Protein: ELNE
Neutrophil elastase (EC 3.4.21.37) (Bone marrow serine protease) (Elastase-2) (Human leukocyte elastase) (HLE) (Medullasin) (PMN elastase)

Gene: ELNE, ELANE
Organism: Homo sapiens
Interactions: 60
UniProt ID: P08246

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001878 - response to yeast
GO:0002020 - protease binding
GO:0002438 - acute inflammatory response to antigenic stimulus
GO:0002523 - leukocyte migration involved in inflammatory response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

344151

A1AT
Alpha-1-antitrypsin

2

20

Small-scale

0.778

High

439052

A2AP
Alpha-2-antiplasmin

2

20

Small-scale

0.778

High

439078

NT2NA
Notch homolog 2 N-terminal-like protein A

1

19

Small-scale

0.740

High

198378

KLK10
Kallikrein-10

1

16

High-throughput

0.691

High

439060

ITIH2
Inter-alpha-trypsin inhibitor heavy chain H2

1

5

High-throughput

0.691

High

439086

NEUS
Neuroserpin

1

20

High-throughput

0.691

High

344265

AACT
Alpha-1-antichymotrypsin

1

20

Small-scale

0.647

High

397677

IC1
Plasma protease C1 inhibitor

1

20

Small-scale

0.647

High

439065

ILEU
Leukocyte elastase inhibitor

1

20

Small-scale

0.647

High

439053

GRAB
Granzyme B

1

14

Small-scale

0.618

High

372854

SLPI
Antileukoproteinase

1

0

Small-scale

0.614

High

344413

A2MG
Alpha-2-macroglobulin

1

10

Small-scale

0.590

High

439061

CAP7
Azurocidin

1

16

Small-scale

0.590

High

439070

FCGRN
IgG receptor FcRn large subunit p51

1

15

Small-scale

0.590

High

439058

ELN
Elastin

2

14

Small-scale

0.584

High

439072

OCRL
Inositol polyphosphate 5-phosphatase OCRL

2

2

High-throughput

0.571

High

197876

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

2

High-throughput

0.536

High

439080

RHBL4
Rhomboid-related protein 4

1

5

High-throughput

0.536

High

439082

MIB2
E3 ubiquitin-protein ligase MIB2

1

1

High-throughput

0.536

High

439085

SRPK1
SRSF protein kinase 1

1

1

High-throughput

0.536

High

439089

FKRP
Ribitol 5-phosphate transferase FKRP

1

0

High-throughput

0.513

High

345172

KNG1
Kininogen-1

1

5

Small-scale

0.501

High

434601

TSP1
Thrombospondin-1

1

20

Small-scale

0.501

High

439064

PROP
Properdin

1

16

Small-scale

0.501

High

439066

SFTPD
Pulmonary surfactant-associated protein D

1

10

Small-scale

0.501

High

439068

CAMP
Cathelicidin antimicrobial peptide

1

3

Small-scale

0.501

High

439077

CCL14
C-C motif chemokine 14

1

1

Small-scale

0.501

High

439088

ACE2
Angiotensin-converting enzyme 2

1

2

Small-scale

0.501

High

439095

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

5

High-throughput

0.489

High

439054

IL8
Interleukin-8

1

0

Small-scale

0.480

High

439059

CEBPB
CCAAT/enhancer-binding protein beta

1

8

Small-scale

0.479

High

439076

CEBPE
CCAAT/enhancer-binding protein epsilon

1

8

Small-scale

0.479

High

439083

DCPS
m7GpppX diphosphatase

1

1

High-throughput

0.479

High

439084

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

1

Small-scale

0.479

High

439092

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

2

High-throughput

0.479

High

439087

GFI1
Zinc finger protein Gfi-1

1

0

Small-scale

0.458

High

362448

C1QA
Complement C1q subcomponent subunit A

1

6

Small-scale

0.457

High

362575

C1QC
Complement C1q subcomponent subunit C

1

8

Small-scale

0.457

High

427029

CATD
Cathepsin D

1

2

Small-scale

0.457

High

439051

CO4A2

1

7

Small-scale

0.457

High

439056

CH60
60 kDa heat shock protein, mitochondrial

1

3

Small-scale

0.457

High

439057

MMP9
Matrix metalloproteinase-9

1

12

Small-scale

0.457

High

439069

ACLY
ATP-citrate synthase

1

3

Small-scale

0.457

High

439071

DCAF7
DDB1- and CUL4-associated factor 7

1

4

Small-scale

0.457

High

439073

TLE5
TLE family member 5

1

3

Small-scale

0.457

High

439074

CHIT1
Chitotriosidase-1

1

2

Small-scale

0.457

High

439079

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

3

Small-scale

0.457

High

439081

N42L2
NEDD4-binding protein 2-like 2

1

2

Small-scale

0.457

High

439091

WDR6
tRNA

1

5

Small-scale

0.457

High

439093

WRP73
WD repeat-containing protein WRAP73

1

3

Small-scale

0.457

High

439094

VPS29
Vacuolar protein sorting-associated protein 29

1

1

Small-scale

0.457

High

410622

DCUP
Uroporphyrinogen decarboxylase

1

0

Small-scale

0.438

High

439075

GAMT
Guanidinoacetate N-methyltransferase

1

0

Small-scale

0.438

High

439090

GBA2
Non-lysosomal glucosylceramidase

1

0

Small-scale

0.438

High

335763

COX2
Cytochrome c oxidase subunit 2

1

1

Small-scale

0.417

High

439062

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

1

Small-scale

0.417

High

439063

HEM0
5-aminolevulinate synthase, erythroid-specific, mitochondrial

1

7

Small-scale

0.417

High

335981

COX3
Cytochrome c oxidase subunit 3

1

0

Small-scale

0.238

Low

439055

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

0

Small-scale

0.238

Low

439067

PIGA
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A

1

0

Small-scale

0.238

Low


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Last updated: 15 Jul 2024