Protein: KLF11
Krueppel-like factor 11 (Transforming growth factor-beta-inducible early growth response protein 2) (TGFB-inducible early growth response protein 2) (TIEG-2)

Gene: KLF11
Organism: Homo sapiens
Interactions: 247
UniProt ID: O14901

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

167230

MK01
Mitogen-activated protein kinase 1

2

6

Small-scale

0.789

High

167229

MK03
Mitogen-activated protein kinase 3

2

6

High-throughput

0.737

High

167370

SIN3A
Paired amphipathic helix protein Sin3a

4

10

Small-scale

0.680

High

116361

H3BUJ7
Transcription factor E4F1

1

18

High-throughput

0.665

High

167199

ZBT14
Zinc finger and BTB domain-containing protein 14

1

19

High-throughput

0.665

High

167204

KS6A4
Ribosomal protein S6 kinase alpha-4

1

5

High-throughput

0.665

High

167240

KS6A3
Ribosomal protein S6 kinase alpha-3

1

5

High-throughput

0.665

High

167246

KLF3
Krueppel-like factor 3

1

19

High-throughput

0.665

High

167262

KLF5
Krueppel-like factor 5

1

19

High-throughput

0.665

High

167273

KS6A2
Ribosomal protein S6 kinase alpha-2

1

5

High-throughput

0.665

High

167275

ZXDC
Zinc finger protein ZXDC

1

18

High-throughput

0.665

High

167327

ZSCA1
Zinc finger and SCAN domain-containing protein 1

1

20

High-throughput

0.665

High

167362

ZN333
Zinc finger protein 333

1

19

High-throughput

0.665

High

167398

MKNK2
MAP kinase-interacting serine/threonine-protein kinase 2

1

2

High-throughput

0.665

High

167402

STK36
Serine/threonine-protein kinase 36

1

3

High-throughput

0.665

High

167409

MS18A
Protein Mis18-alpha

1

1

High-throughput

0.665

High

167415

KLF15
Krueppel-like factor 15

1

19

High-throughput

0.665

High

167198

MS18B
Protein Mis18-beta

1

0

High-throughput

0.630

High

167371

CRBN
Protein cereblon

1

0

High-throughput

0.630

High

167194

KLF11
Krueppel-like factor 11

1

15

High-throughput

0.618

High

167224

EGR1
Early growth response protein 1

1

17

Small-scale

0.618

High

167263

NFYC
Nuclear transcription factor Y subunit gamma

2

6

High-throughput

0.606

High

167233

HD
Huntingtin

2

10

High-throughput

0.596

High

155718

TXND9
Thioredoxin domain-containing protein 9

1

1

High-throughput

0.573

High

167343

APBP2
Amyloid protein-binding protein 2

1

6

High-throughput

0.573

High

167215

PDIA1
Protein disulfide-isomerase

2

7

High-throughput

0.571

High

167235

CBX5
Chromobox protein homolog 5

1

20

Small-scale

0.561

High

167394

BOLA2
BolA-like protein 2

2

0

High-throughput

0.547

High

167219

CLUS
Clusterin

1

1

High-throughput

0.541

High

167425

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

1

High-throughput

0.541

High

48264

E2F8
Transcription factor E2F8

1

11

High-throughput

0.515

High

131227

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

8

High-throughput

0.515

High

167197

PER1
Period circadian protein homolog 1

1

4

High-throughput

0.515

High

167201

TBL1X
F-box-like/WD repeat-containing protein TBL1X

1

14

High-throughput

0.515

High

167202

TADA3
Transcriptional adapter 3

1

5

High-throughput

0.515

High

167210

CBX6
Chromobox protein homolog 6

1

20

High-throughput

0.515

High

167212

A4
Amyloid-beta precursor protein

1

17

High-throughput

0.515

High

167213

FYN
Tyrosine-protein kinase Fyn

1

7

High-throughput

0.515

High

167216

VIME
Vimentin

1

10

High-throughput

0.515

High

167218

ANXA4
Annexin A4

1

4

High-throughput

0.515

High

167220

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

2

High-throughput

0.515

High

167221

ANXA8
Annexin A8

1

4

High-throughput

0.515

High

167223

GATA1
Erythroid transcription factor

1

15

High-throughput

0.515

High

167231

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

5

High-throughput

0.515

High

167232

PRS7
26S proteasome regulatory subunit 7

1

10

High-throughput

0.515

High

167234

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

6

High-throughput

0.515

High

167244

PKNX1
Homeobox protein PKNOX1

1

5

High-throughput

0.515

High

167247

VSX2
Visual system homeobox 2

1

3

High-throughput

0.515

High

167253

GABP1
GA-binding protein subunit beta-1

1

7

High-throughput

0.515

High

167256

TP53B
TP53-binding protein 1

1

3

High-throughput

0.515

High

167261

NDF1
Neurogenic differentiation factor 1

1

8

High-throughput

0.515

High

167264

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

1

4

High-throughput

0.515

High

167265

DPYS
Dihydropyrimidinase

1

3

High-throughput

0.515

High

167266

DELE1
DAP3-binding cell death enhancer 1

1

6

High-throughput

0.515

High

167268

KT33B
Keratin, type I cuticular Ha3-II

1

10

High-throughput

0.515

High

167270

STAT4
Signal transducer and activator of transcription 4

1

5

High-throughput

0.515

High

167276

TBRG1
Transforming growth factor beta regulator 1

1

7

High-throughput

0.515

High

167278

RHG29
Rho GTPase-activating protein 29

1

17

High-throughput

0.515

High

167282

FHL5
Four and a half LIM domains protein 5

1

14

High-throughput

0.515

High

167284

LEG9C
Galectin-9C

1

2

High-throughput

0.515

High

167285

OTU7B
OTU domain-containing protein 7B

1

12

High-throughput

0.515

High

167286

ESRP1
Epithelial splicing regulatory protein 1

1

7

High-throughput

0.515

High

167287

H3C
Histone H3.3C

1

14

High-throughput

0.515

High

167293

Q6PHZ7
NR2C2 protein

1

20

High-throughput

0.515

High

167307

TRI69
E3 ubiquitin-protein ligase TRIM69

1

20

High-throughput

0.515

High

167310

CRLF3
Cytokine receptor-like factor 3

1

1

High-throughput

0.515

High

167316

PHC2
Polyhomeotic-like protein 2

1

14

High-throughput

0.515

High

167319

UBQLN
Ubiquilin-like protein

1

14

High-throughput

0.515

High

167330

VP37A
Vacuolar protein sorting-associated protein 37A

1

1

High-throughput

0.515

High

167331

CEP70
Centrosomal protein of 70 kDa

1

3

High-throughput

0.515

High

167332

BAHD1
Bromo adjacent homology domain-containing 1 protein

1

1

High-throughput

0.515

High

167334

THAP3
THAP domain-containing protein 3

1

4

High-throughput

0.515

High

167340

ASB13
Ankyrin repeat and SOCS box protein 13

1

20

High-throughput

0.515

High

167342

LAR4B
La-related protein 4B

1

8

High-throughput

0.515

High

167344

H2A1C
Histone H2A type 1-C

1

2

High-throughput

0.515

High

167349

HAUS1
HAUS augmin-like complex subunit 1

1

1

High-throughput

0.515

High

167350

ASB9
Ankyrin repeat and SOCS box protein 9

1

13

High-throughput

0.515

High

167352

RNF31
E3 ubiquitin-protein ligase RNF31

1

20

High-throughput

0.515

High

167354

OTUB1
Ubiquitin thioesterase OTUB1

1

1

High-throughput

0.515

High

167355

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

4

High-throughput

0.515

High

167372

PFD5
Prefoldin subunit 5

1

1

High-throughput

0.515

High

167375

AKAP9
A-kinase anchor protein 9

1

5

High-throughput

0.515

High

167376

DPYL5
Dihydropyrimidinase-related protein 5

1

3

High-throughput

0.515

High

167378

FYCO1
FYVE and coiled-coil domain-containing protein 1

1

7

High-throughput

0.515

High

167380

LZTS2
Leucine zipper putative tumor suppressor 2

1

15

High-throughput

0.515

High

167384

PHF23
PHD finger protein 23

1

1

High-throughput

0.515

High

167388

SCAPE
S phase cyclin A-associated protein in the endoplasmic reticulum

1

9

High-throughput

0.515

High

167389

OSBL6
Oxysterol-binding protein-related protein 6

1

1

High-throughput

0.515

High

167390

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

1

13

High-throughput

0.515

High

167393

UBQL3
Ubiquilin-3

1

11

High-throughput

0.515

High

167396

ZHX3
Zinc fingers and homeoboxes protein 3

1

20

High-throughput

0.515

High

167408

UTP6
U3 small nucleolar RNA-associated protein 6 homolog

1

4

High-throughput

0.515

High

167412

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

1

4

High-throughput

0.515

High

167413

RGS17
Regulator of G-protein signaling 17

1

4

High-throughput

0.515

High

167414

KLHL3
Kelch-like protein 3

1

2

High-throughput

0.515

High

167417

DBNL
Drebrin-like protein

1

6

High-throughput

0.515

High

167418

CDC23
Cell division cycle protein 23 homolog

1

6

High-throughput

0.515

High

167419

ZN346
Zinc finger protein 346

1

3

High-throughput

0.515

High

167421

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

2

High-throughput

0.515

High

167422

KLH20
Kelch-like protein 20

1

2

High-throughput

0.515

High

167424

ASB3
Ankyrin repeat and SOCS box protein 3

1

6

High-throughput

0.515

High

167426

MOFA1
MORF4 family-associated protein 1

1

3

High-throughput

0.515

High

167242

ATX1
Ataxin-1

1

9

High-throughput

0.508

High

167251

CBX1
Chromobox protein homolog 1

1

20

Small-scale

0.501

High

167257

CBX3
Chromobox protein homolog 3

1

20

Small-scale

0.501

High

167260

HDAC1
Histone deacetylase 1

1

20

Small-scale

0.501

High

50879

SYCE3
Synaptonemal complex central element protein 3

1

0

High-throughput

0.493

High

167195

TELT
Telethonin

1

0

High-throughput

0.493

High

167196

FANCG
Fanconi anemia group G protein

1

0

High-throughput

0.493

High

167200

TSN2
Tetraspanin-2

1

0

High-throughput

0.493

High

167205

SPF27
Pre-mRNA-splicing factor SPF27

1

0

High-throughput

0.493

High

167206

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.493

High

167207

DXO
Decapping and exoribonuclease protein

1

0

High-throughput

0.493

High

167209

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

1

0

High-throughput

0.493

High

167211

MT2
Metallothionein-2

1

0

High-throughput

0.493

High

167214

CHLE
Cholinesterase

1

0

High-throughput

0.493

High

167222

VATB1
V-type proton ATPase subunit B, kidney isoform

1

0

High-throughput

0.493

High

167225

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

0

High-throughput

0.493

High

167236

RPGP1
Rap1 GTPase-activating protein 1

1

0

High-throughput

0.493

High

167238

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.493

High

167243

BCAT1
Branched-chain-amino-acid aminotransferase, cytosolic

1

0

High-throughput

0.493

High

167248

STXB1
Syntaxin-binding protein 1

1

0

High-throughput

0.493

High

167250

IN35
Interferon-induced 35 kDa protein

1

0

High-throughput

0.493

High

167255

INCA1
Protein INCA1

1

0

High-throughput

0.493

High

167258

CENPR
Centromere protein R

1

0

High-throughput

0.493

High

167259

MED21
Mediator of RNA polymerase II transcription subunit 21

1

0

High-throughput

0.493

High

167267

BECN1
Beclin-1

1

0

High-throughput

0.493

High

167274

UGPA
UTP--glucose-1-phosphate uridylyltransferase

1

0

High-throughput

0.493

High

167280

PKHG4
Puratrophin-1

1

0

High-throughput

0.493

High

167283

HAUS3
HAUS augmin-like complex subunit 3

1

0

High-throughput

0.493

High

167289

PMF1
Polyamine-modulated factor 1

1

0

High-throughput

0.493

High

167295

BRAT1
Integrator complex assembly factor BRAT1

1

0

High-throughput

0.493

High

167300

CYFP1
Cytoplasmic FMR1-interacting protein 1

1

0

High-throughput

0.493

High

167303

CENPV
Centromere protein V

1

0

High-throughput

0.493

High

167304

DPP9
Dipeptidyl peptidase 9

1

0

High-throughput

0.493

High

167306

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

0

High-throughput

0.493

High

167308

TEN1L
CST complex subunit TEN1

1

0

High-throughput

0.493

High

167314

ARCH
Protein archease

1

0

High-throughput

0.493

High

167315

NELFD
Negative elongation factor C/D

1

0

High-throughput

0.493

High

167322

PNKD
Probable thioesterase PNKD

1

0

High-throughput

0.493

High

167336

BRK1
Protein BRICK1

1

0

High-throughput

0.493

High

167337

CHMP7
Charged multivesicular body protein 7

1

0

High-throughput

0.493

High

167338

PRUN2
Protein prune homolog 2

1

0

High-throughput

0.493

High

167341

MYLIP
E3 ubiquitin-protein ligase MYLIP

1

0

High-throughput

0.493

High

167346

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

0

High-throughput

0.493

High

167356

SNF8
Vacuolar-sorting protein SNF8

1

0

High-throughput

0.493

High

167359

GMPPA
Mannose-1-phosphate guanylyltransferase regulatory subunit alpha

1

0

High-throughput

0.493

High

167360

COG3
Conserved oligomeric Golgi complex subunit 3

1

0

High-throughput

0.493

High

167363

BMF
Bcl-2-modifying factor

1

0

High-throughput

0.493

High

167364

LURA1
Leucine rich adaptor protein 1

1

0

High-throughput

0.493

High

167365

KAD8
Adenylate kinase 8

1

0

High-throughput

0.493

High

167366

ZN488
Zinc finger protein 488

1

0

High-throughput

0.493

High

167369

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.493

High

167373

TSNAX
Translin-associated protein X

1

0

High-throughput

0.493

High

167374

HAUS7
HAUS augmin-like complex subunit 7

1

0

High-throughput

0.493

High

167381

PSF3
DNA replication complex GINS protein PSF3

1

0

High-throughput

0.493

High

167391

CK054
Ester hydrolase C11orf54

1

0

High-throughput

0.493

High

167392

VPS11
Vacuolar protein sorting-associated protein 11 homolog

1

0

High-throughput

0.493

High

167395

DSN1
Kinetochore-associated protein DSN1 homolog

1

0

High-throughput

0.493

High

167407

NSE4A
Non-structural maintenance of chromosomes element 4 homolog A

1

0

High-throughput

0.493

High

167411

EIF3K
Eukaryotic translation initiation factor 3 subunit K

1

0

High-throughput

0.493

High

167420

PADI3
Protein-arginine deiminase type-3

1

0

High-throughput

0.493

High

167423

AR2BP
ADP-ribosylation factor-like protein 2-binding protein

1

0

High-throughput

0.493

High

167249

1433Z
14-3-3 protein zeta/delta

1

12

High-throughput

0.481

High

167252

TF65
Transcription factor p65

1

16

High-throughput

0.479

High

167254

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.479

High

46796

A0A384NQ31
Epididymis secretory sperm binding protein

1

3

High-throughput

0.470

High

63281

ODAD3
Outer dynein arm-docking complex subunit 3

1

5

High-throughput

0.470

High

85118

B7Z3E8
cDNA FLJ51208

1

19

High-throughput

0.470

High

116838

I6L9F6
NEFL protein

1

12

High-throughput

0.470

High

167203

STX11
Syntaxin-11

1

7

High-throughput

0.470

High

167217

IBP1
Insulin-like growth factor-binding protein 1

1

3

High-throughput

0.470

High

167226

IBP4
Insulin-like growth factor-binding protein 4

1

2

High-throughput

0.470

High

167227

CX7A1
Cytochrome c oxidase subunit 7A1, mitochondrial

1

1

High-throughput

0.470

High

167228

AOFB
Amine oxidase [flavin-containing] B

1

5

High-throughput

0.470

High

167237

RGR
RPE-retinal G protein-coupled receptor

1

1

High-throughput

0.470

High

167241

CRBA2
Beta-crystallin A2

1

1

High-throughput

0.470

High

167272

RCN1
Reticulocalbin-1

1

7

High-throughput

0.470

High

167291

KLC3
Kinesin light chain 3

1

6

High-throughput

0.470

High

167294

TTC33
Tetratricopeptide repeat protein 33

1

11

High-throughput

0.470

High

167298

AN13D
Ankyrin repeat domain-containing protein 13D

1

17

High-throughput

0.470

High

167309

Q86WV8
TSC complex subunit 1

1

1

High-throughput

0.470

High

167311

TMTC1
Protein O-mannosyl-transferase TMTC1

1

7

High-throughput

0.470

High

167320

SPG16
Sperm-associated antigen 16 protein

1

9

High-throughput

0.470

High

167321

KT222
Keratin-like protein KRT222

1

13

High-throughput

0.470

High

167323

STX19
Syntaxin-19

1

7

High-throughput

0.470

High

167324

T11L2
T-complex protein 11-like protein 2

1

2

High-throughput

0.470

High

167329

Q8NE08
COL25A1 protein

1

2

High-throughput

0.470

High

167333

DDI1
Protein DDI1 homolog 1

1

13

High-throughput

0.470

High

167339

FACR1
Fatty acyl-CoA reductase 1

1

1

High-throughput

0.470

High

167357

MR1L1
MORF4 family-associated protein 1-like 1

1

3

High-throughput

0.470

High

167358

KAZD1
Kazal-type serine protease inhibitor domain-containing protein 1

1

5

High-throughput

0.470

High

167361

LOXL4
Lysyl oxidase homolog 4

1

2

High-throughput

0.470

High

167368

KLH32
Kelch-like protein 32

1

3

High-throughput

0.470

High

167382

WDR83
WD repeat domain-containing protein 83

1

15

High-throughput

0.470

High

167383

EFC4B
EF-hand calcium-binding domain-containing protein 4B

1

3

High-throughput

0.470

High

167386

KIFC3
Kinesin-like protein KIFC3

1

10

High-throughput

0.470

High

167399

CD248
Endosialin

1

18

High-throughput

0.470

High

167404

FGF21
Fibroblast growth factor 21

1

6

High-throughput

0.470

High

4765

A0A1B0GWI1
Coiled-coil domain containing 196

1

0

High-throughput

0.268

Low

50007

A1A512
KIAA0355 protein

1

0

High-throughput

0.268

Low

50306

F168B
Myelin-associated neurite-outgrowth inhibitor

1

0

High-throughput

0.268

Low

99207

F2Z2M7
Polypeptide N-acetylgalactosaminyltransferase 10

1

0

High-throughput

0.268

Low

167208

AQP8
Aquaporin-8

1

0

High-throughput

0.268

Low

167239

GPM6A
Neuronal membrane glycoprotein M6-a

1

0

High-throughput

0.268

Low

167245

PIGP
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P

1

0

High-throughput

0.268

Low

167269

MESD
LRP chaperone MESD

1

0

High-throughput

0.268

Low

167271

LAP4A
Lysosomal-associated transmembrane protein 4A

1

0

High-throughput

0.268

Low

167277

F135B
Protein FAM135B

1

0

High-throughput

0.268

Low

167279

CEP55
Centrosomal protein of 55 kDa

1

0

High-throughput

0.268

Low

167281

EFHC1
EF-hand domain-containing protein 1

1

0

High-throughput

0.268

Low

167288

PLB1
Phospholipase B1, membrane-associated

1

0

High-throughput

0.268

Low

167290

F117B
Protein FAM117B

1

0

High-throughput

0.268

Low

167292

TT23L
Tetratricopeptide repeat protein 23-like

1

0

High-throughput

0.268

Low

167296

CNST
Consortin

1

0

High-throughput

0.268

Low

167297

PPR21
Protein phosphatase 1 regulatory subunit 21

1

0

High-throughput

0.268

Low

167299

K0408
Uncharacterized protein KIAA0408

1

0

High-throughput

0.268

Low

167301

NUP54
Nucleoporin p54

1

0

High-throughput

0.268

Low

167302

SPT12
Spermatogenesis-associated protein 12

1

0

High-throughput

0.268

Low

167305

YRDC
Threonylcarbamoyl-AMP synthase

1

0

High-throughput

0.268

Low

167312

K0825
Uncharacterized protein KIAA0825

1

0

High-throughput

0.268

Low

167313

CBCO1
Ciliary-associated calcium-binding coiled-coil protein 1

1

0

High-throughput

0.268

Low

167317

Q8IXS7
SRGAP3 protein

1

0

High-throughput

0.268

Low

167318

IFT20
Intraflagellar transport protein 20 homolog

1

0

High-throughput

0.268

Low

167325

MET27
Methyltransferase-like protein 27

1

0

High-throughput

0.268

Low

167326

IQUB
IQ motif and ubiquitin-like domain-containing protein

1

0

High-throughput

0.268

Low

167328

ICA1L
Islet cell autoantigen 1-like protein

1

0

High-throughput

0.268

Low

167335

TM174
Transmembrane protein 174

1

0

High-throughput

0.268

Low

167345

BORC5
BLOC-1-related complex subunit 5

1

0

High-throughput

0.268

Low

167347

TSACC
TSSK6-activating co-chaperone protein

1

0

High-throughput

0.268

Low

167351

REX1B
Required for excision 1-B domain-containing protein

1

0

High-throughput

0.268

Low

167353

ASIC4
Acid-sensing ion channel 4

1

0

High-throughput

0.268

Low

167367

COG8
Conserved oligomeric Golgi complex subunit 8

1

0

High-throughput

0.268

Low

167377

PAIP2
Polyadenylate-binding protein-interacting protein 2

1

0

High-throughput

0.268

Low

167379

Q9BR81
Protocadherin gamma subfamily C, 3

1

0

High-throughput

0.268

Low

167385

LRC61
Leucine-rich repeat-containing protein 61

1

0

High-throughput

0.268

Low

167387

TEX12
Testis-expressed protein 12

1

0

High-throughput

0.268

Low

167397

GPN2
GPN-loop GTPase 2

1

0

High-throughput

0.268

Low

167400

CD209
CD209 antigen

1

0

High-throughput

0.268

Low

167401

AMBN
Ameloblastin

1

0

High-throughput

0.268

Low

167403

GKN1
Gastrokine-1

1

0

High-throughput

0.268

Low

167405

CYRIB
CYFIP-related Rac1 interactor B

1

0

High-throughput

0.268

Low

167406

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.268

Low

167410

DKK3
Dickkopf-related protein 3

1

0

High-throughput

0.268

Low

167416

ATIF1
ATPase inhibitor, mitochondrial

1

0

High-throughput

0.268

Low

167348

APH1A
Gamma-secretase subunit APH-1A

1

0

High-throughput

0.251

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025