Protein: HMCS2
Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase)

Gene: HMCS2, HMGCS2
Organism: Homo sapiens
Interactions: 13
UniProt ID: P54868

Gene Ontology (top 5):
GO:0001822 - kidney development
GO:0001889 - liver development
GO:0004421 - hydroxymethylglutaryl-CoA synthase activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

932825

MYOME
Myomegalin

2

1

High-throughput

0.558

High

932829

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

932826

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

Small-scale

0.460

High

932822

1433Z
14-3-3 protein zeta/delta

1

1

High-throughput

0.445

High

690853

1433T
14-3-3 protein theta

1

1

High-throughput

0.437

High

932824

CUL4A
Cullin-4A

1

1

High-throughput

0.437

High

340858

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

2

0

High-throughput

0.328

High

932827

TX101
Testis-expressed protein 101

1

0

High-throughput

0.279

Low

932828

SSRG
Translocon-associated protein subunit gamma

1

0

High-throughput

0.279

Low

772697

MYH9
Myosin-9

1

0

High-throughput

0.269

Low

421787

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.261

Low

576329

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

0

High-throughput

0.249

Low

932823

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025