Protein: RHEB
GTP-binding protein Rheb (EC 3.6.5.-) (Ras homolog enriched in brain)

Gene: RHEB
Organism: Mus musculus
Interactions: 68
UniProt ID: Q921J2

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0000287 - magnesium ion binding
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005681 - spliceosomal complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1282982

CNKR2
Connector enhancer of kinase suppressor of ras 2

1

15

High-throughput

0.691

High

204950

RABE1
Rab GTPase-binding effector protein 1

1

11

High-throughput

0.618

High

607850

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.618

High

1021280

G3BP2
Ras GTPase-activating protein-binding protein 2

1

3

High-throughput

0.618

High

1230024

EHBP1
EH domain-binding protein 1

1

20

High-throughput

0.618

High

1362405

RHG35
Rho GTPase-activating protein 35

1

4

High-throughput

0.618

High

1362882

RHEB
GTP-binding protein Rheb

1

17

High-throughput

0.618

High

1274209

CYFP1
Cytoplasmic FMR1-interacting protein 1

1

0

High-throughput

0.578

High

1296730

ANS1B
Ankyrin repeat and sterile alpha motif domain-containing protein 1B

1

5

High-throughput

0.575

High

1071143

TRIO
Triple functional domain protein

1

8

High-throughput

0.553

High

1189538

Q3TQ10
TSC complex subunit 2

1

11

Small-scale

0.553

High

1189667

LMTK2
Serine/threonine-protein kinase LMTK2

1

20

High-throughput

0.553

High

1281865

SI1L2
Signal-induced proliferation-associated 1-like protein 2

1

13

High-throughput

0.553

High

1317550

FNDC5
Fibronectin type III domain-containing protein 5

1

6

High-throughput

0.553

High

1362891

RUFY3
Protein RUFY3

1

10

High-throughput

0.553

High

1362898

ZO2
Tight junction protein 2

1

6

High-throughput

0.553

High

236993

BNIP3
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

1

2

Small-scale

0.515

High

98399

E9QPD7
Pyruvate carboxylase

1

3

High-throughput

0.479

High

147428

BIN1
Myc box-dependent-interacting protein 1

1

2

High-throughput

0.479

High

237109

SYUA
Alpha-synuclein

1

9

High-throughput

0.479

High

439046

LDHA
L-lactate dehydrogenase A chain

1

6

High-throughput

0.479

High

530967

THIO
Thioredoxin

1

4

High-throughput

0.479

High

591978

LDHB
L-lactate dehydrogenase B chain

1

6

High-throughput

0.479

High

631794

MTAP2
Microtubule-associated protein 2

1

16

High-throughput

0.479

High

693437

MAP4
Microtubule-associated protein 4

1

18

High-throughput

0.479

High

776018

PRDX1
Peroxiredoxin-1

1

5

High-throughput

0.479

High

926891

STMN1
Stathmin

1

1

High-throughput

0.479

High

990037

1433Z
14-3-3 protein zeta/delta

1

8

High-throughput

0.479

High

1188830

STING
Stimulator of interferon genes protein

1

3

High-throughput

0.479

High

1211118

ACACA
Acetyl-CoA carboxylase 1

1

3

High-throughput

0.479

High

1222006

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

15

High-throughput

0.479

High

1222403

PRDX2
Peroxiredoxin-2

1

5

High-throughput

0.479

High

1362477

SYUB
Beta-synuclein

1

9

High-throughput

0.479

High

1362554

EED
Polycomb protein EED

1

10

High-throughput

0.479

High

1362884

ARFG2
ADP-ribosylation factor GTPase-activating protein 2

1

6

High-throughput

0.479

High

1362886

RTN4
Reticulon-4

1

11

High-throughput

0.479

High

1362895

MAP1A
Microtubule-associated protein 1A

1

2

High-throughput

0.479

High

1362896

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

7

High-throughput

0.479

High

1362897

5HT6R
5-hydroxytryptamine receptor 6

1

5

Small-scale

0.479

High

607888

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.458

High

908563

FABP7
Fatty acid-binding protein, brain

1

0

High-throughput

0.458

High

1190278

HAP28
28 kDa heat- and acid-stable phosphoprotein

1

0

High-throughput

0.458

High

1224185

CYTB
Cystatin-B

1

0

High-throughput

0.458

High

1298083

CNOT2
CCR4-NOT transcription complex subunit 2

1

0

High-throughput

0.458

High

1362883

Q924B0
Inositol-1-monophosphatase

1

0

High-throughput

0.458

High

1362893

LZTL1
Leucine zipper transcription factor-like protein 1

1

0

High-throughput

0.458

High

1362894

PROF2
Profilin-2

1

0

High-throughput

0.458

High

237149

STRN
Striatin

1

4

High-throughput

0.437

High

398863

CFAD
Complement factor D

1

9

High-throughput

0.437

High

1221629

SPB6
Serpin B6

1

6

High-throughput

0.437

High

1222744

KCNA4
Potassium voltage-gated channel subfamily A member 4

1

3

High-throughput

0.437

High

1243156

PCNP
PEST proteolytic signal-containing nuclear protein

1

1

High-throughput

0.437

High

1243465

FKB15
FK506-binding protein 15

1

8

High-throughput

0.437

High

1281963

CL16A
Protein CLEC16A

1

6

High-throughput

0.437

High

1298044

Q8C3X1
Serine/threonine-protein phosphatase 6 regulatory subunit 2

1

1

High-throughput

0.437

High

1362444

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

3

High-throughput

0.437

High

1362885

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

2

High-throughput

0.437

High

1362887

TXD12
Thioredoxin domain-containing protein 12

1

5

High-throughput

0.437

High

1362889

TPD54
Tumor protein D54

1

6

High-throughput

0.437

High

601546

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.249

Low

940547

ACYP2
Acylphosphatase-2

1

0

High-throughput

0.249

Low

1220129

F169A
Soluble lamin-associated protein of 75 kDa

1

0

High-throughput

0.249

Low

1282967

BSDC1
BSD domain-containing protein 1

1

0

High-throughput

0.249

Low

1296972

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

0

High-throughput

0.249

Low

1362888

UFC1
Ubiquitin-fold modifier-conjugating enzyme 1

1

0

High-throughput

0.249

Low

1362890

NSF1C
NSFL1 cofactor p47

1

0

High-throughput

0.249

Low

1362892

ATP5H
ATP synthase peripheral stalk subunit d, mitochondrial

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025