Protein: UBP19
Ubiquitin carboxyl-terminal hydrolase 19 (EC 3.4.19.12) (Deubiquitinating enzyme 19) (Ubiquitin thioesterase 19) (Ubiquitin-specific-processing protease 19) (Zinc finger MYND domain-containing protein 9)

Gene: UBP19, USP19
Organism: Homo sapiens
Interactions: 149
UniProt ID: O94966

Gene Ontology (top 5):
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005789 - endoplasmic reticulum membrane
GO:0005829 - cytosol
GO:0008270 - zinc ion binding
GO:0016579 - protein deubiquitination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

322896

HS90A
Heat shock protein HSP 90-alpha

5

9

Small-scale

0.939

High

322899

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

6

20

Small-scale

0.939

High

322897

HS90B
Heat shock protein HSP 90-beta

2

10

High-throughput

0.776

High

322914

BAG6
Large proline-rich protein BAG6

1

10

Small-scale

0.724

High

322964

SIAH1
E3 ubiquitin-protein ligase SIAH1

4

10

Small-scale

0.705

High

276654

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

4

8

High-throughput

0.699

High

322979

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

16

High-throughput

0.691

High

211525

SIAH2
E3 ubiquitin-protein ligase SIAH2

2

19

Small-scale

0.640

High

322943

IRF3
Interferon regulatory factor 3

2

2

High-throughput

0.628

High

322999

DOCK5
Dedicator of cytokinesis protein 5

2

2

High-throughput

0.628

High

323013

CRYL1
Lambda-crystallin homolog

2

1

High-throughput

0.628

High

322931

BIRC3
Baculoviral IAP repeat-containing protein 3

2

13

Small-scale

0.624

High

322923

DMWD
Dystrophia myotonica WD repeat-containing protein

1

15

High-throughput

0.618

High

322886

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

14

High-throughput

0.618

High

322926

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

17

Small-scale

0.618

High

322940

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

2

6

High-throughput

0.611

High

323011

AURKC
Aurora kinase C

3

14

High-throughput

0.609

High

322989

DNJC7
DnaJ homolog subfamily C member 7

2

6

High-throughput

0.601

High

188633

BIRC5
Baculoviral IAP repeat-containing protein 5

2

11

Small-scale

0.584

High

322962

SYVN1
E3 ubiquitin-protein ligase synoviolin

2

12

Small-scale

0.584

High

322986

FER3L
Fer3-like protein

2

5

High-throughput

0.574

High

322893

P53
Cellular tumor antigen p53

1

5

Small-scale

0.561

High

322891

PH4H
Phenylalanine-4-hydroxylase

2

0

Small-scale

0.559

High

322957

CD37L
Hsp90 co-chaperone Cdc37-like 1

1

2

High-throughput

0.554

High

322954

Q6PK50
HSP90AB1 protein

1

10

High-throughput

0.553

High

322965

NUDC3
NudC domain-containing protein 3

1

1

High-throughput

0.553

High

322948

HIF1A
Hypoxia-inducible factor 1-alpha

1

10

Small-scale

0.552

High

322970

TTC9C
Tetratricopeptide repeat protein 9C

2

8

High-throughput

0.549

High

322983

NEUL4
Neuralized-like protein 4

2

2

High-throughput

0.549

High

124702

AIP
AH receptor-interacting protein

1

8

High-throughput

0.536

High

158390

RFXK
DNA-binding protein RFXANK

1

5

High-throughput

0.536

High

322887

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

2

High-throughput

0.536

High

322890

HERC2
E3 ubiquitin-protein ligase HERC2

1

12

High-throughput

0.536

High

322894

CDK1
Cyclin-dependent kinase 1

1

8

High-throughput

0.536

High

322904

RO52
E3 ubiquitin-protein ligase TRIM21

1

16

High-throughput

0.536

High

322917

XPO2
Exportin-2

1

6

High-throughput

0.536

High

322919

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

2

High-throughput

0.536

High

322922

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

6

High-throughput

0.536

High

322925

NU160
Nuclear pore complex protein Nup160

1

1

High-throughput

0.536

High

322928

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

High-throughput

0.536

High

322929

SKP2
S-phase kinase-associated protein 2

1

2

High-throughput

0.536

High

322935

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

1

High-throughput

0.536

High

322944

2A5B
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

1

2

High-throughput

0.536

High

322947

CDC37
Hsp90 co-chaperone Cdc37

1

2

High-throughput

0.536

High

322969

DDX60
Probable ATP-dependent RNA helicase DDX60

1

12

High-throughput

0.536

High

322971

ATAD1
Outer mitochondrial transmembrane helix translocase

1

11

High-throughput

0.536

High

322977

GCN1
Stalled ribosome sensor GCN1

1

12

High-throughput

0.536

High

322988

PARK7
Parkinson disease protein 7

1

1

High-throughput

0.536

High

322996

UN45A
Protein unc-45 homolog A

1

7

High-throughput

0.536

High

322998

RPAP3
RNA polymerase II-associated protein 3

1

6

High-throughput

0.536

High

323008

FKBPL
FK506-binding protein-like

1

12

High-throughput

0.536

High

323009

G3BP2
Ras GTPase-activating protein-binding protein 2

1

2

High-throughput

0.536

High

323015

TNPO3
Transportin-3

1

5

High-throughput

0.536

High

323016

SRPRB
Signal recognition particle receptor subunit beta

1

3

High-throughput

0.536

High

298130

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.513

High

322895

PYGL
Glycogen phosphorylase, liver form

1

0

High-throughput

0.513

High

322902

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

Small-scale

0.513

High

322906

HMOX2
Heme oxygenase 2

1

0

High-throughput

0.513

High

322918

TMM33
Transmembrane protein 33

1

0

High-throughput

0.513

High

322976

CP2W1
Cytochrome P450 2W1

1

0

High-throughput

0.513

High

322993

NMNA2
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2

1

0

High-throughput

0.513

High

322912

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.489

High

322913

ACDSB
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial

1

2

High-throughput

0.489

High

322945

SF3B3
Splicing factor 3B subunit 3

1

3

High-throughput

0.489

High

322946

AAAT
Neutral amino acid transporter B(0)

1

1

High-throughput

0.489

High

322952

NXNL2
Nucleoredoxin-like protein 2

1

2

High-throughput

0.489

High

322984

DOCK7
Dedicator of cytokinesis protein 7

1

2

High-throughput

0.489

High

323000

S61A2
Protein transport protein Sec61 subunit alpha isoform 2

1

2

High-throughput

0.489

High

322905

FLNA
Filamin-A

1

7

Small-scale

0.481

High

322939

CKAP5
Cytoskeleton-associated protein 5

1

9

Small-scale

0.481

High

322987

RING2
E3 ubiquitin-protein ligase RING2

1

20

Small-scale

0.481

High

135430

DNM1L
Dynamin-1-like protein

1

2

Small-scale

0.479

High

213745

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

10

Small-scale

0.479

High

226644

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

7

High-throughput

0.479

High

279087

ULK1
Serine/threonine-protein kinase ULK1

1

11

Small-scale

0.479

High

322900

HSP7C
Heat shock cognate 71 kDa protein

1

7

Small-scale

0.479

High

322901

LAMP2
Lysosome-associated membrane glycoprotein 2

1

3

Small-scale

0.479

High

322907

STIP1
Stress-induced-phosphoprotein 1

1

5

High-throughput

0.479

High

322908

HSP74
Heat shock 70 kDa protein 4

1

11

Small-scale

0.479

High

322910

CCNF
Cyclin-F

1

8

High-throughput

0.479

High

322911

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

322915

MAOX
NADP-dependent malic enzyme

1

3

Small-scale

0.479

High

322916

RORG
Nuclear receptor ROR-gamma

1

5

Small-scale

0.479

High

322920

XIAP
E3 ubiquitin-protein ligase XIAP

1

17

Small-scale

0.479

High

322921

EWS
RNA-binding protein EWS

1

4

Small-scale

0.479

High

322927

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

3

High-throughput

0.479

High

322930

SMAD4
Mothers against decapentaplegic homolog 4

1

12

High-throughput

0.479

High

322932

BIRC2
Baculoviral IAP repeat-containing protein 2

1

17

Small-scale

0.479

High

322933

SQSTM
Sequestosome-1

1

6

Small-scale

0.479

High

322934

HDAC1
Histone deacetylase 1

1

11

Small-scale

0.479

High

322936

CUL3
Cullin-3

1

14

High-throughput

0.479

High

322938

CUL4B
Cullin-4B

1

14

High-throughput

0.479

High

322941

BECN1
Beclin-1

1

2

Small-scale

0.479

High

322942

NF2L1
Endoplasmic reticulum membrane sensor NFE2L1

1

7

Small-scale

0.479

High

322956

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

322972

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

322973

PK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3

1

2

Small-scale

0.479

High

322980

FAF2
FAS-associated factor 2

1

4

Small-scale

0.479

High

322992

DERL1
Derlin-1

1

1

Small-scale

0.479

High

322994

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

1

Small-scale

0.479

High

323002

ARL8B
ADP-ribosylation factor-like protein 8B

1

2

High-throughput

0.479

High

323003

SE1L1
Protein sel-1 homolog 1

1

5

Small-scale

0.479

High

323004

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

323005

TBK1
Serine/threonine-protein kinase TBK1

1

12

Small-scale

0.479

High

323007

HERC5
E3 ISG15--protein ligase HERC5

1

7

Small-scale

0.479

High

323010

CHIP
E3 ubiquitin-protein ligase CHIP

1

7

Small-scale

0.479

High

323014

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.479

High

322949

H31T
Histone H3.1t

1

2

High-throughput

0.470

High

322888

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

0

High-throughput

0.458

High

322955

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

322963

TCAM1
TIR domain-containing adapter molecule 1

1

0

Small-scale

0.458

High

322968

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

4

High-throughput

0.445

High

323012

S27A6
Long-chain fatty acid transport protein 6

1

1

High-throughput

0.445

High

289387

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

12

Small-scale

0.439

High

322990

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

6

Small-scale

0.439

High

217644

TGON2
Trans-Golgi network integral membrane protein 2

1

7

High-throughput

0.437

High

220330

LAT
Linker for activation of T-cells family member 1

1

1

High-throughput

0.437

High

292968

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.437

High

322892

NTRK1
High affinity nerve growth factor receptor

1

11

High-throughput

0.437

High

322909

TGFR1
TGF-beta receptor type-1

1

12

Small-scale

0.437

High

322937

CUL4A
Cullin-4A

1

14

High-throughput

0.437

High

322961

MAVS
Mitochondrial antiviral-signaling protein

1

9

Small-scale

0.437

High

322978

HDAC2
Histone deacetylase 2

1

11

Small-scale

0.437

High

322997

PKHA4
Pleckstrin homology domain-containing family A member 4

1

12

High-throughput

0.437

High

323001

OTULL
Inactive ubiquitin thioesterase OTULINL

1

2

High-throughput

0.437

High

323006

XPO7
Exportin-7

1

9

High-throughput

0.437

High

322950

NSN5B
Putative NOL1/NOP2/Sun domain family member 5B

1

1

High-throughput

0.407

High

322959

NIPA1
Magnesium transporter NIPA1

1

2

High-throughput

0.407

High

322960

MOT9
Monocarboxylate transporter 9

1

1

High-throughput

0.407

High

322975

ZNT7
Zinc transporter 7

1

4

High-throughput

0.407

High

322985

B3A4
Anion exchange protein 4

1

1

High-throughput

0.407

High

322995

SPNS1
Protein spinster homolog 1

1

1

High-throughput

0.407

High

322966

FUND1
FUN14 domain-containing protein 1

2

0

Small-scale

0.331

High

261465

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.279

Low

322898

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.279

Low

322951

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

1

0

High-throughput

0.279

Low

322967

CC117
Coiled-coil domain-containing protein 117

1

0

High-throughput

0.279

Low

322974

FA83F
Protein FAM83F

1

0

High-throughput

0.279

Low

322981

SAAL1
Protein SAAL1

1

0

High-throughput

0.279

Low

322982

SUCB2
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial

1

0

High-throughput

0.279

Low

323018

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.279

Low

322889

ECEL1
Endothelin-converting enzyme-like 1

1

0

Small-scale

0.251

Low

322924

LTOR4
Ragulator complex protein LAMTOR4

1

0

Small-scale

0.251

Low

322903

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

Small-scale

0.249

Low

322958

DET1
DET1 homolog

1

0

High-throughput

0.249

Low

322991

AASD1
Alanyl-tRNA editing protein Aarsd1

1

0

High-throughput

0.249

Low

323017

KPTN
KICSTOR complex protein kaptin

1

0

High-throughput

0.249

Low

322953

PTCRA
Pre T-cell antigen receptor alpha

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025