Protein: PPAL
Lysosomal acid phosphatase (LAP) (EC 3.1.3.2)

Gene: PPAL, ACP2
Organism: Homo sapiens
Interactions: 95
UniProt ID: P11117

Gene Ontology (top 5):
GO:0001501 - skeletal system development
GO:0003993 - acid phosphatase activity
GO:0005764 - lysosome
GO:0005765 - lysosomal membrane
GO:0007040 - lysosome organization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

127260

LEG8
Galectin-8

3

3

High-throughput

0.667

High

536230

LEG3
Galectin-3

3

3

High-throughput

0.650

High

536270

TM192
Transmembrane protein 192

3

0

High-throughput

0.622

High

536288

P2Y12
P2Y purinoceptor 12

2

2

High-throughput

0.611

High

536232

S1PR1
Sphingosine 1-phosphate receptor 1

3

6

High-throughput

0.604

High

536241

TRFR
Thyrotropin-releasing hormone receptor

3

1

High-throughput

0.604

High

480664

LEG1
Galectin-1

2

3

High-throughput

0.601

High

536239

CTR1
High affinity cationic amino acid transporter 1

2

2

High-throughput

0.601

High

536287

LMA2L
VIP36-like protein

2

1

High-throughput

0.601

High

536248

EREP3
Protein ENTREP3

2

0

High-throughput

0.585

High

536299

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

2

0

High-throughput

0.585

High

536297

EVA1B
Protein eva-1 homolog B

2

0

High-throughput

0.576

High

536268

STX12
Syntaxin-12

2

1

High-throughput

0.558

High

536280

LPAR1
Lysophosphatidic acid receptor 1

2

5

High-throughput

0.558

High

536295

FBX6
F-box only protein 6

2

3

High-throughput

0.558

High

190301

COPT1
High affinity copper uptake protein 1

2

1

High-throughput

0.549

High

351868

S1PR4
Sphingosine 1-phosphate receptor 4

2

6

High-throughput

0.549

High

536301

FBX2
F-box only protein 2

2

3

High-throughput

0.549

High

189392

STX7
Syntaxin-7

1

1

High-throughput

0.536

High

190545

COPT2
Protein SLC31A2

1

1

High-throughput

0.536

High

536236

CALX
Calnexin

1

6

High-throughput

0.536

High

536262

S39A5
Zinc transporter ZIP5

1

2

High-throughput

0.536

High

125002

KCNK1
Potassium channel subfamily K member 1

1

0

High-throughput

0.513

High

186464

VA0E1
V-type proton ATPase subunit e 1

1

0

High-throughput

0.513

High

270427

FZD7
Frizzled-7

1

0

High-throughput

0.513

High

536229

LAMP1
Lysosome-associated membrane glycoprotein 1

1

0

High-throughput

0.513

High

536244

CLCN7
H(+)/Cl(-) exchange transporter 7

1

0

High-throughput

0.513

High

536247

1433G
14-3-3 protein gamma

1

0

High-throughput

0.513

High

536251

KDSR
3-ketodihydrosphingosine reductase

1

0

High-throughput

0.513

High

536257

MBLC2
Acyl-coenzyme A thioesterase MBLAC2

1

0

High-throughput

0.513

High

536259

C2D1A
Coiled-coil and C2 domain-containing protein 1A

1

0

High-throughput

0.513

High

536264

TS1R3
Taste receptor type 1 member 3

1

0

High-throughput

0.513

High

536271

AGRG5
Adhesion G-protein coupled receptor G5

1

0

High-throughput

0.513

High

536274

TPC2
Two pore channel protein 2

1

0

High-throughput

0.513

High

536275

SPP2B
Signal peptide peptidase-like 2B

1

0

High-throughput

0.513

High

536282

PMEPA
Protein TMEPAI

1

0

High-throughput

0.513

High

536284

T4S18
Transmembrane 4 L6 family member 18

1

0

High-throughput

0.513

High

536285

TMM74
Transmembrane protein 74

1

0

High-throughput

0.513

High

536303

VPP2
V-type proton ATPase 116 kDa subunit a 2

1

0

High-throughput

0.513

High

536254

PLEC
Plectin

1

0

High-throughput

0.493

High

125177

LEG9
Galectin-9

1

3

High-throughput

0.489

High

209368

SIA8C
Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3

1

1

High-throughput

0.489

High

326430

S1PR2
Sphingosine 1-phosphate receptor 2

1

5

High-throughput

0.489

High

536233

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

2

High-throughput

0.489

High

536237

5HT2C
5-hydroxytryptamine receptor 2C

1

1

High-throughput

0.489

High

536276

GP151
G-protein coupled receptor 151

1

1

High-throughput

0.489

High

536283

RN166
E3 ubiquitin-protein ligase RNF166

1

1

High-throughput

0.489

High

536293

LPAR2
Lysophosphatidic acid receptor 2

1

6

High-throughput

0.489

High

536294

C1QR1
Complement component C1q receptor

1

1

High-throughput

0.489

High

536296

GP173
Probable G-protein coupled receptor 173

1

4

High-throughput

0.489

High

536304

RN114
E3 ubiquitin-protein ligase RNF114

1

1

High-throughput

0.489

High

178162

NPC1
NPC intracellular cholesterol transporter 1

1

1

High-throughput

0.479

High

507465

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

High-throughput

0.479

High

536246

GPR85
Probable G-protein coupled receptor 85

1

4

High-throughput

0.470

High

536281

KLK6
Kallikrein-6

1

3

High-throughput

0.470

High

536234

ENPP1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

1

0

High-throughput

0.458

High

536300

DDX20
Probable ATP-dependent RNA helicase DDX20

1

0

High-throughput

0.458

High

536242

EAA1
Excitatory amino acid transporter 1

1

1

High-throughput

0.445

High

536269

S35F2
Solute carrier family 35 member F2

1

1

High-throughput

0.445

High

536263

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

536258

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.426

High

536260

NPAL3
NIPA-like protein 3

1

0

High-throughput

0.426

High

536272

S38A9
Neutral amino acid transporter 9

1

0

High-throughput

0.426

High

536273

MFSD8
Major facilitator superfamily domain-containing protein 8

1

0

High-throughput

0.426

High

536289

MFSD1
Lysosomal dipeptide transporter MFSD1

1

0

High-throughput

0.426

High

536298

GPC5B
G-protein coupled receptor family C group 5 member B

1

0

High-throughput

0.426

High

536306

SRPRB
Signal recognition particle receptor subunit beta

1

0

High-throughput

0.426

High

170637

CLGN
Calmegin

1

6

High-throughput

0.407

High

536238

5HT1E
5-hydroxytryptamine receptor 1E

1

2

High-throughput

0.407

High

536240

GASR
Gastrin/cholecystokinin type B receptor

1

3

High-throughput

0.407

High

536243

P2RY1
P2Y purinoceptor 1

1

1

High-throughput

0.407

High

536245

CTR2
Cationic amino acid transporter 2

1

2

High-throughput

0.407

High

536278

CTR3
Cationic amino acid transporter 3

1

2

High-throughput

0.407

High

536286

S1PR3
Sphingosine 1-phosphate receptor 3

1

5

High-throughput

0.407

High

377933

TNFA
Tumor necrosis factor

2

0

High-throughput

0.318

High

536255

SGCA
Alpha-sarcoglycan

2

0

High-throughput

0.318

High

350522

CF047
Uncharacterized protein C6orf47

1

0

High-throughput

0.279

Low

536231

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.279

Low

536253

PDCD1
Programmed cell death protein 1

1

0

High-throughput

0.279

Low

536256

ZFY27
Protrudin

1

0

High-throughput

0.279

Low

536261

BTNL3
Butyrophilin-like protein 3

1

0

High-throughput

0.279

Low

536265

LHPL4
LHFPL tetraspan subfamily member 4 protein

1

0

High-throughput

0.279

Low

536277

RN133
E3 ubiquitin-protein ligase RNF133

1

0

High-throughput

0.279

Low

536279

SGCD
Delta-sarcoglycan

1

0

High-throughput

0.279

Low

536290

OPA3
Optic atrophy 3 protein

1

0

High-throughput

0.279

Low

536291

SPRNG
SREBP regulating gene protein

1

0

High-throughput

0.279

Low

536292

IPPK
Inositol-pentakisphosphate 2-kinase

1

0

High-throughput

0.279

Low

536252

PAK1
Serine/threonine-protein kinase PAK 1

1

0

High-throughput

0.268

Low

536267

Q86V38
Atrophin 1

1

0

High-throughput

0.268

Low

536302

GAB2
GRB2-associated-binding protein 2

1

0

High-throughput

0.268

Low

536249

SARNP
SAP domain-containing ribonucleoprotein

1

0

High-throughput

0.249

Low

536266

LDB1
LIM domain-binding protein 1

1

0

High-throughput

0.249

Low

536235

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low

536250

CBX1
Chromobox protein homolog 1

1

0

Small-scale

0.232

Low

536305

PCDG5
Protocadherin gamma-A5

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025