Protein: MCA1
Metacaspase-1 (EC 3.4.22.-) [Cleaved into: Large subunit p20; Small subunit p10]

Gene: MCA1
Organism: Saccharomyces cerevisiae S288C
Interactions: 175
UniProt ID: Q08601

Gene Ontology (top 5):
GO:0004197 - cysteine-type endopeptidase activity
GO:0004198 - calcium-dependent cysteine-type endopeptidase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

996043

MCA1
Metacaspase-1

2

4

Small-scale

0.778

High

812276

BIR1
Protein BIR1

2

0

Small-scale

0.738

High

987377

PIN3
[PSI+] inducibility protein 3

3

2

High-throughput

0.669

High

861163

LSB1
LAS seventeen-binding protein 1

3

2

High-throughput

0.658

High

513011

SSB1
Ribosome-associated molecular chaperone SSB1

3

1

Small-scale

0.633

High

769669

SSB2
Ribosome-associated molecular chaperone SSB2

3

1

Small-scale

0.633

High

628545

SIS1
Protein SIS1

2

1

Small-scale

0.624

High

416098

DED1
ATP-dependent RNA helicase DED1

2

1

Small-scale

0.611

High

544533

HSC82
ATP-dependent molecular chaperone HSC82

2

2

Small-scale

0.611

High

636766

CDC48
Cell division control protein 48

2

1

Small-scale

0.611

High

700659

RSSA1
Small ribosomal subunit protein uS2A

2

1

Small-scale

0.611

High

368462

EF1A
Elongation factor 1-alpha

2

0

Small-scale

0.585

High

399653

RLA0
Large ribosomal subunit protein uL10

2

0

Small-scale

0.585

High

407366

RS3
Small ribosomal subunit protein uS3

2

0

Small-scale

0.585

High

633648

MAS5
Mitochondrial protein import protein MAS5

2

0

Small-scale

0.585

High

777150

MKT1
Post-transcriptional regulator MKT1

2

0

Small-scale

0.585

High

996046

HSP42
Heat shock protein 42

2

0

Small-scale

0.585

High

492672

HSP71
Heat shock protein SSA1

2

1

Small-scale

0.584

High

495162

HSP72
Heat shock protein SSA2

2

1

Small-scale

0.584

High

805068

ARC1
tRNA-aminoacylation cofactor ARC1

2

0

High-throughput

0.576

High

996044

SGT2
Small glutamine-rich tetratricopeptide repeat-containing protein 2

2

0

Small-scale

0.569

High

745375

SRO77
Lethal(2) giant larvae protein homolog SRO77

2

0

High-throughput

0.565

High

367020

HSP82
ATP-dependent molecular chaperone HSP82

1

2

Small-scale

0.536

High

687498

EF2
Elongation factor 2

1

1

Small-scale

0.536

High

599197

RIR1
Ribonucleoside-diphosphate reductase large chain 1

1

0

Small-scale

0.513

High

641085

RL5
Large ribosomal subunit protein uL18

1

0

Small-scale

0.513

High

743034

GBLP
Small ribosomal subunit protein RACK1

1

0

Small-scale

0.513

High

408487

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

1

High-throughput

0.501

High

381627

GAL80
Galactose/lactose metabolism regulatory protein GAL80

1

0

High-throughput

0.486

High

756593

KOG1
Target of rapamycin complex 1 subunit KOG1

1

1

High-throughput

0.481

High

585384

MYO2
Myosin-2

1

0

Small-scale

0.480

High

751456

NSE2
E3 SUMO-protein ligase MMS21

1

0

Small-scale

0.480

High

768198

DDI1
DNA damage-inducible protein 1

1

0

Small-scale

0.480

High

819932

MON2
Protein MON2

1

0

Small-scale

0.480

High

342128

ATPB
ATP synthase subunit beta, mitochondrial

1

1

High-throughput

0.479

High

342786

ENO1
Enolase 1

1

1

High-throughput

0.479

High

343035

ENO2
Enolase 2

1

1

High-throughput

0.479

High

416814

CDC31
Cell division control protein 31

1

1

High-throughput

0.479

High

454486

TBA1
Tubulin alpha-1 chain

1

1

High-throughput

0.479

High

454667

TBA3
Tubulin alpha-3 chain

1

1

High-throughput

0.479

High

477475

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

1

High-throughput

0.479

High

485849

IF4A
ATP-dependent RNA helicase eIF4A

1

3

High-throughput

0.479

High

499101

RL4A
Large ribosomal subunit protein uL4A

1

1

High-throughput

0.479

High

556343

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.479

High

562295

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

2

High-throughput

0.479

High

562447

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

2

High-throughput

0.479

High

588248

HSP60
Heat shock protein 60, mitochondrial

1

4

High-throughput

0.479

High

691768

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

1

High-throughput

0.479

High

707946

GCN1
eIF-2-alpha kinase activator GCN1

1

1

High-throughput

0.479

High

715864

MDJ1
DnaJ homolog 1, mitochondrial

1

1

High-throughput

0.479

High

753055

RRP3
ATP-dependent rRNA helicase RRP3

1

2

High-throughput

0.479

High

753445

ECM29
Proteasome component ECM29

1

1

High-throughput

0.479

High

762032

DHH1
ATP-dependent RNA helicase DHH1

1

1

High-throughput

0.479

High

765825

VAC8
Vacuolar protein 8

1

1

High-throughput

0.479

High

785251

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.479

High

829715

RL4B
Large ribosomal subunit protein uL4B

1

1

High-throughput

0.479

High

962638

ACAC
Acetyl-CoA carboxylase

1

2

High-throughput

0.479

High

715245

TOR1
Serine/threonine-protein kinase TOR1

1

0

High-throughput

0.460

High

333930

ADH1
Alcohol dehydrogenase 1

1

0

High-throughput

0.458

High

334995

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

0

High-throughput

0.458

High

340301

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.458

High

343858

SYMC
Methionine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

361060

TBB
Tubulin beta chain

1

0

High-throughput

0.458

High

389018

SYTC
Threonine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

413744

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

417605

PHSG
Glycogen phosphorylase

1

0

High-throughput

0.458

High

421704

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.458

High

423488

PUR2
Bifunctional purine biosynthetic protein ADE5,7 [Includes: Phosphoribosylamine--glycine ligase

1

0

High-throughput

0.458

High

424750

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.458

High

429782

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.458

High

439735

NUC1
Mitochondrial nuclease

1

0

High-throughput

0.458

High

440926

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

1

0

High-throughput

0.458

High

478579

HSP77
Import motor subunit, mitochondrial

1

0

High-throughput

0.458

High

481240

RL1A
Large ribosomal subunit protein uL1A

1

0

High-throughput

0.458

High

501419

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

0

High-throughput

0.458

High

519639

ERF1
Eukaryotic peptide chain release factor subunit 1

1

0

High-throughput

0.458

High

520652

YPK1
Serine/threonine-protein kinase YPK1

1

0

High-throughput

0.458

High

535142

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.458

High

537493

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.458

High

540171

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.458

High

541580

AMPL
Vacuolar aminopeptidase 1

1

0

High-throughput

0.458

High

561494

NCPR
NADPH--cytochrome P450 reductase

1

0

High-throughput

0.458

High

580589

FAS2
Fatty acid synthase subunit alpha

1

0

High-throughput

0.458

High

583265

METK2
S-adenosylmethionine synthase 2

1

0

High-throughput

0.458

High

599531

VPS1
Vacuolar protein sorting-associated protein 1

1

0

High-throughput

0.458

High

604483

CLH
Clathrin heavy chain

1

0

High-throughput

0.458

High

613764

RS3A2
Small ribosomal subunit protein eS1B

1

0

High-throughput

0.458

High

619773

TOM40
Mitochondrial import receptor subunit TOM40

1

0

High-throughput

0.458

High

624189

DBP2
ATP-dependent RNA helicase DBP2

1

0

High-throughput

0.458

High

630047

BPH1
Beige protein homolog 1

1

0

High-throughput

0.458

High

630441

RNQ1
[PIN+] prion protein RNQ1

1

0

High-throughput

0.458

High

644956

RS5
Small ribosomal subunit protein uS7

1

0

High-throughput

0.458

High

650408

SPT5
Transcription elongation factor SPT5

1

0

High-throughput

0.458

High

657279

URA7
CTP synthase 1

1

0

High-throughput

0.458

High

663532

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

675567

MCM4
DNA replication licensing factor MCM4

1

0

High-throughput

0.458

High

686986

GLNA
Glutamine synthetase

1

0

High-throughput

0.458

High

688467

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

697634

DRI1
Putative RNA-binding protein involved in heterochromatin assembly

1

0

High-throughput

0.458

High

703751

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

715266

TREB
Probable trehalase

1

0

High-throughput

0.458

High

755598

UBA4
Adenylyltransferase and sulfurtransferase UBA4

1

0

High-throughput

0.458

High

763627

FLC2
Flavin carrier protein 2

1

0

High-throughput

0.458

High

765418

RSP5
E3 ubiquitin-protein ligase RSP5

1

0

High-throughput

0.458

High

765576

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.458

High

767751

IMB4
Importin subunit beta-4

1

0

High-throughput

0.458

High

791156

LEM3
Phospholipid-transporting ATPase accessory subunit LEM3

1

0

High-throughput

0.458

High

797313

WWM1
WW domain-containing protein WWM1

1

0

High-throughput

0.458

High

797868

LSB3
LAS seventeen-binding protein 3

1

0

High-throughput

0.458

High

804915

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

811483

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.458

High

812025

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.458

High

814730

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.458

High

860626

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

861380

AP18B
Clathrin coat assembly protein AP180B

1

0

High-throughput

0.458

High

864697

NOG2
Nucleolar GTP-binding protein 2

1

0

High-throughput

0.458

High

887701

ACT
Actin

1

0

High-throughput

0.458

High

965505

NOP3
Serine/arginine

1

0

High-throughput

0.458

High

972926

IMA1
Importin subunit alpha

1

0

High-throughput

0.458

High

977174

CLU
Clustered mitochondria protein 1

1

0

High-throughput

0.458

High

978030

RUVB1
RuvB-like protein 1

1

0

High-throughput

0.458

High

980344

GSF2
Glucose-signaling factor 2

1

0

High-throughput

0.458

High

988731

ELP1
Elongator complex protein 1

1

0

High-throughput

0.458

High

995504

ETT1
Enhancer of translation termination 1

1

0

High-throughput

0.458

High

996045

RPN5
26S proteasome regulatory subunit RPN5

1

0

High-throughput

0.458

High

996047

AHA1
Hsp90 co-chaperone AHA1

1

0

High-throughput

0.458

High

996048

NOP56
Nucleolar protein 56

1

0

High-throughput

0.458

High

697713

TFB1
General transcription and DNA repair factor IIH subunit TFB1

1

0

High-throughput

0.438

High

732192

CAB3
Coenzyme A biosynthesis protein 3

1

0

High-throughput

0.438

High

343155

THDH
Threonine dehydratase, mitochondrial

1

1

High-throughput

0.437

High

561079

EF3A
Elongation factor 3A

1

1

High-throughput

0.437

High

566673

VATA
V-type proton ATPase catalytic subunit A

1

2

High-throughput

0.437

High

630836

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

1

High-throughput

0.437

High

657109

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

1

High-throughput

0.437

High

689389

ARP2
Actin-related protein 2

1

1

High-throughput

0.437

High

697496

ATC5
Phospholipid-transporting ATPase DNF1

1

1

High-throughput

0.437

High

774676

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

1

High-throughput

0.437

High

811969

ARP3
Actin-related protein 3

1

1

High-throughput

0.437

High

996049

ATC4
Phospholipid-transporting ATPase DNF2

1

1

High-throughput

0.437

High

784441

COPB2
Coatomer subunit beta'

2

0

Small-scale

0.318

High

770032

YNU8
Uncharacterized protein YNL208W

2

0

High-throughput

0.305

High

420349

CALM
Calmodulin

1

0

Small-scale

0.292

High

410189

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

0

Small-scale

0.279

Low

774869

COPE
Coatomer subunit epsilon

1

0

Small-scale

0.279

Low

784361

COPB
Coatomer subunit beta

1

0

Small-scale

0.279

Low

784677

BNI1
Protein BNI1

1

0

High-throughput

0.261

Low

424148

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

0

High-throughput

0.249

Low

427303

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

0

High-throughput

0.249

Low

434715

CHS1
Chitin synthase 1

1

0

High-throughput

0.249

Low

549520

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.249

Low

604901

GAS1
1,3-beta-glucanosyltransferase GAS1

1

0

High-throughput

0.249

Low

619644

MPCP
Mitochondrial phosphate carrier protein

1

0

High-throughput

0.249

Low

620625

EXG1
Glucan 1,3-beta-glucosidase I/II

1

0

High-throughput

0.249

Low

626494

ERG6
Sterol 24-C-methyltransferase ERG6

1

0

High-throughput

0.249

Low

629591

CDC10
Cell division control protein 10

1

0

High-throughput

0.249

Low

679941

PMT2
Dolichyl-phosphate-mannose--protein mannosyltransferase 2

1

0

High-throughput

0.249

Low

691162

KRE6
Beta-glucan synthesis-associated protein KRE6

1

0

High-throughput

0.249

Low

699532

SSO1
Protein SSO1

1

0

High-throughput

0.249

Low

701610

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

745618

YBI1
Uncharacterized protein YBL081W

1

0

High-throughput

0.249

Low

745916

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

746963

ECM33
Cell wall protein ECM33

1

0

High-throughput

0.249

Low

751428

FKS1
1,3-beta-glucan synthase component FKS1

1

0

High-throughput

0.249

Low

752339

HXT5
Probable glucose transporter HXT5

1

0

High-throughput

0.249

Low

760836

TCPG
T-complex protein 1 subunit gamma

1

0

High-throughput

0.249

Low

766023

SPF1
Endoplasmic reticulum transmembrane helix translocase

1

0

High-throughput

0.249

Low

767983

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

0

High-throughput

0.249

Low

798124

COPD
Coatomer subunit delta

1

0

High-throughput

0.249

Low

811297

VTC4
Vacuolar transporter chaperone complex subunit 4

1

0

High-throughput

0.249

Low

858409

SEH1
Nucleoporin SEH1

1

0

High-throughput

0.249

Low

866807

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

972486

PDR12
ATP-dependent permease PDR12

1

0

High-throughput

0.249

Low

992461

VPS13
Intermembrane lipid transfer protein VPS13

1

0

High-throughput

0.249

Low

439763

PT111
Protein PET111, mitochondrial

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024