HitPredict - High confidence protein-protein interactions

Protein: HCN2
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1)

Gene: HCN2
Organism: Mus musculus
Interactions: 9
UniProt ID: O88703

Gene Ontology (top 5):
GO:0005222 - intracellularly cAMP-activated cation channel activity
GO:0005248 - voltage-gated sodium channel activity
GO:0005249 - voltage-gated potassium channel activity
GO:0005886 - plasma membrane
GO:0009410 - response to xenobiotic stimulus

Download interactions: TXT MITAB-2.5

Interaction	Interactor	Experiments	Homologs	Category	Interaction Score	Confidence
312805	HCN1 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1	2	13	Small-scale	0.789	High
312808	SHAN3 SH3 and multiple ankyrin repeat domains protein 3	1	6	High-throughput	0.691	High
312804	HCN2 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	1	13	Small-scale	0.647	High
312811	PEX5R PEX5-related protein	1	6	High-throughput	0.536	High
312806	SRC Proto-oncogene tyrosine-protein kinase Src	1	8	Small-scale	0.479	High
312807	SSR3 Somatostatin receptor type 3	1	2	High-throughput	0.479	High
312809	SC6A4 Sodium-dependent serotonin transporter	1	0	High-throughput	0.458	High
312810	BICD1 Protein bicaudal D homolog 1	1	5	High-throughput	0.437	High

Service provided by Combinatics, Japan

Last updated: 11Aug2025