Protein: NMDE1
Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A) (hNR2A)

Gene: NMDE1, GRIN2A
Organism: Homo sapiens
Interactions: 69
UniProt ID: Q12879

Gene Ontology (top 5):
GO:0001540 - amyloid-beta binding
GO:0001964 - startle response
GO:0001975 - response to amphetamine
GO:0004972 - NMDA glutamate receptor activity
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1051656

NMDZ1
Glutamate receptor ionotropic, NMDA 1

14

20

Small-scale

0.978

High

1088763

NMDE2
Glutamate receptor ionotropic, NMDA 2B

4

18

Small-scale

0.890

High

1088761

NMDE1
Glutamate receptor ionotropic, NMDA 2A

2

18

Small-scale

0.799

High

1006056

DLG4
Disks large homolog 4

18

20

Small-scale

0.765

High

248438

NMD3B
Glutamate receptor ionotropic, NMDA 3B

2

18

Small-scale

0.754

High

440518

FYN
Tyrosine-protein kinase Fyn

4

12

Small-scale

0.692

High

287557

LRP6
Low-density lipoprotein receptor-related protein 6

1

4

High-throughput

0.691

High

1088782

DLG3
Disks large homolog 3

3

20

Small-scale

0.665

High

1088762

DLG1
Disks large homolog 1

2

20

Small-scale

0.625

High

557262

SRC
Proto-oncogene tyrosine-protein kinase Src

2

12

Small-scale

0.624

High

835437

GRM5
Metabotropic glutamate receptor 5

1

20

Small-scale

0.618

High

1060863

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

5

Small-scale

0.618

High

1088778

NMD3A
Glutamate receptor ionotropic, NMDA 3A

1

18

Small-scale

0.618

High

1088779

NETO1
Neuropilin and tolloid-like protein 1

1

8

Small-scale

0.618

High

422012

A4
Amyloid-beta precursor protein

2

10

Small-scale

0.584

High

1088768

FAK2
Protein-tyrosine kinase 2-beta

2

20

Small-scale

0.584

High

1088766

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

14

Small-scale

0.550

High

728201

AKT1
RAC-alpha serine/threonine-protein kinase

1

14

High-throughput

0.541

High

1088797

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

17

Small-scale

0.536

High

161133

ABCD4
Lysosomal cobalamin transporter ABCD4

1

3

High-throughput

0.536

High

261166

NSMA
Sphingomyelin phosphodiesterase 2

1

1

High-throughput

0.536

High

342847

HERC2
E3 ubiquitin-protein ligase HERC2

1

9

High-throughput

0.536

High

698616

CALX
Calnexin

1

2

High-throughput

0.536

High

717785

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

2

High-throughput

0.536

High

994193

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

6

High-throughput

0.536

High

1043201

TAP2
Antigen peptide transporter 2

1

2

High-throughput

0.536

High

1088776

MIB1
E3 ubiquitin-protein ligase MIB1

1

4

High-throughput

0.536

High

1088777

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

1

High-throughput

0.536

High

1088783

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

3

High-throughput

0.536

High

1088788

LMF2
Lipase maturation factor 2

1

1

High-throughput

0.536

High

1088792

DJC18
DnaJ homolog subfamily C member 18

1

3

High-throughput

0.536

High

1088793

ABCB9
ABC-type oligopeptide transporter ABCB9

1

2

High-throughput

0.536

High

708849

PTN4
Tyrosine-protein phosphatase non-receptor type 4

2

19

Small-scale

0.521

High

790151

PIGA
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A

1

0

High-throughput

0.513

High

1088767

LY6D
Lymphocyte antigen 6D

1

0

High-throughput

0.513

High

1088773

S27A3
Long-chain fatty acid transport protein 3

1

0

High-throughput

0.513

High

1088780

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

1

0

High-throughput

0.513

High

861587

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

4

Small-scale

0.501

High

997676

CSK21
Casein kinase II subunit alpha

1

6

Small-scale

0.501

High

718110

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

2

High-throughput

0.489

High

1088769

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

2

High-throughput

0.489

High

1088770

2A5B
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

1

2

High-throughput

0.489

High

1088772

2A5E
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

1

2

High-throughput

0.489

High

1088771

DLG2
Disks large homolog 2

1

20

Small-scale

0.481

High

1088785

AP2M1
AP-2 complex subunit mu

1

7

Small-scale

0.481

High

1088790

AP1M1
AP-1 complex subunit mu-1

1

7

Small-scale

0.481

High

154394

DLGP1
Disks large-associated protein 1

1

12

Small-scale

0.479

High

165936

FFAR1
Free fatty acid receptor 1

1

11

Small-scale

0.479

High

713162

NOS1
Nitric oxide synthase 1

1

6

Small-scale

0.479

High

845017

EAA3
Excitatory amino acid transporter 3

1

4

Small-scale

0.479

High

907310

APLP1
Amyloid beta precursor like protein 1

1

9

Small-scale

0.479

High

1055304

APLP2
Amyloid beta precursor like protein 2

1

9

Small-scale

0.479

High

1088787

SGMR1
Sigma non-opioid intracellular receptor 1

1

2

Small-scale

0.479

High

1088796

BCLF1
Bcl-2-associated transcription factor 1

1

0

High-throughput

0.458

High

625343

CSK22
Casein kinase II subunit alpha'

1

5

Small-scale

0.457

High

995008

CSK2B
Casein kinase II subunit beta

1

1

Small-scale

0.457

High

1088781

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

8

High-throughput

0.437

High

1088775

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.426

High

1088764

NDK3
Nucleoside diphosphate kinase 3

1

2

High-throughput

0.407

High

431399

AT5G1
ATP synthase F(0) complex subunit C1, mitochondrial

1

0

High-throughput

0.279

Low

1088765

PDE3B
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

1

0

High-throughput

0.279

Low

1088774

NXNL2
Nucleoredoxin-like protein 2

1

0

High-throughput

0.279

Low

1088784

TTC28
Tetratricopeptide repeat protein 28

1

0

High-throughput

0.279

Low

1088786

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.279

Low

1088789

HIG2A
HIG1 domain family member 2A, mitochondrial

1

0

High-throughput

0.279

Low

1088791

METL9
Protein-L-histidine N-pros-methyltransferase

1

0

High-throughput

0.279

Low

1088794

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.279

Low

1088795

UFSP2
Ufm1-specific protease 2

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025