Protein: MCM3
DNA replication licensing factor MCM3 (EC 3.6.4.12) (Minichromosome maintenance protein 3)

Gene: MCM3
Organism: Saccharomyces cerevisiae S288C
Interactions: 106
UniProt ID: P24279

Gene Ontology (top 5):
GO:0000727 - double-strand break repair via break-induced replication
GO:0000781 - chromosome, telomeric region
GO:0003682 - chromatin binding
GO:0003688 - DNA replication origin binding
GO:0003697 - single-stranded DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

622146

MCM5
Minichromosome maintenance protein 5

23

20

Small-scale

0.989

High

622198

CDC45
Cell division control protein 45

19

15

Small-scale

0.985

High

622161

MCM7
DNA replication licensing factor MCM7

18

20

Small-scale

0.985

High

622147

MCM4
DNA replication licensing factor MCM4

18

20

Small-scale

0.984

High

622191

SLD5
DNA replication complex GINS protein SLD5

18

15

Small-scale

0.983

High

622145

MCM2
DNA replication licensing factor MCM2

15

20

Small-scale

0.983

High

622176

MCM6
DNA replication licensing factor MCM6

8

20

Small-scale

0.962

High

622204

PSF1
DNA replication complex GINS protein PSF1

7

11

Small-scale

0.957

High

622172

CDT1
Cell division cycle protein CDT1

6

3

Small-scale

0.946

High

622167

PSF2
DNA replication complex GINS protein PSF2

6

10

Small-scale

0.939

High

622200

PSF3
DNA replication complex GINS protein PSF3

4

9

Small-scale

0.885

High

622189

CTF4
DNA polymerase alpha-binding protein

9

9

Small-scale

0.745

High

622150

MCM10
Minichromosome maintenance protein 10

7

12

Small-scale

0.741

High

622134

MCM3
DNA replication licensing factor MCM3

1

20

Small-scale

0.713

High

622141

MRC1
Mediator of replication checkpoint protein 1

5

3

Small-scale

0.709

High

339453

CDK1
Cyclin-dependent kinase 1

4

9

Small-scale

0.696

High

526822

DPOLA
DNA polymerase alpha catalytic subunit A

3

10

Small-scale

0.656

High

622177

SLD3
DNA replication regulator SLD3

3

3

Small-scale

0.655

High

412519

CDC7
Cell division control protein 7

3

20

Small-scale

0.651

High

602309

DPOE
DNA polymerase epsilon catalytic subunit A

3

10

Small-scale

0.646

High

622180

TOF1
Topoisomerase 1-associated factor 1

2

9

Small-scale

0.611

High

622199

DIA2
Protein DIA2

2

3

Small-scale

0.611

High

447782

CDC6
Cell division control protein 6

2

20

Small-scale

0.595

High

607203

RFA1
Replication factor A protein 1

2

7

Small-scale

0.595

High

622206

CMR1
DNA damage-binding protein CMR1

2

8

High-throughput

0.586

High

622135

DPB2
DNA polymerase epsilon subunit B

2

3

Small-scale

0.584

High

622159

DEF1
RNA polymerase II degradation factor 1

2

4

High-throughput

0.584

High

622193

CSM3
Chromosome segregation in meiosis protein 3

2

3

Small-scale

0.584

High

493250

HSP72
Heat shock protein SSA2

2

17

High-throughput

0.571

High

510329

SSB1
Ribosome-associated molecular chaperone SSB1

2

18

High-throughput

0.571

High

622158

SPT10
Protein SPT10

2

3

High-throughput

0.571

High

622166

ATAD2
ATPase histone chaperone YTA7

2

5

High-throughput

0.571

High

622186

H3
Histone H3

2

20

High-throughput

0.571

High

622188

CDC14
Tyrosine-protein phosphatase CDC14

1

9

Small-scale

0.561

High

416197

SIR2
NAD-dependent histone deacetylase SIR2

1

12

Small-scale

0.552

High

622165

SSB2
Ribosome-associated molecular chaperone SSB2

2

18

High-throughput

0.552

High

622196

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

6

High-throughput

0.536

High

622201

SMT3
Ubiquitin-like protein SMT3

1

7

Small-scale

0.515

High

412663

KAPA
cAMP-dependent protein kinase type 1

1

3

High-throughput

0.501

High

562685

FUS3
Mitogen-activated protein kinase FUS3

1

11

High-throughput

0.501

High

622136

CG22
G2/mitotic-specific cyclin-2

1

5

Small-scale

0.501

High

622149

DBF4
DDK kinase regulatory subunit DBF4

1

3

Small-scale

0.501

High

622152

IME2
Meiosis induction protein kinase IME2/SME1

1

16

Small-scale

0.501

High

622155

ORC2
Origin recognition complex subunit 2

1

8

Small-scale

0.501

High

622157

SLD2
DNA replication regulator SLD2

1

3

Small-scale

0.501

High

622171

DPB11
DNA replication regulator DPB11

1

2

Small-scale

0.501

High

622173

PTK2
Serine/threonine-protein kinase PTK2/STK2

1

8

High-throughput

0.501

High

622184

ORC1
Origin recognition complex subunit 1

1

20

Small-scale

0.501

High

622203

SKM1
Serine/threonine-protein kinase SKM1

1

8

High-throughput

0.501

High

622163

YHJ3
Uncharacterized protein YHR033W

1

0

High-throughput

0.486

High

333696

ADH1
Alcohol dehydrogenase 1

1

2

High-throughput

0.479

High

340030

KPYK1
Pyruvate kinase 1

1

5

High-throughput

0.479

High

406807

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.479

High

410917

PDC1
Pyruvate decarboxylase isozyme 1

1

3

High-throughput

0.479

High

485654

IF4A
ATP-dependent RNA helicase eIF4A

1

9

High-throughput

0.479

High

550516

PCNA
Proliferating cell nuclear antigen

1

3

Small-scale

0.479

High

557895

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.479

High

560904

EF3A
Elongation factor 3A

1

6

High-throughput

0.479

High

622143

CDC15
Cell division control protein 15

1

5

High-throughput

0.479

High

622144

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

622151

SPT16
FACT complex subunit SPT16

1

5

High-throughput

0.479

High

622154

PP12
Serine/threonine-protein phosphatase PP1-2

1

1

High-throughput

0.479

High

622174

HFM1
ATP-dependent DNA helicase MER3

1

7

Small-scale

0.479

High

622175

UFD1
Ubiquitin fusion degradation protein 1

1

3

Small-scale

0.479

High

622178

CDH1
APC/C activator protein CDH1

1

11

Small-scale

0.479

High

622179

HST2
NAD-dependent protein deacetylase HST2

1

12

High-throughput

0.479

High

622181

IPI3
Pre-rRNA-processing protein IPI3

1

4

Small-scale

0.479

High

622183

APJ1
J domain-containing protein APJ1

1

5

High-throughput

0.479

High

622185

ACT
Actin

1

8

High-throughput

0.479

High

622187

SEN1
Helicase SEN1

1

2

Small-scale

0.479

High

622192

RUVB1
RuvB-like protein 1

1

3

High-throughput

0.479

High

622195

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

3

High-throughput

0.479

High

622202

RUVB2
RuvB-like protein 2

1

3

High-throughput

0.479

High

622142

CSM1
Monopolin complex subunit CSM1

1

1

Small-scale

0.470

High

622182

APC1
Anaphase-promoting complex subunit 1

1

0

High-throughput

0.460

High

524178

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

622162

NSE2
E3 SUMO-protein ligase MMS21

1

0

Small-scale

0.458

High

355359

H2B1
Histone H2B.1

1

20

High-throughput

0.445

High

356267

H4
Histone H4

1

8

High-throughput

0.445

High

365833

HSP82
ATP-dependent molecular chaperone HSP82

1

10

High-throughput

0.445

High

392308

H2A2
Histone H2A.2

1

20

High-throughput

0.445

High

419304

HAP2
Transcriptional activator HAP2

1

2

High-throughput

0.445

High

490403

HSP71
Heat shock protein SSA1

1

17

High-throughput

0.445

High

516274

RAP1
DNA-binding protein RAP1

1

2

High-throughput

0.445

High

560569

BIP
Endoplasmic reticulum chaperone BiP

1

13

High-throughput

0.445

High

605206

AFT1
Iron-regulated transcriptional activator AFT1

1

2

High-throughput

0.445

High

609038

SIN3
Transcriptional regulatory protein SIN3

1

1

High-throughput

0.445

High

622137

SIS1
Protein SIS1

1

5

High-throughput

0.445

High

622138

SWI4
Regulatory protein SWI4

1

7

High-throughput

0.445

High

622139

MAS5
Mitochondrial protein import protein MAS5

1

6

High-throughput

0.445

High

622153

HSP79
Heat shock protein homolog SSE2

1

20

High-throughput

0.445

High

622156

HSP78
Heat shock protein 78, mitochondrial

1

5

High-throughput

0.445

High

622160

SET3
SET domain-containing protein 3

1

5

High-throughput

0.445

High

622164

SSZ1
Ribosome-associated complex subunit SSZ1

1

11

High-throughput

0.445

High

622190

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

15

High-throughput

0.445

High

622194

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

20

High-throughput

0.445

High

622197

RSC58
Chromatin structure-remodeling complex protein RSC58

1

2

High-throughput

0.445

High

622205

RLF2
Chromatin assembly factor 1 subunit p90

1

5

High-throughput

0.445

High

622207

H2AZ
Histone H2A.Z

1

20

High-throughput

0.445

High

342865

ENO2
Enolase 2

1

5

High-throughput

0.437

High

622140

DCC1
Sister chromatid cohesion protein DCC1

1

1

Small-scale

0.437

High

622148

COPG
Coatomer subunit gamma

1

5

High-throughput

0.437

High

622169

COPB
Coatomer subunit beta

1

3

High-throughput

0.437

High

622170

TAF1
Transcription initiation factor TFIID subunit 1

1

0

High-throughput

0.426

High

622168

DJP1
DnaJ-like protein 1

1

7

High-throughput

0.407

High


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Last updated: 15 Jul 2024