Protein: TBK1
Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (T2K) (TANK-binding kinase 1)

Gene: TBK1
Organism: Mus musculus
Interactions: 51
UniProt ID: Q9WUN2

Gene Ontology (top 5):
GO:0002218 - activation of innate immune response
GO:0002753 - cytoplasmic pattern recognition receptor signaling pathway
GO:0003676 - nucleic acid binding
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1490163

TBK1
Serine/threonine-protein kinase TBK1

2

17

Small-scale

0.812

High

1000259

TANK
TRAF family member-associated NF-kappa-B activator

8

5

Small-scale

0.746

High

1189267

STING
Stimulator of interferon genes protein

8

6

Small-scale

0.743

High

1221554

TRAF3
TNF receptor-associated factor 3

7

20

Small-scale

0.736

High

1317374

OPTN
Optineurin

4

20

Small-scale

0.692

High

1282028

TCAM1
TIR domain-containing adapter molecule 1

4

4

Small-scale

0.683

High

1455910

AZI2
5-azacytidine-induced protein 2

3

5

Small-scale

0.656

High

312519

NEMO
NF-kappa-B essential modulator

3

19

Small-scale

0.640

High

1281844

MIB1
E3 ubiquitin-protein ligase MIB1

1

6

High-throughput

0.618

High

312172

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

18

Small-scale

0.618

High

431380

SRC
Proto-oncogene tyrosine-protein kinase Src

1

15

Small-scale

0.618

High

728544

AKT1
RAC-alpha serine/threonine-protein kinase

1

20

Small-scale

0.618

High

757469

FAK1
Focal adhesion kinase 1

1

20

Small-scale

0.618

High

869557

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.618

High

1408868

TLR3
Toll-like receptor 3

1

7

Small-scale

0.618

High

1455800

TLR4
Toll-like receptor 4

1

6

Small-scale

0.618

High

1490164

GSK3B
Glycogen synthase kinase-3 beta

1

19

Small-scale

0.618

High

59201

TBKB1
TANK-binding kinase 1-binding protein 1

2

11

Small-scale

0.611

High

1246351

RIGI
Antiviral innate immune response receptor RIG-I

2

15

Small-scale

0.584

High

1455896

ZBP1
Z-DNA-binding protein 1

2

1

Small-scale

0.584

High

1490158

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

20

Small-scale

0.575

High

1000537

IRF3
Interferon regulatory factor 3

1

14

Small-scale

0.561

High

956837

RAB8B
Ras-related protein Rab-8B

1

5

Small-scale

0.553

High

1223104

FXR1
RNA-binding protein FXR1

1

3

High-throughput

0.536

High

1296595

RNF41
E3 ubiquitin-protein ligase NRDP1

1

20

Small-scale

0.528

High

583156

IRF1
Interferon regulatory factor 1

1

14

Small-scale

0.501

High

811937

TRAF2
TNF receptor-associated factor 2

1

20

Small-scale

0.501

High

940802

IRF5
Interferon regulatory factor 5

1

14

High-throughput

0.501

High

1330600

CIKS
E3 ubiquitin ligase TRAF3IP2

1

5

Small-scale

0.501

High

1223845

DDX3X
ATP-dependent RNA helicase DDX3X

1

9

Small-scale

0.500

High

449254

TNFA
Tumor necrosis factor

1

6

Small-scale

0.479

High

648084

MYD88
Myeloid differentiation primary response protein MyD88

1

6

Small-scale

0.479

High

718498

MSRE
Macrophage scavenger receptor types I and II

1

4

Small-scale

0.479

High

767033

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

11

Small-scale

0.479

High

897531

RN19A
E3 ubiquitin-protein ligase RNF19A

1

3

Small-scale

0.479

High

913187

STAT6
Signal transducer and transcription activator 6

1

3

Small-scale

0.479

High

1021494

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

20

Small-scale

0.479

High

1190289

DTX3L
E3 ubiquitin-protein ligase DTX3L

1

2

Small-scale

0.479

High

1223831

TRI27
Zinc finger protein RFP

1

20

Small-scale

0.479

High

1296815

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

7

Small-scale

0.479

High

1297954

A16L1
Autophagy-related protein 16-1

1

11

High-throughput

0.479

High

1354140

TRAIP
E3 ubiquitin-protein ligase TRAIP

1

18

Small-scale

0.479

High

1362820

EED
Polycomb protein EED

1

7

High-throughput

0.479

High

1362227

DDX41
Probable ATP-dependent RNA helicase DDX41

1

10

Small-scale

0.445

High

1455853

SRCN1
SRC kinase signaling inhibitor 1

1

1

High-throughput

0.445

High

62356

A4FUW1
Regulatory-associated protein of mTOR

1

14

Small-scale

0.437

High

1296556

WDR48
WD repeat-containing protein 48

1

9

Small-scale

0.437

High

1362448

VANG2
Vang-like protein 2

1

1

Small-scale

0.437

High

1424048

RN128
E3 ubiquitin-protein ligase RNF128

1

2

Small-scale

0.437

High

1490165

ICOS
Inducible T-cell costimulator

1

1

Small-scale

0.407

High


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Last updated: 11Aug2025