Protein: PKHA2
Pleckstrin homology domain-containing family A member 2 (PH domain-containing family A member 2) (Tandem PH domain-containing protein 2) (TAPP-2)

Gene: PKHA2, PLEKHA2
Organism: Homo sapiens
Interactions: 86
UniProt ID: Q9HB19

Gene Ontology (top 5):
GO:0001954 - positive regulation of cell-matrix adhesion
GO:0001968 - fibronectin binding
GO:0005543 - phospholipid binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1104804

SNTA1
Alpha-1-syntrophin

2

18

Small-scale

0.789

High

1104876

SNTB2
Beta-2-syntrophin

2

18

Small-scale

0.789

High

783418

TRI23
E3 ubiquitin-protein ligase TRIM23

2

19

High-throughput

0.783

High

1152420

DLG2
Disks large homolog 2

2

7

High-throughput

0.783

High

1368721

DLG3
Disks large homolog 3

2

6

High-throughput

0.783

High

1118452

SNTB1
Beta-1-syntrophin

1

15

High-throughput

0.691

High

1437905

RHG35
Rho GTPase-activating protein 35

1

8

High-throughput

0.691

High

1049801

1433F
14-3-3 protein eta

4

20

Small-scale

0.691

High

299793

MPDZ
Multiple PDZ domain protein

3

20

Small-scale

0.672

High

966889

1433G
14-3-3 protein gamma

3

20

High-throughput

0.662

High

167652

GIPC1
PDZ domain-containing protein GIPC1

3

4

High-throughput

0.653

High

972013

1433E
14-3-3 protein epsilon

2

13

High-throughput

0.628

High

990754

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.628

High

1437904

PKHA1
Pleckstrin homology domain-containing family A member 1

1

16

Small-scale

0.621

High

302967

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

12

High-throughput

0.618

High

375965

RASK
GTPase KRas

1

20

Small-scale

0.618

High

539845

RALA
Ras-related protein Ral-A

1

20

Small-scale

0.618

High

581300

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

Small-scale

0.618

High

710500

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.618

High

901583

RAB7A
Ras-related protein Rab-7a

1

17

Small-scale

0.618

High

987954

GRB2
Growth factor receptor-bound protein 2

1

20

Small-scale

0.618

High

691446

1433T
14-3-3 protein theta

2

20

Small-scale

0.611

High

862710

UTRN
Utrophin

2

7

Small-scale

0.611

High

1216157

FHL5
Four and a half LIM domains protein 5

2

10

High-throughput

0.606

High

1225077

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

13

High-throughput

0.606

High

1348514

LNX1
E3 ubiquitin-protein ligase LNX

2

16

High-throughput

0.606

High

1353628

GIPC2
PDZ domain-containing protein GIPC2

2

4

High-throughput

0.606

High

1398715

AP4AT
AP-4 complex accessory subunit Tepsin

2

1

High-throughput

0.606

High

1435310

EGLN3
Prolyl hydroxylase EGLN3

2

3

High-throughput

0.606

High

1437907

SNTG1
Gamma-1-syntrophin

2

17

High-throughput

0.606

High

1289401

URP2
Fermitin family homolog 3

1

0

Small-scale

0.586

High

1349449

M1AP
Meiosis 1 arrest protein

2

0

High-throughput

0.580

High

269383

HSF2B
Heat shock factor 2-binding protein

2

1

High-throughput

0.553

High

1063626

GOGA2
Golgin subfamily A member 2

2

8

High-throughput

0.553

High

1353621

GIPC3
PDZ domain-containing protein GIPC3

2

4

High-throughput

0.553

High

773646

COPB2
Coatomer subunit beta'

1

4

Small-scale

0.553

High

1396816

SNX27
Sorting nexin-27

1

19

High-throughput

0.553

High

1430476

RAB1B
Ras-related protein Rab-1B

1

10

Small-scale

0.553

High

230113

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

1

High-throughput

0.536

High

260476

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.536

High

262434

DTNB
Dystrobrevin beta

1

6

High-throughput

0.536

High

471927

RU2B
U2 small nuclear ribonucleoprotein B''

1

4

High-throughput

0.536

High

547484

DMD
Dystrophin

1

6

High-throughput

0.536

High

730256

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.536

High

799485

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.536

High

1239673

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

1

High-throughput

0.536

High

1436066

UBE2Z
Ubiquitin-conjugating enzyme E2 Z

1

2

High-throughput

0.536

High

1437909

CTNL1
Alpha-catulin

1

5

High-throughput

0.536

High

1437911

DTNA
Dystrobrevin alpha

1

5

High-throughput

0.536

High

1090184

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

10

Small-scale

0.527

High

1185229

EDRF1
Erythroid differentiation-related factor 1

1

0

High-throughput

0.513

High

1432801

GCP60
Golgi resident protein GCP60

1

0

High-throughput

0.513

High

1437906

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.513

High

1393319

SAHH3
Adenosylhomocysteinase 3

1

1

High-throughput

0.489

High

240119

KPRB
Phosphoribosyl pyrophosphate synthase-associated protein 2

1

3

Small-scale

0.479

High

289700

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

4

Small-scale

0.479

High

344797

AP2A1
AP-2 complex subunit alpha-1

1

6

Small-scale

0.479

High

425040

ADT2
ADP/ATP translocase 2

1

2

Small-scale

0.479

High

428993

RLA0
Large ribosomal subunit protein uL10

1

1

Small-scale

0.479

High

552081

ADT1
ADP/ATP translocase 1

1

2

Small-scale

0.479

High

556353

CADH1
Cadherin-1

1

8

High-throughput

0.479

High

562406

LAMP2
Lysosome-associated membrane glycoprotein 2

1

9

Small-scale

0.479

High

655933

TBG1
Tubulin gamma-1 chain

1

4

Small-scale

0.479

High

711194

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

2

Small-scale

0.479

High

756058

MCM5
DNA replication licensing factor MCM5

1

2

Small-scale

0.479

High

756355

MCM7
DNA replication licensing factor MCM7

1

2

Small-scale

0.479

High

852856

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

1

Small-scale

0.479

High

922510

CLH2
Clathrin heavy chain 2

1

3

Small-scale

0.479

High

1016622

SRSF3
Serine/arginine-rich splicing factor 3

1

2

Small-scale

0.479

High

1026234

CLH1
Clathrin heavy chain 1

1

3

Small-scale

0.479

High

1100402

TIF1B
Transcription intermediary factor 1-beta

1

6

Small-scale

0.479

High

1134390

IMB1
Importin subunit beta-1

1

1

Small-scale

0.479

High

1157939

DDB1
DNA damage-binding protein 1

1

3

Small-scale

0.479

High

1255606

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.479

High

1290975

TAXB1
Tax1-binding protein 1

1

13

High-throughput

0.479

High

1386786

GCP3
Gamma-tubulin complex component 3

1

2

Small-scale

0.479

High

1412536

GCP2
Gamma-tubulin complex component 2

1

2

Small-scale

0.479

High

1437908

TBA8
Tubulin alpha-8 chain

1

3

Small-scale

0.479

High

285726

BAF
Barrier-to-autointegration factor

1

0

Small-scale

0.458

High

380358

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

0

Small-scale

0.458

High

1131462

RFTN1
Raftlin

1

0

Small-scale

0.458

High

925753

SC24C
Protein transport protein Sec24C

1

1

Small-scale

0.437

High

1148945

SC23A
Protein transport protein Sec23A

1

1

Small-scale

0.437

High

1333338

NHLC2
NHL repeat-containing protein 2

1

2

High-throughput

0.437

High

1339717

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.437

High

1437910

COG6
Conserved oligomeric Golgi complex subunit 6

2

0

High-throughput

0.316

High


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Last updated: 11Aug2025