Protein: BMP4
Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B)

Gene: BMP4
Organism: Homo sapiens
Interactions: 166
UniProt ID: P12644

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001649 - osteoblast differentiation
GO:0001656 - metanephros development
GO:0001657 - ureteric bud development
GO:0001658 - branching involved in ureteric bud morphogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

554174

BMR1A
Bone morphogenetic protein receptor type-1A

5

20

Small-scale

0.915

High

554221

BMPR2
Bone morphogenetic protein receptor type-2

4

20

Small-scale

0.890

High

282820

CRLF1
Cytokine receptor-like factor 1

1

1

High-throughput

0.691

High

128525

BMR1B
Bone morphogenetic protein receptor type-1B

1

20

Small-scale

0.647

High

554158

AVR2A
Activin receptor type-2A

1

20

Small-scale

0.647

High

554220

FSTL1
Follistatin-related protein 1

1

9

Small-scale

0.647

High

554231

RGMB
Repulsive guidance molecule B

1

6

Small-scale

0.647

High

554161

CALR
Calreticulin

2

6

High-throughput

0.628

High

554252

TWSG1
Twisted gastrulation protein homolog 1

2

3

Small-scale

0.619

High

554228

CEA21
Cell adhesion molecule CEACAM21

1

3

High-throughput

0.618

High

554251

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

2

0

High-throughput

0.602

High

554269

SUFU
Suppressor of fused homolog

2

0

High-throughput

0.602

High

554170

TNFL8
Tumor necrosis factor ligand superfamily member 8

2

1

High-throughput

0.601

High

533571

CLUS
Clusterin

2

0

High-throughput

0.585

High

554232

SOSD1
Sclerostin domain-containing protein 1

2

2

Small-scale

0.584

High

554184

NMU
Neuromedin-U [Cleaved into: Neuromedin precursor-related peptide 36

2

0

High-throughput

0.576

High

554153

BMP5
Bone morphogenetic protein 5

1

17

High-throughput

0.575

High

554261

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

2

1

High-throughput

0.574

High

253425

CST8
Cystatin-8

1

1

High-throughput

0.536

High

326996

NXPH2
Neurexophilin-2

1

1

High-throughput

0.536

High

452077

PROS
Vitamin K-dependent protein S

1

14

High-throughput

0.536

High

469703

MMP3
Stromelysin-1

1

6

High-throughput

0.536

High

480398

MMP10
Stromelysin-2

1

6

High-throughput

0.536

High

506819

CFC1
Cryptic protein

1

10

High-throughput

0.536

High

554144

PRG2
Bone marrow proteoglycan

1

4

High-throughput

0.536

High

554212

IL5RA
Interleukin-5 receptor subunit alpha

1

3

High-throughput

0.536

High

554224

EP3A
Epididymal secretory protein E3-alpha

1

1

High-throughput

0.536

High

554226

ADIPO
Adiponectin

1

12

High-throughput

0.536

High

554245

CALR3
Calreticulin-3

1

6

High-throughput

0.536

High

554248

GPX7
Glutathione peroxidase 7

1

1

High-throughput

0.536

High

554255

SDF2L
Stromal cell-derived factor 2-like protein 1

1

1

High-throughput

0.536

High

554257

CBLN4
Cerebellin-4

1

11

High-throughput

0.536

High

554267

METRN
Meteorin

1

1

High-throughput

0.536

High

554268

FBX2
F-box only protein 2

1

7

High-throughput

0.536

High

554272

CLC11
C-type lectin domain family 11 member A

1

3

High-throughput

0.536

High

554275

LIPG
Endothelial lipase

1

2

High-throughput

0.536

High

127809

CORT
Cortistatin [Cleaved into: Cortistatin-29; Cortistatin-17]

1

0

High-throughput

0.513

High

423733

APOD
Apolipoprotein D

1

0

High-throughput

0.513

High

472378

FGF4
Fibroblast growth factor 4

1

0

High-throughput

0.513

High

554227

P3H1
Prolyl 3-hydroxylase 1

1

0

High-throughput

0.513

High

554234

IFNE
Interferon epsilon

1

0

High-throughput

0.513

High

554249

CGRE1
Cell growth regulator with EF hand domain protein 1

1

0

High-throughput

0.513

High

554260

IL20
Interleukin-20

1

0

High-throughput

0.513

High

554142

TDGF1
Protein Cripto

1

10

Small-scale

0.501

High

554210

TSG6
Tumor necrosis factor-inducible gene 6 protein

1

16

Small-scale

0.501

High

554237

WFKN2
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2

1

19

Small-scale

0.501

High

554246

WFKN1
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1

1

13

Small-scale

0.501

High

250433

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

1

High-throughput

0.479

High

345311

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

521515

H14
Histone H1.4

1

2

High-throughput

0.479

High

534563

BIP
Endoplasmic reticulum chaperone BiP

1

4

High-throughput

0.479

High

554143

BMP1
Bone morphogenetic protein 1

1

11

Small-scale

0.479

High

554147

H12
Histone H1.2

1

2

High-throughput

0.479

High

554151

EGR1
Early growth response protein 1

1

3

High-throughput

0.479

High

554155

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

554157

PTBP1
Polypyrimidine tract-binding protein 1

1

1

High-throughput

0.479

High

554160

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.479

High

554167

DNJA1
DnaJ homolog subfamily A member 1

1

3

High-throughput

0.479

High

554172

HNF1B
Hepatocyte nuclear factor 1-beta

1

3

High-throughput

0.479

High

554176

IF4A3
Eukaryotic initiation factor 4A-III

1

3

High-throughput

0.479

High

554196

RS15A
Small ribosomal subunit protein uS8

1

1

High-throughput

0.479

High

554201

RS6
Small ribosomal subunit protein eS6

1

1

High-throughput

0.479

High

554204

RL11
Large ribosomal subunit protein uL5

1

1

High-throughput

0.479

High

554206

YBOX1
Y-box-binding protein 1

1

1

High-throughput

0.479

High

554207

SRPK2
SRSF protein kinase 2

1

2

High-throughput

0.479

High

554211

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

3

High-throughput

0.479

High

554218

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

2

High-throughput

0.479

High

554225

PCBP1
Poly(rC)-binding protein 1

1

4

High-throughput

0.479

High

446597

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

554154

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.458

High

554171

RL22
Large ribosomal subunit protein eL22

1

0

High-throughput

0.458

High

554180

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.458

High

554183

RS9
Small ribosomal subunit protein uS4

1

0

High-throughput

0.458

High

554194

RS7
Small ribosomal subunit protein eS7

1

0

High-throughput

0.458

High

554202

RL23
Large ribosomal subunit protein uL14

1

0

High-throughput

0.458

High

554219

DHX9
ATP-dependent RNA helicase A

1

0

High-throughput

0.458

High

554241

ZN622
Cytoplasmic 60S subunit biogenesis factor ZNF622

1

0

High-throughput

0.458

High

554250

GTPB4
GTP-binding protein 4

1

0

High-throughput

0.458

High

69473

A2ML1
Alpha-2-macroglobulin-like protein 1

1

6

High-throughput

0.445

High

424479

PAI2
Plasminogen activator inhibitor 2

1

8

High-throughput

0.445

High

554165

ILEU
Leukocyte elastase inhibitor

1

8

High-throughput

0.445

High

554175

SPB5
Serpin B5

1

8

High-throughput

0.445

High

554193

LYSC
Lysozyme C

1

2

High-throughput

0.445

High

554222

TRI29
Tripartite motif-containing protein 29

1

4

High-throughput

0.445

High

554233

FBX50
F-box only protein 50

1

7

High-throughput

0.445

High

554235

RDHE2
Epidermal retinol dehydrogenase 2

1

1

High-throughput

0.445

High

554244

S10AG
Protein S100-A16

1

3

High-throughput

0.445

High

554256

S10AE
Protein S100-A14

1

3

High-throughput

0.445

High

554266

SPB13
Serpin B13

1

8

High-throughput

0.445

High

554150

RL7
Large ribosomal subunit protein uL30

1

1

High-throughput

0.437

High

554156

RL13
Large ribosomal subunit protein eL13

1

1

High-throughput

0.437

High

554162

MAP4
Microtubule-associated protein 4

1

3

High-throughput

0.437

High

554164

RL12
Large ribosomal subunit protein uL11

1

1

High-throughput

0.437

High

554169

RL9
Large ribosomal subunit protein uL6

1

1

High-throughput

0.437

High

554179

RL27A
Large ribosomal subunit protein uL15

1

1

High-throughput

0.437

High

554186

FXR2
RNA-binding protein FXR2

1

2

High-throughput

0.437

High

554188

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

1

High-throughput

0.437

High

554190

RS3A
Small ribosomal subunit protein eS1

1

1

High-throughput

0.437

High

554195

RS8
Small ribosomal subunit protein eS8

1

1

High-throughput

0.437

High

554198

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.437

High

554199

RS11
Small ribosomal subunit protein uS17

1

1

High-throughput

0.437

High

554200

RL23A
Large ribosomal subunit protein uL23

1

1

High-throughput

0.437

High

554213

EWS
RNA-binding protein EWS

1

9

High-throughput

0.437

High

554223

RBM39
RNA-binding protein 39

1

2

High-throughput

0.437

High

554236

DDX54
ATP-dependent RNA helicase DDX54

1

4

High-throughput

0.437

High

554247

SRPK1
SRSF protein kinase 1

1

2

High-throughput

0.437

High

554258

DDX18
ATP-dependent RNA helicase DDX18

1

2

High-throughput

0.437

High

554262

NHSL3
NHS-like protein 3

1

1

High-throughput

0.437

High

554265

PUF60
Poly(U)-binding-splicing factor PUF60

1

2

High-throughput

0.437

High

554271

SRRM2
Serine/arginine repetitive matrix protein 2

1

1

High-throughput

0.437

High

126222

ST2B1
Sulfotransferase 2B1

1

0

High-throughput

0.426

High

143960

EST2
Cocaine esterase

1

0

High-throughput

0.426

High

554152

IL1RA
Interleukin-1 receptor antagonist protein

1

0

High-throughput

0.426

High

554166

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

0

High-throughput

0.426

High

554242

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.426

High

554243

BPIA2
BPI fold-containing family A member 2

1

0

High-throughput

0.426

High

248660

PEPL
Periplakin

1

2

High-throughput

0.407

High

554145

PLST
Plastin-3

1

2

High-throughput

0.407

High

554159

CALL3
Calmodulin-like protein 3

1

1

High-throughput

0.407

High

554163

RABP2
Cellular retinoic acid-binding protein 2

1

2

High-throughput

0.407

High

554168

DSG3
Desmoglein-3

1

2

High-throughput

0.407

High

554230

AXA81
Annexin A8-like protein 1

1

1

High-throughput

0.407

High

554239

EVPL
Envoplakin

1

2

High-throughput

0.407

High

554253

ES8L2
Epidermal growth factor receptor kinase substrate 8-like protein 2

1

1

High-throughput

0.407

High

554264

CRNN
Cornulin

1

3

High-throughput

0.407

High

554274

PKP3
Plakophilin-3

1

4

High-throughput

0.407

High

50084

S22AN
Solute carrier family 22 member 23

2

0

High-throughput

0.328

High

554259

DCA16
DDB1- and CUL4-associated factor 16

2

0

High-throughput

0.328

High

164725

HS3S1
Heparan sulfate glucosamine 3-O-sulfotransferase 1

1

0

High-throughput

0.279

Low

554216

KIME
Mevalonate kinase

1

0

High-throughput

0.279

Low

336057

ZFYV9
Zinc finger FYVE domain-containing protein 9

1

0

High-throughput

0.265

Low

212146

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

0

High-throughput

0.249

Low

428585

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.249

Low

484878

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.249

Low

541798

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.249

Low

550098

PABP1
Polyadenylate-binding protein 1

1

0

High-throughput

0.249

Low

554149

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.249

Low

554173

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.249

Low

554177

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.249

Low

554181

RL21
Large ribosomal subunit protein eL21

1

0

High-throughput

0.249

Low

554182

RL28
Large ribosomal subunit protein eL28

1

0

High-throughput

0.249

Low

554185

RL14
Large ribosomal subunit protein eL14

1

0

High-throughput

0.249

Low

554189

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

554191

RL26
Large ribosomal subunit protein uL24

1

0

High-throughput

0.249

Low

554192

RL27
Large ribosomal subunit protein eL27

1

0

High-throughput

0.249

Low

554197

RS23
Small ribosomal subunit protein uS12

1

0

High-throughput

0.249

Low

554203

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.249

Low

554205

RL8
Large ribosomal subunit protein uL2

1

0

High-throughput

0.249

Low

554208

RT15
Small ribosomal subunit protein uS15m

1

0

High-throughput

0.249

Low

554209

RL19
Large ribosomal subunit protein eL19

1

0

High-throughput

0.249

Low

554214

RL18A
Large ribosomal subunit protein eL20

1

0

High-throughput

0.249

Low

554215

RL6
Large ribosomal subunit protein eL6

1

0

High-throughput

0.249

Low

554217

RL18
Large ribosomal subunit protein eL18

1

0

High-throughput

0.249

Low

554238

H1X
Histone H1.10

1

0

High-throughput

0.249

Low

554240

RENT1
Regulator of nonsense transcripts 1

1

0

High-throughput

0.249

Low

554270

DIM1
Dimethyladenosine transferase

1

0

High-throughput

0.249

Low

554273

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.249

Low

554229

CL060
Uncharacterized protein C12orf60

1

0

High-throughput

0.238

Low

328420

SCEL
Sciellin

1

0

High-throughput

0.232

Low

348848

CLIC3
Chloride intracellular channel protein 3

1

0

High-throughput

0.232

Low

554146

CBR1
Carbonyl reductase [NADPH] 1

1

0

High-throughput

0.232

Low

554148

AK1C4
Aldo-keto reductase family 1 member C4

1

0

High-throughput

0.232

Low

554178

ADH7
All-trans-retinol dehydrogenase [NAD(+)] ADH7

1

0

High-throughput

0.232

Low

554187

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

1

0

High-throughput

0.232

Low

554254

PAAT
ATPase PAAT

1

0

High-throughput

0.232

Low

554263

SPRR3
Small proline-rich protein 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025