Protein: PTN11
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2)

Gene: PTN11, Ptpn11
Organism: Mus musculus
Interactions: 55
UniProt ID: P35235

Gene Ontology (top 5):
GO:0000077 - DNA damage checkpoint signaling
GO:0001784 - phosphotyrosine residue binding
GO:0004721 - phosphoprotein phosphatase activity
GO:0004725 - protein tyrosine phosphatase activity
GO:0004726 - non-membrane spanning protein tyrosine phosphatase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

767017

GRB2
Growth factor receptor-bound protein 2

3

20

Small-scale

0.827

High

686934

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

20

Small-scale

0.806

High

767009

IL6RB
Interleukin-6 receptor subunit beta

2

18

Small-scale

0.754

High

767034

ITSN1
Intersectin-1

1

11

Small-scale

0.713

High

581973

NTRK2
BDNF/NT-3 growth factors receptor

1

20

Small-scale

0.691

High

767031

GAB1
GRB2-associated-binding protein 1

4

14

Small-scale

0.676

High

767007

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

7

14

Small-scale

0.674

High

767000

STA5A
Signal transducer and activator of transcription 5A

1

17

Small-scale

0.665

High

767012

TIE2
Angiopoietin-1 receptor

1

20

Small-scale

0.647

High

767005

LIRB3
Paired immunoglobulin-like receptor B

5

20

Small-scale

0.641

High

205457

SOCS3
Suppressor of cytokine signaling 3

1

20

Small-scale

0.625

High

362436

ABL1
Tyrosine-protein kinase ABL1

1

20

Small-scale

0.618

High

599250

FES
Tyrosine-protein kinase Fes/Fps

1

20

Small-scale

0.618

High

757441

FAK1
Focal adhesion kinase 1

1

20

Small-scale

0.618

High

767001

LEPR
Leptin receptor

1

18

Small-scale

0.618

High

767008

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.618

High

767011

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.618

High

767027

ITCH
E3 ubiquitin-protein ligase Itchy

1

2

Small-scale

0.618

High

767030

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

2

Small-scale

0.618

High

767015

Q3ZB59
Growth factor receptor bound protein 2-associated protein 2

3

15

Small-scale

0.585

High

767014

CBLB
E3 ubiquitin-protein ligase CBL-B

2

12

Small-scale

0.584

High

767023

BTLA
B- and T-lymphocyte attenuator

2

2

Small-scale

0.584

High

767026

FRS2
Fibroblast growth factor receptor substrate 2

2

6

Small-scale

0.584

High

766998

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

16

Small-scale

0.575

High

767018

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.575

High

651483

CBL
E3 ubiquitin-protein ligase CBL

2

14

Small-scale

0.571

High

723718

CTND1
Catenin delta-1

1

20

Small-scale

0.561

High

705055

I23O1
Indoleamine 2,3-dioxygenase 1

1

1

Small-scale

0.536

High

728731

CEAM1
Cell adhesion molecule CEACAM1

1

20

Small-scale

0.536

High

766999

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

11

High-throughput

0.536

High

767013

PECA1
Platelet endothelial cell adhesion molecule

1

18

Small-scale

0.536

High

767019

LRB4A
Leukocyte immunoglobulin-like receptor subfamily B member 4A

2

20

Small-scale

0.514

High

98122

E9Q604
Integrin alpha M

1

11

High-throughput

0.501

High

767021

RIGI
Antiviral innate immune response receptor RIG-I

1

3

Small-scale

0.484

High

204992

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

5

High-throughput

0.479

High

312130

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

8

Small-scale

0.479

High

599252

GHR
Growth hormone receptor

1

20

Small-scale

0.479

High

618525

FAS
Fatty acid synthase

1

2

Small-scale

0.479

High

725202

HXA10
Homeobox protein Hox-A10

1

2

Small-scale

0.479

High

767003

TRAF6
TNF receptor-associated factor 6

1

8

Small-scale

0.479

High

767004

DAB1
Disabled homolog 1

1

6

Small-scale

0.479

High

767029

1433B
14-3-3 protein beta/alpha

1

3

Small-scale

0.479

High

767033

TBK1
Serine/threonine-protein kinase TBK1

1

11

Small-scale

0.479

High

767006

SMRC1
SWI/SNF complex subunit SMARCC1

1

2

High-throughput

0.457

High

767010

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

12

High-throughput

0.457

High

767028

Q8K4V6
Paired immunoglobulin-like receptor B

1

20

Small-scale

0.457

High

767002

CAV3
Caveolin-3

1

5

High-throughput

0.445

High

767035

GAB2
GRB2-associated-binding protein 2

1

15

High-throughput

0.445

High

767025

SIG10
Sialic acid-binding Ig-like lectin 10

1

20

Small-scale

0.442

High

767016

LC7L3
Luc7-like protein 3

1

0

High-throughput

0.438

High

767022

CLM8
CMRF35-like molecule 8

1

5

Small-scale

0.437

High

767024

TNR14
Tumor necrosis factor receptor superfamily member 14

1

11

Small-scale

0.437

High

767032

COP1
E3 ubiquitin-protein ligase COP1

1

5

Small-scale

0.437

High

767020

HEAT6
HEAT repeat-containing protein 6

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025