Protein: SPI1
Transcription factor PU.1 (31 kDa-transforming protein) (SFFV proviral integration 1 protein)

Gene: SPI1
Organism: Mus musculus
Interactions: 52
UniProt ID: P17433

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 - cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

604508

CDN2B
Cyclin-dependent kinase 4 inhibitor B

2

7

Small-scale

0.776

High

604500

IRF8
Interferon regulatory factor 8

5

10

Small-scale

0.702

High

604524

IRF4
Interferon regulatory factor 4

3

10

Small-scale

0.660

High

432060

JUN
Transcription factor Jun

3

19

Small-scale

0.650

High

604516

PAX5
Paired box protein Pax-5

1

3

Small-scale

0.618

High

107047

F8VPR5
histone acetyltransferase

2

20

Small-scale

0.609

High

604496

GATA1
Erythroid transcription factor

2

14

Small-scale

0.606

High

74250

EP300
Histone acetyltransferase p300

2

20

Small-scale

0.584

High

604507

CEBPA
CCAAT/enhancer-binding protein alpha

2

14

Small-scale

0.584

High

604517

EMX1
Homeobox protein EMX1

1

17

High-throughput

0.541

High

604501

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

14

Small-scale

0.536

High

604530

TLR9
Toll-like receptor 9

1

5

Small-scale

0.534

High

236949

MTG16
Protein CBFA2T3

1

1

Small-scale

0.515

High

604504

HXA10
Homeobox protein Hox-A10

1

15

Small-scale

0.515

High

604509

FUS
RNA-binding protein FUS

1

7

Small-scale

0.515

High

604511

HDAC2
Histone deacetylase 2

1

10

Small-scale

0.515

High

604518

SIN3A
Paired amphipathic helix protein Sin3a

1

5

Small-scale

0.515

High

604527

NONO
Non-POU domain-containing octamer-binding protein

1

5

Small-scale

0.515

High

604528

TRI33
E3 ubiquitin-protein ligase TRIM33

1

20

Small-scale

0.515

High

604519

PRDM1
PR domain zinc finger protein 1

1

4

Small-scale

0.501

High

108301

G3X940
Histone acetyltransferase

1

20

Small-scale

0.479

High

148600

GATA2
Endothelial transcription factor GATA-2

1

14

Small-scale

0.479

High

148759

PTGDS
Prostaglandin-H2 D-isomerase

1

3

Small-scale

0.479

High

449230

TNFA
Tumor necrosis factor

1

1

Small-scale

0.479

High

482127

JUNB
Transcription factor JunB

1

20

Small-scale

0.479

High

483856

CSF1R
Macrophage colony-stimulating factor 1 receptor

1

2

Small-scale

0.479

High

532183

IL1B
Interleukin-1 beta

1

3

Small-scale

0.479

High

578572

JUND
Transcription factor JunD

1

19

Small-scale

0.479

High

599237

IL7RA
Interleukin-7 receptor subunit alpha

1

1

Small-scale

0.479

High

604499

TAL1
T-cell acute lymphocytic leukemia protein 1 homolog

1

14

Small-scale

0.479

High

604502

CEBPB
CCAAT/enhancer-binding protein beta

1

20

Small-scale

0.479

High

604512

GFI1
Zinc finger protein Gfi-1

1

4

Small-scale

0.479

High

604513

LDB1
LIM domain-binding protein 1

1

3

Small-scale

0.479

High

604514

C2TA
MHC class II transactivator

1

2

Small-scale

0.479

High

604515

DAB2
Disabled homolog 2

1

3

Small-scale

0.479

High

604521

PML
Protein PML

1

18

Small-scale

0.479

High

604525

RIGI
Antiviral innate immune response receptor RIG-I

1

3

High-throughput

0.479

High

604532

TLR4
Toll-like receptor 4

1

5

Small-scale

0.479

High

604523

AGRE1
Adhesion G protein-coupled receptor E1

1

1

Small-scale

0.470

High

604506

ID2
DNA-binding protein inhibitor ID-2

1

0

High-throughput

0.460

High

604526

SMAD3
Mothers against decapentaplegic homolog 3

1

3

Small-scale

0.445

High

604498

CYTC
Cystatin-C

1

2

Small-scale

0.437

High

604503

CCL5
C-C motif chemokine 5

1

3

Small-scale

0.437

High

604505

CD68
Macrosialin

1

3

Small-scale

0.437

High

604520

I12R1
Interleukin-12 receptor subunit beta-1

1

1

Small-scale

0.437

High

604522

ARGI1
Arginase-1

1

1

Small-scale

0.437

High

555567

FGL2
Fibroleukin

1

0

Small-scale

0.269

Low

604529

CEL3B
Chymotrypsin-like elastase family member 3B

1

0

Small-scale

0.269

Low

465759

FCGR2
Low affinity immunoglobulin gamma Fc region receptor II

1

0

Small-scale

0.249

Low

604497

CXCL9
C-X-C motif chemokine 9

1

0

Small-scale

0.249

Low

604510

CDC42
Cell division control protein 42 homolog

1

0

Small-scale

0.249

Low

604531

TREM1
Triggering receptor expressed on myeloid cells 1

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025