Protein: O83946
diguanylate cyclase (EC 2.7.7.65)

Gene: O83946, TP_0981
Organism: Treponema pallidum subsp. pallidum str. Nichols
Interactions: 28
UniProt ID: O83946

Gene Ontology (top 5):
GO:0005886 - plasma membrane
GO:0016301 - kinase activity
GO:0043709 - cell adhesion involved in single-species biofilm formation
GO:0052621 - diguanylate cyclase activity
GO:1902201 - negative regulation of bacterial-type flagellum-dependent cell motility

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

308588

GYRA
DNA gyrase subunit A

1

1

High-throughput

0.417

High

311500

O83745
HD-GYP domain-containing protein

1

10

High-throughput

0.417

High

311732

O83847
HD-GYP domain-containing protein

1

10

High-throughput

0.417

High

311894

FLAB3
Flagellin FlaB3

2

0

High-throughput

0.295

High

308955

RS18
Small ribosomal subunit protein bS18

1

0

High-throughput

0.238

Low

308977

Y064
Uncharacterized protein TP_0064

1

0

High-throughput

0.238

Low

309162

O83127
Cyclic nucleotide binding protein

1

0

High-throughput

0.238

Low

309178

O83130
RNA polymerase sigma-24 factor

1

0

High-throughput

0.238

Low

309459

SYP
Proline--tRNA ligase

1

0

High-throughput

0.238

Low

309805

O83282
Uncharacterized protein

1

0

High-throughput

0.238

Low

310008

O83312
Spore coat polysaccharide biosynthesis protein

1

0

High-throughput

0.238

Low

310169

Y359
Uncharacterized protein TP_0359

1

0

High-throughput

0.238

Low

310320

O83411
Flagellar basal body rod protein FlgB

1

0

High-throughput

0.238

Low

310895

O83542
V-type ATPase, subunit E, putative

1

0

High-throughput

0.238

Low

311028

O83574
J domain-containing protein

1

0

High-throughput

0.238

Low

311220

O83654
Tetratricopeptide repeat protein

1

0

High-throughput

0.238

Low

311307

Y661
Uncharacterized protein TP_0661

1

0

High-throughput

0.238

Low

311409

IOJAP
Ribosomal silencing factor RsfS

1

0

High-throughput

0.238

Low

311665

O83804
GerMN domain-containing protein

1

0

High-throughput

0.238

Low

311697

O83815
Heat shock protein, putative

1

0

High-throughput

0.238

Low

311767

RIMM
Ribosome maturation factor RimM

1

0

High-throughput

0.238

Low

311861

O83927
Flagellar basal-body rod protein

1

0

High-throughput

0.238

Low

311889

O83954
P26

1

0

High-throughput

0.238

Low

311890

RLPA
Probable endolytic peptidoglycan transglycosylase RlpA

1

0

High-throughput

0.238

Low

311891

RECR
Recombination protein RecR

1

0

High-throughput

0.238

Low

311892

O83970
DNA polymerase III subunit gamma/tau

1

0

High-throughput

0.238

Low

311893

GATC
Glutamyl-tRNA(Gln) amidotransferase subunit C

1

0

High-throughput

0.238

Low

311895

TPL
Protein tpl

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025