Protein: LEUC
3-isopropylmalate dehydratase (EC 4.2.1.33) (Alpha-IPM isomerase) (IPMI) (Isopropylmalate isomerase)

Gene: LEUC, LEU1
Organism: Saccharomyces cerevisiae S288C
Interactions: 61
UniProt ID: P07264

Gene Ontology (top 5):
GO:0003861 - 3-isopropylmalate dehydratase activity
GO:0005829 - cytosol
GO:0008652 - amino acid biosynthetic process
GO:0009098 - L-leucine biosynthetic process
GO:0009316 - 3-isopropylmalate dehydratase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

425131

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

3

1

High-throughput

0.640

High

365581

HSP82
ATP-dependent molecular chaperone HSP82

3

4

High-throughput

0.633

High

425101

HSC82
ATP-dependent molecular chaperone HSC82

3

4

High-throughput

0.633

High

425108

SIS1
Protein SIS1

2

3

High-throughput

0.584

High

425098

HSP72
Heat shock protein SSA2

2

10

High-throughput

0.552

High

425125

SSB2
Ribosome-associated molecular chaperone SSB2

2

11

High-throughput

0.552

High

333661

ADH1
Alcohol dehydrogenase 1

2

2

High-throughput

0.537

High

425135

ULP1
Ubiquitin-like-specific protease 1

2

2

High-throughput

0.535

High

425134

YG5B
Uncharacterized RNA-binding protein YGR250C

1

3

High-throughput

0.515

High

425120

YHS2
MIP18 family protein YHR122W

1

2

Small-scale

0.501

High

425118

HMT1
Protein arginine N-methyltransferase 1

1

2

Small-scale

0.494

High

425129

ERG10
Acetyl-CoA acetyltransferase

1

0

High-throughput

0.493

High

425130

ETFB
Probable electron transfer flavoprotein subunit beta

1

0

High-throughput

0.493

High

339342

CDK1
Cyclin-dependent kinase 1

1

1

High-throughput

0.479

High

410854

PDC1
Pyruvate decarboxylase isozyme 1

1

2

High-throughput

0.479

High

425104

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

1

1

High-throughput

0.479

High

425109

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.479

High

425123

DHH1
ATP-dependent RNA helicase DHH1

1

2

High-throughput

0.479

High

425124

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

1

High-throughput

0.479

High

425143

SCC2
Sister chromatid cohesion protein 2

1

2

High-throughput

0.479

High

425146

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

3

Small-scale

0.479

High

425105

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.458

High

425126

MET18
DNA repair/transcription protein MET18/MMS19

1

0

Small-scale

0.458

High

425153

TFB5
General transcription and DNA repair factor IIH subunit TFB5

1

0

Small-scale

0.458

High

425097

HSP71
Heat shock protein SSA1

1

10

High-throughput

0.445

High

425099

SSB1
Ribosome-associated molecular chaperone SSB1

1

11

High-throughput

0.445

High

425111

HSP7F
Heat shock protein homolog SSE1

1

14

High-throughput

0.445

High

425122

CAJ1
Protein CAJ1

1

1

High-throughput

0.445

High

425100

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

425114

IXR1
Intrastrand cross-link recognition protein

1

1

Small-scale

0.437

High

425116

CENPA
Histone H3-like centromeric protein CSE4

1

1

High-throughput

0.437

High

425117

LONM
Lon protease homolog, mitochondrial

1

2

High-throughput

0.437

High

425121

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

1

Small-scale

0.437

High

425127

ULP2
Ubiquitin-like-specific protease 2

1

2

Small-scale

0.437

High

425128

RLP7
Ribosome biogenesis protein RLP7

1

1

High-throughput

0.437

High

425136

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.437

High

425141

RUVB1
RuvB-like protein 1

1

4

High-throughput

0.437

High

425144

SIZ1
E3 SUMO-protein ligase SIZ1

1

1

High-throughput

0.437

High

425145

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

425149

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

425150

SIZ2
E3 SUMO-protein ligase SIZ2

1

1

High-throughput

0.437

High

425151

SMT3
Ubiquitin-like protein SMT3

1

2

High-throughput

0.437

High

425152

RUVB2
RuvB-like protein 2

1

4

High-throughput

0.437

High

425147

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

0

High-throughput

0.426

High

425113

HSP78
Heat shock protein 78, mitochondrial

1

4

High-throughput

0.407

High

425138

TDA1
Serine/threonine-protein kinase TDA1

1

0

High-throughput

0.279

Low

425106

SYMM
Methionine--tRNA ligase, mitochondrial

1

0

High-throughput

0.269

Low

425107

DPB2
DNA polymerase epsilon subunit B

1

0

High-throughput

0.269

Low

425102

SPO16
Sporulation-specific protein 16

1

0

Small-scale

0.249

Low

425103

PGTB1
Geranylgeranyl transferase type-1 subunit beta

1

0

High-throughput

0.249

Low

425110

HOG1
Mitogen-activated protein kinase HOG1

1

0

High-throughput

0.249

Low

425112

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.249

Low

425115

SPT10
Protein SPT10

1

0

High-throughput

0.249

Low

425119

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.249

Low

425132

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.249

Low

425133

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

425137

VPS60
Vacuolar protein-sorting-associated protein 60

1

0

Small-scale

0.249

Low

425139

BUL2
Ubiquitin ligase-binding protein BUL2

1

0

Small-scale

0.249

Low

425140

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.249

Low

425142

RAV2
Regulator of V-ATPase in vacuolar membrane protein 2

1

0

Small-scale

0.249

Low

425148

SGO1
Shugoshin

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024