Protein: TRAF3
TNF receptor-associated factor 3 (EC 2.3.2.27) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (RING-type E3 ubiquitin transferase TRAF3)

Gene: TRAF3
Organism: Mus musculus
Interactions: 100
UniProt ID: Q60803

Gene Ontology (top 5):
GO:0001817 - regulation of cytokine production
GO:0002224 - toll-like receptor signaling pathway
GO:0005164 - tumor necrosis factor receptor binding
GO:0005739 - mitochondrion
GO:0006915 - apoptotic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1221554

TBK1
Serine/threonine-protein kinase TBK1

7

20

Small-scale

0.736

High

1221533

MAVS
Mitochondrial antiviral-signaling protein

4

16

Small-scale

0.687

High

1221520

TCAM1
TIR domain-containing adapter molecule 1

4

13

Small-scale

0.686

High

648054

MYD88
Myeloid differentiation primary response protein MyD88

3

18

Small-scale

0.670

High

693162

TNR5
Tumor necrosis factor receptor superfamily member 5

3

20

Small-scale

0.656

High

811906

TRAF2
TNF receptor-associated factor 2

1

19

Small-scale

0.618

High

999814

TRAF5
TNF receptor-associated factor 5

1

17

Small-scale

0.618

High

999839

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.618

High

1221510

DLG4
Disks large homolog 4

2

9

High-throughput

0.611

High

148444

BIRC3
Baculoviral IAP repeat-containing protein 3

2

20

Small-scale

0.595

High

1000253

TANK
TRAF family member-associated NF-kappa-B activator

2

10

Small-scale

0.584

High

894453

TNR3
Tumor necrosis factor receptor superfamily member 3

1

20

Small-scale

0.536

High

1189915

HECD3
E3 ubiquitin-protein ligase HECTD3

2

20

Small-scale

0.533

High

74100

OTU7B
OTU domain-containing protein 7B

1

16

Small-scale

0.515

High

1221525

RNF41
E3 ubiquitin-protein ligase NRDP1

1

18

Small-scale

0.515

High

1221549

TLR4
Toll-like receptor 4

1

11

Small-scale

0.515

High

1221514

MYSM1
Deubiquitinase MYSM1

1

12

Small-scale

0.512

High

107071

F8VPR5
histone acetyltransferase

1

13

Small-scale

0.479

High

107140

F8VQ72
Mitogen-activated protein kinase kinase kinase 1

1

19

Small-scale

0.479

High

483864

CSF1R
Macrophage colony-stimulating factor 1 receptor

1

4

Small-scale

0.479

High

711226

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

8

Small-scale

0.479

High

746559

RASK
GTPase KRas

1

19

Small-scale

0.479

High

778168

BTK
Tyrosine-protein kinase BTK

1

19

Small-scale

0.479

High

861875

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

20

Small-scale

0.479

High

869542

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.479

High

1180419

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog

1

6

Small-scale

0.479

High

1189493

NLRX1
NLR family member X1

1

20

Small-scale

0.479

High

1189682

ESYT2
Extended synaptotagmin-2

1

3

Small-scale

0.479

High

1189884

SC24A
Protein transport protein Sec24A

1

3

Small-scale

0.479

High

1190004

TRAD1
TRAF-type zinc finger domain-containing protein 1

1

9

Small-scale

0.479

High

1217084

SAMC
Mitochondrial S-adenosylmethionine carrier protein

1

12

Small-scale

0.479

High

1221504

SC6A4
Sodium-dependent serotonin transporter

1

2

High-throughput

0.479

High

1221506

I17RA
Interleukin-17 receptor A

1

5

Small-scale

0.479

High

1221508

EWS
RNA-binding protein EWS

1

10

Small-scale

0.479

High

1221511

BIRC2
Baculoviral IAP repeat-containing protein 2

1

20

Small-scale

0.479

High

1221512

ASPP1
Apoptosis-stimulating of p53 protein 1

1

17

Small-scale

0.479

High

1221513

TIF1A
Transcription intermediary factor 1-alpha

1

19

Small-scale

0.479

High

1221519

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

8

Small-scale

0.479

High

1221522

RT07
Small ribosomal subunit protein uS7m

1

2

Small-scale

0.479

High

1221523

Q80ZX0
SEC24 homolog B, COPII coat complex component

1

3

Small-scale

0.479

High

1221528

MEF2C
Myocyte-specific enhancer factor 2C

1

1

Small-scale

0.479

High

1221531

CIKS
E3 ubiquitin ligase TRAF3IP2

1

12

Small-scale

0.479

High

1221534

ACLY
ATP-citrate synthase

1

2

Small-scale

0.479

High

1221538

ATD3A
ATPase family AAA domain-containing protein 3A

1

6

Small-scale

0.479

High

1221539

RTN4
Reticulon-4

1

6

Small-scale

0.479

High

1221541

CHM4B
Charged multivesicular body protein 4b

1

5

Small-scale

0.479

High

1221542

TR13C
Tumor necrosis factor receptor superfamily member 13C

1

5

Small-scale

0.479

High

1221544

PGAM1
Phosphoglycerate mutase 1

1

5

Small-scale

0.479

High

1221546

ASC
Apoptosis-associated speck-like protein containing a CARD

1

9

Small-scale

0.479

High

1221551

CHIP
E3 ubiquitin-protein ligase CHIP

1

15

Small-scale

0.479

High

1221537

WWOX
WW domain-containing oxidoreductase

1

0

Small-scale

0.458

High

204649

TNR11
Tumor necrosis factor receptor superfamily member 11A

1

20

High-throughput

0.457

High

630395

TNR9
Tumor necrosis factor receptor superfamily member 9

1

20

Small-scale

0.457

High

866565

TNR4
Tumor necrosis factor receptor superfamily member 4

1

20

Small-scale

0.457

High

1221550

SRCN1
SRC kinase signaling inhibitor 1

1

3

High-throughput

0.445

High

72997

KRT36
Keratin, type I cuticular Ha6

1

20

Small-scale

0.437

High

74095

KPRP
Keratinocyte proline-rich protein

1

3

Small-scale

0.437

High

108291

G3X928
SEC23-interacting protein

1

2

Small-scale

0.437

High

205388

NUDC
Nuclear migration protein nudC

1

7

Small-scale

0.437

High

683936

EZRI
Ezrin

1

9

Small-scale

0.437

High

846711

MSH2
DNA mismatch repair protein Msh2

1

1

Small-scale

0.437

High

846993

H14
Histone H1.4

1

9

Small-scale

0.437

High

944136

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

1

20

Small-scale

0.437

High

964788

DCAF7
DDB1- and CUL4-associated factor 7

1

9

Small-scale

0.437

High

967105

1433G
14-3-3 protein gamma [Cleaved into: 14-3-3 protein gamma, N-terminally processed]

1

20

Small-scale

0.437

High

968102

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

6

Small-scale

0.437

High

997609

TBA1C
Tubulin alpha-1C chain

1

20

Small-scale

0.437

High

1022002

KRT86
Keratin, type II cuticular Hb6

1

20

Small-scale

0.437

High

1029584

CREB1
Cyclic AMP-responsive element-binding protein 1

1

6

Small-scale

0.437

High

1189433

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

3

Small-scale

0.437

High

1189509

Q3TMF4
small monomeric GTPase

1

18

Small-scale

0.437

High

1189552

Q3TRA8
Uncharacterized protein

1

5

Small-scale

0.437

High

1189697

FUBP2
Far upstream element-binding protein 2

1

9

Small-scale

0.437

High

1190245

AAK1
AP2-associated protein kinase 1

1

9

Small-scale

0.437

High

1221505

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

17

Small-scale

0.437

High

1221507

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

8

Small-scale

0.437

High

1221509

FXR1
RNA-binding protein FXR1

1

8

Small-scale

0.437

High

1221515

SWP70
Switch-associated protein 70

1

11

Small-scale

0.437

High

1221516

CE170
Centrosomal protein of 170 kDa

1

10

Small-scale

0.437

High

1221517

KDSR
3-ketodihydrosphingosine reductase

1

1

Small-scale

0.437

High

1221518

KRT87
Keratin, type II cuticular 87

1

20

Small-scale

0.437

High

1221521

PELO
Protein pelota homolog

1

1

Small-scale

0.437

High

1221524

PCID2
PCI domain-containing protein 2

1

4

Small-scale

0.437

High

1221526

RB39A
Ras-related protein Rab-39A

1

10

Small-scale

0.437

High

1221527

VCIP1
Deubiquitinating protein VCPIP1

1

2

Small-scale

0.437

High

1221529

Q8CHD7
MKIAA0678 protein

1

10

Small-scale

0.437

High

1221530

ABLM1
Actin-binding LIM protein 1

1

20

Small-scale

0.437

High

1221535

S27A4
Long-chain fatty acid transport protein 4

1

1

Small-scale

0.437

High

1221536

STK38
Serine/threonine-protein kinase 38

1

14

Small-scale

0.437

High

1221543

EF1G
Elongation factor 1-gamma

1

7

Small-scale

0.437

High

1221545

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

2

Small-scale

0.437

High

1221547

KRT81
Keratin, type II cuticular Hb1

1

20

Small-scale

0.437

High

1221548

KC1E
Casein kinase I isoform epsilon

1

13

Small-scale

0.437

High

1221552

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

20

Small-scale

0.437

High

1221553

COR1B
Coronin-1B

1

9

Small-scale

0.437

High

1221555

Q9Z1A1
TFG protein

1

6

Small-scale

0.437

High

147447

SC22B
Vesicle-trafficking protein SEC22b

1

0

Small-scale

0.249

Low

1189626

TEX30
Testis-expressed protein 30

1

0

Small-scale

0.249

Low

1221532

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

Small-scale

0.249

Low

1221540

GDIR1
Rho GDP-dissociation inhibitor 1

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025