Protein: SRC
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)

Gene: SRC
Organism: Mus musculus
Interactions: 78
UniProt ID: P05480

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0002102 - podosome
GO:0002376 - immune system process
GO:0004672 - protein kinase activity
GO:0004713 - protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

431327

FAK1
Focal adhesion kinase 1

4

20

Small-scale

0.873

High

431314

SRC
Proto-oncogene tyrosine-protein kinase Src

3

20

Small-scale

0.834

High

431319

KPCE
Protein kinase C epsilon type

2

14

Small-scale

0.799

High

431316

CSF1R
Macrophage colony-stimulating factor 1 receptor

2

20

Small-scale

0.754

High

431331

STAT3
Signal transducer and activator of transcription 3

2

16

Small-scale

0.754

High

431373

FAK2
Protein-tyrosine kinase 2-beta

2

20

Small-scale

0.754

High

431323

CBL
E3 ubiquitin-protein ligase CBL

6

20

Small-scale

0.737

High

431318

INSR
Insulin receptor

1

20

Small-scale

0.691

High

431326

AKT1
RAC-alpha serine/threonine-protein kinase

1

20

Small-scale

0.691

High

431343

AGAP2
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

1

16

High-throughput

0.691

High

431345

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

13

High-throughput

0.691

High

267114

DOK2
Docking protein 2

1

20

Small-scale

0.690

High

424695

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

16

Small-scale

0.647

High

431352

TRPC6
Short transient receptor potential channel 6

1

8

Small-scale

0.647

High

431353

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

1

10

Small-scale

0.647

High

431372

TRPC4
Short transient receptor potential channel 4

1

12

Small-scale

0.647

High

431375

TRPC5
Short transient receptor potential channel 5

1

6

Small-scale

0.647

High

431364

PAXI
Paxillin

2

20

Small-scale

0.624

High

431330

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

Small-scale

0.618

High

431332

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.618

High

431334

EPHB2
Ephrin type-B receptor 2

1

20

Small-scale

0.618

High

431339

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.618

High

431341

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.618

High

431350

SHC3
SHC-transforming protein 3

1

19

Small-scale

0.618

High

431351

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

20

Small-scale

0.618

High

431355

DLG4
Disks large homolog 4

1

17

High-throughput

0.618

High

431356

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.618

High

431361

SHC2
SHC-transforming protein 2

1

19

Small-scale

0.618

High

431362

ARRB1
Beta-arrestin-1

1

8

Small-scale

0.618

High

431365

ARRB2
Beta-arrestin-2

1

8

Small-scale

0.618

High

431367

TLR3
Toll-like receptor 3

1

13

Small-scale

0.618

High

431369

TLR9
Toll-like receptor 9

1

12

Small-scale

0.618

High

431370

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

20

Small-scale

0.618

High

431371

TLR4
Toll-like receptor 4

1

13

Small-scale

0.618

High

431376

GAB1
GRB2-associated-binding protein 1

1

20

Small-scale

0.618

High

431380

TBK1
Serine/threonine-protein kinase TBK1

1

15

Small-scale

0.618

High

431320

ENOA
Alpha-enolase

2

4

Small-scale

0.602

High

431347

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

2

20

Small-scale

0.602

High

236548

ITB3
Integrin beta-3

2

11

Small-scale

0.584

High

431340

NMDE2
Glutamate receptor ionotropic, NMDA 2B

2

12

Small-scale

0.584

High

431346

Q5U3L0
SH3 domain-binding protein 2

1

5

Small-scale

0.579

High

431358

EFS
Embryonal Fyn-associated substrate

1

20

Small-scale

0.579

High

431321

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

20

Small-scale

0.575

High

431348

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

20

Small-scale

0.561

High

431329

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

12

High-throughput

0.536

High

431315

CSF1
Macrophage colony-stimulating factor 1

1

7

Small-scale

0.515

High

431336

WASP
Actin nucleation-promoting factor WAS

1

20

Small-scale

0.515

High

431368

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

3

Small-scale

0.515

High

431379

CHIP
E3 ubiquitin-protein ligase CHIP

1

10

Small-scale

0.515

High

431342

ENAH
Protein enabled homolog

1

19

Small-scale

0.501

High

431349

TRPC1
Short transient receptor potential channel 1

1

12

Small-scale

0.501

High

431363

FRS2
Fibroblast growth factor receptor substrate 2

1

20

Small-scale

0.501

High

431377

TRPC2
Short transient receptor potential channel 2

1

12

Small-scale

0.501

High

431324

CXA1
Gap junction alpha-1 protein

1

11

Small-scale

0.500

High

74245

EP300
Histone acetyltransferase p300

1

15

Small-scale

0.479

High

147390

S1PR1
Sphingosine 1-phosphate receptor 1

1

8

Small-scale

0.479

High

148353

DIAP1
Protein diaphanous homolog 1

1

14

Small-scale

0.479

High

266841

ATX2
Ataxin-2

1

11

Small-scale

0.479

High

312806

HCN2
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

1

8

Small-scale

0.479

High

431322

ESR1
Estrogen receptor

1

20

Small-scale

0.479

High

431325

SSR3
Somatostatin receptor type 3

1

10

High-throughput

0.479

High

431328

NMDE1
Glutamate receptor ionotropic, NMDA 2A

1

12

Small-scale

0.479

High

431333

CAV3
Caveolin-3

1

8

Small-scale

0.479

High

431335

TRAF6
TNF receptor-associated factor 6

1

14

Small-scale

0.479

High

431337

5HT4R
5-hydroxytryptamine receptor 4

1

6

Small-scale

0.479

High

431338

DAB1
Disabled homolog 1

1

18

Small-scale

0.479

High

431344

DTX3L
E3 ubiquitin-protein ligase DTX3L

1

7

Small-scale

0.479

High

431354

K1C14
Keratin, type I cytoskeletal 14

1

8

Small-scale

0.479

High

431357

ITA2
Integrin alpha-2

1

6

Small-scale

0.479

High

431359

Q6P7T9
Nuclear factor of activated T-cells c1 isoform IA-IXS

1

9

Small-scale

0.479

High

431360

RIGI
Antiviral innate immune response receptor RIG-I

1

6

High-throughput

0.479

High

431366

K2C5
Keratin, type II cytoskeletal 5

1

1

Small-scale

0.479

High

431378

PDC6I
Programmed cell death 6-interacting protein

1

9

Small-scale

0.479

High

431381

SKP2
S-phase kinase-associated protein 2

1

6

Small-scale

0.479

High

431374

SRCN1
SRC kinase signaling inhibitor 1

1

8

Small-scale

0.445

High

431382

K1C16
Keratin, type I cytoskeletal 16

1

9

Small-scale

0.437

High

431317

CASB
Beta-casein

1

0

Small-scale

0.261

Low


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Last updated: 11Aug2025