Protein: SPAG8
Sperm-associated antigen 8 (HSD-1) (Sperm membrane protein 1) (SMP-1) (Sperm membrane protein BS-84)

Gene: SPAG8
Organism: Homo sapiens
Interactions: 122
UniProt ID: Q99932

Gene Ontology (top 5):
GO:0001669 - acrosomal vesicle
GO:0001673 - male germ cell nucleus
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

750469

CSTF2
Cleavage stimulation factor subunit 2

3

1

High-throughput

0.675

High

480286

RU1C
U1 small nuclear ribonucleoprotein C

3

1

High-throughput

0.654

High

1005637

PITX1
Pituitary homeobox 1

3

0

High-throughput

0.639

High

221047

HAIR
Lysine-specific demethylase hairless

2

1

High-throughput

0.606

High

281399

GGYF1
GRB10-interacting GYF protein 1

2

1

High-throughput

0.606

High

1156050

ZIC1
Zinc finger protein ZIC 1

2

1

High-throughput

0.606

High

1186972

KR151
Keratin-associated protein 15-1

2

1

High-throughput

0.606

High

1187744

KR133
Keratin-associated protein 13-3

2

1

High-throughput

0.606

High

1272295

DOK3
Docking protein 3

2

1

High-throughput

0.606

High

1397786

TEKT5
Tektin-5

2

1

High-throughput

0.606

High

1408108

TEKT3
Tektin-3

2

1

High-throughput

0.606

High

1408112

CSTFT
Cleavage stimulation factor subunit 2 tau variant

2

1

High-throughput

0.606

High

1408118

ZN581
Zinc finger protein 581

2

1

High-throughput

0.606

High

1408123

UBQL1
Ubiquilin-1

2

1

High-throughput

0.606

High

1203493

ACTMP
Actin maturation protease

2

0

High-throughput

0.589

High

63254

VP37C
Vacuolar protein sorting-associated protein 37C

2

0

High-throughput

0.580

High

192127

PA2GX
Group 10 secretory phospholipase A2

2

0

High-throughput

0.580

High

210339

PHF1
PHD finger protein 1

2

0

High-throughput

0.580

High

228352

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

2

0

High-throughput

0.580

High

288493

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

2

0

High-throughput

0.580

High

300477

KRT34
Keratin, type I cuticular Ha4

2

0

High-throughput

0.580

High

574444

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

2

0

High-throughput

0.580

High

666896

CCNC
Cyclin-C

2

0

High-throughput

0.580

High

893732

MEOX1
Homeobox protein MOX-1

2

0

High-throughput

0.580

High

950640

KR108
Keratin-associated protein 10-8

2

0

High-throughput

0.580

High

1006293

CTG1B
Cancer/testis antigen 1

2

0

High-throughput

0.580

High

1081454

INCA1
Protein INCA1

2

0

High-throughput

0.580

High

1133158

LASP1
LIM and SH3 domain protein 1

2

0

High-throughput

0.580

High

1186533

KR192
Keratin-associated protein 19-2

2

0

High-throughput

0.580

High

1186552

KR212
Keratin-associated protein 21-2

2

0

High-throughput

0.580

High

1186693

KRA62
Keratin-associated protein 6-2

2

0

High-throughput

0.580

High

1186851

KR196
Keratin-associated protein 19-6

2

0

High-throughput

0.580

High

1187911

KR197
Keratin-associated protein 19-7

2

0

High-throughput

0.580

High

1200192

SMUG1
Single-strand selective monofunctional uracil DNA glycosylase

2

0

High-throughput

0.580

High

1213534

UBAP2
Ubiquitin-associated protein 2

2

0

High-throughput

0.580

High

1215010

INT11
Integrator complex subunit 11

2

0

High-throughput

0.580

High

1220038

TTC23
Tetratricopeptide repeat protein 23

2

0

High-throughput

0.580

High

1244057

KR261
Keratin-associated protein 26-1

2

0

High-throughput

0.580

High

1307055

KR111
Keratin-associated protein 11-1

2

0

High-throughput

0.580

High

1309109

GLCTK
Glycerate kinase

2

0

High-throughput

0.580

High

1323665

BATF2
Basic leucine zipper transcriptional factor ATF-like 2

2

0

High-throughput

0.580

High

1332930

SMYD1
Histone-lysine N-methyltransferase SMYD1

2

0

High-throughput

0.580

High

1381894

TET5B
Terminal nucleotidyltransferase 5B

2

0

High-throughput

0.580

High

1385383

ARMC5
Armadillo repeat-containing protein 5

2

0

High-throughput

0.580

High

1390704

DYL2
Dynein light chain 2, cytoplasmic

2

0

High-throughput

0.580

High

1400120

SYGP1
Ras/Rap GTPase-activating protein SynGAP

2

0

High-throughput

0.580

High

1402043

TRIB3
Tribbles homolog 3

2

0

High-throughput

0.580

High

1404647

PFD5
Prefoldin subunit 5

2

0

High-throughput

0.580

High

1408106

B9D2
B9 domain-containing protein 2

2

0

High-throughput

0.580

High

1408107

RUSC1
AP-4 complex accessory subunit RUSC1

2

0

High-throughput

0.580

High

1408110

KRA31
Keratin-associated protein 3-1

2

0

High-throughput

0.580

High

1408115

PATZ1
POZ-, AT hook-, and zinc finger-containing protein 1

2

0

High-throughput

0.580

High

1408116

DMRT3
Doublesex- and mab-3-related transcription factor 3

2

0

High-throughput

0.580

High

1408119

PEF1
Peflin

2

0

High-throughput

0.580

High

1408120

SRGEF
Secretion-regulating guanine nucleotide exchange factor

2

0

High-throughput

0.580

High

1408122

CDC23
Cell division cycle protein 23 homolog

2

0

High-throughput

0.580

High

1408126

GPSM3
G-protein-signaling modulator 3

2

0

High-throughput

0.580

High

1292927

Q86WV8
TSC complex subunit 1

2

1

High-throughput

0.558

High

1402279

RANB9
Ran-binding protein 9

1

0

Small-scale

0.549

High

1289285

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

0

High-throughput

0.549

High

1408117

UBQL4
Ubiquilin-4

1

1

High-throughput

0.541

High

220293

FRS3
Fibroblast growth factor receptor substrate 3

1

1

High-throughput

0.515

High

944049

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.515

High

1215277

Q5TAL4
U1 small nuclear ribonucleoprotein C

1

1

High-throughput

0.515

High

162675

ANM5
Protein arginine N-methyltransferase 5

1

3

High-throughput

0.508

High

938130

ANM2
Protein arginine N-methyltransferase 2

1

3

High-throughput

0.508

High

1273156

KDM3B
Lysine-specific demethylase 3B

1

1

High-throughput

0.508

High

1293405

CARM1
Histone-arginine methyltransferase CARM1

1

3

High-throughput

0.508

High

1407832

ANM1
Protein arginine N-methyltransferase 1

1

3

High-throughput

0.508

High

142404

PEX7
Peroxisomal targeting signal 2 receptor

1

0

High-throughput

0.493

High

242718

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.493

High

246116

KIF1B
Kinesin-like protein KIF1B

1

0

High-throughput

0.493

High

415818

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.493

High

422980

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.493

High

451254

NFL
Neurofilament light polypeptide

1

0

High-throughput

0.493

High

791661

SYUA
Alpha-synuclein

1

0

High-throughput

0.493

High

834360

GARS
Glycine--tRNA ligase

1

0

High-throughput

0.493

High

843913

HD
Huntingtin

1

0

High-throughput

0.493

High

876142

TCPE
T-complex protein 1 subunit epsilon

1

0

High-throughput

0.493

High

890044

PSN1
Presenilin-1

1

0

High-throughput

0.493

High

898525

PPT1
Palmitoyl-protein thioesterase 1

1

0

High-throughput

0.493

High

927113

ATX3
Ataxin-3

1

0

High-throughput

0.493

High

927517

ATX1
Ataxin-1

1

0

High-throughput

0.493

High

929828

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.493

High

954593

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

0

High-throughput

0.493

High

1096188

TADBP
TAR DNA-binding protein 43

1

0

High-throughput

0.493

High

1123790

DCTN1
Dynactin subunit 1

1

0

High-throughput

0.493

High

1279718

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

0

High-throughput

0.493

High

1327942

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

0

High-throughput

0.493

High

1356260

F222B
Protein FAM222B

1

0

High-throughput

0.493

High

1365173

NDRG1
Protein NDRG1

1

0

High-throughput

0.493

High

1408109

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.493

High

1408125

RNF11
RING finger protein 11

1

0

High-throughput

0.493

High

1408111

NSD3
Histone-lysine N-methyltransferase NSD3

1

0

High-throughput

0.486

High

1408114

JMJD4
2-oxoglutarate and iron-dependent oxygenase JMJD4

1

0

High-throughput

0.486

High

2911

A0A0C4DGF1
Zinc finger and BTB domain containing 32

1

1

High-throughput

0.483

High

1364977

TSC1
Hamartin

1

2

High-throughput

0.481

High

1408124

ZBT32
Zinc finger and BTB domain-containing protein 32

1

2

High-throughput

0.481

High

1399995

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

0

High-throughput

0.480

High

1216595

Q5THT1
Kelch like family member 32

1

1

High-throughput

0.470

High

1315912

ZNF34
Zinc finger protein 34

1

0

High-throughput

0.460

High

363774

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

1399036

KLH32
Kelch-like protein 32

1

1

High-throughput

0.439

High

1408113

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.439

High

699471

PROP
Properdin

2

0

High-throughput

0.320

High

50349

F168B
Myelin-associated neurite-outgrowth inhibitor

2

0

High-throughput

0.316

High

66272

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

2

0

High-throughput

0.316

High

506764

PRR35
Proline-rich protein 35

2

0

High-throughput

0.316

High

506791

NHLC4
NHL-repeat-containing protein 4

2

0

High-throughput

0.316

High

532144

RET3
Retinol-binding protein 3

2

0

High-throughput

0.316

High

1307113

KRA71
Keratin-associated protein 7-1

2

0

High-throughput

0.316

High

1311458

TRI42
Tripartite motif-containing protein 42

2

0

High-throughput

0.316

High

1392980

CC120
Coiled-coil domain-containing protein 120

2

0

High-throughput

0.316

High

1408121

EGFL7
Epidermal growth factor-like protein 7

2

0

High-throughput

0.316

High

109500

G5E9A7
DM1 locus, WD repeat containing

1

0

High-throughput

0.268

Low

117017

J3KQ12
Seipin

1

0

High-throughput

0.268

Low

301656

WFS1
Wolframin

1

0

High-throughput

0.268

Low

891016

NDUV1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

1

0

High-throughput

0.268

Low

1408127

HEMK1
MTRF1L release factor glutamine methyltransferase

1

0

High-throughput

0.268

Low

959525

YPEL3
Protein yippee-like 3

1

0

High-throughput

0.251

Low

1191394

MGT5B
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

1

0

High-throughput

0.251

Low

1389541

RN125
E3 ubiquitin-protein ligase RNF125

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025