Protein: FRS2
Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1)

Gene: FRS2
Organism: Homo sapiens
Interactions: 90
UniProt ID: Q8WU20

Gene Ontology (top 5):
GO:0001702 - gastrulation with mouth forming second
GO:0001759 - organ induction
GO:0003281 - ventricular septum development
GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005104 - fibroblast growth factor receptor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

992487

SOS1
Son of sevenless homolog 1

5

2

Small-scale

0.906

High

985997

PTN11
Tyrosine-protein phosphatase non-receptor type 11

8

6

Small-scale

0.754

High

924725

GRB2
Growth factor receptor-bound protein 2

10

20

Small-scale

0.750

High

508122

FGFR1
Fibroblast growth factor receptor 1

8

20

Small-scale

0.750

High

610460

CBL
E3 ubiquitin-protein ligase CBL

3

5

Small-scale

0.664

High

601554

FGFR2
Fibroblast growth factor receptor 2

3

20

Small-scale

0.640

High

279656

FLOT1
Flotillin-1

2

2

Small-scale

0.631

High

1081545

NTRK3
NT-3 growth factor receptor

2

20

Small-scale

0.619

High

1083873

NTRK2
BDNF/NT-3 growth factors receptor

2

20

Small-scale

0.619

High

547152

EZRI
Ezrin

1

3

High-throughput

0.618

High

1035392

GAB1
GRB2-associated-binding protein 1

1

2

Small-scale

0.618

High

1259720

E41LA
Band 4.1-like protein 4A

1

2

High-throughput

0.618

High

1259724

GAB2
GRB2-associated-binding protein 2

1

1

Small-scale

0.618

High

385225

NTRK1
High affinity nerve growth factor receptor

2

20

Small-scale

0.606

High

434249

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

2

20

Small-scale

0.595

High

659007

MK01
Mitogen-activated protein kinase 1

2

4

Small-scale

0.594

High

1259721

ANLN
Anillin

1

0

High-throughput

0.586

High

338745

EGFR
Epidermal growth factor receptor

2

20

Small-scale

0.584

High

350391

RASK
GTPase KRas

2

6

High-throughput

0.584

High

433914

LYN
Tyrosine-protein kinase Lyn

2

20

Small-scale

0.584

High

872680

EPHA4
Ephrin type-A receptor 4

2

10

Small-scale

0.584

High

914243

RB11A
Ras-related protein Rab-11A

2

1

High-throughput

0.584

High

915865

RHOB
Rho-related GTP-binding protein RhoB

2

16

High-throughput

0.584

High

916721

RS6
Small ribosomal subunit protein eS6

2

1

High-throughput

0.576

High

1259722

SH2B1
SH2B adapter protein 1

1

20

Small-scale

0.575

High

1259715

SRBS1
Sorbin and SH3 domain-containing protein 1

1

9

Small-scale

0.573

High

1054170

BECN1
Beclin-1

2

0

High-throughput

0.551

High

784053

KPCI
Protein kinase C iota type

1

2

Small-scale

0.527

High

411450

INSR
Insulin receptor

1

18

Small-scale

0.501

High

647635

MK03
Mitogen-activated protein kinase 3

1

4

Small-scale

0.501

High

802675

CRK
Adapter molecule crk

1

20

Small-scale

0.501

High

960109

CDK3
Cyclin-dependent kinase 3

1

1

High-throughput

0.481

High

1038008

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

High-throughput

0.481

High

155411

NRP1
Neuropilin-1

1

1

High-throughput

0.479

High

178692

STX7
Syntaxin-7

1

1

High-throughput

0.479

High

208173

SPY2
Protein sprouty homolog 2

1

1

Small-scale

0.479

High

318194

DIRA3
GTP-binding protein Di-Ras3

1

3

High-throughput

0.479

High

348822

RASN
GTPase NRas

1

6

High-throughput

0.479

High

411805

LCK
Tyrosine-protein kinase Lck

1

20

High-throughput

0.479

High

436429

RHOC
Rho-related GTP-binding protein RhoC

1

14

High-throughput

0.479

High

452461

PGFRB
Platelet-derived growth factor receptor beta

1

13

Small-scale

0.479

High

545522

RAC2
Ras-related C3 botulinum toxin substrate 2

1

13

High-throughput

0.479

High

564628

RHOQ
Rho-related GTP-binding protein RhoQ

1

17

High-throughput

0.479

High

567193

CXA1
Gap junction alpha-1 protein

1

2

High-throughput

0.479

High

591949

RAB4A
Ras-related protein Rab-4A

1

1

High-throughput

0.479

High

592399

RAB5A
Ras-related protein Rab-5A

1

1

High-throughput

0.479

High

608060

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.479

High

609443

FGFR3
Fibroblast growth factor receptor 3

1

20

High-throughput

0.479

High

666626

LTK
Leukocyte tyrosine kinase receptor

1

20

High-throughput

0.479

High

670130

MARCS
Myristoylated alanine-rich C-kinase substrate

1

3

High-throughput

0.479

High

713853

RYK
Tyrosine-protein kinase RYK

1

20

High-throughput

0.479

High

845632

RAB9A
Ras-related protein Rab-9A

1

3

High-throughput

0.479

High

850685

KS6A3
Ribosomal protein S6 kinase alpha-3

1

2

High-throughput

0.479

High

876454

AFAD
Afadin

1

5

High-throughput

0.479

High

884550

RAB25
Ras-related protein Rab-25

1

1

High-throughput

0.479

High

892505

RAC3
Ras-related C3 botulinum toxin substrate 3

1

15

High-throughput

0.479

High

894251

CDC42
Cell division control protein 42 homolog

1

18

High-throughput

0.479

High

900731

RHOA
Transforming protein RhoA

1

15

High-throughput

0.479

High

925468

RAC1
Ras-related C3 botulinum toxin substrate 1

1

15

High-throughput

0.479

High

940507

CXAR
Coxsackievirus and adenovirus receptor

1

1

High-throughput

0.479

High

951184

RHOG
Rho-related GTP-binding protein RhoG

1

13

High-throughput

0.479

High

974945

CAV1
Caveolin-1

1

1

High-throughput

0.479

High

1017728

STX4
Syntaxin-4

1

1

High-throughput

0.479

High

1066444

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

1070322

RAB35
Ras-related protein Rab-35

1

3

High-throughput

0.479

High

1071664

KS6A2
Ribosomal protein S6 kinase alpha-2

1

2

High-throughput

0.479

High

1073455

KS6A1
Ribosomal protein S6 kinase alpha-1

1

2

High-throughput

0.479

High

1084117

OCLN
Occludin

1

1

High-throughput

0.479

High

1110036

AR13B
ADP-ribosylation factor-like protein 13B

1

1

High-throughput

0.479

High

1140659

RN123
E3 ubiquitin-protein ligase RNF123

1

4

High-throughput

0.479

High

1148141

RNF43
E3 ubiquitin-protein ligase RNF43

1

4

High-throughput

0.479

High

1183478

RHOU
Rho-related GTP-binding protein RhoU

1

19

High-throughput

0.479

High

1230298

CXD3
Gap junction delta-3 protein

1

2

High-throughput

0.479

High

1256849

PARD3
Partitioning defective 3 homolog

1

1

High-throughput

0.479

High

1259717

DNJC5
DnaJ homolog subfamily C member 5

1

2

High-throughput

0.479

High

1259718

RHOJ
Rho-related GTP-binding protein RhoJ

1

17

High-throughput

0.479

High

1259719

RHOF
Rho-related GTP-binding protein RhoF

1

18

High-throughput

0.479

High

1259723

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.479

High

212949

STX6
Syntaxin-6

1

0

High-throughput

0.458

High

305562

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.458

High

522091

CADH1
Cadherin-1

1

0

High-throughput

0.458

High

577046

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

0

High-throughput

0.458

High

793407

MUC18
Cell surface glycoprotein MUC18

1

0

High-throughput

0.458

High

913014

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

1152002

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.458

High

1259716

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

1259714

YJU2
Splicing factor YJU2

1

1

High-throughput

0.439

High

1259713

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.437

High

132546

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

1203790

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024