Protein: PDE4D
3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) (cAMP-specific phosphodiesterase 4D)

Gene: PDE4D
Organism: Homo sapiens
Interactions: 63
UniProt ID: Q08499

Gene Ontology (top 5):
GO:0002027 - regulation of heart rate
GO:0004114 - 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 - 3',5'-cyclic-AMP phosphodiesterase activity
GO:0005246 - calcium channel regulator activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

991143

PDE4B
3',5'-cyclic-AMP phosphodiesterase 4B

2

8

High-throughput

0.802

High

929415

RACK1
Small ribosomal subunit protein RACK1

4

3

Small-scale

0.704

High

685923

ARRB2
Beta-arrestin-2

4

4

Small-scale

0.698

High

653906

PDE4A
3',5'-cyclic-AMP phosphodiesterase 4A

1

7

High-throughput

0.691

High

995915

PDE4D
3',5'-cyclic-AMP phosphodiesterase 4D

1

8

Small-scale

0.647

High

568640

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

3

10

Small-scale

0.646

High

750238

COIL
Coilin

3

0

High-throughput

0.646

High

827178

ARRB1
Beta-arrestin-1

2

4

Small-scale

0.586

High

795858

MAGA6
Melanoma-associated antigen 6

1

1

High-throughput

0.573

High

995918

TRAF1
TNF receptor-associated factor 1

1

1

High-throughput

0.573

High

792977

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

3

Small-scale

0.561

High

995923

ITSN1
Intersectin-1

1

2

High-throughput

0.552

High

995924

MYOME
Myomegalin

1

1

Small-scale

0.552

High

962749

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.537

High

433724

LYN
Tyrosine-protein kinase Lyn

1

6

Small-scale

0.536

High

241689

F262
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2

1

2

High-throughput

0.536

High

320517

OXSR1
Serine/threonine-protein kinase OSR1

1

4

High-throughput

0.536

High

546388

PGAM2
Phosphoglycerate mutase 2

1

2

High-throughput

0.536

High

995927

ZDH17
Palmitoyltransferase ZDHHC17

1

1

High-throughput

0.532

High

995930

OPTN
Optineurin

1

4

High-throughput

0.515

High

995934

ABCF3
ATP-binding cassette sub-family F member 3

1

0

High-throughput

0.513

High

337449

ABL1
Tyrosine-protein kinase ABL1

1

6

Small-scale

0.501

High

349270

RASH
GTPase HRas

1

1

Small-scale

0.501

High

394603

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

412154

FYN
Tyrosine-protein kinase Fyn

1

6

Small-scale

0.501

High

522940

SRC
Proto-oncogene tyrosine-protein kinase Src

1

6

Small-scale

0.501

High

822000

KC1A
Casein kinase I isoform alpha

1

5

Small-scale

0.501

High

835699

GSK3B
Glycogen synthase kinase-3 beta

1

1

Small-scale

0.501

High

924519

GRB2
Growth factor receptor-bound protein 2

1

8

Small-scale

0.501

High

995928

PIAS4
E3 SUMO-protein ligase PIAS4

1

1

Small-scale

0.501

High

995939

FBX7
F-box only protein 7

1

1

High-throughput

0.501

High

973755

AKA12
A-kinase anchor protein 12

1

0

Small-scale

0.493

High

995933

RXFP1
Relaxin receptor 1

1

4

Small-scale

0.484

High

655338

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

0

Small-scale

0.480

High

658907

MK01
Mitogen-activated protein kinase 1

1

0

Small-scale

0.480

High

995921

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

0

Small-scale

0.480

High

557542

PP2BB
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

1

3

Small-scale

0.479

High

655531

IP3KB
Inositol-trisphosphate 3-kinase B

1

1

High-throughput

0.479

High

926732

CANB1
Calcineurin subunit B type 1

1

1

Small-scale

0.479

High

994071

PP2BA
Protein phosphatase 3 catalytic subunit alpha

1

3

Small-scale

0.479

High

995917

AKAP6
A-kinase anchor protein 6

1

2

Small-scale

0.479

High

995919

CUL1
Cullin-1

1

1

Small-scale

0.479

High

995937

SHAN2
SH3 and multiple ankyrin repeat domains protein 2

1

3

Small-scale

0.479

High

995916

GOG8D
Putative golgin subfamily A member 8D

1

3

High-throughput

0.470

High

734606

TRI23
E3 ubiquitin-protein ligase TRIM23

1

0

High-throughput

0.460

High

625390

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.458

High

817973

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

819584

INAR2
Interferon alpha/beta receptor 2

1

0

Small-scale

0.458

High

861716

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.458

High

995922

PAQRB
Monocyte to macrophage differentiation factor

1

0

Small-scale

0.458

High

995929

ATOH1
Transcription factor ATOH1

1

0

Small-scale

0.458

High

995936

FBX2
F-box only protein 2

1

0

Small-scale

0.458

High

995938

ZBTB1
Zinc finger and BTB domain-containing protein 1

1

0

Small-scale

0.458

High

601661

RYR1
Ryanodine receptor 1

1

5

Small-scale

0.445

High

995920

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

6

High-throughput

0.445

High

517220

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.438

High

995931

CF418
Cilia- and flagella-associated protein 418

1

0

Small-scale

0.438

High

623538

AKAP5
A-kinase anchor protein 5

1

0

Small-scale

0.426

High

995925

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

1

0

High-throughput

0.279

Low

995932

CLPB
Mitochondrial disaggregase

1

0

High-throughput

0.279

Low

995926

LRC31
Leucine-rich repeat-containing protein 31

1

0

High-throughput

0.249

Low

995935

DS13B
Dual specificity protein phosphatase 13B

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024