Protein: HYAL2
Hyaluronidase-2 (Hyal-2) (EC 3.2.1.35) (Hyaluronoglucosaminidase-2) (Lung carcinoma protein 2) (LuCa-2)

Gene: HYAL2
Organism: Homo sapiens
Interactions: 90
UniProt ID: Q12891

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0000302 - response to reactive oxygen species
GO:0001618 - virus receptor activity
GO:0001822 - kidney development
GO:0002244 - hematopoietic progenitor cell differentiation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

731839

CEAM8
Cell adhesion molecule CEACAM8

1

0

High-throughput

0.656

High

1089133

BTNL2
Butyrophilin-like protein 2

1

0

High-throughput

0.656

High

1089095

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

3

0

High-throughput

0.638

High

1089094

PON2
Serum paraoxonase/arylesterase 2

3

0

High-throughput

0.634

High

596747

DPEP1
Dipeptidase 1

2

1

High-throughput

0.628

High

1089128

DPEP2
Dipeptidase 2

3

1

High-throughput

0.609

High

300346

KRT34
Keratin, type I cuticular Ha4

2

1

High-throughput

0.606

High

1059628

KRA11
Keratin-associated protein 1-1

2

1

High-throughput

0.606

High

1089096

K1H1
Keratin, type I cuticular Ha1

2

1

High-throughput

0.606

High

636489

FUT3
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

2

0

High-throughput

0.602

High

1089110

S39A5
Zinc transporter ZIP5

2

0

High-throughput

0.602

High

1089122

TECT2
Tectonic-2

2

0

High-throughput

0.602

High

170744

CLGN
Calmegin

2

4

High-throughput

0.601

High

1089101

KRA62
Keratin-associated protein 6-2

2

0

High-throughput

0.580

High

1089129

PELI2
E3 ubiquitin-protein ligase pellino homolog 2

2

0

High-throughput

0.580

High

1014491

SMAD3
Mothers against decapentaplegic homolog 3

1

2

Small-scale

0.561

High

1089091

SMAD4
Mothers against decapentaplegic homolog 4

1

2

Small-scale

0.561

High

1089097

SMAD2
Mothers against decapentaplegic homolog 2

1

2

Small-scale

0.561

High

591287

CD44
CD44 antigen

2

0

Small-scale

0.559

High

1089131

WWOX
WW domain-containing oxidoreductase

1

0

Small-scale

0.549

High

1089125

KRA32
Keratin-associated protein 3-2

1

0

High-throughput

0.549

High

380421

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

1

High-throughput

0.536

High

426079

PPB1
Alkaline phosphatase, placental type

1

1

High-throughput

0.536

High

488308

PPBI
Intestinal-type alkaline phosphatase

1

1

High-throughput

0.536

High

688552

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

2

High-throughput

0.536

High

1089099

PRSS8
Prostasin

1

1

High-throughput

0.536

High

1089100

CL12B
C-type lectin domain family 12 member B

1

2

High-throughput

0.536

High

1089111

TS1R3
Taste receptor type 1 member 3

1

1

High-throughput

0.536

High

1089115

TS1R2
Taste receptor type 1 member 2

1

1

High-throughput

0.536

High

1089118

CLC2B
C-type lectin domain family 2 member B

1

2

High-throughput

0.536

High

1089130

SDF2L
Stromal cell-derived factor 2-like protein 1

1

1

High-throughput

0.536

High

1089126

TRI54
Tripartite motif-containing protein 54

1

0

High-throughput

0.518

High

214123

DHH
Desert hedgehog protein

1

0

High-throughput

0.513

High

219301

B4GA1
Beta-1,4-glucuronyltransferase 1

1

0

High-throughput

0.513

High

316496

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

0

High-throughput

0.513

High

341299

ECEL1
Endothelin-converting enzyme-like 1

1

0

High-throughput

0.513

High

351774

LGI1
Leucine-rich glioma-inactivated protein 1

1

0

High-throughput

0.513

High

506842

CFC1
Cryptic protein

1

0

High-throughput

0.513

High

519606

LYAG
Lysosomal alpha-glucosidase

1

0

High-throughput

0.513

High

593350

PGFRA
Platelet-derived growth factor receptor alpha

1

0

High-throughput

0.513

High

607365

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

0

High-throughput

0.513

High

818829

TYRP2
L-dopachrome tautomerase

1

0

High-throughput

0.513

High

880002

DNSL1
Deoxyribonuclease-1-like 1

1

0

High-throughput

0.513

High

935724

MFAP4
Microfibril-associated glycoprotein 4

1

0

High-throughput

0.513

High

946234

ATS12
A disintegrin and metalloproteinase with thrombospondin motifs 12

1

0

High-throughput

0.513

High

1030156

IL5RA
Interleukin-5 receptor subunit alpha

1

0

High-throughput

0.513

High

1089092

PTC1
Protein patched homolog 1

1

0

High-throughput

0.513

High

1089106

NCEH1
Neutral cholesterol ester hydrolase 1

1

0

High-throughput

0.513

High

1089108

LYPD4
Ly6/PLAUR domain-containing protein 4

1

0

High-throughput

0.513

High

1089112

GLT10
Polypeptide N-acetylgalactosaminyltransferase 10

1

0

High-throughput

0.513

High

1089113

TMM25
Transmembrane protein 25

1

0

High-throughput

0.513

High

1089114

LYPD1
Ly6/PLAUR domain-containing protein 1

1

0

High-throughput

0.513

High

1089117

SIA8D
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

1

0

High-throughput

0.513

High

1089120

T106A
Transmembrane protein 106A

1

0

High-throughput

0.513

High

1089121

ASIC4
Acid-sensing ion channel 4

1

0

High-throughput

0.513

High

1089124

TSN18
Tetraspanin-18

1

0

High-throughput

0.513

High

1089134

POLH
DNA polymerase eta

1

0

High-throughput

0.513

High

1089135

B3GN3
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3

1

0

High-throughput

0.513

High

1089136

LIPG
Endothelial lipase

1

0

High-throughput

0.513

High

422013

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.493

High

570409

GFAP
Glial fibrillary acidic protein

1

0

High-throughput

0.493

High

713089

NOS3
Nitric oxide synthase 3

1

0

High-throughput

0.493

High

843521

HD
Huntingtin

1

0

High-throughput

0.493

High

889975

PSN1
Presenilin-1

1

0

High-throughput

0.493

High

1089102

KRA63
Keratin-associated protein 6-3

1

0

High-throughput

0.493

High

1089132

ATX10
Ataxin-10

1

0

High-throughput

0.493

High

567843

PRG2
Bone marrow proteoglycan

1

1

High-throughput

0.489

High

1089119

GGH
Gamma-glutamyl hydrolase

1

1

High-throughput

0.489

High

1089127

KLK15
Kallikrein-15

1

2

High-throughput

0.489

High

949864

KR103
Keratin-associated protein 10-3

1

1

High-throughput

0.481

High

774323

BASI
Basigin

1

0

High-throughput

0.458

High

190351

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.426

High

222270

PSCA
Prostate stem cell antigen

1

0

High-throughput

0.426

High

749324

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

0

High-throughput

0.426

High

1089098

TAZ
Tafazzin

3

0

High-throughput

0.347

High

70188

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

1089093

FHL3
Four and a half LIM domains protein 3

1

0

High-throughput

0.299

High

327047

NXPH3
Neurexophilin-3

1

0

High-throughput

0.279

Low

342548

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.279

Low

388712

C1QB
Complement C1q subcomponent subunit B

1

0

High-throughput

0.279

Low

548007

PSPC
Surfactant protein C

1

0

High-throughput

0.279

Low

933172

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

0

High-throughput

0.279

Low

1089090

SG2A2
Mammaglobin-A

1

0

High-throughput

0.279

Low

1089103

GXLT1
Glucoside xylosyltransferase 1

1

0

High-throughput

0.279

Low

1089104

MPPE1
Metallophosphoesterase 1

1

0

High-throughput

0.279

Low

1089105

FSTL4
Follistatin-related protein 4

1

0

High-throughput

0.279

Low

1089107

BRID5
BRICHOS domain-containing protein 5

1

0

High-throughput

0.279

Low

1089109

IGFL3
Insulin growth factor-like family member 3

1

0

High-throughput

0.279

Low

1089116

CA054
Uncharacterized protein C1orf54

1

0

High-throughput

0.279

Low

1089123

LCFC1
Sperm-egg fusion protein LLCFC1

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025