Protein: UBA1
Ubiquitin-activating enzyme E1 1 (EC 6.2.1.45)

Gene: UBA1
Organism: Saccharomyces cerevisiae S288C
Interactions: 95
UniProt ID: P22515

Gene Ontology (top 5):
GO:0004839 - ubiquitin activating enzyme activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0006511 - ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

410211

UBC2
Ubiquitin-conjugating enzyme E2 2

7

20

Small-scale

0.959

High

539443

UBC3
Ubiquitin-conjugating enzyme E2-34 kDa

6

20

Small-scale

0.952

High

600919

UBC1
Ubiquitin-conjugating enzyme E2 1

5

20

Small-scale

0.924

High

477133

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

5

17

Small-scale

0.924

High

549788

UBC4
Ubiquitin-conjugating enzyme E2 4

4

20

Small-scale

0.888

High

608684

UBC6
Ubiquitin-conjugating enzyme E2 6

3

20

Small-scale

0.866

High

608719

UBC7
Ubiquitin-conjugating enzyme E2 7

3

20

Small-scale

0.845

High

608679

UBCX
Ubiquitin-conjugating enzyme E2-21 kDa

2

20

Small-scale

0.778

High

608714

UBC13
Ubiquitin-conjugating enzyme E2 13

1

19

High-throughput

0.691

High

608672

UBA1
Ubiquitin-activating enzyme E1 1

1

12

Small-scale

0.647

High

608711

UBC9
SUMO-conjugating enzyme UBC9

1

20

Small-scale

0.647

High

608715

UBC12
NEDD8-conjugating enzyme UBC12

1

20

Small-scale

0.647

High

608687

SERC
Phosphoserine aminotransferase

3

0

High-throughput

0.634

High

608701

SSB2
Ribosome-associated molecular chaperone SSB2

3

9

High-throughput

0.611

High

608708

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

3

High-throughput

0.584

High

408274

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

9

Small-scale

0.575

High

365811

HSP82
ATP-dependent molecular chaperone HSP82

2

3

High-throughput

0.571

High

367748

EF1A
Elongation factor 1-alpha

2

1

Small-scale

0.571

High

543217

HSC82
ATP-dependent molecular chaperone HSC82

2

3

High-throughput

0.571

High

493227

HSP72
Heat shock protein SSA2

2

9

High-throughput

0.552

High

549704

STI1
Heat shock protein STI1

1

6

High-throughput

0.536

High

586360

PRP6
Pre-mRNA-splicing factor 6

1

3

High-throughput

0.536

High

608673

KC11
Casein kinase I homolog 1

1

2

High-throughput

0.536

High

608683

HSP79
Heat shock protein homolog SSE2

1

15

High-throughput

0.515

High

608692

KSP1
Serine/threonine-protein kinase KSP1

1

2

High-throughput

0.515

High

526187

KIN2
Serine/threonine-protein kinase KIN2

1

0

High-throughput

0.513

High

608709

CTK3
CTD kinase subunit gamma

1

0

High-throughput

0.513

High

608713

GCH1
GTP cyclohydrolase 1

1

0

High-throughput

0.513

High

608731

RAD59
DNA repair protein RAD59

1

0

High-throughput

0.513

High

608678

HRR25
Casein kinase I homolog HRR25

1

1

High-throughput

0.501

High

608691

CHK1
Serine/threonine-protein kinase CHK1

1

2

High-throughput

0.501

High

608699

KC13
Casein kinase I homolog 3

1

2

High-throughput

0.501

High

608706

SMK1
Sporulation-specific mitogen-activated protein kinase SMK1

1

2

High-throughput

0.501

High

608712

MRK1
Serine/threonine-protein kinase MRK1

1

2

High-throughput

0.501

High

608733

SKS1
Serine/threonine-protein kinase SKS1

1

2

High-throughput

0.501

High

423512

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

0

High-throughput

0.493

High

608680

CYS3
Cystathionine gamma-lyase

1

0

High-throughput

0.493

High

608689

NU133
Nucleoporin NUP133

1

0

High-throughput

0.493

High

608690

DPOA2
DNA polymerase alpha subunit B

1

0

High-throughput

0.493

High

608696

IPL1
Spindle assembly checkpoint kinase

1

0

High-throughput

0.493

High

608718

CSL4
Exosome complex component CSL4

1

0

High-throughput

0.493

High

608703

ULP2
Ubiquitin-like-specific protease 2

1

2

High-throughput

0.481

High

608704

MPH1
ATP-dependent DNA helicase MPH1

1

2

Small-scale

0.481

High

608720

ULP1
Ubiquitin-like-specific protease 1

1

2

High-throughput

0.481

High

608734

CMR1
DNA damage-binding protein CMR1

1

2

High-throughput

0.481

High

381423

GAL1
Galactokinase

1

0

High-throughput

0.479

High

485648

IF4A
ATP-dependent RNA helicase eIF4A

1

2

High-throughput

0.479

High

605904

RAD53
Serine/threonine-protein kinase RAD53

1

2

High-throughput

0.479

High

608675

SIS1
Protein SIS1

1

4

High-throughput

0.479

High

608677

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

608681

HS104
Heat shock protein 104

1

2

High-throughput

0.479

High

608693

ECM29
Proteasome component ECM29

1

1

High-throughput

0.479

High

608698

DHH1
ATP-dependent RNA helicase DHH1

1

1

High-throughput

0.479

High

567928

MDHM
Malate dehydrogenase, mitochondrial

1

0

Small-scale

0.458

High

608685

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

608694

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

608695

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

608717

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

608721

ESP1
Separin

1

0

High-throughput

0.458

High

608722

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

608725

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

608726

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

608729

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

608730

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.458

High

424349

PYR1
Multifunctional protein URA2

1

2

High-throughput

0.445

High

490369

HSP71
Heat shock protein SSA1

1

9

High-throughput

0.445

High

510292

SSB1
Ribosome-associated molecular chaperone SSB1

1

9

High-throughput

0.445

High

555820

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.445

High

587936

HSP60
Heat shock protein 60, mitochondrial

1

1

High-throughput

0.445

High

608676

SCJ1
DnaJ-related protein SCJ1

1

2

High-throughput

0.445

High

608682

HSP7F
Heat shock protein homolog SSE1

1

15

High-throughput

0.445

High

608686

PRS7
26S proteasome regulatory subunit 7 homolog

1

2

High-throughput

0.445

High

608688

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.445

High

608707

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.445

High

608727

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

3

High-throughput

0.445

High

340028

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.426

High

360746

TBB
Tubulin beta chain

1

0

High-throughput

0.426

High

454190

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.426

High

597283

PSA1
Proteasome subunit alpha type-1

1

0

High-throughput

0.426

High

608674

PSA3
Proteasome subunit alpha type-3

1

0

High-throughput

0.426

High

608697

TCPZ
T-complex protein 1 subunit zeta

1

0

High-throughput

0.426

High

608710

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.426

High

608702

JEM1
DnaJ-like chaperone JEM1

1

2

High-throughput

0.407

High

608705

DJP1
DnaJ-like protein 1

1

2

High-throughput

0.407

High

608723

YD415
Probable aminopeptidase YDR415C

2

0

High-throughput

0.307

High

420227

CALM
Calmodulin

1

0

High-throughput

0.279

Low

608724

SEN15
tRNA-splicing endonuclease subunit SEN15

1

0

High-throughput

0.279

Low

427179

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

0

High-throughput

0.269

Low

608732

RAX2
Bud site selection protein RAX2

1

0

High-throughput

0.269

Low

343537

PMG1
Phosphoglycerate mutase 1

1

0

High-throughput

0.261

Low

608716

MPS2
Monopolar spindle protein 2

1

0

Small-scale

0.251

Low

608700

DPO5
rDNA transcriptional regulator POL5

1

0

High-throughput

0.249

Low

608728

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

540030

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024