Protein: HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) (Hyperpolarization-activated cation channel 2) (HAC-2)

Gene: HCN1
Organism: Mus musculus
Interactions: 50
UniProt ID: O88704

Gene Ontology (top 5):
GO:0003254 - regulation of membrane depolarization
GO:0005222 - intracellularly cAMP-activated cation channel activity
GO:0005248 - voltage-gated sodium channel activity
GO:0005249 - voltage-gated potassium channel activity
GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

312805

HCN2
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

2

13

Small-scale

0.789

High

312824

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

2

6

High-throughput

0.789

High

312812

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

13

Small-scale

0.716

High

312814

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

12

High-throughput

0.691

High

312815

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

1

15

High-throughput

0.691

High

312822

TNIK
Traf2 and NCK-interacting protein kinase

1

8

High-throughput

0.691

High

312827

PAK3
Serine/threonine-protein kinase PAK 3

1

10

High-throughput

0.691

High

312830

GIT1
ARF GTPase-activating protein GIT1

1

9

High-throughput

0.691

High

312845

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit [Cleaved into: cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed]

1

15

High-throughput

0.691

High

312851

GSK3B
Glycogen synthase kinase-3 beta

1

2

High-throughput

0.691

High

312817

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

11

High-throughput

0.618

High

312820

CTRO
Citron Rho-interacting kinase

1

6

High-throughput

0.618

High

312826

CSK21
Casein kinase II subunit alpha

1

3

High-throughput

0.618

High

109219

G5E884
non-specific serine/threonine protein kinase

1

8

High-throughput

0.618

High

312839

PEX5R
PEX5-related protein

2

6

Small-scale

0.611

High

267181

HCN4
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

1

13

High-throughput

0.575

High

312738

PAK1
Serine/threonine-protein kinase PAK 1

1

10

High-throughput

0.575

High

98189

E9Q6P9
Voltage-dependent T-type calcium channel subunit alpha-1H

1

5

Small-scale

0.553

High

312832

BRSK2
Serine/threonine-protein kinase BRSK2

1

8

High-throughput

0.553

High

312813

BSN
Protein bassoon

1

7

High-throughput

0.536

High

312819

RP3A
Rabphilin-3A

1

5

High-throughput

0.536

High

312823

NF1
Neurofibromin

1

3

High-throughput

0.536

High

312825

KCD16
BTB/POZ domain-containing protein KCTD16

1

7

High-throughput

0.536

High

312828

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

8

High-throughput

0.536

High

312831

Q68FG2
Spectrin beta chain

1

8

High-throughput

0.536

High

312834

ASIC1
Acid-sensing ion channel 1

1

1

High-throughput

0.536

High

312835

KCD12
BTB/POZ domain-containing protein KCTD12

1

8

High-throughput

0.536

High

312837

DLG1
Disks large homolog 1

1

4

High-throughput

0.536

High

312841

SH3K1
SH3 domain-containing kinase-binding protein 1

1

2

High-throughput

0.536

High

312842

MPDZ
Multiple PDZ domain protein

1

3

High-throughput

0.536

High

312846

DSCAM
Cell adhesion molecule DSCAM

1

7

High-throughput

0.536

High

312847

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

1

4

High-throughput

0.536

High

312848

ARHG7
Rho guanine nucleotide exchange factor 7

1

2

High-throughput

0.536

High

312849

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

1

4

High-throughput

0.536

High

312850

SHRM3
Protein Shroom3

1

4

High-throughput

0.536

High

312852

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

1

1

High-throughput

0.536

High

312836

GABR2
Gamma-aminobutyric acid type B receptor subunit 2

1

0

High-throughput

0.513

High

312838

GEPH
Gephyrin [Includes: Molybdopterin adenylyltransferase

1

0

High-throughput

0.513

High

312833

SPKAP
A-kinase anchor protein SPHKAP

1

1

High-throughput

0.489

High

312843

SH319
SH3 domain-containing protein 19

1

10

High-throughput

0.489

High

204975

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

1

High-throughput

0.479

High

312818

SSR3
Somatostatin receptor type 3

1

2

High-throughput

0.479

High

312844

CNTP2
Contactin-associated protein-like 2

1

4

High-throughput

0.479

High

108375

G3X9H5
Huntingtin

1

0

High-throughput

0.458

High

97846

TENS1
Tensin-1

1

3

High-throughput

0.445

High

312821

AP2S1
AP-2 complex subunit sigma

1

2

High-throughput

0.437

High

312840

Q8C6V6
Phosphatase tensin-type domain-containing protein

1

1

High-throughput

0.437

High

312816

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

0

High-throughput

0.279

Low

312829

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025