophil gelatinase-associated lipocalin

1

0

High-throughput

0.279

Low

197904

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

0

High-throughput

0.279

Low

197915

LACRT
Extracellular glycoprotein lacritin

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024