Protein: CSN8
COP9 signalosome complex subunit 8 (SGN8) (Signalosome subunit 8) (COP9 homolog) (hCOP9) (JAB1-containing signalosome subunit 8)

Gene: CSN8, COPS8
Organism: Homo sapiens
Interactions: 99
UniProt ID: Q99627

Gene Ontology (top 5):
GO:0000338 - protein deneddylation
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1305361

CSN3
COP9 signalosome complex subunit 3

16

5

Small-scale

0.985

High

1272557

CSN5
COP9 signalosome complex subunit 5

13

4

Small-scale

0.982

High

1024210

CSN1
COP9 signalosome complex subunit 1

11

5

Small-scale

0.977

High

1184954

CSN6
COP9 signalosome complex subunit 6

10

1

Small-scale

0.976

High

1305357

CSN7A
COP9 signalosome complex subunit 7a

10

3

Small-scale

0.972

High

897300

CSN2
COP9 signalosome complex subunit 2

9

7

Small-scale

0.970

High

1305342

CSN4
COP9 signalosome complex subunit 4

8

1

Small-scale

0.968

High

1305351

CSN7B
COP9 signalosome complex subunit 7b

5

3

Small-scale

0.925

High

1043183

CUL4A
Cullin-4A

10

7

Small-scale

0.755

High

1043536

CUL4B
Cullin-4B

7

7

Small-scale

0.752

High

1265889

DDB2
DNA damage-binding protein 2

6

2

Small-scale

0.730

High

1042368

CUL3
Cullin-3

6

7

Small-scale

0.729

High

1041445

CUL2
Cullin-2

4

7

High-throughput

0.704

High

1082352

DDB1
DNA damage-binding protein 1

4

1

Small-scale

0.696

High

1041162

CUL1
Cullin-1

4

7

Small-scale

0.694

High

1305364

DCAF1
DDB1- and CUL4-associated factor 1

4

0

Small-scale

0.664

High

1274027

CUL5
Cullin-5

3

7

Small-scale

0.656

High

1255945

DCA11
DDB1- and CUL4-associated factor 11

3

0

High-throughput

0.646

High

1296805

LLR1
Leucine-rich repeat protein 1

3

0

High-throughput

0.638

High

1260884

DCAF4
DDB1- and CUL4-associated factor 4

2

1

High-throughput

0.628

High

1305344

BTBD2
BTB/POZ domain-containing protein 2

2

4

High-throughput

0.628

High

1305349

BTBD1
BTB/POZ domain-containing protein 1

2

4

High-throughput

0.628

High

1028019

ERCC8
DNA excision repair protein ERCC-8

3

0

Small-scale

0.613

High

850760

BMX
Cytoplasmic tyrosine-protein kinase BMX

2

0

High-throughput

0.602

High

1079135

STK11
Serine/threonine-protein kinase STK11

2

0

High-throughput

0.602

High

1261295

RN138
E3 ubiquitin-protein ligase RNF138

2

0

High-throughput

0.602

High

1268435

APBP2
Amyloid protein-binding protein 2

2

0

High-throughput

0.602

High

1305354

DTL
Denticleless protein homolog

2

0

High-throughput

0.602

High

1305360

FEM1B
Protein fem-1 homolog B

2

0

High-throughput

0.602

High

1305356

KLH13
Kelch-like protein 13

2

2

High-throughput

0.601

High

1263345

CSN9
COP9 signalosome complex subunit 9

2

0

Small-scale

0.585

High

1292378

DCNL1
DCN1-like protein 1

2

0

Small-scale

0.585

High

1302545

CRBN
Protein cereblon

2

0

Small-scale

0.585

High

1305339

CSN8
COP9 signalosome complex subunit 8

1

1

Small-scale

0.575

High

1236688

USBP1
Harmonin-binding protein USHBP1

1

0

High-throughput

0.549

High

475153

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

1

High-throughput

0.536

High

1075444

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

1

High-throughput

0.536

High

1079584

NEDD8
NEDD8

1

1

High-throughput

0.536

High

1123654

DCAF6
DDB1- and CUL4-associated factor 6

1

2

High-throughput

0.536

High

1153790

KLH10
Kelch-like protein 10

1

2

High-throughput

0.536

High

1234370

WDTC1
WD and tetratricopeptide repeats protein 1

1

2

High-throughput

0.536

High

1289616

FBX17
F-box only protein 17

1

1

High-throughput

0.536

High

1305341

KLDC3
Kelch domain-containing protein 3

1

3

High-throughput

0.536

High

1305355

KLHL8
Kelch-like protein 8

1

2

High-throughput

0.536

High

1305366

USH1C
Harmonin

1

1

High-throughput

0.536

High

263955

HYPM
Huntingtin-interacting protein M

1

0

High-throughput

0.513

High

452861

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

863996

CLH2
Clathrin heavy chain 2

1

0

High-throughput

0.513

High

1185083

DET1
DET1 homolog

1

0

High-throughput

0.513

High

1204267

HOGA1
4-hydroxy-2-oxoglutarate aldolase, mitochondrial

1

0

High-throughput

0.513

High

1204455

FBX11
F-box only protein 11

1

0

High-throughput

0.513

High

1262994

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

1

0

High-throughput

0.513

High

1305340

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

High-throughput

0.513

High

1305363

FBX7
F-box only protein 7

1

0

High-throughput

0.513

High

878611

ALR
FAD-linked sulfhydryl oxidase ALR

1

0

Small-scale

0.512

High

476259

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.501

High

1077094

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

Small-scale

0.480

High

1081375

E2F4
Transcription factor E2F4

1

1

High-throughput

0.479

High

1305350

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

1305352

FBX6
F-box only protein 6

1

1

High-throughput

0.479

High

205880

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

295173

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

622615

RAE1
Rab proteins geranylgeranyltransferase component A 1

1

0

High-throughput

0.458

High

717303

CTNB1
Catenin beta-1

1

0

Small-scale

0.458

High

727182

DDIT3
DNA damage-inducible transcript 3 protein

1

0

Small-scale

0.458

High

828357

CENPA
Histone H3-like centromeric protein A

1

0

Small-scale

0.458

High

885052

FBXW4
F-box/WD repeat-containing protein 4

1

0

Small-scale

0.458

High

896195

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

921404

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

High-throughput

0.458

High

943891

RAE1L
mRNA export factor RAE1

1

0

High-throughput

0.458

High

1039467

IRF5
Interferon regulatory factor 5

1

0

Small-scale

0.458

High

1072434

ELOB
Elongin-B

1

0

High-throughput

0.458

High

1171392

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1243901

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

1246155

COP1
E3 ubiquitin-protein ligase COP1

1

0

High-throughput

0.458

High

1262806

PHIP
PH-interacting protein

1

0

Small-scale

0.458

High

1267115

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1270676

REQU
Zinc finger protein ubi-d4

1

0

High-throughput

0.458

High

1305343

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1305345

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

Small-scale

0.458

High

1305347

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

0

Small-scale

0.458

High

1305348

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

0

High-throughput

0.458

High

1305358

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1305359

DS13B
Dual specificity protein phosphatase 13B

1

0

High-throughput

0.458

High

1305362

NOD1
Nucleotide-binding oligomerization domain-containing protein 1

1

0

Small-scale

0.458

High

1305365

MAFB
Transcription factor MafB

1

0

High-throughput

0.458

High

1305353

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

1159424

FBX42
F-box only protein 42

1

2

High-throughput

0.437

High

1239005

DC4L2
DDB1- and CUL4-associated factor 4-like protein 2

1

1

Small-scale

0.437

High

497490

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

1063112

ABRX2
BRISC complex subunit Abraxas 2

1

0

Small-scale

0.426

High

1295576

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.426

High

1305346

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

577471

PACA
Pituitary adenylate cyclase-activating polypeptide

2

0

High-throughput

0.318

High

849808

SUOX
Sulfite oxidase, mitochondrial

2

0

High-throughput

0.316

High

863903

CRBA4
Beta-crystallin A4

1

0

High-throughput

0.279

Low

1121795

ANR39
Ankyrin repeat domain-containing protein 39

1

0

High-throughput

0.279

Low

297668

RHBT1
Rho-related BTB domain-containing protein 1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024