Protein: MMP2
72 kDa type IV collagenase (EC 3.4.24.24) (72 kDa gelatinase) (Gelatinase A) (Matrix metalloproteinase-2) (MMP-2) (TBE-1) [Cleaved into: PEX]

Gene: MMP2
Organism: Homo sapiens
Interactions: 58
UniProt ID: P08253

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001541 - ovarian follicle development
GO:0001542 - ovulation from ovarian follicle
GO:0001553 - luteinization
GO:0001666 - response to hypoxia

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

439223

TIMP2
Metalloproteinase inhibitor 2

10

20

Small-scale

0.976

High

362710

FINC
Fibronectin

3

12

Small-scale

0.876

High

439230

TIMP3
Metalloproteinase inhibitor 3

3

20

Small-scale

0.866

High

439254

TIMP4
Metalloproteinase inhibitor 4

3

20

Small-scale

0.845

High

344780

TIMP1
Metalloproteinase inhibitor 1

2

20

Small-scale

0.818

High

439244

COL12
Collectin-12

2

20

High-throughput

0.811

High

439227

CO5A1

3

20

Small-scale

0.670

High

439231

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

3

19

Small-scale

0.662

High

393958

A4
Amyloid-beta precursor protein

3

7

Small-scale

0.660

High

439251

PGCB
Brevican core protein

1

15

Small-scale

0.647

High

358587

CO2A1
Collagen alpha-1(II) chain

2

20

High-throughput

0.628

High

358647

CO4A1

2

20

High-throughput

0.628

High

439220

CO4A2

2

20

High-throughput

0.628

High

439221

CO6A1

2

13

High-throughput

0.628

High

439222

CO6A2

2

20

High-throughput

0.628

High

439237

COEA1
Collagen alpha-1(XIV) chain

2

17

High-throughput

0.628

High

439243

H2A2C
Histone H2A type 2-C

2

2

High-throughput

0.628

High

439250

EDA
Ectodysplasin-A

2

17

High-throughput

0.628

High

439253

COCA1

2

17

High-throughput

0.628

High

439236

REL
Proto-oncogene c-Rel

2

3

High-throughput

0.606

High

439252

KLH15
Kelch-like protein 15

2

0

High-throughput

0.602

High

439249

PCSK9
Proprotein convertase subtilisin/kexin type 9

1

4

Small-scale

0.586

High

439234

CCL7
C-C motif chemokine 7

1

5

Small-scale

0.586

High

419136

ITAV
Integrin alpha-V

2

11

Small-scale

0.584

High

434602

TSP1
Thrombospondin-1

1

8

Small-scale

0.552

High

439229

TSP2
Thrombospondin-2

1

7

Small-scale

0.552

High

439226

CAN3
Calpain-3

1

4

High-throughput

0.541

High

237015

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

1

2

High-throughput

0.536

High

439240

CO4A6

1

20

High-throughput

0.536

High

439246

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

4

High-throughput

0.536

High

259259

UBP12
Ubiquitin carboxyl-terminal hydrolase 12

1

2

High-throughput

0.515

High

431443

HS90A
Heat shock protein HSP 90-alpha

1

4

Small-scale

0.515

High

439232

MTR1A
Melatonin receptor type 1A

1

5

High-throughput

0.508

High

439233

MTR1B
Melatonin receptor type 1B

1

5

High-throughput

0.508

High

344414

A2MG
Alpha-2-macroglobulin

1

4

Small-scale

0.501

High

351224

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

6

Small-scale

0.501

High

358454

CO1A1
Collagen alpha-1(I) chain

1

20

Small-scale

0.501

High

436001

CO1A2
Collagen alpha-2(I) chain

1

20

Small-scale

0.501

High

439224

LEG3
Galectin-3

1

16

Small-scale

0.501

High

439225

PZP
Pregnancy zone protein

1

4

Small-scale

0.501

High

439228

LYOX
Protein-lysine 6-oxidase

1

5

Small-scale

0.501

High

439242

PCOC1
Procollagen C-endopeptidase enhancer 1

1

3

Small-scale

0.501

High

439247

SCUB3
Signal peptide, CUB and EGF-like domain-containing protein 3

1

16

Small-scale

0.501

High

439248

GT252
Procollagen galactosyltransferase 2

1

2

High-throughput

0.489

High

439241

WFDC2
WAP four-disulfide core domain protein 2

1

0

Small-scale

0.479

High

204948

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.479

High

351037

LDLR
Low-density lipoprotein receptor

1

3

Small-scale

0.479

High

396553

ITB3
Integrin beta-3

1

13

Small-scale

0.479

High

403741

ITB1
Integrin beta-1

1

14

Small-scale

0.479

High

439235

NGAL
Neutrophil gelatinase-associated lipocalin

1

3

Small-scale

0.479

High

439238

SKP2
S-phase kinase-associated protein 2

1

1

Small-scale

0.479

High

439239

CUL4A
Cullin-4A

1

0

High-throughput

0.458

High

439257

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.457

High

427410

ANXA2
Annexin A2

1

2

Small-scale

0.445

High

439256

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

1

High-throughput

0.445

High

439245

RN123
E3 ubiquitin-protein ligase RNF123

1

6

High-throughput

0.437

High

330819

PAK4
Serine/threonine-protein kinase PAK 4

1

0

Small-scale

0.292

High

439255

OSB10
Oxysterol-binding protein-related protein 10

1

0

High-throughput

0.269

Low


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Last updated: 15 Jul 2024